Ringer Lactate solution is an isotonic solution of electrolytes. The constituents of Ringer Lactate and their concentrations are designed to match those of plasma.
The pharmacokinetic properties of the solution are those of its constituents (sodium, potassium, calcium and chloride).
The main effect of Ringer Lactate is the expansion of the extracellular compartment including both the interstitial fluid and the intravascular fluid.
The lactate is metabolised into bicarbonate, mainly in the liver, and produces an alkalinising effect on the plasma.
In healthy volunteers receiving Ringer Lactate, central venous pressure changes were associated with a secretion of atrial natriuretic peptide.
In healthy volunteers, Ringer Lactate decreased serum osmolality, increased blood pH, and the time until first urination was shorter than that with normal saline.
There is no significant changes in glucagon, norepinephrine, epinephrine, blood glucose and insulin levels in aortic surgery patients receiving Ringer Lactate.
When medication is added to Ringer Lactate, the overall pharmacodynamics of the solution will depend on the nature of the drug used.
Pharmacotherapeutic group: plasma substitutes and infusion solutions / electrolytes, ATC code: B05BB01 (B: blood and haemopoietic organs)
Ringer Lactate solution is an isotonic solution of electrolytes. The constituents of Ringer Lactate and their concentrations are designed to match those of plasma.
The pharmacodynamic properties of the solution are those of its constituents (sodium, potassium, calcium and chloride).
The main effect of Ringer Lactate is the expansion of the extracellular compartment including both the interstitial fluid and the intravascular fluid.
The lactate is metabolised into bicarbonate, mainly in the liver, and produces an alkalinising effect on the plasma.
In healthy volunteers receiving Ringer Lactate, central venous pressure changes were associated with a secretion of atrial natriuretic peptide.
In healthy volunteers, Ringer Lactate decreased serum osmolality, increased blood pH, and the time until first urination was shorter than that with normal saline.
There is no significant changes in glucagon, norepinephrine, epinephrine, blood glucose and insulin levels in aortic surgery patients receiving Ringer Lactate.
When medication is added to Ringer Lactate, the overall pharmacodynamics of the solution will depend on the nature of the drug used.