My HPRA: Register

Medicinal Product Shortages

The HPRA is responsible for co-ordinating the management of shortages of human medicines on the Irish market. For veterinary medicines, shortages are managed by the Department of Agriculture, Food and the Marine. 

The HPRA works with a variety of stakeholders including manufacturers, wholesale distributors, marketing authorisation holders, healthcare professionals, the Health Service Executive, patients and representative groups to respond to potential shortages and reduce the impact of shortages on patients.

The definition of a shortage is when the supply of a medicinal product is inadequate to meet the needs of the patient. 

The HPRA, in collaboration with stakeholders, has published a framework for a multi-stakeholder approach to handling shortages of human medicinal products. The aim of the framework is to help prevent shortages from occurring and to reduce the impact of shortages on patients by co-ordinating the management of potential or actual shortages as they arise. You can see the shortages case study on Adrenaline auto-injectors (AAIs) as an example of how the framework operates in practice. 


Information on reporting shortages for:

Marketing Authorisation Holders

Please complete the Notification of medicinal product shortage from marketing authorisation holder form and return to  shortages@hpra.ie and to the HSE Corporate Pharmaceutical Unit.

Wholesale Distributors and Manufacturers

Please complete the Report of medicinal product shortage affecting the Irish market from wholesale distributors and manufacturers form and return this form to  shortages@hpra.ie.

Patients and Healthcare Professionals

Please complete the Report of medicinal product shortage affecting the Irish market from patients and healthcare professionals form and return to  shortages@hpra.ie. When completing this form, please include as much information as possible.

Veterinary Medicines

Please contact the Department of Agriculture, Food and the Marine.

 

Current and resolved shortages

The HPRA publishes a list of shortages currently affecting the Irish market that have been notified to us and that may have a medium or high impact on patients. This list can be found below. More information on the impact level can be found in the framework for a multi-stakeholder approach to handling shortages of human medicinal products.

The HPRA maintains a consolidated list of resolved shortages for a period of six months. Details of shortages that have been resolved in the last six months can be found 
here.
 


Please use search function below to find relevant product or active ingredient


Product name Active ingredient Reason for shortage Date of shortage
 Additional information
Acetylcysteine Essential-Healthcare 600mg Effervescent Tablets

PA2130/002/001
 Acetylcysteine
 Manufacturing delays 

(multiple countries affected)		 Date of shortage: 
Late December 2021 

Expected return date: 
Mid February 2022		 Last updated:
11th January 2022 
Adizem-XL 180mg Prolonged Release Capsules 

PA1688/001/005  
  Diltiazem
 Manufacturing delays 

(multiple countries affected)		 Date of shortage: 
Week commencing 31st January 

Expected return date:
16th March 2022		 Last updated: 
17th January 2022
Adrenaline (Epinephrine) 1:1,000 Solution for Injection

PA0073/035/001
 Adrenaline
 Unexpected increase in demand  Date of shortage: 
Late November 2021 

Expected return date: 
February  2022 		 Last updated: 
29th November 2021

HCP Letter
Aripiprazole 15mg Tablets

PA1986/019/003 
  Aripiprazole Manufacturing delays Date of shortage:
20th December 2021

Expected return date:
Week commencing 31st January 2022
 Last updated: 
10th December 2021 
Axsain 0.075% w/w Cream

PA1986/088/001
 Capsacin  Manufacturing delays 

(multiple countries affected) 		 Date of shortage: 
Week commencing 15th November 2021 

Expected return date:
January 2022		 Last updated: 
17th December 2021
BCG-Medac Powder and Solvent for Suspension for Intravesical Use

PA0623/004/001 		 Bacillus Calmette Guerin bacteria  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
1st October 2019

Expected return date:
2022		 Last updated:
3rd February 2021
Beromun 1mg Powder for Solution for Infusion

EU/1/99/097/001 		 Tasonermin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
December 2020

Expected return date:
Awaiting update		 Last updated:
21st January 2022
Bonviva 3mg/ml Solution for Injection

EU/1/03/265/5-6
 Ibandronic Acid Awaiting information  Date of shortage:
Mid November 2021 

Expected return date: 
Awaiting information  
 Last updated: 
19th November 2021
Calcium Acetate 500mg Tablets

PA0281/063/001
 Calcium Acetate API unavailability  Date of shortage: 
Week commencing 26th July 2021

Expected return date: 
Awaiting update		 Last updated: 
11th January 2022
Cefotaxime 1g Powder for solution for injection or infusion

PA0281/223/002 
 Cefotaxime Manufacturing delays  Date of shortage: 
30th November 2021 

Expected return date: 
Awaiting update
 Last updated: 
24th November 2021
 
Champix 0.5mg Film Coated Tablet

EU/1/06/360/001
 Varenicline 
 Quality issue

(multiple countries affected)		 Date of shortage: 
Week commencing 21st June 2021 

Expected return date: 
Unknown at present 		 Last updated:
18th June 2021

HCP letter
Champix 1mg Film Coated Tablet

EU/1/06/360/005
 Varenicline Quality issue

(multiple countries affected)		 Date of shortage: 
Week commencing 21st June

Expected return date: 
Unknown at present 		 Last updated: 
18th June 2021

HCP letter
Champix 0.5 mg + 1 mg Film Coated Tablet

EU/1/06/360/003
 Varenicline 
 Quality issue 

(multiple countries affected)		 Date of shortage: 
Week commencing 21st June 

Expected return date: 
Unknown at present 		 Last updated: 
18th June 2021

HCP letter
Chlorhexidine Acetate 0.015% w/v and Cetrimide 0.15% w/v Irrigation Solution

PA2299/005/001
 Chlorhexidine acetate & cetrimide
 Unexpected increase in demand Date of shortage: 
September 2021 

Expected return date: 
Awaiting update		 Last updated: 
11th January 2022
Chlorpromazine Elixir BP 25mg/5ml Oral Solution

PA0281/124/001 		 Chlorpromazine hydrochloride  Manufacturing delays  Date of shortage:
End of February 2021

Expected return date:
End January 2022		 Last updated:
5th October 2021
 
HCP letter
Cholestagel 625mg Film Coated Tablets

EU/1/03/268/003
 Colesevelam  Unexpected increase in demand 

(multiple countries affected) 		 Date of shortage: 
17th November 2021 

Expected return date: 
Late January 2022  		 Last updated: 
5th January 2022
Ciprofloxacin 2mg/ml Solution for Infusion

PA1122/005/001

(200ml presentation only)		 Ciprofloxacin   Shipping delay  Date of shortage: 
Late December 2021

Expected return date: 
Awaiting update		 Last updated: 
14th January 2022
Claforan Powder for Solution for Injection 500mg

PA0540/037/002		 Cefotaxime Unexpected increase in demand Date of shortage:
Late December 2022

Expected return date:
Mid February 2022		 Last updated:
21st January 2022
Claforan Powder for Solution for Injection 1g

PA0540/037/003
 Cefotaxime Unexpected increase in demand  Date of shortage: 
 Week commencing 24th January 2022

Expected return date: 
Mid February 2022		 Last updated: 
21st January 2022
Clarithromycin 500mg Powder for Concentrate for Solution for Infusion

PA1142/022/001
Clarithromycin		 Manufacturing delays  Date of shortage: 
End of November 
2021

Expected return date: 
March 2022		 Last updated: 
15th November 2021
Clexane 6,000 IU (60mg) /0.6 mL Solution for Injection in Pre-Filled Syringes

PA0540/097/006
 Enoxaparin sodium
 Manufacturing delays 

(multiple countries affected)		 Date of shortage: 
27th December 2021

Expected return date: March 2022		 Last updated: 
5th January 2021

HCP letter
Clexane Forte 12,000 IU (120mg) /0.8ml Solution for Injection in Pre Filled Syringes 

PA0540/097/008
 Enoxaparin sodium  API unavailability   Date of shortage: 
22nd October 2021 

Expected return date: 
January 2022		 Last updated: 
10th December 2021

HCP letter
Co-Amoxiclav 500mg/100mg Powder for Solution for Injection/Infusion

PA1457/001/001
 Amoxicillin & clavulanic acid
 Manufacturing delays Date of shortage: 
13th October 2021 

Expected return date: 
Unknown at present 		 Last updated: 
13th December 2021
Co-Amoxiclav Teva 1000 mg/200 mg Powder for Solution for Injection/Infusion

PA0749/011/002
 Amoxicillin & Clavulanic acid
 Manufacturing delays

(multiple countries affected) 		 Date of shortage: 
Week commencing 27th December 2021

Expected return date: 
24th January 2022		  Last updated: 
15th December 2021

HCP letter
Co-Amoxiclav 1000mg/200mg Powder for Solution for Injection/Infusion

PA1457/001/002		 Amoxicillin & clavulanic acid Unexpected increase in demand Date of shortage:
5th February 2020

Expected return date:
Unknown at present 
 Last updated:
13th December 2021
Cozaar 100mg Film Coated Tablets

PA23198/002/003
 Losartan  Manufacturing delays  Date of shortage: 
Week commencing 15th November 2021 

Expected return date: 
February 2022		 Last updated: 
14th December 2021
Cozaar Comp 100mg/12.5mg Film Coated Tablets

PA23198/001/001
 Losartan & Hydrochlorothiazide  Manufacturing delays  Date of shortage: 
29th December 2021

Expected return date:
Late January 2022 
  Last updated: 
14th January  2022
Cozatan 50mg Film Coated Tablets

PA0126/167/001
 Losartan   Quality issue Date of shortage: 
20th October 2021

Expected return date:  
18th January 2022		 Last updated: 
18th November 2021
Cozatan 100mg Film Coated Tablets

PA0126/167/002
 Losartan   Quality issue Date of shortage: 
20th October 2021

Expected return date:  
18th January 2022		 Last updated: 
18th November 2021
Cozatan Comp 50mg/12.5mg Film Coated Tablets

PA0126/184/001
 Losartan potassium & hydrochlorothiazide
 Quality issue  Date of shortage: 
20th October 2021

Expected return date:
Awaiting update		 Last updated: 
4th January 2022
Cozatan Comp 100mg/25mg Film Coated Tablets

PA0126/184/002
 Losartan potassium & hydrochlorothiazide
 Quality issue Date of shortage: 
20th October 2021 

Expected return date: 
10th April 2022		 Last updated: 
30th November 2021
Denzapine 50mg/ml Oral Suspension

PA0126/235/005
 Clozapine  Unexpected increase in demand Date of shortage: 
11th January 2022

Expected return date: 
Early February 2022 		 Last updated: 
14th January 2022

HCP letter
Depo-Provera 150mg/ml Suspension for Injection 

PA0822/124/001
 Medroxyprogestrone acetate  Regulatory issue  Date of shortage: 
15th November 2021 

Expected return date: 
Late January 2022		 Last updated: 
18th January 2022
Deslor 5mg Film Coated Tablets

PA0711/202/001
 Desloratidine Awaiting information   Date of shortage: 
19th September  2021  

Expected return date: 
Awaiting update		 Last updated: 
17th January 2022 
Desmopressin 100mcg/ml Nasal Drop Solution

PA1009/001/001 		 Desmopressin  Manufacturing delays due to quality issue

(multiple countries affected) 		 Date of shortage:
Mid December 2020

Expected return date:
2022 		 Last updated:
11th December 2020 
Desmospray Desmopressin Nasal Spray

PA1009/005/001 		 Desmopressin  Quality issue

(multiple countries affected) 		 Date of shortage:
22nd July 2020

Expected return date:
2022 		 Last updated:
11th December 2020 
Dexamethasone Phosphate 4mg/ml Solution for Injection or Infusion

PA0281/237/002
  Dexamethasone Manufacturing delays Date of shortage: 
Late December 2021

Expected return date:
March 2022		  Last updated: 
17th January 2022
Dexamethasone Phosphate 4mg/ml Solution for Injection

PA0822/201/001		  Dexamethasone Unexpected increase in demand  Date of shortage:
17th January 2022

Expected return date:
Week commencing 24th January 2022		 Last updated:
18th January 2022

HCP letter
Diazemuls 5mg/ml Emulsion for Injection

PA2315/098/001 		 Diazepam  Manufacturing delays  Date of shortage:
Mid February 2020

Expected return date:
Unknown at present		 Last updated:
30th March 2021 
Dioralyte Blackcurrant Powder for Oral Solution (20 pack)

PA0540/098/001
 Sodium chloride, potassium chloride, glucose, disodium hydrogen citrate  Unexpected increase in demand  Date of shortage: 
17th September 2021

Expected return date: 
Awaiting update		 Last updated: 
9th December 2021
Dioralyte Citrus Powder for Oral Solution
(20 pack)

PA0540/098/002
 Sodium chloride, potassium chloride, glucose, disodium hydrogen citrate
 Unexpected increase in demand Date of shortage: 
17th September 2021

Expected return date: 
Awaiting update
 Last updated: 
9th December 2021
Dioralyte Rebalance Citrus Powder for Oral Solution
(6 pack)

PA0540/194/002
 Sodium chloride, potassium chloride, glucose, disodium hydrogen citrate
 Unexpected increase in demand Date of shortage: 
17th September 2021

Expected return date: 
Awaiting update
 Last updated: 
9th December 2021
Dioralyte Rebalance Natural Powder for Oral Solution
(6 pack)

PA0540/194/003
 Sodium chloride, potassium chloride, glucose, disodium hydrogen citrate
 Unexpected increase in demand   Date of shortage:
3rd November 2021 

Expected return date: 
Awaiting update		 Last updated: 
9th December 2021
Emerade 150mcg Solution in a Pre-Filled Pen

PA1696/009/001 		 Adrenaline  Quality issue

(multiple countries affected) 		 Date of shortage:
30th September 2019

Expected return date:
Unknown at present 		 Last updated:
18th December 2020

Alternatives are available 
Emerade 300mcg Solution in a Pre-Filled Pen

PA1696/009/002 		 Adrenaline  Quality issue

(multiple countries affected) 		 Date of shortage:
30th September 2019

Expected return date:
Unknown at present 		 Last updated:
18th December 2020

Alternatives are available 
Emerade 500mcg Solution in a Pre-Filled Pen

PA1696/009/003 		 Adrenaline  Quality issue

(multiple countries affected) 		 Date of shortage:
30th September 2019

Expected return date:
Unknown at present 		 Last updated:
18th December 2020

Alternatives are available 
Esomeprazole Ticerin 40mg Powder for Solution for Injection of Infusion

PA1852/002/001 		 Esomeprazole  Unavailability of API  Date of shortage:
Early October 2020

Expected return date:
2022		 Last updated:
13th December 2021
Estradot 100mcg/24 hours, Transdermal Patch
PA0896/010/004		  Estradiol Unexpected increase in demand Date of shortage:
4th January 2022

Expected return date:
Mid February 2022		 Last updated:
5th January 2022
Evorel 50mcg per 24 hours Transdermal Patch

PA22668/008/001		 Estradiol  Unexpected increase in demand Date of shortage: 
Mid January 2022

Expected return date: 
End February 2022 		 Last updated: 
4th January 2022
Evorel Conti 50/170mcg per 24 hours Transdermal Patch

PA22668/009/001
 Estradiol & Norethisterone 
 Unexpected  increase in demand Date of shortage: 
15th December 2021

Expected return date: 
Early February 2022		 Last updated:
19th January 2022
Ezetimibe Rowa 10mg Tablets

PA0074/074/001
 Ezetimibe Manufacturing delays  Date of shortage: 
4th November 2021 

Expected return date:
Awaiting update		 Last updated: 
4th January 2022
Ezetimibe/Simvastatin Rowex 10mg/20mg Tablets

PA0711/262/001
 Ezetimibe & simvastatin
 Manufacturing delays  Date of shortage: 22nd July 2021

Expected return date: 
Awaiting update		 Last updated: 
17th January 2022
Ezetimibe/Simvastatin Rowex 10mg/80mg Tablets

PA0711/262/003
 Ezetimibe & simvastatin
 Manufacturing delays  Date of shortage: 
22nd July 2021

Expected return date:
Awaiting update		 Last updated: 
17th January 2022
Ezetimibe/Simvastatin Clonmel 10mg/80mg Tablets

PA0126/281/004
 Ezetimibe & simvastatin
 Manufacturing delays Date of shortage: 
Week commencing 20th September 2021

Expected return date:  
26th January 2022		 Last updated: 
9th November 2021
Ezetimibe/Simvastatin 10mg/80mg Tablets

PA0577/180/003
 Ezetimibe & Simvastatin
 Unexpected increase in demand   Date of shortage: 
11th November 2021 

Expected return date: 
January 2022 		 Last updated: 
16th November 2021
Exelon 9.5mg/day Transdermal patch

EU/1/98/066/24
 Rivastigmine  Quality issue

(multiple countries affected) 		 Date of shortage: 
21st October 2021 

Expected return date: 
March 2022		 Last updated: 16th November 2021
Fexofenadine Hydrochloride 120mg Film Coated Tablets

PA22871/004/002
  Fexofenadine Unexpected increase in demand  Date of shortage: 
11th January 2022 

Expected return date: 
Unknown at present 		  Last updated: 
18th January 2022
Fexofenadine Hydrochloride 180mg Film Coated Tablets

PA22871/004/003
  Fexofenadine Unexpected increase in demand  Date of shortage: 
11th January 2022

Expected return date :
Week commencing 31st January 2022 		 Last updated: 
18th January 2022
Flecainide 50mg Tablets

PA1986/050/001
 Flecainide
 API unavailability   Date of shortage: 
Week commencing 15th November 2021

Expected return date: 
Awaiting update		 Last updated: 
4th January 2022
Fortum 1g Powder for Solution for Injection or Infusion

PA1077/007/002
 Ceftazidime   Regulatory issue Date of shortage: 
12th January 2022 

Expected return date: 
Mid February 2022		 Last updated: 
12th January 2022
Fostepor Once Weekly 70mg Tablets

PA0577/086/002
 Alendronic acid Manufacturing delay Date of shortage: 
15th December 2021

Expected return date: 
Awaiting update		 Last updated: 
17th January 2022
Frovex 2.5mg Film Coated Tablets

PA0865/009/001
  Frovatriptan Quality issue

(multiple countries affected)		 Date of shortage: 
11th January 2022 

Expected return date: 
April 2022		  Last updated: 
21st January 2022
Gamanil 70mg Film Coated Tablets

P1701/004/001
 Lofepramine  Regulatory issue   Date of shortage: 
Late November 2021 

Expected return date: 
January 2022		 Last updated: 
19th November 2021
Gentamicin 40mgml Solution for Injection or Infusion

PA0281/242/002
 Gentamicin  Manufacturing delays Date of shortage: Week commencing 20th December 2021 

Expected return date: 
January 2022		 Last updated: 
17th December 2021
Gerax 250mcg Tablets

PA1445/024/001
  Alprazolam Manufacturing delays Date of shortage: 
Mid November 2021

Expected return date: 
March 2022		 Last updated: 
18th January 2022
Germentin 125mg/31.25mg per 5ml Powder for Oral Suspension

PA0577/034/002
 Amoxicillin & clavulanic acid   Shipping delays Date of shortage: 
Late December 

Expected return date: 
Early February 2022		 Last updated: 
17th December 2021
Hemosol B0 Solution for Haemodialysis/Haemofiltration

PA2299/051/002
  Various  Unexpected increase in demand 

(multiple countries affected) 		 Date of shortage: 
20th January 2022 

Expected return date: 
24th January 2022		 Last updated: 
21st January 2022
Hydromorphone 20mg/ml Solution for Injection/Infusion

PA0549/030/001 		 Hydromorphone  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid June 2020

Expected return date:
February 2022		 Last updated:
18th October 2021
Hydromorphone 50mg/ml Solution for Injection/Infusion

PA0549/030/002 		 Hydromorphone  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid August 2020

Expected return date:
February 2022		 Last updated:
18th October 2021
Inegy 10mg/80mg Tablets 

PA23198/024/004
 Ezetimibe & Simvastatin
 Manufacturing delays Date of shortage: 
21st November 2021

Expected return date: 
Awaiting update		 Last updated: 
17th January 2022
Innohep 2500IU/ml Solution for Injection

PA0046/060/008
  Tinzaparin Manufacturing delays 

(multiple countries affected) 		 Date of shortage:
13th January 2022

Expected return date: 
February 2022 		 Last updated: 
20th January 2022 

HCP letter
Innohep 4,500 IU, Solution for Injection

PA0046/060/007
 Tinzaparin
 Manufacturing delays

(multiple countries affected)		 Date of shortage: 
9th December 2021 

Expected return date: 
February 2022		 Last updated: 
15th December 2021 

HCP letter
Innohep 10,000 IU in 0.5 ml, Solution for Injection

PA0046/060/010
  Tinzaparin Manufacturing delays

(multiple countries affected)		 Date of shortage: 
10th December 2021 

Expected return date: 
February 2022		 Last updated: 
17th December 2021

HCP letter
Instanyl 50mcg Nasal Spray 

EU/1/09/531/010-013
 Fentanyl  Quality issue 
(multiple countries affected)		 Date of shortage: 
1st August 2021 

Expected return date: 
February 2022		 Last updated: 
20th August 2021
Instanyl 100mcg Nasal Spray 

EU/1/09/531/014-017
 Fentanyl  Quality issue

(multiple countries affected) 		 Date of shortage: 
2nd April 2021

Expected return date: 
February 2022		 Last updated: 
20th August 2021
Instanyl 200mcg Nasal Spray

EU/1/09/531/018-021
 Fentanyl  Quality issue

(multiple countries affected) 		 Date of shortage: 
2nd April 2021

Expected return date: 
February 2022		 Last updated:
20th August 2021
Invokana 100mg Tablets

EU/1/13/884/002  
 Canagliflozin
 Unexpected increase in demand  Date of shortage: 
Week commencing 31st January 2022

Expected return date:
Late February 2022  		 Last updated: 
17th January 2022
Invokana 300mg Tablets  

EU/1/13/884/006 
 Canagliflozin  Unexpected increase in demand Date of shortage: 
3rd January 2022

Expected return date: 
29th January 2022		 Last updated: 
15th December 2021
Januvia 50mg Film Coated Tablets

EU/1/07/383/008
 Sitagliptin 
 Unexpected increase in demand   Date of shortage: 
Week commencing 3rd January 2022

Expected return date: 
Mid February 2022		 Last updated: 
17th December 2021
Letrozole Mylan 2.5 mg Film Coated Tablets

PA0577/116/001
 Letrozole Unexpected increase in demand  Date of shortage: 
Late November 2021 

Expected return date: 
February 2022 		 Last updated: 
15th November 2021
Letrozole 2.5mg Film Coated Tablets

PA2315/109/001
 Letrozole  Awaiting information   Date of shortage: 
Week commencing 25th October 2021

Expected return date: 
January 2022		 Last updated: 
16th December 2021 
Letrozole 2.5mg Film Coated Tablets

PA0126/198/001
 Letrozole  Manufacturing delays  Date of shortage: 
22nd October 2021 

Expected return date: 
8th February 2022		 Last updated: 
18th January 2022
Letrozole Teva 2.5 mg Film Coated Tablets

PA0749/085/001
 Letrozole  API unavailability 

(multiple countries affected) 		 Date of shortage: 
Week commencing 9th August 2021

Expected return date: 
January 2021		 Last updated: 
5th October 2021
Lispril Hydrochlorothiazide 20mg/12.5mg Tablet

PA0711/051/002 		 Lisinopril & Hydrochlorothiazide  Manufacturing delays  Date of shortage:
8th September 2020

Expected return date:
Awaiting update		 Last updated:
30th November 2021
Losartan Potassium Pinewood 50mg Film Coated Tablets

PA0281/154/002
 Losartan Quality issues  Date of shortage: 
28th October 2021 

Expected return date: 
Awaiting update		 Last updated: 
11th January 2022
Losartan 50mg Tablets

PA2315/059/002 		 Losartan  Manufacturing delays  Date of shortage:
25th September 2019

Expected return date:
Unknown at present 		 Last updated:
13th April 2021
Losartan Rowa 100mg Film Coated Tablets

PA0074/082/003
 Losartan Quality issue

(multiple countries affected)		 Date of shortage:
Week commencing 29th November 2021

Expected return date:  Week commencing 31st January 2022		 Last updated: 
7th January 2022
Losartan 100mg Tablet

PA2315/059/003 		 Losartan  Manufacturing delays  Date of shortage:
October 2019

Expected return date:
Unknown at present 		 Last updated:
13th April 2021
Losartan/Hydrochlorothiazide Teva 50mg/12.5mg Film Coated Tablets

PA0749/026/001		 Losartan & Hydrochlorothiazide  Quality issue Date of shortage: Late October 2021  

Expected return date: 
March 2022		 Last updated: 
22nd October 2021
Losartan/Hydrochlorothiazide Teva 100mg/25mg Film-Coated Tablets

PA0749/026/002		 Losartan & Hydrochlorothiazide Quality issue  Date of shortage: 
Late October 2021

Expected return date: 
March 2022		 Last updated: 
22nd October 2021
Macroleif 13.8mg  Powder for Oral Solution

PA0711/224/001		 Macrogol 3350
Sodium chloride
Sodium hydrogen carbonate		 Manufacturing delays  Date of shortage:
21st December 2021

Expected return date:
March 2022 		 Last updated: 
6th January 2022 
Marcain 0.5% w/v with Adrenaline (Epinephrine, 5 micrograms per ml) (1:200,000) Solution for Injection

PA1691/025/002
 Bupivacaine & adrenaline Manufacturing delay

(multiple countries affected) 		 Date of shortage: 
1st July 2021

Expected return date: 
Unknown at present 
 Last updated: 
24th September  2021 
Mefac 250mg Capsule

PA0074/015/001 		 Mefenamic acid  Manufacturing delays  Date of shortage:
End of June 2019

Expected return date:
Unknown at present		 Last updated:
23rd April 2021
 
Metaraminol 10mg/ml Solution for Injection or Infusion 

PA22893/001/001		 Metaraminol  Awaiting update Date of shortage: 
Early April 2021 

Expected return date:
Awaiting update		 Last updated: 
30th June 2021
Minulet 75mcg/30mcg Coated Tablets

PA0822/093/001
 Ethinyloestradiol & Gestodene  Manufacturing delays Date of shortage: 
10th December 2021

Expected return date: 
Awaiting update
 Last updated: 
11th January 2022
Mirap 45mg Tablet

PA0711/062/003
 Mirtazapine  Manufacturing delays Date of shortage: 
21st December 2021

Expected return date: 
February 2022		 Last updated: 
7th January 2022
Molaxole Powder for Oral Solution

PA2010/025/001
 Macrogol 3350, Sodium chloride, Potassium chloride, Sodium hydrogen carbonate  Regulatory issue Date of shortage: 29th November 2021 

Expected return date: 
Unknown at present 		 Last updated: 
18th November 2021 
Monotrim 100mg Tablets

PA22643/002/002
 Trimethoprim
 Manufacturing delays Date of shortage: 
Week commencing 20th December 2021

Expected return date: 
Late January 2022		 Last updated: 
17th December 2021
Mydrilate 0.5% w/v Eye Drops

PA22709/003/001
 Cyclopentolate Manufacturing delay  Date of shortage:
15th November 2021

Expected return date: 
Awaiting update		 Last updated: 
17th January 2022
Naloxone Hydrochloride 400mcg/ml Solution for Injection or Infusion 

PA0073/111/002
 Naloxone Manufacturing delays  Date of shortage: 
18th October 2021

Expected return date: 
21st January 2022		 Last updated: 
18th January 2022
Nebivolol Teva 5mg Tablets

PA0749/078/001
  Nebivolol API unavailability 

(multiple countries affected) 		 Date of shortage: 
Week commencing 17th January 2022

Expected return date: 
Week commencing 7th February 2022		 Last updated: 
11th January 2022
NeoRecormon 6000IU Solution for Injection in Pre Filled Syringe

EU/1/97/031/044
 Epoetin  Unexpected increase in demand  Date of shortage: 
Week commencing 17th January 2022

Expected return date: 
Week commencing 7th February 2022 		 Last updated: 
18th January 2022
Ondansetron 2 mg/ml Solution for Injection or Infusion

PA0577/083/001
 Ondansetron  Unexpected increase in demand  Date of shortage: 
Early November 2021 

Expected return date: 
Awaiting update		 Last updated: 
17th January 2022
Osteomel Once Weekly 70mg Tablets

PA0126/148/002
 Alendronic acid  Unexpected increase in demand   Date of shortage: 
Week commencing 20th December 2021 

Expected return date: 
Awaiting update		 Last updated: 
17th January 2022
Oxycodone hydrochloride 50mg/ml Solution for Injection or Infusion

PA0281/235/002
 Oxycodone  Manufacturing delays   Date of shortage: 
1st November 2021 

Expected return date: 
Unknown at present  		 Last updated: 
4th November 2021
OxyNorm Dispersa 10mg Orodispersible Tablets

PA1688/006/008
 Oxycodone  Manufacturing delays 

(multiple countries affected)		 Date of shortage: 
Week commencing 17th January 2022

Expected return date: 
Unknown at present 		 Last updated; 
17th January 2022
Palexia 4mg/ml Oral Solution

PA2242/012/010 		 Tapentadol hydrochloride  Quality issue

(multiple countries affected) 		 Date of shortage:
15th February 2021

Expected return date:
Unknown at present 		 Last updated: 
22nd February 2021
Palladone SR 24mg Prolonged Release Capsules  

PA1688/007/011
 Hydromorphone Manufacturing  delays Date of shortage: 
Week commencing 17th January 2022

Expected return date: 
23rd February 2022 		  Last updated: 
17th January 2022
Panadol 500mg Tablets 
(24 pack only) 

PA0678/107/001
 Paracetamol  Unexpected increase in demand  Date of shortage: 
18th January 2022 

Expected return date: 
12th February 2022  		 Last updated: 
20th January 2022
Perinal Cutaneous Spray hydrocortisone 0.2% w/w / lidocaine hydrochloride monohydrate 1.0% w/w

PA0278/017/002
 Hydrocortisone & Lidocaine Hydrochloride  Manufacturing delays  Date of shortage:
February 2021

Expected return date:
January 2022		 Last updated: 
8th April 2021
Phenergan 5mg/5ml Oral Solution

PA23180/011/001
  Promethazine  Awaiting information  Date of shortage:
20th December 2021 

Expected return date: 
Unknown at present  		 Last updated: 
5th January 2022
Pinamox 125mg/5ml Powder for Oral Suspension

PA0298/010/001
 Amoxicillin  Manufacturing delays Date of shortage: 
11th January 2022

Expected return date: 
Week commencing 24th January 2022		 Last updated: 
14th January 2022
Qlaira Film Coated Tablets

PA1410/058/001
  Estradiol API unavailability  Date of shortage: 
Mid November 2021

Expected return date: 
Q2 2022		 Last updated: 
7th October 2021

HCP letter
Questran 4g Powder for Oral Suspension

PA2239/005/001 		 Colestyramine  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid June 2019

Expected return date:
April 2022		 Last updated:
7th December 2021 
Relpax 40mg Film Coated Tablets

PA23055/002/002
 Eletriptan
 Manufacturing delays  Date of shortage:
Week commencing 28th December

Expected return date: 
Awaiting update
 Last updated: 
20th January 2022
Rifadin 100mg/5ml Oral Suspension

PA0540/066/004
  Rifampicin  Manufacturing delays

(multiple countries affected) 		 Date of shortage: 
Late December 2021 

Expected return date: 
24th January 2022		 Last updated: 
5th January 2022
Rosuvastatin 5mg Film Coated Tablets

PA2315/068/001
 Rosuvastatin Quality issue  Date of shortage:
27th August 2021

Expected return date: 
Q2 2022		  Last updated: 
30th August 2021
Rosuvastatin 10mg Film Coated Tablets

PA2315/068/002
 Rosuvastatin  Quality issue Date of shortage: 
27th August 2021 

Expected return date: 
Q2 2022 		 Last updated: 
30th August 2021 
Rosuvastatin 20mg Film Coated Tablets

PA2315/068/003
 Rosuvastatin   Distribution issue Date of shortage: 
18th October 2021 

Expected return date: 
Awaiting update		 Last updated: 
17th January 2022
Rosuvastatin 40mg Film Coated Tablets

PA2315/068/004
 Rosuvastatin   Distribution issue
 Date of shortage: 
18th October 2021 

Expected return date: 
Awaiting update
 Last updated: 
17th January 2022
Rowalief 500mg Film Coated Tablets


PA0074/065/001
 Paracetamol  Unexpected increase in demand  Date of shortage: 
Week commencing 8th November 2021 

Expected return date: 
Week commencing 24th January 2022		 Last updated: 
7th January 2022
Salmeterol &
Fluticasone 

PA22668/009/001
 Salmeterol &
Fluticasone 
 Shipping delays Date of shortage: 
14th December 2021

Expected return date: 
January 2022		  Last updated: 
16th December 2021
Sprilon 12.5% Zinc Oxide & 1.04% Dimethicone Cutaneous Spray Suspension

PA22906/001/001 		 Zinc oxide & Dimethicone  Manufacturing delays  Date of shortage:
October 2019

Expected return date:
Awaiting update		 Last updated:
22nd October 2021
Stesolid Rectal Solution 5mg

PA2315/137/001
 Diazepam  Manufacturing delays Date of shortage: 
Late August 2021

Expected return date: 
Week commencing 17th January 2022		 Last updated: 
17th January 2022
Stesolid Rectal Solution 10mg

PA2315/137/002
  Diazepam Manufacturing delays  Date of shortage: 
Week commencing 19th July
2021

Expected return date: 
Week commencing 17th January 2022		 Last updated: 
17th January 2022
Subutex 2mg Sublingual Tablets

PA22617/001/002
Buprenorphine  Manufacturing delays 

(multiple countries affected)		 Date of shortage: 
7th January 2022 

Expected return date: 
28th February 2022
 Last updated: 
11th January 2022
Targin 5mg/2.5mg Prolonged Release Tablet  

PA1688/010/001
 Oxycodone & naloxone
  Manufacturing delays 

(multiple countries affected)		 Date of shortage: 
Week commencing 24th January 2022

Expected return date: 
April 2022 		 Last updated: 
17th January 2022
Telmisartan Rowa 40mg Tablets

PA0074/078/002
 Telmisartan  Unexpected increase in demand  Date of shortage: 
7th September 2021

Expected return date: 
Week commencing 31st January 2022		 Last updated: 
7th January 2022
Temodal 5mg Capsules

EU/1/98/096/024		  Temozolomide Unexpected increase in demand  Date of shortage:
30th December 2021

Expected return date:
Week commencing 24th January 2022		 Last updated:
4th January 2022
Tracrium 10mg/ml, Solution for Injection or Infusion

(5ml and 25ml ampoule)
  Atracurium Unexpected increase in demand   Date of shortage:
10th December 2021 

Expected return date: 
11th February 2022		 Last updated: 
30th November 2021
Trimoptin 100mg Tablets

PA0298/014/001
 Trimethoprim
 Manufacturing delays  Date of shortage: 
10th January 2022 

Expected return date: 
Mid March 2022		 Last updated: 
18th January 2022
Trimoptin 200mg Tablets

PA0298/014/002
  Trimethoprim Manufacturing delays Date of shortage: 
10th January 2022

Expected return date: 
Mid March 2022 		 Last updated: 
18th January 2022
Ultiva 1mg Powder for Concentrate for Solution for Infusion

PA1691/032/001		 Remifentanyl Awaiting information Date of shortage:
5th January 2022

Expected return date:
4th February 2022 		 Last updated:
6th January 2022
ViATIM, Suspension and Solution for Suspension for Injection in Pre Filled Syringe. Hepatitis A (inactivated, adsorbed) and Typhoid Polysaccharide Vaccine

PA2131/014/001
 Vi polysaccharide of salmonella typhi
& Hepatitis a virus 		 Unexpected increase in demand Date of shortage: 
Late January 2022

Expected return date: 
Mid March 2022 		 Last updated: 
21st January 2022 
Visudyne 15mg Powder for Solution for Infusion

EU/1/00/140/001
 Verteporfin  Manufacturing delay  Date of shortage: 
May 2021

Expected return date: 
Late January 2022		 Last updated: 
16th December 2021

HCP letter
Vokanamet 150mg/1000mg Film Coated Tablets

EU/1/14/918/011 
 Canagliflozin & metformin 
 Manufatcturing delays Date of shortage: 
Week commencing 17th January 

Expected return date:
Unknown at present  		 Last updated: 
17th January 2022
Voriconazole 200mg Powder for Solution for Infusion

PA2059/020/001
  Voriconazole Unexpected increase in demand 

(multiple countries affected)		 Date of shortage: 
Week commencing 29th November 2021 

Expected return date: 
February 2022		 Last updated: 
29th November 2021
Zacin 0.025% w/w Cream

PA1986/090/001
 Capsaicin
 Manufacturing delays 

(multiple countries affected) 		 Date of shortage: 
Week commencing 22nd November 2021

Expected return date:
January 2022 
 Last updated: 
17th December 2021
Zerbaxa 1g/0.5g Powder for Concentrate for Solution for Infusion

EU/1/15/1032/001 		 Ceftolozone & Tazobactam  Quality issue

(multiple countries affected) 		 Date of shortage:
18th December 2020

Expected return date:
Unknown at present 		 Last updated:
4th March 2021 
Zofran 4mg/5ml Syrup

PA0896/036/003
 Ondansetron  Regulatory issue 

(multiple countries affected)		 Date of shortage:
February 2022

Expected return date:
Unknown at present   		 Last updated: 
19th January 2022
Zofran Zydis 8mg Oral Lyophilisate

PA0896/036/008
 Ondansterton  Manufacturing delays  Date of shortage: 
February 2022

Expected return date: 
March 2022 		 Last updated: 
14th January 2022 
Xatger 10mg Prolonged Release Tablets

PA0577/079/002
 Alfuzosin 
 Manufacturing delays Date of shortage:
End November 2021 

Expected return date: 
Awaiting update		 Last updated: 
7th January 2022
Xomolix 2.5mg/ml Solution for Injection

PA2288/003/002
 Droperidol  Quality issue

(multiple countries affected)		 Date of shortage: 
29th May 2021

Expected return date: 
Unknown at present  		 Last updated: 
2nd July 2021
Xylocaine 10 mg/delivered dose Mucosal Spray

PA1691/028/001
 Lidocaine  Shipping delay  Date of shortage: 
6th December 2021

Expected return date: 
January 2022		 Last updated: 
29th November 2021

Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL
Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL
Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL



Date of shortage: 
2nd July 2021

Expected return date: 
Unknown at present  
Date of shortage: 
2nd July 2021

Expected return date: 
Unknown at present  

Date of shortage: 
18th October 2021 

Expected return date: 
Early January 2022 
Date of shortage: 
18th October 2021 

Expected return date: 
Early January 2022 

Product name Active ingredient Reason for shortage Date of shortage
 Additional information
Abstral 100mcg Sublingual Tablets

PA2288/004/002
  Fentanyl  Manufacturing delay 

(multiple countries affected) 		 Date of shortage: 
3rd September 2021 

Expected return date: 
Week commencing 1st October 2021		 Last updated: 
22nd October 2021
Abstral 200mcg Sublingual Tablets

PA2288/004/003
 Fentanyl Manufacturing delays 

(multiple countries affected)		 Date of shortage:
15th August 2021

Return date: 
Week commencing 25th October 2021		 Last updated: 
22nd October 2021
Abstral 300mcg Sublingual Tablets

PA2288/004/004
 Fentanyl  Manufacturing delays 

(multiple countries affected) 		 Date of shortage: 
5th October 2021

Expected return date: 
Week commencing 25th October 2021
 Last updated: 
22nd October 2021
Abstral 400mcg Sublingual Tablets

PA2288/004/005
 Fentanyl  Manufacturing delays 

(multiple countries affected)
 Date of shortage: 
4th October 2021

Expected return date: 
Early December 2021		 Last updated: 
22nd October 2021
Abstral 600mcg Sublingual Tablets

PA2288/004/006
 Fentanyl   Manufacturing delay 

(multiple countries affected)		 Date of shortage: 
2nd September 2021 

Expected return date: 
Week commencing 25th October 2021		 Last updated: 
22nd October 2021
Abstral 700mcg Sublingual Tablets

PA2288/004/007
 Fentanyl Manufacturing delay 

(multiple countries affected) 		 Date of shortage: 
2nd September 2021

Expected return date: 
Early December 2021		 Last updated: 
22nd October 2021
Adizem-XL 180mg Prolonged Release Capsules

PA1688/001/005
 Dilitazem  Manufacturing delays Date of shortage: 
1st October 2021

Expected return date: 
November 2021 		 Last updated: 
27th September 2021
Amitriptyline 25mg Film Coated Tablets

PA0126/041/001
 Amitriptyline
 API unavailability Date of shortage: 
2nd September 2021 

Expected return date: 
Late October 2021		 Last updated: 
7th September 2021 

HCP letter
Astilin 10mg Tablets

PA23163/001/001
 Amitriptyline  Awaiting update Date of shortage: 
27th August 2021

Expected return date: 
29th October 2021		 Last updated: 
5th October 2021

HCP letter
Ativan 4mg/ml Solution for Injection

PA0822/090/002 		 Lorazepam  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Early August 2020

Expected return date:
Unknown at present		 Last updated:
14th May 2021 
 
HCP letter
BCG-Medac Powder and Solvent for Suspension for Intravesical Use

PA0623/004/001 		 Bacillus Calmette Guerin bacteria  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
1st October 2019

Expected return date:
2022		 Last updated:
3rd February 2021
Bendroflumethiazide 2.5mg Tablets

PA22749/021/001
 Bendroflumethiazide
  Regulatory issue Date of shortage:
3rd September 2021

Expected return date: 
Awaiting update		 Last updated: 
1st October 2021
Beromun 1mg Powder for Solution for Infusion

EU/1/99/097/001 		 Tasonermin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
December 2020

Expected return date:
November 2021		 Last updated:
1st June 2021
Calcium Acetate 500mg Tablets

PA0281/063/001
 Calcium Acetate API unavailability  Date of shortage: 
Week commencing 26th July 2021

Expected return date: 
Late December 2021		 Last updated: 
30th September 2021
Canesten HC 1% w/w + 1% w/w Cream

PA1410/040/002
 Clotrimazole & Hydrocortisone  Manufacturing delays Date of shortage: 
30th September 2021 

Expected return date:
5th November 2021		 Last updated: 
22nd September 2021
Catapres Tablets 100mcg

PA2256/003/001
  Clonidine Manufacturing delays

(multiple countries affected)		 Date of shortage: 
25th July 2021

Expected return date: 
25th October 2021		 Last updated: 
21st June 2021 
Champix 0.5mg Film Coated Tablet

EU/1/06/360/001
 Varenicline 
 Quality issue

(multiple countries affected)		 Date of shortage: 
Week commencing 21st June 2021 

Expected return date: 
Unknown at present 		 Last updated:
18th June 2021

HCP letter
Champix 1mg Film Coated Tablet

EU/1/06/360/005
 Varenicline Quality issue

(multiple countries affected)		 Date of shortage: 
Week commencing 21st June

Expected return date: 
Unknown at present 		 Last updated: 
18th June 2021

HCP letter
Champix 0.5 mg + 1 mg Film Coated Tablet

EU/1/06/360/003
 Varenicline 
 Quality issue 

(multiple countries affected)		 Date of shortage: 
Week commencing 21st June 

Expected return date: 
Unknown at present 		 Last updated: 
18th June 2021

HCP letter
Chlorhexidine Acetate 0.015% w/v and Cetrimide 0.15% w/v Irrigation Solution

PA2299/005/001
 Chlorhexidine acetate & cetrimide
 Unexpected increase in demand Date of shortage: 
September 2021 

Expected return date: 
Mid November 2021 		 Last updated: 
20th October 2021
Chlorpromazine Elixir BP 25mg/5ml Oral Solution

PA0281/124/001 		 Chlorpromazine hydrochloride  Manufacturing delays  Date of shortage:
End of February 2021

Expected return date:
End January 2022		 Last updated:
5th October 2021
 
HCP letter
Clexane Forte 12,000 IU (120mg) /0.8ml Solution for Injection in Pre Filled Syringes 

PA0540/097/008
 Enoxaparin sodium  API unavailability   Date of shortage: 
22nd October 2021 

Expected return date: 
Unknown at present		 Last updated: 
13th October 2021
Co-Amoxiclav 500mg/100mg Powder for Solution for Injection/Infusion

PA1457/001/001
 Amoxicillin & Clavulanic acid
 Manufacturing delays Date of shortage: 
13th October 2021 

Expected return date: 
Awaiting update		 Last updated: 
18th October 2021 
Co-Amoxiclav 1000mg/200mg Powder for Solution for Injection/Infusion

PA1457/001/002		 Amoxicillin & clavalunic acid Unexpected increase in demand Date of shortage:
5th February 2020

Expected return date:
Awaiting update
 Last updated:
19th October 2021
CoAprovel 300mg/12.5mg Tablets

EU/1/98/086/004
 Irbesartan & Hydrochlorothiazide  Shipping delay  Date of shortage: 
5th November 2021

Expected return date: 
Late November 2021  		 Last updated: 
22nd October 2021 
Cyklokapron 100 mg/mL Solution for Injection/Infusion

PA0822/117/001
 Tranexamic acid Manufacturing delays Date of shortage: 
Week commencing 18th October 2021

Expected return date: 
Week commencing 15th November 2021 		 Last updated: 
5th October 2021 
Deslor 5mg Film Coated Tablets

PA0711/202/001
 Desloratidine Awaiting information   Date of shortage: 
19th September  2021  

Expected return date: 
Late December 2021		 Last updated: 
October 2021 
Desmopressin 100mcg/ml Nasal Drop Solution

PA1009/001/001 		 Desmopressin  Manufacturing delays due to quality issue

(multiple countries affected) 		 Date of shortage:
Mid December 2020

Expected return date:
2022 		 Last updated:
11th December 2020 
Desmospray Desmopressin Nasal Spray

PA1009/005/001 		 Desmopressin  Quality issue

(multiple countries affected) 		 Date of shortage:
22nd July 2020

Expected return date:
2022 		 Last updated:
11th December 2020 
Diazemuls 5mg/ml Emulsion for Injection

PA2315/098/001 		 Diazepam  Manufacturing delays  Date of shortage:
Mid February 2020

Expected return date:
Unknown at present		 Last updated:
30th March 2021 
Dioralyte Blackcurrant Powder for Oral Solution (20 pack)

PA0540/098/001
 Sodium chloride, potassium chloride, glucose, disodium hydrogen citrate  Unexpected increase in demand  Date of shortage: 
17th September 2021

Expected return date: 
1st November 2021		 Last updated: 
30th September 2021
Dioralyte Citrus Powder for Oral Solution
(20 pack)

PA0540/098/002
 Sodium chloride, potassium chloride, glucose, disodium hydrogen citrate
 Unexpected increase in demand Date of shortage: 
17th September 2021

Expected return date: 
1st November 2021
 Last updated: 
30th September 2021
Dioralyte Rebalance Citrus Powder for Oral Solution
(6 pack)

PA0540/194/002
 Sodium chloride, potassium chloride, glucose, disodium hydrogen citrate
 Unexpected increase in demand Date of shortage: 
17th September 2021

Expected return date: 
1st November 2021
 Last updated: 
30th September 2021
Doxatan 4mg Tablets

PA0126/202/003 		 Doxazosin  Manufacturing delay   Date of shortage: 
4th October 2021

Expected return date:
Week commencing 1st November 2021		 Last updated: 
20th October 2021
Emerade 150mcg Solution in a Pre-Filled Pen

PA1696/009/001 		 Adrenaline  Quality issue

(multiple countries affected) 		 Date of shortage:
30th September 2019

Expected return date:
Unknown at present 		 Last updated:
18th December 2020

Alternatives are available 
Emerade 300mcg Solution in a Pre-Filled Pen

PA1696/009/002 		 Adrenaline  Quality issue

(multiple countries affected) 		 Date of shortage:
30th September 2019

Expected return date:
Unknown at present 		 Last updated:
18th December 2020

Alternatives are available 
Emerade 500mcg Solution in a Pre-Filled Pen

PA1696/009/003 		 Adrenaline  Quality issue

(multiple countries affected) 		 Date of shortage:
30th September 2019

Expected return date:
Unknown at present 		 Last updated:
18th December 2020

Alternatives are available 
Epanutin Infatabs 50mg Chewable Tablets

PA0822/011/005		 Phenytoin Manufacturing delays

(multiple countries affected)		 Date of shortage:
Early November 2019

Expected return date:
Unknown at present		 Last updated:
4th June 2020
 
HCP Letter
Esomeprazole Ticerin 40mg Powder for Solution for Injection of Infusion

PA1852/002/001 		 Esomeprazole  Unavailability of API  Date of shortage:
Early October 2020

Expected return date:
Late November 2021		 Last updated:
12th October 2021
Ezetimibe Rowa 10mg Tablets

PA0074/074/001
 Ezetimibe Awaiting information  Date of shortage: 
19th October 2021 

Expected return date: 
Late November 2021 		 Last updated: 
21st October 2021
Ezetimibe Teva 10mg tablets

PA1986/012/001
 Ezetimibe  Quality Issue  Date of shortage: 
18th October 2021 

Expected return date: 
13th December 2021		 Last updated: 
4th October 2021
Ezetimibe 10mg tablets

PA0577/198/001
 Ezetimibe
 Manufacturing delays  Date of shortage: 
Late August 2021 

Expected return date: 
Early November 2021		 Last updated: 
4th October 2021
Ezetimibe/Simvastatin Rowex 10mg/20mg Tablets

PA0711/262/001
 Ezetimibe & simvastatin
 Manufacturing delays  Date of shortage: 22nd July 2021

Expected return date: 
October 2021		 Last updated: 
20th September 2021
Ezetimibe/Simvastatin Rowex 10mg/80mg Tablets

PA0711/262/003
 Ezetimibe & simvastatin
 Manufacturing delays  Date of shortage: 
22nd July 2021

Expected return date: 
End November 2021
 Last updated: 
20th October 2021 
Ezetimibe/Simvastatin Teva Pharma 10mg/80mg Tablets

PA1986/067/003
 Ezetimibe & simvastatin
 API unavailability

(multiple countries impacted) 		 Date of shortage: 
30th August 2021 

Expected return date: 
Awaiting update		 Last updated: 
20th October 2021 
Ezetimibe/Simvastatin Clonmel 10mg/20mg Tablets

PA0126/281/002
Ezetimibe & simvastatin
 Manufacturing delays   Date of shortage: 
Week commencing 20th September 2021

Expected return date: 
Unknown at present		 Last updated: 
20th September 2021
Ezetimibe/Simvastatin Clonmel 10mg/80mg Tablets

PA0126/281/004
 Ezetimibe & simvastatin
 Manufacturing delays Date of shortage: 
Week commencing 20th September 2021

Expected return date:  
Unknown at present		 Last updated: 
20th September 2021
Folinic Acid (as Calcium Folinate) 7.5mg/ml Solution for Injection

PA0822/198/002
 Folinic Acid  Unexpected increase in demand Date of shortage: 
Week commencing 27th September 2021

Expected return date: 
Awaiting update		 Last updated:
18th October 2021
Fomicyt 40mg/ml Powder for Solution for Infusion

PA1972/001/001
 Fosfomycin sodium Regulatory issue  Date of Shortage: 
October 2021 

Expected return date: 
Unknown at present		 Last updated: 
12th October 2021
Gentisone HC 0.3% w/v & 1.0% w/v Ear Drops, Suspension

PA1142/014/001
 Gentamicin & Hydrocortisone Unavailability of API 

(multiple countries affected)		 Date of shortage: 
23rd August 2021

Expected return date:
Late November 2021		 Last updated: 
9th August 2021
Hydromorphone 20mg/ml Solution for Injection/Infusion

PA0549/030/001 		 Hydromorphone  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid June 2020

Expected return date:
February 2022		 Last updated:
18th October 2021
Hydromorphone 50mg/ml Solution for Injection/Infusion

PA0549/030/002 		 Hydromorphone  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid August 2020

Expected return date:
February 2022		 Last updated:
18th October 2021
Imodium Plus 2mg/125mg Tablets

PA0330/050/001
 Loperamide & simeticone  Manufacturing delay  Date of shortage: 
11th October 2021 

Expected return date:
Week commencing 22nd November 2021		 Last updated: 
20th October 2021
Innohep 10,000 IU/ml Solution for Injection

PA0046/060/002
 Tinzaparin sodium
 Unexpected increase in demand

(multiple countries affected)		 Date of shortage: 
20th September 2021

Expected return date: 
Mid-November 2021
 Last updated: 
23rd September 2021
Instanyl 50mcg Nasal Spray 

EU/1/09/531/010-013
 Fentanyl  Quality issue 
(multiple countries affected)		 Date of shortage: 
1st August 2021 

Expected return date: 
February 2022
 Last updated: 
20th August 2021
Instanyl 100mcg Nasal Spray 

EU/1/09/531/014-017
 Fentanyl  Quality issue

(multiple countries affected) 		 Date of shortage: 
2nd April 2021

Expected return date: 
February 2022		 Last updated: 
20th August 2021
Instanyl 200mcg Nasal Spray

EU/1/09/531/018-021
 Fentanyl  Quality issue

(multiple countries affected) 		 Date of shortage: 
2nd April 2021

Expected return date: 
February 2022		 Last updated:
20th August 2021
Invokana 300mg Film Coated Tablets

EU/1/13/884/005-008		 Canagliflozin
 Unexpected increase in demand  Date of shortage: 
18th October 2021

Expected return date: 
Early November 2021 		 Last updated: 
12th October 2021
Letrozole 2.5mg Film Coated Tablets

PA2315/109/001
 Letrozole  Awaiting information   Date of shortage: 
Week commencing 25th October 2021

Expected return date: 
End November 2021		 Last updated: 
18th October 2021 
Letrozole 2.5mg Film Coated Tablets

PA0126/198/001
 Letrozole  Manufacturing delays  Date of shortage: 
22nd October 2021 

Expected return date: 
22nd December 2021		 Last updated: 
18th October 2021
Letrozole Teva 2.5 mg Film Coated Tablets

PA0749/085/001
 Letrozole  API unavailability 

(multiple countries affected) 		 Date of shortage: 
Week commencing 9th August 2021

Expected return date: 
January 2021		 Last updated: 
5th October 2021
Lispril Hydrochlorothiazide 20mg/12.5mg Tablet

PA0711/051/002 		 Lisinopril & Hydrochlorothiazide  Manufacturing delays  Date of shortage:
8th September 2020

Expected return date:
Week commencing 1st November 2021		 Last updated:
20th October 2021
Losartan 50mg Tablet 

PA2315/059/002 		 Losartan  Manufacturing delays  Date of shortage:
25th September 2019

Expected return date:
Unknown at present 		 Last updated:
13th April 2021
Losartan 100mg Tablet

PA2315/059/003 		 Losartan  Manufacturing delays  Date of shortage:
October 2019

Expected return date:
Unknown at present		 Last updated:
13th April 2021
Losartan/Hydrochlorothiazide Teva 50mg/12.5mg Film-Coated Tablets

PA0749/026/001
 Losartan & Hydrochlorothiazide
  Quality issue Date of shortage: Late October 2021  

Expected return date: 
March 2022		 Last updated: 
22nd October 2021
Losartan/Hydrochlorothiazide Teva 100mg/25mg Film-Coated Tablets

PA0749/026/002
 Losartan & Hydrochlorothiazide
 Quality issue  Date of shortage: 
Late October 2021

Expected return date: 
March 2022		 Last updated: 
22nd October 2021
Marcain 0.5% w/v with Adrenaline (Epinephrine, 5 micrograms per ml) (1:200,000) Solution for Injection

PA1691/025/002
 Bupivacaine & adrenaline Manufacturing delay

(multiple countries affected) 		 Date of shortage: 
1st July 2021

Expected return date: 
Unknown at present 
 Last updated: 
24th September  2021 
Mefac 250mg Capsule

PA0074/015/001 		 Mefenamic acid  Manufacturing delays  Date of shortage:
End of June 2019

Expected return date:
Unknown at present		 Last updated:
23rd April 2021
 
Metaraminol 10mg/ml Solution for Injection or Infusion 

PA22893/001/001		 Metaraminol  Awaiting update Date of shortage: 
Early April 2021 

Expected return date:
Awaiting update		 Last updated: 
30th June 2021
Metformin Hydrochloride 500mg/5ml Oral Solution

PA23081/008/001
 Metformin  Regulatory Issue Date of shortage: 
13th August 2021

Expected return date: 
Unknown at present		 Last updated: 
10th August 2021
Mydrilate 1.0% w/v Eye Drops

PA22709/003/002
 Cyclopentolate Manufacturing delay  Date of shortage:
Early September 2021

Expected return date: 
Mid-October 2021		 Last updated: 
27th September 2021 
Naloxone Hydrochloride 400mcg/ml Solution for Injection or Infusion 

PA0073/111/002
 Naloxone Manufacturing delay  Date of shortage: 
18th October 2021

Expected return date: 
3rd December 2021 		 Last updated: 
19th October 2021
Nanocis 0.24mg Kit for Radiopharmaceutical Preparation

PA0677/006/001
 Rhenium sulphide
 Awaiting information  Date of shortage: 
Week commencing 20th September 2021 

Expected return date: 
Week commencing 8th November 2021		 Last updated: 
1st October 2021
Odrik 2mg Hard Capsule

PA2010/005/003
 Trandolapril
 Manufacturing delays Date of shortage: 
5th October 2021

Expected return date: 
Late October 2021 		 Last updated: 
28th September 2021
Oramox 125mg/5ml Powder for Oral Suspension

PA0298/019/001
 Amoxicillin
 Unexpected increase in demand  Date of shortage:
22nd October 2021 

Expected return date: 
Unknown at present 		 Last updated: 
19th October 2021 
OxyContin 5mg Prolonged Release Tablets 

PA1688/005/001
  Oxycodone Manufacturing delays  Date of shortage: 
18th October 2021

Expected return date: 
Early November 2021		 Last updated:
12th October 2021
OxyNorm Dispersa 5mg Orodispersible Tablets

PA1688/006/007
 Oxycodone  Unexpected increase in demand  Date of shortage: 
5th October 2021 

Expected return date: 
4th November 2021		 Last updated: 
18th October 2021
OxyNorm Dispersa 10mg Orodispersible Tablets

PA1688/006/008
 Oxycodone Manufacturing delays  Date of shortage: 
18th October 2021

Expected return date:
Unknown at present 		  Last updated: 
12th October 2021
OxyNorm Dispersa 20mg Orodispersible Tablets

PA1688/006/009
 Oxycodone Manufacturing delays  Date of shortage: 
26th October 2021 

Expected return date:
February 2022		 Last updated: 
20th October 2021 
Palexia 4mg/ml Oral Solution

PA2242/012/010 		 Tapentadol hydrochloride  Quality issue

(multiple countries affected) 		 Date of shortage:
15th February 2021

Expected return date:
Unknown at present 		 Last updated: 
22nd February 2021
Paralief 500mg Tablets 

24 pack only

PA0126/020/001
 Paracetamol API unavailability  Date of shortage: 
Week commencing 23rd August 2021

Expected return date: 
27th October 2021
 Last updated: 
28th August 2021
Perinal Cutaneous Spray hydrocortisone 0.2% w/w / lidocaine hydrochloride monohydrate 1.0% w/w

PA0278/017/002
 Hydrocortisone & Lidocaine Hydrochloride  Manufacturing delays  Date of shortage:
February 2021

Expected return date:
January 2022		 Last updated: 
8th April 2021
Qlaira Film Coated Tablets

PA1410/058/001
  Estradiol API unavailability  Date of shortage: 
Mid November 2021

Expected return date: 
Q2 2022		 Last updated: 
7th October 2021

HCP letter
Questran 4g Powder for Oral Suspension

PA2239/005/001 		 Colestyramine  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid June 2019

Expected return date:
January 2022		 Last updated:
30th March 2021 
Rifater 50mg/300mg/120mg Tablets

PA0822/143/002
 Isoniazid & Pyrazinamide & Rifampicin Quality issue

(multiple countries impacted)		 Date of shortage: 
23rd July 2021

Expected return date: 
26th October 2021		 Last updated:
18th October 2021

AMRIC guidance V3
Rosuvastatin 5mg Film Coated Tablets

PA2315/068/001
 Rosuvastatin Quality issue  Date of shortage:
27th August 2021

Expected return date: 
Q2 2022		  Last updated: 
30th August 2021
Rosuvastatin 10mg Film Coated Tablets

PA2315/068/002
 Rosuvastatin  Quality issue Date of shortage: 
27th August 2021 

Expected return date: 
Q2 2022 		 Last updated: 
30th August 2021 
Rosuvastatin 20mg Film Coated Tablets

PA2315/068/003
 Rosuvastatin   Distribution issue Date of shortage: 
18th October 2021 

Expected return date: 
Early January 2022 		 Last updated: 
21st October 2021 
Rosuvastatin 40mg Film Coated Tablets

PA2315/068/004
 Rosuvastatin   Distribution issue
 Date of shortage: 
18th October 2021 

Expected return date: 
Early January 2022 
 Last updated: 
21st October 2021 
Sevelamer Carbonate 800mg Film Coated Tablets

PA0577/205/001
 Sevelamer  Manufacturing delays Date of shortage: 
Late October

Expected return date: 
Unknown at present  		 Last updated: 
22nd October 2021
Sprilon 12.5% Zinc Oxide & 1.04% Dimethicone Cutaneous Spray Suspension

PA22906/001/001 		 Zinc oxide & Dimethicone  Manufacturing delays  Date of shortage:
October 2019

Expected return date:
Mid-December 2021		 Last updated:
22nd October 2021
Stesolid Rectal Solution 5mg

PA2315/137/001
 Diazepam  Manufacturing delays Date of shortage: 
Late August 2021

Expected return date: 
November 2021		 Last updated: 
12th August 2021
Stesolid Rectal Solution 10mg

PA2315/137/002
  Diazepam Manufacturing delays  Date of shortage: 
Week commencing 19th July 2021. 

Expected return date: 
November 2021		 Last updated: 
21st July 2021
Targin 20mg/10mg Prolonged Release Tablets

PA1688/010/001		 Oxycodone & Naloxone  Shipping delays Date of shortage: 
27th September 2021 

Expected return date: 
28th October 2021
 Last updated: 
22nd October 2021
Telmisartan Rowa 40mg Tablets

PA0074/078/002
 Telmisartan  Unexpected increase in demand  Date of shortage: 
7th September 2021

Expected return date: 
Late November 2021		  Last updated: 
20th October 2021
Tevanate Once Weekly 70mg Tablets

PA0749/016/001
 Alendronic acid API unavailability  Date of shortage: 
6th September 2021 

Expected return date: 
Late November 2021 		 Last updated: 
23rd August 2021 
Tracrium 10 mg/ml, Solution for injection or infusion

(25ml ampoule)

PA1691/029/002
 Atracurium  Unexpected increase in demand Date of shortage: 
24th September 2021 

Expected return date: 
20th November 2021 		 Last updated: 
24th September 2021
Trandate 200mg Film Coated Tablet

PA1638/006/003 		 Labetalol hydrochloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
July 2019

Expected return date:
End October 2021		 Last updated:
11th October 2021
TPN – various B. Braun products
 Various  Manufacturing delays  Date of shortage: 
4th October 2021

Expected return date: 
Unknown at present		 Last updated: 
5th October 2021

HCP letter
Ultraproct 0.92mg/ + 0.95mg/g + 5mg/g Rectal Ointment

PA22650/004/001
 Fluocortolone Pivalate; Fluocortolone caproate; Cinchocaine hydrochloride  Regulatory issue Date of shortage: 
Late September 2021

Expected return date: 
Late December 2021
 Last updated: 
15th September 2021
Uniphyllin Continus 200mg Prolonged Release Tablets

PA1688/011/001
Product name Active ingredient Reason for shortage Date of shortage
 Additional information
Abstral 100mcg Sublingual Tablets

PA2288/004/002
  Fentanyl  Manufacturing delay 

(multiple countries affected) 		 Date of shortage: 
3rd September 2021 

Expected return date: 
Week commencing 1st October 2021		 Last updated: 
22nd October 2021
Abstral 200mcg Sublingual Tablets

PA2288/004/003
 Fentanyl Manufacturing delays 

(multiple countries affected)		 Date of shortage:
15th August 2021

Return date: 
Week commencing 25th October 2021		 Last updated: 
22nd October 2021
Abstral 300mcg Sublingual Tablets

PA2288/004/004
 Fentanyl  Manufacturing delays 

(multiple countries affected) 		 Date of shortage: 
5th October 2021

Expected return date: 
Week commencing 25th October 2021
 Last updated: 
22nd October 2021
Abstral 400mcg Sublingual Tablets

PA2288/004/005
 Fentanyl  Manufacturing delays 

(multiple countries affected)
 Date of shortage: 
4th October 2021

Expected return date: 
Early December 2021		 Last updated: 
22nd October 2021
Abstral 600mcg Sublingual Tablets

PA2288/004/006
 Fentanyl   Manufacturing delay 

(multiple countries affected)		 Date of shortage: 
2nd September 2021 

Expected return date: 
Week commencing 25th October 2021		 Last updated: 
22nd October 2021
Abstral 700mcg Sublingual Tablets

PA2288/004/007
 Fentanyl Manufacturing delay 

(multiple countries affected) 		 Date of shortage: 
2nd September 2021

Expected return date: 
Early December 2021		 Last updated: 
22nd October 2021
Adizem-XL 180mg Prolonged Release Capsules

PA1688/001/005
 Dilitazem  Manufacturing delays Date of shortage: 
1st October 2021

Expected return date: 
November 2021 		 Last updated: 
27th September 2021
Amitriptyline 25mg Film Coated Tablets

PA0126/041/001
 Amitriptyline
 API unavailability Date of shortage: 
2nd September 2021 

Expected return date: 
Late October 2021		 Last updated: 
7th September 2021 

HCP letter
Astilin 10mg Tablets

PA23163/001/001
 Amitriptyline  Awaiting update Date of shortage: 
27th August 2021

Expected return date: 
29th October 2021		 Last updated: 
5th October 2021

HCP letter
Ativan 4mg/ml Solution for Injection

PA0822/090/002 		 Lorazepam  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Early August 2020

Expected return date:
Unknown at present		 Last updated:
14th May 2021 
 
HCP letter
BCG-Medac Powder and Solvent for Suspension for Intravesical Use

PA0623/004/001 		 Bacillus Calmette Guerin bacteria  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
1st October 2019

Expected return date:
2022		 Last updated:
3rd February 2021
Bendroflumethiazide 2.5mg Tablets

PA22749/021/001
 Bendroflumethiazide
  Regulatory issue Date of shortage:
3rd September 2021

Expected return date: 
Awaiting update		 Last updated: 
1st October 2021
Beromun 1mg Powder for Solution for Infusion

EU/1/99/097/001 		 Tasonermin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
December 2020

Expected return date:
November 2021		 Last updated:
1st June 2021
Calcium Acetate 500mg Tablets

PA0281/063/001
 Calcium Acetate API unavailability  Date of shortage: 
Week commencing 26th July 2021

Expected return date: 
Late December 2021		 Last updated: 
30th September 2021
Canesten HC 1% w/w + 1% w/w Cream

PA1410/040/002
 Clotrimazole & Hydrocortisone  Manufacturing delays Date of shortage: 
30th September 2021 

Expected return date:
5th November 2021		 Last updated: 
22nd September 2021
Catapres Tablets 100mcg

PA2256/003/001
  Clonidine Manufacturing delays

(multiple countries affected)		 Date of shortage: 
25th July 2021

Expected return date: 
25th October 2021		 Last updated: 
21st June 2021 
Champix 0.5mg Film Coated Tablet

EU/1/06/360/001
 Varenicline 
 Quality issue

(multiple countries affected)		 Date of shortage: 
Week commencing 21st June 2021 

Expected return date: 
Unknown at present 		 Last updated:
18th June 2021

HCP letter
Champix 1mg Film Coated Tablet

EU/1/06/360/005
 Varenicline Quality issue

(multiple countries affected)		 Date of shortage: 
Week commencing 21st June

Expected return date: 
Unknown at present 		 Last updated: 
18th June 2021

HCP letter
Champix 0.5 mg + 1 mg Film Coated Tablet

EU/1/06/360/003
 Varenicline 
 Quality issue 

(multiple countries affected)		 Date of shortage: 
Week commencing 21st June 

Expected return date: 
Unknown at present 		 Last updated: 
18th June 2021

HCP letter
Chlorhexidine Acetate 0.015% w/v and Cetrimide 0.15% w/v Irrigation Solution

PA2299/005/001
 Chlorhexidine acetate & cetrimide
 Unexpected increase in demand Date of shortage: 
September 2021 

Expected return date: 
Mid November 2021 		 Last updated: 
20th October 2021
Chlorpromazine Elixir BP 25mg/5ml Oral Solution

PA0281/124/001 		 Chlorpromazine hydrochloride  Manufacturing delays  Date of shortage:
End of February 2021

Expected return date:
End January 2022		 Last updated:
5th October 2021
 
HCP letter
Clexane Forte 12,000 IU (120mg) /0.8ml Solution for Injection in Pre Filled Syringes 

PA0540/097/008
 Enoxaparin sodium  API unavailability   Date of shortage: 
22nd October 2021 

Expected return date: 
Unknown at present		 Last updated: 
13th October 2021
Co-Amoxiclav 500mg/100mg Powder for Solution for Injection/Infusion

PA1457/001/001
 Amoxicillin & Clavulanic acid
 Manufacturing delays Date of shortage: 
13th October 2021 

Expected return date: 
Awaiting update		 Last updated: 
18th October 2021 
Co-Amoxiclav 1000mg/200mg Powder for Solution for Injection/Infusion

PA1457/001/002		 Amoxicillin & clavalunic acid Unexpected increase in demand Date of shortage:
5th February 2020

Expected return date:
Awaiting update
 Last updated:
19th October 2021
CoAprovel 300mg/12.5mg Tablets

EU/1/98/086/004
 Irbesartan & Hydrochlorothiazide  Shipping delay  Date of shortage: 
5th November 2021

Expected return date: 
Late November 2021  		 Last updated: 
22nd October 2021 
Cyklokapron 100 mg/mL Solution for Injection/Infusion

PA0822/117/001
 Tranexamic acid Manufacturing delays Date of shortage: 
Week commencing 18th October 2021

Expected return date: 
Week commencing 15th November 2021 		 Last updated: 
5th October 2021 
Deslor 5mg Film Coated Tablets

PA0711/202/001
 Desloratidine Awaiting information   Date of shortage: 
19th September  2021  

Expected return date: 
Late December 2021		 Last updated: 
October 2021 
Desmopressin 100mcg/ml Nasal Drop Solution

PA1009/001/001 		 Desmopressin  Manufacturing delays due to quality issue

(multiple countries affected) 		 Date of shortage:
Mid December 2020

Expected return date:
2022 		 Last updated:
11th December 2020 
Desmospray Desmopressin Nasal Spray

PA1009/005/001 		 Desmopressin  Quality issue

(multiple countries affected) 		 Date of shortage:
22nd July 2020

Expected return date:
2022 		 Last updated:
11th December 2020 
Diazemuls 5mg/ml Emulsion for Injection

PA2315/098/001 		 Diazepam  Manufacturing delays  Date of shortage:
Mid February 2020

Expected return date:
Unknown at present		 Last updated:
30th March 2021 
Dioralyte Blackcurrant Powder for Oral Solution (20 pack)

PA0540/098/001
 Sodium chloride, potassium chloride, glucose, disodium hydrogen citrate  Unexpected increase in demand  Date of shortage: 
17th September 2021

Expected return date: 
1st November 2021		 Last updated: 
30th September 2021
Dioralyte Citrus Powder for Oral Solution
(20 pack)

PA0540/098/002
 Sodium chloride, potassium chloride, glucose, disodium hydrogen citrate
 Unexpected increase in demand Date of shortage: 
17th September 2021

Expected return date: 
1st November 2021
 Last updated: 
30th September 2021
Dioralyte Rebalance Citrus Powder for Oral Solution
(6 pack)

PA0540/194/002
 Sodium chloride, potassium chloride, glucose, disodium hydrogen citrate
 Unexpected increase in demand Date of shortage: 
17th September 2021

Expected return date: 
1st November 2021
 Last updated: 
30th September 2021
Doxatan 4mg Tablets

PA0126/202/003 		 Doxazosin  Manufacturing delay   Date of shortage: 
4th October 2021

Expected return date:
Week commencing 1st November 2021		 Last updated: 
20th October 2021
Emerade 150mcg Solution in a Pre-Filled Pen

PA1696/009/001 		 Adrenaline  Quality issue

(multiple countries affected) 		 Date of shortage:
30th September 2019

Expected return date:
Unknown at present 		 Last updated:
18th December 2020

Alternatives are available 
Emerade 300mcg Solution in a Pre-Filled Pen

PA1696/009/002 		 Adrenaline  Quality issue

(multiple countries affected) 		 Date of shortage:
30th September 2019

Expected return date:
Unknown at present 		 Last updated:
18th December 2020

Alternatives are available 
Emerade 500mcg Solution in a Pre-Filled Pen

PA1696/009/003 		 Adrenaline  Quality issue

(multiple countries affected) 		 Date of shortage:
30th September 2019

Expected return date:
Unknown at present 		 Last updated:
18th December 2020

Alternatives are available 
Epanutin Infatabs 50mg Chewable Tablets

PA0822/011/005		 Phenytoin Manufacturing delays

(multiple countries affected)		 Date of shortage:
Early November 2019

Expected return date:
Unknown at present		 Last updated:
4th June 2020
 
HCP Letter
Esomeprazole Ticerin 40mg Powder for Solution for Injection of Infusion

PA1852/002/001 		 Esomeprazole  Unavailability of API  Date of shortage:
Early October 2020

Expected return date:
Late November 2021		 Last updated:
12th October 2021
Ezetimibe Rowa 10mg Tablets

PA0074/074/001
 Ezetimibe Awaiting information  Date of shortage: 
19th October 2021 

Expected return date: 
Late November 2021 		 Last updated: 
21st October 2021
Ezetimibe Teva 10mg tablets

PA1986/012/001
 Ezetimibe  Quality Issue  Date of shortage: 
18th October 2021 

Expected return date: 
13th December 2021		 Last updated: 
4th October 2021
Ezetimibe 10mg tablets

PA0577/198/001
 Ezetimibe
 Manufacturing delays  Date of shortage: 
Late August 2021 

Expected return date: 
Early November 2021		 Last updated: 
4th October 2021
Ezetimibe/Simvastatin Rowex 10mg/20mg Tablets

PA0711/262/001
 Ezetimibe & simvastatin
 Manufacturing delays  Date of shortage: 22nd July 2021

Expected return date: 
October 2021		 Last updated: 
20th September 2021
Ezetimibe/Simvastatin Rowex 10mg/80mg Tablets

PA0711/262/003
 Ezetimibe & simvastatin
 Manufacturing delays  Date of shortage: 
22nd July 2021

Expected return date: 
End November 2021
 Last updated: 
20th October 2021 
Ezetimibe/Simvastatin Teva Pharma 10mg/80mg Tablets

PA1986/067/003
 Ezetimibe & simvastatin
 API unavailability

(multiple countries impacted) 		 Date of shortage: 
30th August 2021 

Expected return date: 
Awaiting update		 Last updated: 
20th October 2021 
Ezetimibe/Simvastatin Clonmel 10mg/20mg Tablets

PA0126/281/002
Ezetimibe & simvastatin
 Manufacturing delays   Date of shortage: 
Week commencing 20th September 2021

Expected return date: 
Unknown at present		 Last updated: 
20th September 2021
Ezetimibe/Simvastatin Clonmel 10mg/80mg Tablets

PA0126/281/004
 Ezetimibe & simvastatin
 Manufacturing delays Date of shortage: 
Week commencing 20th September 2021

Expected return date:  
Unknown at present		 Last updated: 
20th September 2021
Folinic Acid (as Calcium Folinate) 7.5mg/ml Solution for Injection

PA0822/198/002
 Folinic Acid  Unexpected increase in demand Date of shortage: 
Week commencing 27th September 2021

Expected return date: 
Awaiting update		 Last updated:
18th October 2021
Fomicyt 40mg/ml Powder for Solution for Infusion

PA1972/001/001
 Fosfomycin sodium Regulatory issue  Date of Shortage: 
October 2021 

Expected return date: 
Unknown at present		 Last updated: 
12th October 2021
Gentisone HC 0.3% w/v & 1.0% w/v Ear Drops, Suspension

PA1142/014/001
 Gentamicin & Hydrocortisone Unavailability of API 

(multiple countries affected)		 Date of shortage: 
23rd August 2021

Expected return date:
Late November 2021		 Last updated: 
9th August 2021
Hydromorphone 20mg/ml Solution for Injection/Infusion

PA0549/030/001 		 Hydromorphone  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid June 2020

Expected return date:
February 2022		 Last updated:
18th October 2021
Hydromorphone 50mg/ml Solution for Injection/Infusion

PA0549/030/002 		 Hydromorphone  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid August 2020

Expected return date:
February 2022		 Last updated:
18th October 2021
Imodium Plus 2mg/125mg Tablets

PA0330/050/001
 Loperamide & simeticone  Manufacturing delay  Date of shortage: 
11th October 2021 

Expected return date:
Week commencing 22nd November 2021		 Last updated: 
20th October 2021
Innohep 10,000 IU/ml Solution for Injection

PA0046/060/002
 Tinzaparin sodium
 Unexpected increase in demand

(multiple countries affected)		 Date of shortage: 
20th September 2021

Expected return date: 
Mid-November 2021
 Last updated: 
23rd September 2021
Instanyl 50mcg Nasal Spray 

EU/1/09/531/010-013
 Fentanyl  Quality issue 
(multiple countries affected)		 Date of shortage: 
1st August 2021 

Expected return date: 
February 2022
 Last updated: 
20th August 2021
Instanyl 100mcg Nasal Spray 

EU/1/09/531/014-017
 Fentanyl  Quality issue

(multiple countries affected) 		 Date of shortage: 
2nd April 2021

Expected return date: 
February 2022		 Last updated: 
20th August 2021
Instanyl 200mcg Nasal Spray

EU/1/09/531/018-021
 Fentanyl  Quality issue

(multiple countries affected) 		 Date of shortage: 
2nd April 2021

Expected return date: 
February 2022		 Last updated:
20th August 2021
Invokana 300mg Film Coated Tablets

EU/1/13/884/005-008		 Canagliflozin
 Unexpected increase in demand  Date of shortage: 
18th October 2021

Expected return date: 
Early November 2021 		 Last updated: 
12th October 2021
Letrozole 2.5mg Film Coated Tablets

PA2315/109/001
 Letrozole  Awaiting information   Date of shortage: 
Week commencing 25th October 2021

Expected return date: 
End November 2021		 Last updated: 
18th October 2021 
Letrozole 2.5mg Film Coated Tablets

PA0126/198/001
 Letrozole  Manufacturing delays  Date of shortage: 
22nd October 2021 

Expected return date: 
22nd December 2021		 Last updated: 
18th October 2021
Letrozole Teva 2.5 mg Film Coated Tablets

PA0749/085/001
 Letrozole  API unavailability 

(multiple countries affected) 		 Date of shortage: 
Week commencing 9th August 2021

Expected return date: 
January 2021		 Last updated: 
5th October 2021
Lispril Hydrochlorothiazide 20mg/12.5mg Tablet

PA0711/051/002 		 Lisinopril & Hydrochlorothiazide  Manufacturing delays  Date of shortage:
8th September 2020

Expected return date:
Week commencing 1st November 2021		 Last updated:
20th October 2021
Losartan 50mg Tablet 

PA2315/059/002 		 Losartan  Manufacturing delays  Date of shortage:
25th September 2019

Expected return date:
Unknown at present 		 Last updated:
13th April 2021
Losartan 100mg Tablet

PA2315/059/003 		 Losartan  Manufacturing delays  Date of shortage:
October 2019

Expected return date:
Unknown at present		 Last updated:
13th April 2021
Losartan/Hydrochlorothiazide Teva 50mg/12.5mg Film-Coated Tablets

PA0749/026/001
 Losartan & Hydrochlorothiazide
  Quality issue Date of shortage: Late October 2021  

Expected return date: 
March 2022		 Last updated: 
22nd October 2021
Losartan/Hydrochlorothiazide Teva 100mg/25mg Film-Coated Tablets

PA0749/026/002
 Losartan & Hydrochlorothiazide
 Quality issue  Date of shortage: 
Late October 2021

Expected return date: 
March 2022		 Last updated: 
22nd October 2021
Marcain 0.5% w/v with Adrenaline (Epinephrine, 5 micrograms per ml) (1:200,000) Solution for Injection

PA1691/025/002
 Bupivacaine & adrenaline Manufacturing delay

(multiple countries affected) 		 Date of shortage: 
1st July 2021

Expected return date: 
Unknown at present 
 Last updated: 
24th September  2021 
Mefac 250mg Capsule

PA0074/015/001 		 Mefenamic acid  Manufacturing delays  Date of shortage:
End of June 2019

Expected return date:
Unknown at present		 Last updated:
23rd April 2021
 
Metaraminol 10mg/ml Solution for Injection or Infusion 

PA22893/001/001		 Metaraminol  Awaiting update Date of shortage: 
Early April 2021 

Expected return date:
Awaiting update		 Last updated: 
30th June 2021
Metformin Hydrochloride 500mg/5ml Oral Solution

PA23081/008/001
 Metformin  Regulatory Issue Date of shortage: 
13th August 2021

Expected return date: 
Unknown at present		 Last updated: 
10th August 2021
Mydrilate 1.0% w/v Eye Drops

PA22709/003/002
 Cyclopentolate Manufacturing delay  Date of shortage:
Early September 2021

Expected return date: 
Mid-October 2021		 Last updated: 
27th September 2021 
Naloxone Hydrochloride 400mcg/ml Solution for Injection or Infusion 

PA0073/111/002
 Naloxone Manufacturing delay  Date of shortage: 
18th October 2021

Expected return date: 
3rd December 2021 		 Last updated: 
19th October 2021
Nanocis 0.24mg Kit for Radiopharmaceutical Preparation

PA0677/006/001
 Rhenium sulphide
 Awaiting information  Date of shortage: 
Week commencing 20th September 2021 

Expected return date: 
Week commencing 8th November 2021		 Last updated: 
1st October 2021
Odrik 2mg Hard Capsule

PA2010/005/003
 Trandolapril
 Manufacturing delays Date of shortage: 
5th October 2021

Expected return date: 
Late October 2021 		 Last updated: 
28th September 2021
Oramox 125mg/5ml Powder for Oral Suspension

PA0298/019/001
 Amoxicillin
 Unexpected increase in demand  Date of shortage:
22nd October 2021 

Expected return date: 
Unknown at present 		 Last updated: 
19th October 2021 
OxyContin 5mg Prolonged Release Tablets 

PA1688/005/001
  Oxycodone Manufacturing delays  Date of shortage: 
18th October 2021

Expected return date: 
Early November 2021		 Last updated:
12th October 2021
OxyNorm Dispersa 5mg Orodispersible Tablets

PA1688/006/007
 Oxycodone  Unexpected increase in demand  Date of shortage: 
5th October 2021 

Expected return date: 
4th November 2021		 Last updated: 
18th October 2021
OxyNorm Dispersa 10mg Orodispersible Tablets

PA1688/006/008
 Oxycodone Manufacturing delays  Date of shortage: 
18th October 2021

Expected return date:
Unknown at present 		  Last updated: 
12th October 2021
OxyNorm Dispersa 20mg Orodispersible Tablets

PA1688/006/009
 Oxycodone Manufacturing delays  Date of shortage: 
26th October 2021 

Expected return date:
February 2022		 Last updated: 
20th October 2021 
Palexia 4mg/ml Oral Solution

PA2242/012/010 		 Tapentadol hydrochloride  Quality issue

(multiple countries affected) 		 Date of shortage:
15th February 2021

Expected return date:
Unknown at present 		 Last updated: 
22nd February 2021
Paralief 500mg Tablets 

24 pack only

PA0126/020/001
 Paracetamol API unavailability  Date of shortage: 
Week commencing 23rd August 2021

Expected return date: 
27th October 2021
 Last updated: 
28th August 2021
Perinal Cutaneous Spray hydrocortisone 0.2% w/w / lidocaine hydrochloride monohydrate 1.0% w/w

PA0278/017/002
 Hydrocortisone & Lidocaine Hydrochloride  Manufacturing delays  Date of shortage:
February 2021

Expected return date:
January 2022		 Last updated: 
8th April 2021
Qlaira Film Coated Tablets

PA1410/058/001
  Estradiol API unavailability  Date of shortage: 
Mid November 2021

Expected return date: 
Q2 2022		 Last updated: 
7th October 2021

HCP letter
Questran 4g Powder for Oral Suspension

PA2239/005/001 		 Colestyramine  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid June 2019

Expected return date:
January 2022		 Last updated:
30th March 2021 
Rifater 50mg/300mg/120mg Tablets

PA0822/143/002
 Isoniazid & Pyrazinamide & Rifampicin Quality issue

(multiple countries impacted)		 Date of shortage: 
23rd July 2021

Expected return date: 
26th October 2021		 Last updated:
18th October 2021

AMRIC guidance V3
Rosuvastatin 5mg Film Coated Tablets

PA2315/068/001
 Rosuvastatin Quality issue  Date of shortage:
27th August 2021

Expected return date: 
Q2 2022		  Last updated: 
30th August 2021
Rosuvastatin 10mg Film Coated Tablets

PA2315/068/002
 Rosuvastatin  Quality issue Date of shortage: 
27th August 2021 

Expected return date: 
Q2 2022 		 Last updated: 
30th August 2021 
Rosuvastatin 20mg Film Coated Tablets

PA2315/068/003
 Rosuvastatin   Distribution issue Date of shortage: 
18th October 2021 

Expected return date: 
Early January 2022 		 Last updated: 
21st October 2021 
Rosuvastatin 40mg Film Coated Tablets

PA2315/068/004
 Rosuvastatin   Distribution issue
 Date of shortage: 
18th October 2021 

Expected return date: 
Early January 2022 
 Last updated: 
21st October 2021 
Sevelamer Carbonate 800mg Film Coated Tablets

PA0577/205/001
 Sevelamer  Manufacturing delays Date of shortage: 
Late October

Expected return date: 
Unknown at present  		 Last updated: 
22nd October 2021
Sprilon 12.5% Zinc Oxide & 1.04% Dimethicone Cutaneous Spray Suspension

PA22906/001/001 		 Zinc oxide & Dimethicone  Manufacturing delays  Date of shortage:
October 2019

Expected return date:
Mid-December 2021		 Last updated:
22nd October 2021
Stesolid Rectal Solution 5mg

PA2315/137/001
 Diazepam  Manufacturing delays Date of shortage: 
Late August 2021

Expected return date: 
November 2021		 Last updated: 
12th August 2021
Stesolid Rectal Solution 10mg

PA2315/137/002
  Diazepam Manufacturing delays  Date of shortage: 
Week commencing 19th July 2021. 

Expected return date: 
November 2021		 Last updated: 
21st July 2021
Targin 20mg/10mg Prolonged Release Tablets

PA1688/010/001		 Oxycodone & Naloxone  Shipping delays Date of shortage: 
27th September 2021 

Expected return date: 
28th October 2021
 Last updated: 
22nd October 2021
Telmisartan Rowa 40mg Tablets

PA0074/078/002
 Telmisartan  Unexpected increase in demand  Date of shortage: 
7th September 2021

Expected return date: 
Late November 2021		  Last updated: 
20th October 2021
Tevanate Once Weekly 70mg Tablets

PA0749/016/001
 Alendronic acid API unavailability  Date of shortage: 
6th September 2021 

Expected return date: 
Late November 2021 		 Last updated: 
23rd August 2021 
Tracrium 10 mg/ml, Solution for injection or infusion

(25ml ampoule)

PA1691/029/002
 Atracurium  Unexpected increase in demand Date of shortage: 
24th September 2021 

Expected return date: 
20th November 2021 		 Last updated: 
24th September 2021
Trandate 200mg Film Coated Tablet

PA1638/006/003 		 Labetalol hydrochloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
July 2019

Expected return date:
End October 2021		 Last updated:
11th October 2021
TPN – various B. Braun products
 Various  Manufacturing delays  Date of shortage: 
4th October 2021

Expected return date: 
Unknown at present		 Last updated: 
5th October 2021

HCP letter
Ultraproct 0.92mg/ + 0.95mg/g + 5mg/g Rectal Ointment

PA22650/004/001
 Fluocortolone Pivalate; Fluocortolone caproate; Cinchocaine hydrochloride  Regulatory issue Date of shortage: 
Late September 2021

Expected return date: 
Late December 2021
 Last updated: 
15th September 2021
Uniphyllin Continus 200mg Prolonged Release Tablets

PA1688/011/001

Date of shortage: 
20th October 2021 

Expected return date: 
Unknown at present

Anapen 300 micrograms in 0.3ml solution for injection in a pre-filled syringe


Contact us:

Medicinal Product Shortages Unit
Health Products Regulatory Authority 
Kevin O’Malley House
Earlsfort Terrace,
Dublin 2
Tel: +353 1 676 4971
Fax: +353 1 676 7836
shortages@hpra.ie