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Medicinal Product Shortages

The HPRA is responsible for co-ordinating the management of shortages of medicines on the Irish market. The HPRA works with a variety of stakeholders including manufacturers, wholesale distributors, marketing authorisation holders, healthcare professionals, the Health Service Executive, patients and representative groups to respond to potential shortages and reduce the impact of shortages on patients.

The definition of a shortage is when the supply of a medicinal product is inadequate to meet the needs of the patient. 

The HPRA, in collaboration with stakeholders, has published a framework for a multi-stakeholder approach to handling shortages of human medicinal products. The aim of the framework is to help prevent shortages from occurring and to reduce the impact of shortages on patients by co-ordinating the management of potential or actual shortages as they arise. You can see the shortages case study on Adrenaline auto-injectors (AAIs) as an example of how the framework operates in practice. 


Information on reporting shortages for:

Marketing Authorisation Holders

Please complete the  Notification of medicinal product shortage from marketing authorisation holder form and return to  shortages@hpra.ie and to the HSE Corporate Pharmaceutical Unit.

Wholesale Distributors and Manufacturers

Please complete the  Report of Medicinal Products Shortages from Wholesale Distributors and Manufacturers form and return this form to  shortages@hpra.ie.

Patients and Healthcare Professionals

Please complete the  Report of a Medicinal Product Shortage from Patients and Healthcare Professionals form and return to  shortages@hpra.ie. When completing this form, please include as much information as possible.


Current and resolved shortages

The HPRA publishes a list of shortages currently affecting the Irish market that have been notified to us and that may have a medium or high impact on patients. This list can be found below. More information on the impact level can be found in the framework for a multi-stakeholder approach to handling shortages of human medicinal products.

The HPRA maintains a consolidated list of resolved shortages for a period of six months. Details of shortages that have been resolved in the last six months can be found here.
 

Hormone replacement therapy (HRT) shortages

HRT shortages have impacted multiple countries over the past year and are not restricted to Ireland. While there are shortages of some specific brands, alternatives are available to meet patient need. The suppliers have stated that the causes of the shortages relate to both active substance availability and manufacturing delays. It is not related to Brexit. The HPRA continues to be in frequent contact with the suppliers to maintain efforts to expedite re-supply as soon as possible. The HPRA website will be will be kept up to date as additional information becomes available.

 

If a patient has any concerns about their medicine, the HPRA advises that they should discuss their treatment a doctor or pharmacist.


Please use search function below to find relevant product or active ingredient

 
Product name Active ingredient Reason for shortage Date of shortage
 Additional information
Abstral 100mcg Sublingual Tablet

PA2288/004/002 		 Fentanyl  Manufacturing delays  Date of shortage:
22nd January 2020

Expected return date:
Awaiting update		 Last updated:
24th March 2020 
Abstral 200mcg Sublingual Tablet

PA2288/004/003 		 Fentanyl  Manufacturing delays  Date of shortage:
22nd January 2020

Expected return date:
Awaiting update		 Last updated:
24th March 2020 
Abstral 300mcg Sublingual Tablet

PA2288/004/004 		 Fentanyl  Manufacturing delays  Date of shortage:
22nd January 2020

Expected return date:
Awaiting update		 Last updated:
24th March 2020 
Abstral 400mcg Sublingual Tablet

PA2288/004/005 		 Fentanyl  Manufacturing delays  Date of shortage:
22nd January 2020

Expected return date:
Awaiting update		 Last updated:
24th March 2020 
Abstral 600mcg Sublingual Tablet

PA2288/004/006 		 Fentanyl  Manufacturing delays  Date of shortage:
22nd January 2020

Expected return date:
Awaiting update		 Last updated:
24th March 2020 
Abstral 800mcg Sublingual Tablet

PA2288/004/007 		 Fentanyl  Manufacturing delays  Date of shortage:
22nd January 2020

Expected return date:
Awaiting update		 Last updated:
24th March 2020 
Accupro 20mg Film Coated Tablet

PA0822/007/003 		 Quinapril hydrochloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid March 2019

Expected return date:
April 2020		 Last updated:
6th February 2020
 

 
Accuretic 20/12.5mg Film Coated Tablet

PA0822/008/002 		 Quinapril hydrochloride & Hydrochlorothiazide  Manufacturing delays 

(multiple countries affected)		 Date of shortage:
Early January 2019

Expected return date:
May 2020		 Last updated:
6th February 2020
 

 
           
Adalat LA 20mg Prolonged Release Tablet

PA1410/025/005		 Nifedipine  Manufacturing delays

(multiple countries affected)		 Date of shortage:
November 2017
 
Expected return date:
Not before 2021		 Last updated:
29th November 2019
 
Adalat LA 30mg Prolonged Release Tablet

PA1410/025/006		 Nifedipine  Manufacturing delays

(multiple countries affected)		 Date of shortage:
24th June 2018

Expected return date:
Not before 2021
 Last updated:
29th November 2019 
 
Adalat LA 60mg Prolonged Release Tablet

PA1410/025/007 		 Nifedipine Manufacturing delays

(multiple countries affected)		 Date of shortage:
September 2018

Expected return date:
Not before 2021		 Last updated:
29th November 2019
 
Alendronate/Colecalciferol Teva 70mg/5600IU Tablet

PA0749/196/002 		 Alendronate & Colecalciferol  Manufacturing delays  Date of shortage:
January 2019

Expected return date:
Q2 2020 		 Last updated:
16th January 2020 
Amisulpride 50mg Tablet

PA0577/182/001 		 Amisulpride  Manufacturing delays  Date of shortage:
July 2019

Expected return date:
End of March 2020 		 Last updated:
20th January 2020 
Amisulpride 200mg Tablet

PA0577/182/002 		 Amisulpride  Manufacturing delays  Date of shortage:
February 2019

Expected return date:
End of March 2020 		 Last updated:
20th January 2020 
Amoxil Vials 500mg Powder for Solution for Injection or Infusion

PA1077/033/004 		 Amoxicillin  Unavailability of API

(multiple countries affected) 		 Date of shortage:
25th February 2020

Expected return date:
June 2020 		 Last updated:
23rd March 2020 
Angeliq 1mg/2mg Tablet

PA1410/013/001 		 Estradiol & Drospirenone  Unavailability of API

(multiple countries affected) 		 Date of shortage:
23rd March 2020

Expected return date:
20th April 2020 		 Last updated:
4th March 2020 
Areloger 15mg Film Coated Tablet

PA0577/057/002 		 Meloxicam  Manufacturing delays  Date of shortage:
Early August 2019

Expected return date:
August 2020		 Last updated:
18th February 2020 
Atecor CT 50mg/12.5mg Tablet

PA0711/020/001 		 Chlortalidone & Atenolol  Unexpected increase in demand  Date of shortage:
Early March 2020

Expected return date:
Mid April 2020 		 Last updated:
6th March 2020 
Atecor CT 100mg/25mg Tablet

PA0711/020/002 		 Chlortalidone & Atenolol  Unexpected increase in demand  Date of shortage:
Early March 2020

Expected return date:
End of March 2020 		 Last updated:
6th March 2020 
Axsain 0.075% w/w Cream

PA0827/004/001 		 Capsaicin  Manufacturing delays 

(multiple countries affected)		 Date of shortage:
Mid June 2019

Expected return date:
Q2 2020		 Last updated:
26th March 2020 
BCG-Medac Powder and Solvent for Suspension for Intravesical Use

PA0623/004/001 		 Bacillus Calmette Guerin bacteria  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
1st October 2019

Expected return date:
Unknown at present 		 Last updated:
7th November 2019 
Becotide 50mcg Evohaler

PA1077/042/006 		 Beclometasone  Manufacturing delays  Date of shortage:
23rd March 2020

Expected return date:
6th April 2020 		 Last updated:
24th March 2020 
Blopress 4mg Tablet

PA2229/001/002 		 Candesartan  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid October 2019

Expected return date:
April 2020 		 Last updated:
22nd October 2019 
Candist 4mg Tablet

PA0126/206/001 		 Candesartan  Unexpected increase in demand  Date of shortage:
Mid December 2019

Expected return date:
End of March 2020 		 Last updated:
20th March 2020 
Canesten Duopack - 100mg Pessary & 1% w/w Cream

PA1410/039/005 		 Clotrimazole  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
February 2018

Expected return date:
End of September 2020 		 Last updated:
27th March 2020
 
HCP Letter
Canesten 200mg Pessary

PA1410/039/008 		 Clotrimazole  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
February 2018

Expected return date:
Early April 2020 		 Last updated:
9th January 2020
 
HCP Letter
Canesten 500mg Pessary

PA1410/039/009 		 Clotrimazole  Manufacturing delay

(multiple countries affected) 		 Date of shortage:
January 2018

Expected return date:
Early May 2020		 Last updated:
27th March 2020
             
HCP Letter
Celebrex 100mg Hard Capsule

PA0822/116/001 		 Celecoxib  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of March 2020

Expected return date:
Mid May 2020 		 Last updated:
2nd March 2020 
Celebrex 200mg Hard Capsule

PA0822/116/002 		 Celecoxib  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid March 2020

Expected return date:
Mid April 2020 		 Last updated:
2nd March 2020 
Celecoxib 100mg Capsule

PA2315/228/001 		 Celecoxib  Manufacturing delays  Date of shortage:
February 2020

Expected return date:
May 2020 		 Last updated:
26th February 2020 
Celecoxib 200mg Capsule

PA2315/228/002 		 Celecoxib  Manufacturing delays  Date of shortage:
February 2020

Expected return date:
May 2020 		 Last updated:
26th February 2020 
Centrax 10mg Tablet

PA0822/010/001 		 Prazepam  Manufacturing delays  Date of shortage:
End of March 2020

Expected return date:
Mid April 2020
 		 Last updated:
27th March 2020 
Cimeldine 400mg Film Coated Tablet

PA0126/077/002 		 Cimetidine  API delay  Date of shortage:
9th December 2019

Expected return date:
20th April 2020 		 Last updated:
31st January 2020 
Ciprofloxacin Teva 250mg Film Coated Tablet


PA0749/031/002 		 Ciprofloxacin  Manufacturing delays  Date of shortage:
Early September 2019

Expected return date:
Early April 2020		 Last updated:
13th March 2020
Ciprofloxacin Teva 500mg Film Coated Tablet

PA0749/031/003 		 Ciprofloxacin  Manufacturing delays  Date of shortage:
Mid August 2019

Expected return date:
Early April 2020		 Last updated:
13th March 2020 
Ciproxin 500mg Tablet

PA1410/028/003 		 Ciprofloxacin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
September 2018

Expected return date:
End of May 2020 		 Last updated:
18th March 2020
 
HCP Letter
Co-Amoxiclav 500mg/100mg Powder for Solution for Injection and Infusion

PA1457/001/001		 Amoxicillin & clavalunic acid Unexpected increase in demand Date of shortage:
24th May 2019

Expected return date:
Unknown at present		 Last updated:
11th March 2020 
Co-Amoxiclav 1000mg/200mg Poweder for solution for injection/infusion

PA1339/005/002		 Amoxicillin & clavalunic acid Unexpected increased demand Date of shortage:
5th February 2020

Expected return date:
Unknown at present
 Last updated:
11th March 2020 
Cozaar Comp 100mg/12.5mg Film coated Tablet

PA1286/001/001 		 Losartan & Hydrochlorothiazide  Unexpected increase in demand  Date of shortage:
27th March 2020

Expected return date:
Mid April 2020 		 Last updated:
24th March 2020 
Cozatan 50mg Film Coated Tablet

PA0126/167/001 		 Losartan potassium  Active substance impurity  Date of shortage:
Mid June 2019

Expected return date:
April 2020		 Last updated:
18th November 2019 
Cozatan 100mg Film Coated Tablet

PA0126/167/002 		 Losartan potassium  Manufacturing delays  Date of shortage:
End of January 2020

Expected return date:
Early May 2020 		 Last updated:
5th February 2020 
Creon 25000 Gastro-resistant Capsule

PA2010/008/002 		 Pancreatin  Unexpected increase in demand  Date of shortage:
18th March 2020

Expected return date:
Mid April 2020 		 Last updated:
23rd March 2020 
Diazemuls 5mg/ml Emulsion for Injection

PA2315/098/001 		 Diazepam  Manufacturing delays  Date of shortage:
Mid February 2020

Expected return date:
Unknown at present 		 Last updated:
19th February 2020 
Emerade 150mcg Solution in a Pre-Filled Pen

PA1696/009/001 		 Adrenaline  Quality issue

(multiple countries affected) 		 Date of shortage:
30th September 2019

Expected return date:
Unknown at present 		 Last updated:
30th September 2019

Alternatives are available 
Emerade 300mcg Solution in a Pre-Filled Pen

PA1696/009/002 		 Adrenaline  Quality issue

(multiple countries affected) 		 Date of shortage:
30th September 2019

Expected return date:
Unknown at present 		 Last updated:
30th September 2019

Alternatives are available 
Emerade 500mcg Solution in a Pre-Filled Pen

PA1696/009/003 		 Adrenaline  Quality issue

(multiple countries affected) 		 Date of shortage:
30th September 2019

Expected return date:
Unknown at present 		 Last updated:
30th September 2019

Alternatives are available 
Epanutin 50mg Capsule

PA0822/011/002 		 Phenytoin  Manufacturing delays  Date of shortage:
28th February 2020

Expected return date:
Week commencing 6th April 2020 		 Last updated:
16th March 2020

HCP Letter
Epanutin 300mg Capsule

PA0822/011/004 		 Phenytoin  Manufacturing delays  Date of shortage:
2nd March 2020

Expected return date:
Week commencing 6th April 2020 		 Last updated:
19th March 2020 

HCP Letter
Epanutin Infatabs 50mg Chewable Tablets

PA0822/011/005		 Phenytoin Manufacturing delays

(multiple countries affected)		 Date of shortage:
Early November 2019

Expected return date:
Unknown at present		 Last updated:
19th March 2020
 
HCP Letter
Epanutin Ready Mixed Parenteral 250mg/5ml Solution for Injection or Infusion

PA0822/011/006 		 Phenytoin  Manufacturing delays

(multiple countries affected)		 Date of shortage:
Mid July 2019

Expected return date:
May 2020 		 Last updated:
26th February 2020
 
HCP Letter
Erwinase 10000% v/v Powder for Solution for Injection

PA1020/002/001  		 Cristanspase Manufacturing delays

(multiple countries affected)		 Date of shortage:
5th October 2018

Expected return date:
Awaiting update
 Last updated:
18th November 2019
             

                         

 
Erythrocin 250mg Tablet

PA1142/008/002 		 Erythrocin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Early August 2019

Expected return date:
29th May 2020		 Last updated:
4th February 2020 
Erythrocin 500mg Tablet

PA1142/008/003 		 Erythrocin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of February 2020

Expected return date:
Early April 2020 		 Last updated:
20th March 2020 
Erythroped PI SF 125mg/5ml Granules for Oral Suspension

PA1142/006/002 		 Erythromycin  Manufacturing delays 

(multiple countries affected)		 Date of shortage:
End of June 2019

Expected return date:
26th May 2020 		 Last updated:
4th February 2020 
Erythroped SF 250mg/5ml Granules for Oral Suspension

PA1142/006/001 		 Erythromycin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid November 2019

Expected return date:
12th June 2020		 Last updated:
4th February 2020 
Etoposide 20mg/ml Solution for Infusion

PA0749/002/001 		 Etoposide  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
24th February 2020

Expected return date:
May 2020 		 Last updated:
24th February 2020 
Evorel 50mcg Transdermal Patch

PA22668/008/001 		 Estradiol  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
October 2019

Expected return date:
May 2020 		 Last updated:
24th February 2020
 
HCP Letter
 
Evorel Conti 50mcg/170mcg Transdermal Patch

PA22668/009/001 		 Estradiol & Norethisterone Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Early January 2020

Expected return date:
May 2020 		 Last updated:
24th February 2020
 
HCP Letter
 
             
Ezetimibe/Simvastatin Clonmel 10mg/10mg 

PA0126/281/001		 Ezetimibe & Simvastatin  Manufacturing delay  Date of shortage:
6th January 2020

Expected return date:
20th April 2020 
 Last updated:
10th February 2020
Flixotide 125mcg Evohaler

PA1077/044/001		 Fluticasone  Unexpected increase in demand  Date of shortage:
24th March 2020

Expected return date:
Week commencing 30th March 2020		 Last updated:
27th March 2020 
Folinic Acid 10mg/ml Solution for Injection

(50mg/5mg presentation only)

PA0822/198/003 		 Folinic acid  Manufacturing delays  Date of shortage:
End of March 2020

Expected return date:
Week commencing 6th April 2020 		 Last updated:
20th March 2020 
Folinic Acid 10mg/ml Solution for Injection

(100mg/10ml presentation only)

PA0822/198/003 		 Folinic acid  Manufacturing delays  Date of shortage:
5th July 2019

Expected return date:
July 2020		 Last updated:
10th February 2020
Frisium 10mg Tablet

PA0540/043/001 		 Clobazam  Manufacturing delays  Date of shortage:
23rd March 2020

Expected return date:
30th March 2020 		 Last updated:
23rd March 2020 
Frumil Low Strength 20mg/2.5mg Tablet

PA0540/101/001 		 Furosemide & Amiloride  Unexpected increase in demand

(multiple countries affected) 		 Date of shortage:
26th February 2020

Expected return date:
17th April 2020 		 Last updated:
19th March 2020 
Genotropin Miniquick 0.4mg Powder and Solvent for Solution for Injection

PA0822/128/004 		 Somatropin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid February 2020

Expected return date:
Q3 2020		 Last updated:
19th February 2020 
Genotropin Miniquick 0.6mg Powder and Solvent for Solution for Injection

PA0822/128/005 		 Somatropin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
4th February 2020

Expected return date:
Q3 2020 		 Last updated:
5th February 2020 
Genotropin Miniquick 0.8mg Powder and Solvent for Solution for Injection

PA0822/128/006 		 Somatropin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
4th March 2020 
 
Expected return date:
Q3 2020 		 Last updated:
4th March 2020 
Genotropin Miniquick 1mg Powder and Solvent for Solution for Injection

PA0822/128/007
 Somatropin  Manufacturing delays

(multiple countries affected)
 Date of shortage:
6th February 2020

Expected return date:
Q3 2020 
 Last updated:
10th February 2020
Genotropin Miniquick 1.4mg Powder and Solvent for Solution for Injection

PA0822/128/009 		 Somatropin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
3rd February 2020

Expected return date:
Q3 2020 		 Last updated:
5th February 2020 
Genotropin Miniquick 1.6mg Powder and Solvent for Solution for Injection

PA0822/128/010 		 Somatropin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid March 2020

Expected return date:
Q3 2020 		 Last updated:
12th March 2020 
Genotropin Miniquick 1.8mg Powder and Solvent for Solution for Injection

PA0822/128/011 
 Somatropin
 Manufacturing delays

(multiple countries affected) 
 Date of shortage:
10th February 2020

Expected return date:
Q3 2020 
 Last updated:
10th February 2020 
Genotropin Miniquick 2mg Powder and Solvent for Solution for Injection

PA0822/128/012 
 Somatropin
 Manufacturing delays

(multiple countries affected)  		 Date of shortage:
6th February 2020

Expected return date:
Q3 2020 
 Last updated:
10th February 2020
Gentamicin 40 mg/ml Injection, vials

PA0822/203/001
 Gentamicin
 Manufacturing delays

(multiple countries impacted)		 Date of shortage:
9th December 2019

Expected return date:
August 2020
 Last updated:
10th February 2020
Geodon 80mg Capsule

PA0822/214/004 		 Ziprasidone  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Early March 2020

Expected return date:
6th April 2020 		 Last updated:
25th March 2020 
Gerozac 20mg Capsule

PA0577/200/001 		 Fluoxetine  Manufacturing delays  Date of shortage:
Early December 2019

Expected return date:
Awaiting update 		 Last updated:
13th March 2020 
Gerozac 60mg Capsule

PA0577/071/001 		 Fluoxetine  Manufacturing delays  Date of shortage:
Early December 2020

Expected return date:
May 2020 		 Last updated:
18th February 2020 
Gertac 150mg Film Coated Tablet

PA0577/023/001 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers 

AHDMP Guidance for Prescribers
Gertac 300mg Film Coated Tablet

PA0577/023/002 		 Ranitidine  Active substance impurities

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers 

AHDMP Guidance for Prescribers
HBVAXPRO 40mcg Suspension for Injection

EU/1/01/183/015 		 Hepatitis B  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
12th November 2019

Expected return date:
End of 2020 		 Last updated:
13th November 2019 
Hypnovel 10mg/2ml Solution for Injection

PA2239/007/001 		 Midazolam  Manufactuirng delays  Date of shortage:
20th March 2020

Expected return date:
Awaiting update 		 Last updated:
23rd March 2020 
Hypovase 1mg Tablet

PA0822/195/002 		 Prazosin hydrochloride  Manufacturing delay 

(multiple countries affected)		 Date of shortage:
Mid June 2019

Expected return date:
May 2020		 Last updated:
19th February 2020
Hytrin 5mg Tablet

PA1142/005/003 		 Terazosin  Manufacturing delays

(multiple countries affected)		 Date of shortage:
Mid February 2020

Expected return date:
End of March 2020 		 Last updated:
28th February 2020 
Indivina 1mg/2.5mg Tablet

PA1327/005/001 		 Medroxyprogestrone & Estradiol  Manufacturing delays  Date of shortage:
February 2020

Expected return date:
May 2020 		 Last updated:
25th February 2020 
Indivina 2mg/5mg Tablet

PA1327/005/003 		 Medroxyprogestrone & Estradiol  Manufacturing delays  Date of shortage:
February 2020

Expected return date:
May 2020 		 Last updated:
25th February 2020 
Inspra 25mg Film Coated Tablet

PA0822/020/002 		 Eplerenone  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
12th February 2020

Expected return date:
6th April 2020 		 Last updated:
16th March 2020 
Irprestan 150mg Film Coated Tablet

PA1380/021/002 		 Irprestan  Active substance impurity

(multiple countries affected) 		 Date of shortage:
February 2019

Expected return date:
Unknown at present		 Last updated:
8th August 2019 
Lanoxin PG 62.5mcg Tablet 

PA1691/001/003
 Digoxin  Manufacturing delays  Date of shortage:
10th February 2020

Expected return date:
Early May 2020
 Last updated:
17th February 2020 

HCP Letter
Lanoxin PG 250mcg Tablet

PA1691/001/004 		 Digoxin  Manufacturing delays  Date of shortage:
17th March 2020

Expected return date:
23rd May 2020 		 Last updated:
18th March 2020 
Lercanidipine Mylan 10mg Tablet

PA0577/155/001		 Lercanidipine  Unexpected increase in demand  Date of shortage:
Early November 2019

Expected return date:
October 2020 		 Last updated:
21st January 2020 
Lercanidipine Mylan 20mg Tablet

PA0577/155/002 		 Lercanidipine  Unexpected increase in demand  Date of shortage:
Early November 2019

Expected return date:
October 2020 		 Last updated:
21st January 2020
Letrozole Teva 2.5mg Film Coated Tablet

PA0749/085/001 		 Letrozole  Manufacturing delays  Date of shortage:
Mid December 2019

Expected return date:
Q2 2020 		 Last updated:
5th March 2020 
Levofloxacin 5mg/ml Solution for Infusion

PA1122/013/001 		 Levofloxacin  Unexpected increase in demand  Date of shortage:
23rd March 2020

Expected return date:
Mid April 2020 		 Last updated:
26th March 2020 
Lopid 300 mg Capsules

PA0822/014/001		 Gemfibrozil Capacity constraints at manufacturer Date of shortage:
2nd March 2020

Expected return date:
Awaiting update
 Last updated:
16th March 2020 
Losartan 50mg Tablet 

PA2315/059/002 		 Losartan  Manufacturing delays  Date of shortage:
25th September 2019

Expected return date:
Unknown at present 		 Last updated:
10th October 2019 
Losartan 100mg Tablet

PA0749/090/004 		 Losartan  Unavailability of API

(multiple countries affected) 		 Date of shortage:
Early January 2020

Expected return date:
Q2 2020 		 Last updated:
28th January 2020 
Losartan 100mg Tablet

PA2315/059/003 		 Losartan  Manufacturing delays  Date of shortage:
October 2019

Expected return date:
Unknown at present 		 Last updated:
10th October 2019 
Losartan Hydrochlorothiazide 50mg/12.5mg Tablet

PA0749/026/001 		 Losartan & Hydrochlorothiazide  Unavailability of API

(multiple countries affected) 		 Date of shortage:
24th November 2019

Expected return date:
Q2 2020		 Last updated:
28th January 2020 
Marcain Heavy Steripack 0.5% w/v Solution for Injection

PA1691/024/003		 Bupivacaine hydrochloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of November 2019

Expected return date:
7th April 2020
 		 Last updated:
18th March 2020 
Maxibar 98.45% w/w Powder for Oral Suspension

PA1826/002/001 		 Barium sulphate  Manufacturing delays  Date of shortage:
End of June 2019

Expected return date:
Awaiting update		 Last updated:
26th November 2019 
Mefac 250mg Capsule

PA0074/015/001 		 Mefenamic acid  Manufacturing delays  Date of shortage:
End of June 2019

Expected return date:
June 2020 		 Last updated:
27th June 2019
Minims Atropine Sulphate 1% Eye Drop Solution

PA0555/017/001 		 Atropine  Manufacturing delays  Date of shortage:
July 2019

Expected return date:
End of July 2020		 Last updated:
5th March 2020 
Mitomycin Kyowa 10mg Powder for Solution for Injection

PA2288/002/001
  Mitomycin Quality issue

(multiple countries affected)		 Date of shortage:
3rd October 2019

Expected return date:
Unknown at present
 Last updated:
13th December 2019
Mitomycin Kyowa 40mg Powder for Solution for Injection

PA2288/002/002
  Mitomycin Quality issue

(multiple countries affected)		 Date of shortage:
3rd October 2019

Expected return date:
Unknown at present
 Last updated:
13th December 2019
Morphine Sulphate Injection BP 30mg/ml Solution for Injection

PA0361/004/005 		 Morphine Sulphate  Manufacturing delays  Date of shortage:
October 2018

Expected return date:
During 2020		 Last updated:
16th October 2019 
Muse 250mcg Urethral Stick

PA2010/028/002		 Alprostadil  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid March 2019
 
Expected return date:
Unknown at present		 Last updated:
12th February 2020
Neotigason 10mg Capsule

PA1380/050/001 		 Acitretin  Manufacturing delays  Date of shortage:
Mid February 2020

Expected return date:
Mid April 2020 		 Last updated:
13th March 2020

HCP Letter
Neotigason 25mg Capsule

PA1380/050/002 		 Acitretin  Manufacturing delays  Date of shortage:
Early January 2020

Expected return date:
Mid April 2020 		 Last updated:
13th March 2020
 
HCP Letter 
Olanzapine 10mg Tablet

EU/1/07/427/011-014 		 Olanzapine  Unavailability of API

(multiple countries affected) 		 Date of shortage:
End of January 2020

Expected return date:
Q2 2020 		 Last updated:
5th March 2020
Olmesartan 10mg Tablet

PA2315/113/001 		 Olmesartan  Manufacturing delay  Date of shortage:
October 2019

Expected return date:
Unknown at present 		 Last updated:
26th March 2020 
Olmesartan Medoxomil Clonmel 10mg Film Coated Tablet

PA0126/273/001 		 Olmesartan   Manufacturing delay  Date of shortage:
2nd December 2019

Expected return date:
23rd March 2020 		 Last updated:
20th March 2020 
Oxaliplatin 5mg/ml Concentrate for Solution for Infusion

PA2059/049/001		 Oxaliplatin  Manufacturing delays  Date of shortage:
End of October 2019

Expected return date:
Awaiting update 		 Last updated:
19th March 2020 
Paramax 500mg/5mg Tablet

PA0540/154/001 		 Paracetamol & Metoclopramide  Manufacturing delays  Date of shortage:
End of December 2019

Expected return date:
4th May 2020 		 Last updated:
2nd March 2020 
Pepcid AC 10mg Tablet

PA0330/053/001 		 Famotidine  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
February 2020

Expected return date:
End of March 2020 		 Last updated:
11th March 2020 
Perdamel 0.5mg Film Coated Tablet

PA0126/169/002 		 Risperidone  Manufacturing delays  Date of shortage:
20th January 2020

Expected return date:
Early May 2020 		 Last updated:
5th February 2020 
Piperacillin with Tazobactam 2.25g Powder for Solution for Injection

PA1339/001/001 		 Piperacillin sodium & Tazobactam sodium Manufacturing delays

(multiple countries affected)		 Date of shortage:
January 2018

Expected return date:
Unknown at present		 Last updated:
12th July 2019
Piperacillin with Tazobactam 4.5g Powder for Solution for Injection

PA1339/001/002 		 Piperacillin sodium & Tazobactam sodium Manufacturing delays

(multiple countries affected)		 Date of shortage:
January 2018

Expected return date:
Unknown at present		 Last updated:
12th July 2019
Pneumovax 23 Solution for Injection in Pre-filled Syringe

PA1286/055/002 		 Pneumococcal Polysaccharide Vacine  Unexpected increase in demand

(multiple countries affected)		 Date of shortage:
16th March 2020

Expected return date:
July 2020 		 Last updated:
23rd March 2020 
Proctosedyl Ointment

PA0540/062/001 		 Hydrocortisone, Framycetin; Aesculin & Cinchocaine  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of November 2019

Expected return date:
Unknown at present		 Last updated:
2nd March 2020 
Proscar 5mg Film coated Tablet

PA1286/017/001 		 Finasteride  Manufacturing delays  Date of shortage:
Mid February 2020

Expected return date:
Mid April 2020 		 Last updated:
17th February 2020 
Prozamel 20mg Cpasule

PA0126/110/001 		 Fluoxetine  Manufcaturing delays
 		 Date of shortage:
End of March 2020

Expected return date:
Mid October 2020 		 Last updated:
24th March 2020 
Questran 4g Powder for Oral Suspension

PA2239/005/001 		 Colestyramine  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid June 2019

Expected return date:
April 2020 		 Last updated:
2nd August 2019 
Raporsin 8mg Prolonged Release Tablet

PA2315/005/001 		 Doxazosin  Manufacturing delays  Date of shortage:
Mid November 2019

Expected return date:
Awaiting update 		 Last updated:
19th March 2020 
Rifadin 150mg Capsule

PA0540/066/001 		 Rifampicin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of March 2020

Expected return date:
End of April 2020 		 Last updated:
25th March 2020 
Rifadin 300mg Capsule

PA0540/006/002 		 Rifampicin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid March 2020

Expected return date:
End of April 2020 		 Last updated:
25th March 2020 
Sofradex Ear/Eye Drops

PA0540/070/002 		 Framycetin, Gramicidin & Dexamethasone  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid January 2020

Expected return date:
Unknown at present		 Last updated:
10th March 2020 
Sprilon 12.5% Zinc Oxide & 1.04% Dimethicone Cutaneous Spray Suspension

PA22906/001/001 		 Zinc oxide & Dimethicone  Manufacturing delays  Date of shortage:
October 2019

Expected return date:
September 2020 		 Last updated:
3rd December 2019 
Stilnoct 10mg Film Coated Tablet 

PA0540/160/002		 Zolpidem  Delay in delivery Date of shortage:
26th February 2020

Expected return date:
30th March 2020		 Last updated:
19th March 2020 
Sustiva 600mg Film Coated Tablet

EU/1/99/110/009 		 Efavirenz  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of January 2020
 
Expected return date:
End of April 2020 		 Last updated:
6th March 2020
 
HCP Letter
Syntocinon Ampoules 10IU/ml Concentrate for Solution for Infusion or Solution for Intramuscular Injection

PA2206/003/002 		 Oxytocin  Manufacturing delays  Date of shortage:
9th December 2019

Expected return date:
End of March 2020		 Last updated:
18th March 2020
Tamox 10mg Tablet

PA0711/022/001 		 Tamoxifen  Unexpected increase in demand Date of shortage:
18th October 2019
 
Expected return date:
May 2020		 Last updated:
19th February 2020
 
Prescriber Communication

Pharmacist Communication

Patients:
www.hse.ie/tamoxifen
 
Tamoxifen 20mg Tablet

PA0577/207/001 		 Tamoxifen  Unexpected increase in demand  Date of shortage:
9th October 2019

Expected return date:
End of March 2020		 Last updated:
27th February 2020
 
Prescriber Communication

Pharmacist Communication

Patients:
www.hse.ie/tamoxifen
Tavanic 5mg/ml Solution for Infusion

PA0540/077/001 		 Levofloxacin  Unexpected increase in demand  Date of shortage:
24th March 2020

Expected return date:
Awaiting update 		 Last updated:
26th March 2020 
Tefin 75mg Suppositories

PA1684/001/001 		 Ibuprofen  Manufacturing delays  Date of shortage:
August 2019

Expected return date:
March 2020 		 Last updated:
13th November 2019 
Tefin 150mg Suppositories

PA1684/001/002 		 Ibuprofen  Manufacturing delays  Date of shortage:
August 2019

Expected return date:
March 2020 		 Last updated:
13th November 2019 
Tobi Podhaler 28mg Inhalation Powder; Capsule

EU/1/10/652/002 		 Tobramycin  Unexpected increase in demand  Date of shortage:
27th March 2020

Expected return date:
End of April 2020 		 Last updated:
26th March 2020 
Trandate 5mg/ml Solution for Injection

PA1638/006/001 		 Labetalol hydrochloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
16th May 2019

Expected return date:
Awaiting update		 Last updated:
4th March 2020 
Trandate 100mg Film Coated Tablet

PA1638/006/002 		 Labetalol hydrochloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
July 2019

Expected return date:
March 2020		 Last updated:
29th January 2020 
Trandate 200mg Film Coated Tablet

PA1638/006/003 		 Labetalol hydrochloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
July 2019

Expected return date:
March 2020		 Last updated:
29th January 2020
Tranexamic acid 100mg/ml Solution for Injection

PA2315/178/001 		 Tranexamic acid  Manufacturing delays  Date of shortage:
Early July 2019

Expected return date:
Unknown at present 		 Last updated:
13th November 2019 
Ranitic 75mg Film Coated Tablet

PA0711/024/004 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers
             
AHDMP Guidance for Prescribers
Ranitic 150mg Film Coated Tablet

PA0711/024/001 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers

AHDMP Guidance for Prescribers
 
Ranitic 300mg Film Coated Tablet

PA0711/024/002 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers
 
AHDMP Guidance for Prescribers
Ranitidine 150mg/10ml Oral Solution

PA22741/009/001 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers
 
AHDMP Guidance for Prescribers
Ultiva 2mg Powder for Concentrate for Solution for Infusion

PA1691/032/002 		 Remifentanyl  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
17th January 2020

Expected return date:
20th April 2020 		 Last updated:
18th March 2020 
Valsartan Actavis 40mg Film Coated Tablet 

PA1380/022/001		 Valsartan Active substance impurity

(multiple countries affected)
                        		 Date of shortage:
July 2018

Expected return date:
Awaiting update		 Last updated: 
14th January 2020
Valsartan Actavis 80mg Film Coated Tablet

PA1380/022/002
     		 Valsartan Active substance impurity

(multiple countries affected)		 Date of shortage:
July 2018

Expected return date:
Awaiting update		 Last updated:
14th January 2020
Valsartan Actavis 160mg Film Coated Tablet 

PA1380/022/003		 Valsartan Active substance impurity

(multiple countries affected)		 Date of shortage:
July 2018

Expected return date:
Awaiting update
 		 Last updated:
14th January 2020
Valsartan Mylan 40mg Film Coated Tablet

PA0577/134/001 		 Valsartan  Unexpected increase in demand 

(multiple countries affected)		 Date of shortage:
Early November 2018
 
Expected return date:
Unknown at present		 Last updated:
13th May 2019
Valsartan Mylan 80mg Film Coated Tablet

PA0577/134/002 		 Valsartan  Unexpected increase in demand 

(multiple countries affected)		 Date of shortage:
Early November 2018

Expected return date:
Unknown at present		 Last updated:
13th May 2019
Valsartan Mylan 160mg Film Coated Tablet

PA0577/134/003 		 Valsartan  Unexpected increase in demand

(multiple countries affected) 		 Date of shortage:
Early November 2018

Expected return date:
Unknown at present 		 Last updated:
13th May 2019 
Valsartan Teva 80mg Film Coated Tablet

PA0749/084/002 		 Valsartan Unexpected increase in demand

(multiple countries affected)		 Date of shortage:
July 2018

Expected return date:
March 2020		 Last updated:
16th January 2020
Valsartan Teva 160mg Film coated Tablet

PA0749/084/003 		 Valsartan  Unexpected increase in demand

(multiple countries affected)		 Date of shortage:
Awaiting update

Expected return date:
March 2020		 Last updated:
16th January 2020
Valsartan / Hydrochlorothiazide 160mg/ 25mg Film Coated Tablet

PA2315/181/003 		 Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)		 Date of shortage:
July 2018

Expected return date:
Awaiting update		 Last updated: 
21st February 2020
Valtan 40mg Film Coated Tablet 

PA0126/211/001 		 Valsartan Unexpected increase in demand

(multiple countries affected)		 Date of shortage:
24th October 2018

Expected return date:
Awaiting update		 Last updated:
18th November 2019
Valtan 80mg Film Coated Tablet

PA0126/211/002 		 Valsartan  Unexpected increase in demand

(multiple countries affected)		 Date of shortage:
26th September 2018
 
Expected return date:
Awaiting update
 Last updated:
18th November 2019
Valtan 160mg Film Coated Tablet

PA0126/211/003		 Valsartan  Unexpected increase in demand 

(multiple countries affected)		 Date of shortage:
24th October 2018

Expected return date:
Awaiting update		 Last updated:
18th November 2019
Vatan 40mg Film Coated Tablet

PA0711/183/001		 Valsartan  Active substance impurity

(multiple countries affected) 		 Date of shortage:
July 2018

Expected return date:
Awaiting update		 Last updated:
18th November 2019
Vatan 80mg Film Coated Tablets

PA0711/183/002 		 Valsartan  Active Substance Impurity

(multiple countries affected) 		 Date of shortage:
July 2018

Expected return date:
Awaiting update		 Last updated:
18th November 2019
Vatan 160mg Film Coated Tablets

PA0711/183/003 		 Valsartan Active Substance impurity

(multiple countries affected) 		  
Date of shortage:
July 2018

Expected return date:
Awaiting update		 Last updated:
18th November 2019
Warticon 0.15% w/w Cream 

PA1113/017/001 		 Podophyllotoxin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Early October 2019

Expected return date:
April 2020 		 Last updated:
12th November 2019

HCP Letter
Zacin 0.025% w/w Cream

PA0827/008/001 		 Capsaicin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid July 2019

Expected return date:
Q2 2020 		 Last updated:
26th March 2020 
Zantac 25mg/ml Solution for Injection/Infusion

PA1077/013/001 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers
 
AHDMP Guidance for Prescribers
Zantac 75mg Film Coated Tablet

PA1186/013/001 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers

AHDMP Guidance for Prescribers
 
Zantac 150mg Effervescent Tablet

PA1077/013/005 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers
 
AHDMP Guidance for Prescribers
Zantac 150mg Film Coated Tablet

PA1077/013/003 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers
 
AHDMP Guidance for Prescribers
Zantac 150mg/10ml Oral Solution

PA1077/013/002		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers
 
AHDMP Guidance for Prescribers
Zantac 300mg Film Coated Tablet

PA1077/013/004 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers
 
AHDMP Guidance for Prescribers
Zoely 2.5mg/1.5mg Film Coated Tablet 

EU/1/11/690/001		 Nomegestrol acetate & Esradiol  Unavailability of API

(multiple countries affected) 		 Date of shortage:
Early August 2019

Expected return date:
End of 2020		 Last updated:
27th January 2020
 
HCP Letter

Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL
Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL
Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL




Contact us:

Medicinal Product Shortages Unit
Health Products Regulatory Authority 
Kevin O’Malley House
Earlsfort Terrace,
Dublin 2
Tel: +353 1 676 4971
Fax: +353 1 676 7836
shortages@hpra.ie