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Medicinal Product Shortages

The HPRA is responsible for co-ordinating the management of shortages of medicines on the Irish market. The HPRA works with a variety of stakeholders including manufacturers, wholesale distributors, marketing authorisation holders, healthcare professionals, the Health Service Executive, patients and representative groups to respond to potential shortages and reduce the impact of shortages on patients.

The definition of a shortage is when the supply of a medicinal product is inadequate to meet the needs of the patient. 

The HPRA, in collaboration with stakeholders, has published a framework for a multi-stakeholder approach to handling shortages of human medicinal products. The aim of the framework is to help prevent shortages from occurring and to reduce the impact of shortages on patients by co-ordinating the management of potential or actual shortages as they arise. You can see the shortages case study on Adrenaline auto-injectors (AAIs) as an example of how the framework operates in practice. 


Information on reporting shortages for:

Marketing Authorisation Holders

Please complete the  Notification of medicinal product shortage from marketing authorisation holder form and return to  shortages@hpra.ie and to the HSE Corporate Pharmaceutical Unit.

Wholesale Distributors and Manufacturers

Please complete the  Report of Medicinal Products Shortages from Wholesale Distributors and Manufacturers form and return this form to  shortages@hpra.ie.

Patients and Healthcare Professionals

Please complete the  Report of a Medicinal Product Shortage from Patients and Healthcare Professionals form and return to  shortages@hpra.ie. When completing this form, please include as much information as possible.


Current and resolved shortages

The HPRA publishes a list of shortages currently affecting the Irish market that have been notified to us and that may have a medium or high impact on patients. This list can be found below. More information on the impact level can be found in the framework for a multi-stakeholder approach to handling shortages of human medicinal products.

The HPRA maintains a consolidated list of resolved shortages for a period of six months. Details of shortages that have been resolved in the last six months can be found here.

Tamoxifen shortage

There is intermittent supply of tamoxifen affecting multiple countries, including Ireland. This is caused by an international shortage of the active pharmaceutical ingredient and is not related in any way to Brexit.

Alternative supplies of tamoxifen are available during the shortage although patients might have to use a different brand of the medicine. Patients can speak to their pharmacist or medical team if they have queries. Normal supplies are expected to resume by December 2019.

The HSE has established a website to provide information for patients at www.hse.ie/tamoxifen as well as providing guidance for healthcare professionals.

Both the HPRA and the HSE websites will be kept up to date as additional information becomes available.


Please use search function below to find relevant product or active ingredient


Product name Active ingredient Reason for shortage Date of shortage
 Additional information
Accupro 5mg Film Coated Tablet 

PA0822/007/001		 Quinapril hydrochloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
5th April 2019

Expected return date:
Awaiting update		 Last updated:
3rd December 2019 
 

 
Accupro 10mg Film Coated Tablet

PA0822/007/002 		 Quinapril hydrochloride  Unexpected increase in demand  Date of shortage:
30th May 2019

Expected return date:
Awaiting update		 Last updated:
3rd December 2019
 
Accupro 20mg Film Coated Tablet

PA0822/007/003 		 Quinapril hydrochloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid March 2019

Expected return date:
Awaiting update		 Last updated:
3rd December 2019
 

 
Accupro 40mg Film Coated Tablet 

PA0822/007/004 		 Quinapril hydrochloride  Manufacturing delays 

(multiple countries affected)		 Date of shortage:
End of November 2018

Expected return date:
Awaiting update		 Last updated:
3rd December 2019
 

 
Accuretic 20/12.5mg Film Coated Tablet

PA0822/008/002 		 Quinapril hydrochloride & Hydrochlorothiazide  Manufacturing delays 

(multiple countries affected)		 Date of shortage:
Early January 2019

Expected return date:
Awaiting update		 Last updated:
3rd December 2019
 

 
           
Aciclovir 25mg/ml Concentrate for Solution for Infusion

PA2299/041/001 		 Aciclovir sodium  Manufacturing issue  Date of shortage:
December 2018

Expected return date:
Awaiting update		 Last updated:
18th November 2019 
Actonel 5mg Film Coated Tablet

PA2315/140/001 		 Risedronate  Manufacturing delay 

(multiple countries affected)		 Date of shortage:
June 2019

Expected return date:
January 2020 		 Last updated:
26th July 2019 
Adalat LA 20mg Prolonged Release Tablet

PA1410/025/005		 Nifedipine  Manufacturing delays

(multiple countries affected)		 Date of shortage:
November 2017
 
Expected return date:
Not before 2021		 Last updated:
29th November 2019
 
Adalat LA 30mg Prolonged Release Tablet

PA1410/025/006		 Nifedipine  Manufacturing delays

(multiple countries affected)		 Date of shortage:
24th June 2018

Expected return date:
Not before 2021
 Last updated:
29th November 2019 
 
Adalat LA 60mg Prolonged Release Tablet

PA1410/025/007 		 Nifedipine Manufacturing delays

(multiple countries affected)		 Date of shortage:
September 2018

Expected return date:
Not before 2021		 Last updated:
29th November 2019
 
Alendronate/Colecalciferol Teva 70mg/5600IU Tablet

PA0749/196/002 		 Alendronate & Colecalciferol  Manufacturing delays  Date of shortage:
January 2019

Expected return date:
Q1 2020 		 Last updated:
30th September 2019 
Arcoxia 90mg Tablet

PA1997/001/003 		 Etoricoxib  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
9th December 2019

Expected return date:
17th December 2019 		 Last updated:
3rd December 2019 
Areloger 15mg Film Coated Tablet

PA0577/057/002 		 Meloxicam  Manufacturing delays  Date of shortage:
Early August 2019

Expected return date:
January 2020 		 Last updated:
1st August 2019 
Arthrotec 75mg/200mcg Modified Release Tablet

PA0822/112/002 		 Diclofenac sodium & Misoprostol  Manufacturing delay  Date of shortage:
Early October 2019

Expected return date:
Early December 2019		 Last updated:
29th October 2019 

HCP Letter
Axsain 0.075% w/w Cream

PA0827/004/001 		 Capsaicin  Manufacturing delays 

(multiple countries affected)		 Date of shortage:
Mid June 2019

Expected return date:
Q1 2020		 Last updated:
31st October 2019 
BCG-Medac Powder and Solvent for Suspension for Intravesical Use

PA0623/004/001 		 Bacillus Calmette Guerin bacteria  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
1st October 2019

Expected return date:
Unknown at present 		 Last updated:
7th November 2019 
Betnovate RD 0.025% w/w Cream

PA1077/001/004 		 Betamethasone  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Early October 2019

Expected return date:
Mid January 2020 		 Last updated:
24th September 2019 
Betnovate RD 0.025% w/w Ointment

PA1077/001/005 		 Betamethasone  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Early September 2019

Expected return date:
Early January 2019 		 Last updated:
24th September 2019 
Blopress 2mg Tablet

PA2229/001/001
 		 Candesartan  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Early June 2019

Expected return date:
Awaiting update		 Last updated:
6th December 2019 
Blopress 4mg Tablet

PA2229/001/002 		 Candesartan  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid October 2019

Expected return date:
April 2020 		 Last updated:
22nd October 2019 
Blopress 8mg Tablet

PA2229/001/003		 Candesartan  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End June 2019

Expected return date:
Awaiting update
 Last updated:
6th December 2019 
Bupivacaine 2.5mg/ml Solution for Injection

PA2315/058/001
 		 Bupivacaine  Manufacturing delays  Date of shortage:
June 2019

Expected return date:
December 2019		 Last updated:
13th November 2019 
Bupivacaine 5mg/ml Solution for Injection

PA2315/058/002		 Bupivacaine Manufacturing delays Date of shortage:
June 2019

Expected return date:
December 2019		 Last updated:
13th November 2019
Burinex 1mg Tablet
 
PA22650/001/001		 Bumetanide  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Early November 2019

Expected return date:
3rd January 2020		 Last updated:
3rd December 2019 
By-Mycin 100mg Capsule

PA1457/010/002 		 Doxycycline  Unexpected increase in demand  Date of shortage:
Early November 2019

Expected return date:
December 2019 		 Last updated:
30th October 2019 
Canesten Combi -  500mg Pessary & 2% w/w Cream

PA1410/039/001 		 Clotrimazole  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
January 2018

Expected return date:
December 2019 		 Last updated:
23rd August 2019

HCP Letter
Canesten Duopack - 100mg Pessary & 1% w/w Cream

PA1410/039/005 		 Clotrimazole  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
February 2018

Expected return date:
Q1 2020 		 Last updated:
23rd August 2019

HCP Letter
Canesten 200mg Pessary

PA1410/039/008 		 Clotrimazole  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
February 2018

Expected return date:
Q1 2020 		 Last updated:
23rd August 2019

HCP Letter
Canesten 500mg Pessary

PA1410/039/009 		 Clotrimazole  Manufacturing delay

(multiple countries affected) 		 Date of shortage:
January 2018

Expected return date:
December 2019 		 Last updated:
23rd August 2019

HCP Letter
Caverject 10mcg Powder and Solvent for Solution for Injection

PA0822/115/002 		 Alprostadil  Unexpected increase in demand

(multiple countries affected) 		 Date of shortage:
Early December 2019

Expected return date:
March 2020 		 Last updated:
25th November 2019 
Ciprofloxacin Teva 250mg Film Coated Tablet


PA0749/031/002 		 Ciprofloxacin  Manufacturing delays  Date of shortage:
Early September 2019

Expected return date:
Unknown at present 		 Last updated:
31st October 2019 
Ciprofloxacin Teva 500mg Film Coated Tablet

PA0749/031/003 		 Ciprofloxacin  Manufacturing delays  Date of shortage:
Mid August 2019

Expected return date:
Unknown at present		 Last updated:
31st October 2019 
Ciproxin 500mg Tablet

PA1410/028/003 		 Ciprofloxacin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
September 2018

Expected return date:
Q2 2020 		 Last updated:
26th September 2019

HCP Letter
Ciproxin 750mg Tablet

PA1410/028/004 		 Ciprofloxacin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid October 2019

Expected return date:
Q2 2020 		 Last updated:
26th September 2019

HCP Letter 
Citalopram 40mg Tablet

PA0749/019/003 		 Citalopram  Manufacturing delays  Date of shortage:
End of October

Expected return date:
January 2020 		 Last updated:
7th November 2019 
Colomycin Injection 1 Million IU Powder for Solution for Injection, Infusion or Inhalation 

PA1986/046/001		 Colistimethate  Manufacturing delays  Date of shortage:
Mid October 2019

Expected return date:
6th December 2019		 Last updated:
6th December 2019 
Co-Amoxiclav 500mg/100mg Powder for Solution for Injection and Infusion

PA1457/001/001		 Amoxicillin & clavalunic acid Unexpected increase in demand Date of shortage:
24th May 2019

Expected return date:
Early December 2019		 Last updated:
3rd December 2019 
Co-Amoxiclav 1000mg/200mg Powder for Solution for Injection and Infusion

PA1457/001/002 		 Amoxicillin & clavalunic acid  Unexpected increase in demand  Date of shortage:
Early October 2019

Expected return date:
Early December 2019 		 Last updated:
3rd December 2019 
Co-Amoxiclav TEVA 1000 mg/200 mg Powder for Solution for Injection/Infusion

PA0749/011/002

 Amoxicillin & clavalunic acid   Production issues Date of shortage:
December 2019

Expected return date:
January 2020 (3rd week) 		 Last updated:
4th December 2019
Co-Vatan 80mg/12.5mg Film Coated Tablet

PA0711/182/001 		 Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)		 Date of shortage:
July 2018

Expected date of return:
Unknown at present
 Last updated: 
13th May 2019
Co-Vatan 160mg/12.5mg Film Coated Tablet

PA0711/182/002  		 Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)		 Date of shortage:
July 2018

Expected return date:
Unknown at present 		 Last updated:
13th May 2019
Co-Vatan 160mg/25mg Film Coated Tablet 

PA0711/182/003		 Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)		 Date of shortage:
July 2018

Expected return date: 
Unknown at present		 Last updated:
13th May 2019
Cozatan 50mg Film Coated Tablet

PA0126/167/001 		 Losartan potassium  Active substance impurity  Date of shortage:
Mid June 2019

Expected return date:
April 2020		 Last updated:
18th November 2019 
Crystapen 600mg Powder for Solution for Injection or Infusion

PA0126/313/001 		 Benzylpenicillin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of September 2019

Expected return date:
Mid December 2019 		 Last updated:
25th September 2019 

HCP Letter
Cytotec 200mcg Tablet

PA0822/118/001 		 Misoprostol  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of August 2019

Expected return date:
Early December 2019 		 Last updated:
24th October 2019 
 
Difene 25mg Capsule

PA2256/001/001 		 Diclofenac  Unexpected increase in demand  Date of shortage:
Early November 2019

Expected return date:
February 2020 		 Last updated:
12th November 2019 
Difene 50mg Capsule

PA2256/001/002 		 Diclofenac  Manufacturing delays  Date of shortage:
Mid July 2019

Expected return date:
December 2019		 Last updated:
11th November 2019
Diovan 160mg Film Coated Tablet

PA0896/009/002 		 Valsartan  Unexpected increase in demand  Date of shortage:
Mid July 2019

Expected return date:
Awaiting update 		 Last updated:
26th November 2019 
Doxatan 2mg Tablet

PA0126/202/002 		 Doxazosin  Unexpected increase in demand  Date of shortage:
Early August 2019

Expected return date:
16th December 2019 		 Last updated:
1st October 2019 
Duphaston 10mg Tablet

PA2010/010/001 		 Dydrogesterone  Manufacturing delays  Date of shortage:
19th November 2019

Expected return date:
Awaiting update		 Last updated:
6th December 2019 
Efexor XL 37.5mg Prolonged Release Capsule

PA0822/072/001 		 Venlafaxine  Manufacturing delays  Date of shortage:
9th December 2019

Expected return date:
End of January 2020 		 Last updated:
3rd December 2019 
Emerade 150mcg Solution in a Pre-Filled Pen

PA1696/009/001 		 Adrenaline  Quality issue

(multiple countries affected) 		 Date of shortage:
30th September 2019

Expected return date:
Unknown at present 		 Last updated:
30th September 2019

Alternatives are available 
Emerade 300mcg Solution in a Pre-Filled Pen

PA1696/009/002 		 Adrenaline  Quality issue

(multiple countries affected) 		 Date of shortage:
30th September 2019

Expected return date:
Unknown at present 		 Last updated:
30th September 2019

Alternatives are available 
Emerade 500mcg Solution in a Pre-Filled Pen

PA1696/009/003 		 Adrenaline  Quality issue

(multiple countries affected) 		 Date of shortage:
30th September 2019

Expected return date:
Unknown at present 		 Last updated:
30th September 2019

Alternatives are available 
Epanutin Infatabs 50mg Chewable Tablets

PA0822/011/005		 Phenytoin Manufacturing delays

(multiple countries affected)		 Date of shortage:
Early November 2019

Expected return date:
Unknown at present		 Last updated:
30th October 2019

HCP Letter
Epanutin Ready Mixed Parenteral 250mg/5ml Solution for Injection or Infusion

PA0822/011/006 		 Phenytoin  Manufacturing delays

(multiple countries affected)		 Date of shortage:
Mid July 2019

Expected return date:
January 2020 		 Last updated:
16th July 2019

HCP Letter
Erwinase 10000% v/v Powder for Solution for Injection

PA1020/002/001  		 Cristanspase Manufacturing delays

(multiple countries affected)		 Date of shortage:
5th October 2018

Expected return date:
Awaiting update
 Last updated:
18th November 2019
             

                         

 
Erythrocin 250mg Tablet

PA1142/008/002 		 Erythrocin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Early August 2019

Expected return date:
Mid January 2020		 Last updated:
26th November 2019 
Erythroped PI SF 125mg/5ml Granules for Oral Suspension

PA1142/006/002 		 Erythromycin  Manufacturing delays 

(multiple countries affected)		 Date of shortage:
End of June 2019

Expected return date:
Unknown at present 		 Last updated:
16th October 2019 
Erythroped SF 250mg/5ml Granules for Oral Suspension

PA1142/006/001 		 Erythromycin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid November 2019

Expected return date:
Unknown at present 		 Last updated:
13th November 2019 
Esomeprazole Krka 20mg Gastro-Resistant Capsule

PA1347/017/001 		 Esomeprazole  Unexpected increase in demand

(multiple countries affected) 		 Date of shortage:
End of November 2019

Expected return date:
23rd December 2019 		 Last updated:
6th December 2019 
Estradot 50mcg Transdermal Patch

PA0896/010/002 		 Estradiol  Manufacturing delays  Date of shortage:
19th November 2019

Expected return date:
Awaiting update 		 Last updated:
21st November 2019 
Estradot 100mcg Transdermal Patch

PA0896/010/004 		 Estradiol  Manufacturing delays  Date of shortage:
19th November 2019

Expected return date:
Awaiting update 		 Last updated:
21st November 2019 
Etoposide 20mg/ml Concentrate for Solution for Infusion

PA2315/207/001 		 Etoposide  Manufacturing delays  Date of shortage:
End of May 2019

Expected return date:
December 2019 		 Last updated:
26th August 2019 
Etoricoxib 60mg Film Coated Tablet

PA1986/002/002 		 Etoricoxib  Manufacturing delays  Date of shortage:
Early October 2019

Expected return date:
January 2020 		 Last updated:
3rd October 2019 
Evorel 50mcg Transdermal Patch

PA22612/014/001 		 Estradiol  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
October 2019

Expected return date:
Mid 2020 		 Last updated:
28th August 2019

HCP Letter
Evorel Conti 50mcg/170mcg Transdermal Patch

PA22612/015/001 		 Estradiol & Norethisterone Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid January 2020

Expected return date:
Mid 2020 		 Last updated:
6th December 2019

HCP Letter 
Fluorouracil 25mg/ml Solution for Injection or Infusion

(2.5g/100ml presentation only)

PA0822/223/001 		 Fluorouracil  Manufacturing delays

(multiple markets affected) 		 Date of shortage:
Early August 2019

Expected return date:
Mid December 2019		 Last updated:
3rd December 2019 
Fluorouracil 25mg/ml Solution for Injection or Infusion

(500mg/20ml presentation only)

PA0822/223/001		 Fluorouracil  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
6th December 2019

Expected return date:
February 2020 		 Last updated:
3rd December 2019 
Folinic Acid 10mg/ml Solution for Injection (100mg/10ml presentation only)

PA0822/198/003 		 Folinic acid  Manufacturing delays  Date of shortage:
5th July 2019

Expected return date:
End of January 2020 		 Last updated:
18th July 2019 
Folonic Acid 15mg Tablet

PA0822/198/001 		 Calcium folinate  Manufacturing delays  Date of shortage:
8th November 2019

Expected return date:
9th December 2019 		 Last updated:
26th November 2019

HCP Letter 
Gabitril 5mg Film Coated Tablet

PA0749/199/001 		 Tiagabine  Manufacturing delays 

(multiple countries affected)		 Date of shortage:
Mid July 2019

Expected return date:
9th December 2019		 Last updated:
6th December 2019 
Gabitril 10mg Film Coated Tablet

PA0749/199/002 		 Tiagabine  Manufacturing delays  Date of shortage:
Early November 2019

Expected return date:
9th December 2019		 Last updated:
6th December 2019 
Gabitril 15mg Film Coated Tablet

PA0749/199/003 		 Tiagabine  Manufacturing delays  Date of shortage:
Early November 2019

Expected return date:
9th December 2019		 Last updated:
6th December 2019 
Galfer 305mg Capsule

PA0126/314/001 		 Ferrous Fumarate  Manufacturing delays  Date of shortage:
Early September 2019

Expected return date:
Awaiting update 		 Last updated:
6th December 2019
 
HCP Letter
Genotropin 5.3mg Powder and Solvent for Solution for Injection

PA0822/128/001 		 Somatropin  Manufacturing delays

(multiple countries affected) 		 Date of shortage: 
Early December 2019

Expected return date:
End of January 2020		 Last updated:
4th November 2019

HCP Letter

Product is on allocation 
Gerax 0.25mg Tablet

PA0577/010/001 		 Alprazolam  Unexpected increase in demand  Date of shortage:
18th June 2019

Expected return date:
Awaiting update		 Last updated:
26th November 2019 
Gerax 0.5mg Tablet

PA0577/010/002 		 Alprazolam  Unexpected increase in demand  Date of shortage:
Early September 2019

Expected return date:
January 2020		 Last updated:
17th September 2019 
Gerax 1mg Tablet

PA0577/010/003		 Alprazolam  Unexpected increase in demand  Date of shortage:
End of August 2019

Expected return date:
January 2020 		 Last updated:
28th August 2019 
Gertac 150mg Film Coated Tablet

PA0577/023/001 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers 

AHDMP Guidance for Prescribers
Gertac 300mg Film Coated Tablet

PA0577/023/002 		 Ranitidine  Active substance impurities

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers 

AHDMP Guidance for Prescribers
HBVAXPRO 40mcg Suspension for Injection

EU/1/01/183/015 		 Hepatitis B  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
12th November 2019

Expected return date:
End of 2020 		 Last updated:
13th November 2019 
Hyaluronidase 1500IU Powder for Solution for Injection or Infusion

PA1339/011/001 		 Hyaluronidase  Manufacturing delays  Date of shortage:
23rd April 2019

Expected return date:
Unknown at present		 Last updated:
26th November 2019 
Hypovase 1mg Tablet

PA0822/195/002 		 Prazosin hydrochloride  Manufacturing delay 

(multiple countries affected)		 Date of shortage:
Mid June 2019

Expected return date:
February 2020		 Last updated:
24th October 2019 
Innohep 14,000IU in 0.7ml Solution for Injection

PA0046/060/011 		 Tinzaparin sodium  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid September 2019

Expected return date:
Mid December 2019		 Last updated:
6th December 2019

HCP Letter
 
Innovace 20mg Tablet

PA1286/011/004 		 Enalapril  Manufacturing delays  Date of shortage:
Mid September 2019

Expected return date:
Mid December 2019
 		 Last updated:
7th November 2019 
Intuniv 1mg Prolonged Release Tablet

EU/1/15/1040/001-002 		 Guanfacine  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Early November 2019

Expected return date:
End of January 2020 		 Last updated:
26th November 2019 
Irbesartan 75mg Film Coated Tablet

PA0126/205/001 		 Irbesartan  Increase in demand  Date of shortage:
Mid May 2019

Expected return date:
January 2020		 Last updated:
18th September 2019 
Irbesartan 150mg Film Coated Tablet

PA0126/205/002 		 Irbesartan  Increase in demand  Date of shortage:
Mid May 2019

Expected return date:
January 2020 		 Last updated:
18th September 2019  
Irbesartan 300mg Film Coated Tablet

PA0126/205/003 		 Irbesartan  API Impurity  Date of shortage:
End of August 2019

Expected return date:
Unknown at present 		 Last updated:
20th September 2019 
Irinotecan Hydrochloride 40mg/2ml Concentrate for Solution for Infusion

PA1986/068/001 		 Irinotecan  Manufacturing delays  Date of shortage:
Mid October 2019

Expected return date:
February 2020 		 Last updated:
13th November 2019 
Irprestan 150mg Film Coated Tablet

PA1380/021/002 		 Irprestan  Active substance impurity

(multiple countries affected) 		 Date of shortage:
February 2019

Expected return date:
Unknown at present		 Last updated:
8th August 2019 
Isoptin 80mg Film Coated Tablet

PA2010/003/002 		 Verapamil hydrochloride  Manufacturing delays  Date of shortage:
End of September 2019

Expected return date:
End of December 2019 		 Last updated:
12th November 2019 
Lercanidipine Mylan 10mg Tablet

PA0577/155/001		 Lercanidipine  Unexpected increase in demand  Date of shortage:
Early November 2019

Expected return date:
May 2020 		 Last updated:
13th November 2019 
Lercanidipine Mylan 20mg Tablet

PA0577/155/002 		 Lercanidipine  Unexpected increase in demand  Date of shortage:
Early November 2019

Expected return date:
May 2020 		 Last updated:
13th November 2019 
Lipantil Micro 67mg Capsule

PA2010/015/001 		 Fenofibrate  Manufacturing delays  Date of shortage:
21st October 2019

Expected return date:
Mid December 2019 		 Last updated:
6th November 2019 
Losartan 50mg Tablet

PA0749/090/003 		 Losartan  Unavailability of API

(multiple countries affected) 		 Date of shortage:
24th November 2019

Expected return date:
Unknown at present 		 Last updated:
18th November 2019 
Losartan 50mg Tablet 

PA2315/059/002 		 Losartan  Manufacturing delays  Date of shortage:
25th September 2019

Expected return date:
Unknown at present 		 Last updated:
10th October 2019 
Losartan 100mg Tablet

PA2315/059/003 		 Losartan  Manufacturing delays  Date of shortage:
October 2019

Expected return date:
Unknown at present 		 Last updated:
10th October 2019 
Losartan Hydrochlorothiazide 50mg/12.5mg Tablet

PA0749/026/001 		 Losartan & Hydrochlorothiazide  Unavailability of API

(multiple countries affected) 		 Date of shortage:
24th November 2019

Expected return date:
Unknown at present 		 Last updated:
18th November 2019 
Losartan Hydrochlorothiazide 100mg/25mg Tablet

PA0749/026/002 		 Losartan & Hydrochlorothiazide  Manufacturing delays  Date of shortage:
End of September 2019

Expected return date:
Mid December 2019 		 Last updated:
9th October 2019 
Marcain Heavy Steripack 0.5% w/v Solution for Injection

PA1691/024/003		 Bupivacaine hydrochloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of November 2019

Expected return date:
March 2020
 		 Last updated:
26th November 2019 
Marcain Polyamp Steripack 0.25% w/v Solution for Injection

PA1691/024/001 		 Bupivacaine hydrochloride  Manufacturing delays  Date of shortage:
End of October 2019

Expected return date:
Awaiting update		 Last updated:
12th November 2019 
Marcain Polyamp Steripack 0.5% w/v Solution for Injection

PA1691/024/002 		 Bupivacaine hydrochloride  Quality issue  Date of shortage:
September 2019

Expected return date:
January 2020 		 Last updated:
30th October 2019 
Maxibar 98.45% w/w Powder for Oral Suspension

PA1826/002/001 		 Barium sulphate  Manufacturing delays  Date of shortage:
End of June 2019

Expected return date:
Awaiting update		 Last updated:
26th November 2019 
Mefac 250mg Capsule

PA0074/015/001 		 Mefenamic acid  Manufacturing delay  Date of shortage:
End of June 2019

Expected return date:
June 2020 		 Last updated:
27th June 2019
Mercilon 150mcg/20mcg Tablet

PA1286/052/001 		 Desogestrel & Ethinylestradiol  Manufacturing delay  Date of shortage:
18th November 2019

Expected return date:
Early December 2019 		 Last updated:
14th November 2019 
Minims Atropine Sulphate 1% Eye Drop Solution

PA0555/017/001 		 Atropine  Manufacturing delays  Date of shortage:
July 2019

Expected return date:
Q1 2020		 Last updated:
12th November 2019 
Minims Phenylephrine 2.5% w/w Eye Drops

PA22698/013/002 		 Phenylephrine  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of November 2019

Expected return date:
January 2020 		 Last updated:
26th November 2019 
Miochol-E 20mg Powder and Solvent for Instillation Solution for Intraocular Use

PA1245/002/001 		 Acetylcholine chloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
5th August 2019

Expected return date:
Awaiting update		 Last updated:
26th November 2019 
Mitomycin Kyowa 10mg Powder for Solution for Injection

PA2288/002/001
  Mitomycin Quality issue

(multiple countries affected)		 Date of shortage:
3rd October 2019

Expected return date:
Unknown at present
 Last updated:
18th November 2019
Mitomycin Kyowa 40mg Powder for Solution for Injection

PA2288/002/002
  Mitomycin Quality issue

(multiple countries affected)		 Date of shortage:
3rd October 2019

Expected return date:
Unknown at present
 Last updated:
18th November 2019
Mivacron 2mg/ml Solution for Injection
(20mg/10ml presentation only)

PA1691/033/001 		 Mivacurium  Manufacturing delays
(multiple countries affected) 		 Date of shortage:
Mid October 2019

Expected return date:
12th December 2019		 Last updated:
12th November 2019 
Morphine Sulphate 10mg/ml Solution for Injection

PA0073/020/001 		 Morphine Sulphate  Manufacturing delays  Date of shortage:
25th November 2019

Expected return date:
Mid December 2019 		 Last updated:
25th November 2019 
Morphine Sulphate Injection BP 30mg/ml Solution for Injection

PA0361/004/005 		 Morphine Sulphate  Manufacturing delays  Date of shortage:
October 2018

Expected return date:
During 2020		 Last updated:
16th October 2019 
Muse 250mcg Urethral Stick

PA2010/028/002		 Alprostadil  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid March 2019
 
Expected return date:
Awaiting update		 Last updated:
3rd December 2019 
Muse 500mcg Urethral Stick

PA2010/028/003 		 Alprostadil  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid March 2019
 
Expected return date:
Awaiting update		 Last updated:
3rd December 2019 
Muse 1000mcg Urethral Stick

PA2010/028/004 		 Alprostadil  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Start of March 2019
 
Expected return date:
Awaiting update		 Last updated:
3rd December 2019 
Mysoline 250mg Tablet

PA1777/001/001 		 Primidone  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid July 2019

Expected return date:
April 2020		 Last updated:
24th October 2019 
Noctamid 1mg Tablet

PA1410/009/001 		 Lormetazepam  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid June 2019

Expected return date:
January 2020		 Last updated:
24th October 2019

Product is on allocation 
Ondansetron 4mg Tablet

PA0749/009/001 		 Ondansetron  Manufacturing delays  Date of shortage:
Early October 2019

Expected return date:
Mid December 2019 		 Last updated:
31st October 2019 
Osteomel Once Weekly 70mg Tablet

PA0126/148/002 		 Alendronic acid  Manufacturing delays  Date of shortage:
End of September 2019

Expected return date:
6th January 2020		 Last updated:
15th November 2019 
Oxaliplatin 5mg/ml Concentrate for Solution for Infusion

PA2059/049/001		 Oxaliplatin  Manufacturing delays  Date of shortage:
End of October 2019

Expected return date:
Awaiting update 		 Last updated:
6th November 2019 
Paracetamol Rx 500mg Tablet

PA2315/065/003 		 Paracetamol  Manufacturing delays  Date of shortage:
End of October 2019

Expected return date:
End of December 2019		 Last updated:
26th November 2019 
Piperacillin with Tazobactam 2.25g Powder for Solution for Injection

PA1339/001/001 		 Piperacillin sodium & Tazobactam sodium Manufacturing delays

(multiple countries affected)		 Date of shortage:
January 2018

Expected return date:
Unknown at present		 Last updated:
12th July 2019
Piperacillin with Tazobactam 4.5g Powder for Solution for Injection

PA1339/001/002 		 Piperacillin sodium & Tazobactam sodium Manufacturing delays

(multiple countries affected)		 Date of shortage:
January 2018

Expected return date:
Unknown at present		 Last updated:
12th July 2019
Pneumovax 23 Solution for Injection in Pre-Filled Syringe

PA1286/055/002 		 Pneumococcal Polysaccharide Vaccine  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of October 2019

Expected return date:
February 2020 		 Last updated:
13th November 2019 
Proctosedyl Ointment

PA0540/062/001 		 Hydrocortisone, Framycetin; Aesculin & Cinchocaine  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of November 2019

Expected return date:
Mid January 2020 		 Last updated:
26th November 2019 
Questran 4g Powder for Oral Suspension

PA2239/005/001 		 Colestyramine  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid June 2019

Expected return date:
April 2020 		 Last updated:
2nd August 2019 
Raporsin 8mg Prolonged Release Tablet

PA2315/005/001 		 Doxazosin  Manufacturing delays  Date of shortage:
Mid November 2019

Expected return date:
Awaiting update 		 Last updated:
22nd November 2019 
Septrin 80mg/400mg Tablet

PA1691/010/001 		 Sulfamethoxazole & Trimethoprim  Manufacturing delays 

(multiple countries affected)		 Date of shortage:
27th April 2019

Expected return date:
2nd January 2020		 Last updated:
23rd October 2019 
Septrin Forte 160mg/800mg Tablet

PA1691/010/002 		 Sulfamethoxazole & Trimethoprim  Manufacturing delays  Date of shortage:
End of October 2019

Expected return date:
6th January 2020 		 Last updated:
25th November 2019 
Septrin Paediatric 40mg/200mg Oral Suspension

(100ml presentation)

PA1691/010/003 		 Sulfamethoxazole & Trimethoprim  Unexpected increase in demand  Date of shortage:
Early December 2019
 
Expected return date:
Early January 2020		 Last updated:
26th November 2019 
Sprilon 12.5% Zinc Oxide & 1.04% Dimethicone Cutaneous Spray Suspension

PA22906/001/001 		 Zinc oxide & Dimethicone  Manufacturing delays  Date of shortage:
October 2019

Expected return date:
September 2020 		 Last updated:
3rd December 2019 
Surmontil 25mg Film Coated Tablet

PA0540/128/005 		 Trimipramine Maleate  Unavailability of API

(multiple countries affected) 		 Date of shortage:
End of August 2019

Expected return date:
10th December 2019		 Last updated:
11th November 2019

Pharmacist Communication

Prescriber Communication
Tamox 10mg Tablet

PA0711/022/001 		 Tamoxifen  Unexpected increase in demand Date of shortage:
18th October 2019
 
Expected return date:
February 2020		 Last updated:
6th November 2019
 
Prescriber Communication

Pharmacist Communication

Patients:
www.hse.ie/tamoxifen
 
Tamoxifen 20mg Tablet

PA0577/207/001 		 Tamoxifen  Unexpected increase in demand  Date of shortage:
9th October 2019

Expected return date:
Mid January 2020		 Last updated:
13th November 2019
 
Prescriber Communication

Pharmacist Communication

Patients:
www.hse.ie/tamoxifen
Tefin 75mg Suppositories

PA1684/001/001 		 Ibuprofen  Manufacturing delays  Date of shortage:
August 2019

Expected return date:
March 2020 		 Last updated:
13th November 2019 
Tefin 150mg Suppositories

PA1684/001/002 		 Ibuprofen  Manufacturing delays  Date of shortage:
August 2019

Expected return date:
March 2020 		 Last updated:
13th November 2019 
Temozolomide 100mg Capsule

EU/1/09/606/005-006 		 Temozolomide  Manufacturing delays  Date of shortage:
26th September 2019

Expected return date:
Q1 2020 		 Last updated:
31st October 2019 
Temozolomide 250mg Capsule

EU/1/09/606/011-012 		 Temozolomide  Manufacturing delays  Date of shortage:
Mid October 2019

Expected return date:
Q1 2020 		 Last updated:
7th November 2019 
Teveten 600mg Film Coated Tablet

PA2010/017/002 		 Eprosartan  Manufacturing delays  Date of shortage:
18th October 2019

Expected return date:
Mid December 2019 		 Last updated:
6th November 2019 
Trandate 5mg/ml Solution for Injection

PA1638/006/001 		 Labetalol hydrochloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
16th May 2019

Expected return date:
February 2020		 Last updated:
6th November 2019 
Trandate 100mg Film Coated Tablet

PA1638/006/002 		 Labetalol hydrochloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
July 2019

Expected return date:
January 2020		 Last updated:
6th November 2019 
Trandate 200mg Film Coated Tablet

PA1638/006/003 		 Labetalol hydrochloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
July 2019

Expected return date:
March 2020		 Last updated:
6th November 2019 
Tranexamic acid 100mg/ml Solution for Injection

PA2315/178/001 		 Tranexamic acid  Manufacturing delays  Date of shortage:
Early July 2019

Expected return date:
Unknown at present 		 Last updated:
13th November 2019 
Ranitic 75mg Film Coated Tablet

PA0711/024/004 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers
             
AHDMP Guidance for Prescribers
Ranitic 150mg Film Coated Tablet

PA0711/024/001 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers

AHDMP Guidance for Prescribers
 
Ranitic 300mg Film Coated Tablet

PA0711/024/002 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers
 
AHDMP Guidance for Prescribers
Ranitidine 150mg/10ml Oral Solution

PA22741/009/001 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers
 
AHDMP Guidance for Prescribers
Valsartan Actavis 40mg Film Coated Tablet 

PA1380/022/001		 Valsartan Active substance impurity

(multiple countries affected)
                        		 Date of shortage:
July 2018

Expected return date:
End of 2019		 Last updated: 
22nd May 2019
Valsartan Actavis 80mg Film Coated Tablet

PA1380/022/002
     		 Valsartan Active substance impurity

(multiple countries affected)		 Date of shortage:
July 2018

Expected return date:
End of 2019		 Last updated:
22nd May 2019
Valsartan Actavis 160mg Film Coated Tablet 

PA1380/022/003		 Valsartan Active substance impurity

(multiple countries affected)		 Date of shortage:
July 2018

Expected return date:
End of 2019
 		 Last updated:
22nd May 2019
Valsartan Mylan 40mg Film Coated Tablet

PA0577/134/001 		 Valsartan  Unexpected increase in demand 

(multiple countries affected)		 Date of shortage:
Early November 2018
 
Expected return date:
Unknown at present		 Last updated:
13th May 2019
Valsartan Mylan 80mg Film Coated Tablet

PA0577/134/002 		 Valsartan  Unexpected increase in demand 

(multiple countries affected)		 Date of shortage:
Early November 2018

Expected return date:
Unknown at present		 Last updated:
13th May 2019
Valsartan Mylan 160mg Film Coated Tablet

PA0577/134/003 		 Valsartan  Unexpected increase in demand

(multiple countries affected) 		 Date of shortage:
Early November 2018

Expected return date:
Unknown at present 		 Last updated:
13th May 2019 
Valsartan Mylan 320mg Film Coated Tablet 

PA0577/134/004		 Valsartan  Unexpected increase in demand

(multiple countries affected) 		 Date of shortage:
Early November 2018

Expected return date:
Unknown at present		 Last updated:
13th May 2019 
Valsartan Teva 40mg Film Coated Tablet

PA0749/084/001 		 Valsartan Unexpected increase in demand

(multiple countries affected) 		 Date of shortage: 
July 2018

Expected return date:
Unknown at present		 Last updated:
6th December 2019
Valsartan Teva 80mg Film Coated Tablet

PA0749/084/002 		 Valsartan Unexpected increase in demand

(multiple countries affected)		 Date of shortage:
July 2018

Expected return date:
Q1 2020		 Last updated:
6th December 2019
Valsartan Teva 160mg Film coated Tablet

PA0749/084/003 		 Valsartan  Unexpected increase in demand

(multiple countries affected)		 Date of shortage:
Awaiting update

Expected return date:
Q1 2020		 Last updated:
6th December 2019 
Valsartan / Hydrochloride 80mg/12.5mg Film Coated Tablet

PA2315/181/001		 Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)		 Date of shortage:
July 2018

Expected return date:
Q1 2020		 Last updated: 
6th December 2019
Valsartan / Hydrochlorothiazide 160mg/12.5mg Film Coated Tablet 

PA2315/181/002		 Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)		 Date of shortage:
July 2018

Expected return date:
Q1 2020		 Last updated:
6th December 2019
Valsartan / Hydrochlorothiazide 160mg/ 25mg Film Coated Tablet

PA2315/181/003 		 Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)		 Date of shortage:
July 2018

Expected return date:
End of 2019		 Last updated: 
22nd May 2019
Valtan 40mg Film Coated Tablet 

PA0126/211/001 		 Valsartan Unexpected increase in demand

(multiple countries affected)		 Date of shortage:
24th October 2018

Expected return date:
Awaiting update		 Last updated:
18th November 2019
Valtan 80mg Film Coated Tablet

PA0126/211/002 		 Valsartan  Unexpected increase in demand

(multiple countries affected)		 Date of shortage:
26th September 2018
 
Expected return date:
Awaiting update
 Last updated:
18th November 2019
Valtan 160mg Film Coated Tablet

PA0126/211/003		 Valsartan  Unexpected increase in demand 

(multiple countries affected)		 Date of shortage:
24th October 2018

Expected return date:
Awaiting update		 Last updated:
18th November 2019
Vatan 40mg Film Coated Tablet

PA0711/183/001		 Valsartan  Active substance impurity

(multiple countries affected) 		 Date of shortage:
July 2018

Expected return date:
Awaiting update		 Last updated:
18th November 2019
Vatan 80mg Film Coated Tablets

PA0711/183/002 		 Valsartan  Active Substance Impurity

(multiple countries affected) 		 Date of shortage:
July 2018

Expected return date:
Awaiting update		 Last updated:
18th November 2019
Vatan 160mg Film Coated Tablets

PA0711/183/003 		 Valsartan Active Substance impurity

(multiple countries affected) 		  
Date of shortage:
July 2018

Expected return date:
Awaiting update		 Last updated:
18th November 2019
Warfant 3mg Tablet

PA0073/139/002 		 Warfarin  Manufacturing delays  Date of shortage:
End of October 2019

Expected return date:
Mid March 2020 		 Last updated:
10th October 2019 

HCP Letter
Warticon 0.15% w/w Cream 

PA1113/017/001 		 Podophyllotoxin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Early October 2019

Expected return date:
April 2020 		 Last updated:
12th November 2019

HCP Letter
Zacin 0.025% w/w Cream

PA0827/008/001 		 Capsaicin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid July 2019

Expected return date:
Q1 2020 		 Last updated:
31st October 2019 
Zantac 25mg/ml Solution for Injection/Infusion

PA1077/013/001 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers
 
AHDMP Guidance for Prescribers
Zantac 75mg Film Coated Tablet

PA1186/013/001 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers

AHDMP Guidance for Prescribers
 
Zantac 150mg Effervescent Tablet

PA1077/013/005 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers
 
AHDMP Guidance for Prescribers
Zantac 150mg Film Coated Tablet

PA1077/013/003 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers
 
AHDMP Guidance for Prescribers
Zantac 150mg/10ml Oral Solution

PA1077/013/002		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers
 
AHDMP Guidance for Prescribers
Zantac 300mg Film Coated Tablet

PA1077/013/004 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers
 
AHDMP Guidance for Prescribers
Zestan 5mg Tablet

PA0126/112/002 		 Lisinopril dihydrate  Manufacturing delays  Date of shortage:
Mid February 2019

Expected return date:
11th December 2019		 Last updated:
1st October 2019 
Zimovane 7.5mg Film Coated Tablet

PA2010/057/001 		 Zopiclone  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid October 2019

Expected return date:
End of December 2019 		 Last updated:
11th November 2019 
Zoely 2.5mg/1.5mg Film Coated Tablet 

EU/1/11/690/001		 Nomegestrol acetate & Esradiol  Unavailability of API

(multiple countries affected) 		 Date of shortage:
Early August 2019

Expected return date:
End of 2020		 Last updated:
25th September 2019 

HCP Letter

Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL
Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL
Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL




Contact us:

Medicinal Product Shortages Unit
Health Products Regulatory Authority 
Kevin O’Malley House
Earlsfort Terrace,
Dublin 2
Tel: +353 1 676 4971
Fax: +353 1 676 7836
shortages@hpra.ie