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Medicinal Product Shortages

The HPRA is responsible for co-ordinating the management of shortages of medicines on the Irish market. The HPRA works with a variety of stakeholders including manufacturers, wholesale distributors, marketing authorisation holders, healthcare professionals, the Health Service Executive, patients and representative groups to respond to potential shortages and reduce the impact of shortages on patients.

The definition of a shortage is when the supply of a medicinal product is inadequate to meet the needs of the patient. 

The HPRA, in collaboration with stakeholders, has published a framework for a multi-stakeholder approach to handling shortages of human medicinal products. The aim of the framework is to help prevent shortages from occurring and to reduce the impact of shortages on patients by co-ordinating the management of potential or actual shortages as they arise. You can see the shortages case study on Adrenaline auto-injectors (AAIs) as an example of how the framework operates in practice. 


Information on reporting shortages for:

Marketing Authorisation Holders

Please complete the  Notification of medicinal product shortage from marketing authorisation holder form and return to  shortages@hpra.ie and to the HSE Corporate Pharmaceutical Unit.

Wholesale Distributors and Manufacturers

Please complete the  Report of Medicinal Products Shortages from Wholesale Distributors and Manufacturers form and return this form to  shortages@hpra.ie.

Patients and Healthcare Professionals

Please complete the  Report of a Medicinal Product Shortage from Patients and Healthcare Professionals form and return to  shortages@hpra.ie. When completing this form, please include as much information as possible.


Current and resolved shortages

The HPRA publishes a list of shortages currently affecting the Irish market that have been notified to us and that may have a medium or high impact on patients. This list can be found below. More information on the impact level can be found in the framework for a multi-stakeholder approach to handling shortages of human medicinal products.

The HPRA maintains a consolidated list of resolved shortages for a period of six months. Details of shortages that have been resolved in the last six months can be found here.

Tamoxifen shortage

There is intermittent supply of tamoxifen affecting multiple countries, including Ireland. This is caused by an international shortage of the active pharmaceutical ingredient and is not related in any way to Brexit.

Alternative supplies of tamoxifen are available during the shortage although patients might have to use a different brand of the medicine. Patients can speak to their pharmacist or medical team if they have queries. Normal supplies are expected to resume by December 2019.

The HSE has established a website to provide information for patients at www.hse.ie/tamoxifen as well as providing guidance for healthcare professionals.

Both the HPRA and the HSE websites will be kept up to date as additional information becomes available.


Please use search function below to find relevant product or active ingredient


Product name Active ingredient Reason for shortage Date of shortage
 Additional information
Accupro 5mg Film Coated Tablet 

PA0822/007/001		 Quinapril hydrochloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
5th April 2019

Expected return date:
November 2019 		 Last updated:
6th August 2019 
 

 
Accupro 10mg Film Coated Tablet

PA0822/007/002 		 Quinapril hydrochloride  Unexpected increase in demand  Date of shortage:
30th May 2019

Expected return date:
November 2019		 Last updated:
6th August 2019
 
Accupro 20mg Film Coated Tablet

PA0822/007/003 		 Quinapril hydrochloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid March 2019

Expected return date:
November 2019		 Last updated:
6th August 2019
 

 
Accupro 40mg Film Coated Tablet 

PA0822/007/004 		 Quinapril hydrochloride  Manufacturing delays 

(multiple countries affected)		 Date of shortage:
End of November 2018

Expected return date:
November 2019 		 Last updated:
6th August 2019
 

 
Accuretic 20/12.5mg Film Coated Tablet

PA0822/008/002 		 Quinapril hydrochloride & Hydrochlorothiazide  Manufacturing delays 

(multiple countries affected)		 Date of shortage:
Early January 2019

Expected return date:
November 2019		 Last updated:
6th August 2019
 

 
           
Aciclovir 25mg/ml Concentrate for Solution for Infusion

PA2299/041/001 		 Aciclovir sodium  Manufacturing issue  Date of shortage:
December 2018

Expected return date:
November 2019		 Last updated:
24th September 2019 
Actonel 5mg Film Coated Tablet

PA2315/140/001 		 Risedronate  Manufacturing delay 

(multiple countries affected)		 Date of shortage:
June 2019

Expected return date:
January 2020 		 Last updated:
26th July 2019 
Adalat LA 20mg Prolonged Release Tablet

PA1410/025/005		 Nifedipine  Manufacturing delays

(multiple countries affected)		 Date of shortage:
November 2017
 
Expected return date:
End of 2019		 Last updated:
24th January 2019
 
Adalat LA 30mg Prolonged Release Tablet

PA1410/025/006		 Nifedipine  Manufacturing delays

(multiple countries affected)		 Date of shortage:
24th June 2018

Expected return date:
End of 2019		 Last updated:
24th January 2019 
 
Adalat LA 60mg Prolonged Release Tablet

PA1410/025/007 		 Nifedipine Manufacturing delays

(multiple countries affected)		 Date of shortage:
September 2018

Expected return date:
End of 2019		 Last updated:
24th January 2019
 
Alendronate/Colecalciferol Teva 70mg/5600IU Tablet

PA0749/196/002 		 Alendronate & Colecalciferol  Manufacturing delays  Date of shortage:
January 2019

Expected return date:
Q1 2020 		 Last updated:
30th September 2019 
Alprazolam 0.25mg Tablet

PA0711/140/001 		 Alprazolam  Unexpected increase in demand  Date of shortage:
Early June 2019

Expected return date:
Awaiting update		 Last updated:
3rd October 2019 
Arcoxia 120mg Tablet

PA1997/001/004 		 Etoricoxib  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Early October 2019
 
Expected return date:
Early December 2019		 Last updated:
1st October 2019 
Areloger 15mg Film Coated Tablet

PA0577/057/002 		 Meloxicam  Manufacturing delays  Date of shortage:
Early August 2019

Expected return date:
January 2020 		 Last updated:
1st August 2019 
Arthrotec 75mg/200mcg Modified Release Tablet

PA0822/112/002 		 Diclofenac sodium & Misoprostol  Manufacturing delay  Date of shortage:
Early October 2019

Expected return date:
Mid October 2019 		 Last updated:
23rd September 2019 
Axsain 0.075% w/w Cream

PA0827/004/001 		 Capsaicin  Manufacturing delays 

(multiple countries affected)		 Date of shortage:
Mid June 2019

Expected return date:
November 2019 		 Last updated:
9th September 2019 
Azactam 2g Powder for Solution for Injection or Infusion

PA0002/052/003 		 Aztreonam  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
6th September 2019

Expected return date:
Mid October 2019 		 Last updated:
9th September 2019 

HCP Letter
Betnovate RD 0.025% w/w Cream

PA1077/001/004 		 Betamethasone  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Early October 2019

Expected return date:
Mid January 2020 		 Last updated:
24th September 2019 
Betnovate RD 0.025% w/w Ointment

PA1077/001/005 		 Betamethasone  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Early September 2019

Expected return date:
Early January 2019 		 Last updated:
24th September 2019 
Bupivacaine 2.5mg/ml Solution for Injection

PA2315/058/001
 		 Bupivacaine  Manufacturing delays  Date of shortage:
June 2019

Expected return date:
Awaiting update 		 Last updated:
8th October 2019 
Bupivacaine 5mg/ml Solution for Injection

PA2315/058/002		 Bupivacaine Manufacturing delays Date of shortage:
June 2019

Expected return date:
Awaiting update		 Last updated:
8th October 2019
Campral EC 333mg Gastro-resistant Tablet

PA2286/007/001 		 Acamprosate calcium  Unavailability of API

(multiple countries affected) 		 Date of shortage:
End of August 2019

Expected return date:
November 2019 		 Last updated:
29th August 2019 

HCP Letter
Canesten Combi -  500mg Pessary & 2% w/w Cream

PA1410/039/001 		 Clotrimazole  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
January 2018

Expected return date:
December 2019 		 Last updated:
23rd August 2019

HCP Letter
Canesten Duopack - 100mg Pessary & 1% w/w Cream

PA1410/039/005 		 Clotrimazole  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
February 2018

Expected return date:
Q1 2020 		 Last updated:
23rd August 2019

HCP Letter
Canesten 200mg Pessary

PA1410/039/008 		 Clotrimazole  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
February 2018

Expected return date:
Q1 2020 		 Last updated:
23rd August 2019

HCP Letter
Canesten 500mg Pessary

PA1410/039/009 		 Clotrimazole  Manufacturing delay

(multiple countries affected) 		 Date of shortage:
January 2018

Expected return date:
December 2019 		 Last updated:
23rd August 2019

HCP Letter
Centyl K 2.5mg + 573mg Tablet

PA22650/002/002 		 Bendroflumethiazide & Potassium citrate  Manufacturing delays  Date of shortage:
Mid October 2019

Expected return date:
18th November 2019 		 Last updated:
9th October 2019 
Champix 1mg Film Coated Tablet

EU/1/06/360/016 		 Varenicline  Manufacturing delays  Date of shortage:
14th October 2019

Expected return date:
28th October 2019 		 Last updated:
16th October 2019

HCP Letter 
Ciprofloxacin Teva 250mg Film Coated Tablet
(20 pack size)

PA0749/031/002 		 Ciprofloxacin  Manufacturing delays  Date of shortage:
Early September 2019

Expected return date:
Unknown at present 		 Last updated:
20th September 2019 
Ciprofloxacin Teva 500mg Film Coated Tablet

PA0749/031/003 		 Ciprofloxacin  Manufacturing delays  Date of shortage:
Mid August 2019

Expected return date:
Unknown at present		 Last updated:
20th September 2019 
Ciproxin 500mg Tablet

PA1410/028/003 		 Ciprofloxacin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
September 2018

Expected return date:
Q2 2020 		 Last updated:
26th September 2019

HCP Letter
Ciproxin 750mg Tablet

PA1410/028/004 		 Ciprofloxacin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid October 2019

Expected return date:
Q2 2020 		 Last updated:
26th September 2019

HCP Letter 
Co-Amoxiclav 500mg/100mg Powder for Solution for Injection and Infusion Amoxicillin & clavalunic acid Unexpected increase in demand Date of shortage:
24th May 2019

Expected return date:
Awaiting update		 Last updated:
9th October 2019 
Co-Vatan 80mg/12.5mg Film Coated Tablet

PA0711/182/001 		 Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)		 Date of shortage:
July 2018

Expected date of return:
Unknown at present
 Last updated: 
13th May 2019
Co-Vatan 160mg/12.5mg Film Coated Tablet

PA0711/182/002  		 Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)		 Date of shortage:
July 2018

Expected return date:
Unknown at present 		 Last updated:
13th May 2019
Co-Vatan 160mg/25mg Film Coated Tablet 

PA0711/182/003		 Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)		 Date of shortage:
July 2018

Expected return date: 
Unknown at present		 Last updated:
13th May 2019
Cozatan 50mg Film Coated Tablet

PA0126/167/001 		 Losartan potassium  Active substance impurity  Date of shortage:
Mid June 2019

Expected return date:
End of October 2019		 Last updated:
18th September 2019 
Cozatan 100mg Film Coated Tablet

PA0126/167/002 		 Losartan potassium  Active substance impurity  Date of shortage:
May 2019

Expected return date:
End of October 2019		 Last updated:
18th September 2019 
Cozatan Comp 50mg/12.5mg Film Coated Tablet

PA0126/184/001 		 Losartan potassium & Hydrochlorothiazide  Active substance impurity  Date of shortage:
Early July 2019

Expected return date:
End of October 2019 		 Last updated:
8th October 2019
Cozatan Comp 100mg/25mg Film Coated Tablet

PA0126/184/002 		 Losartan potassium & Hydrochlorothiazide  Active substance impurity  Date of shortage:
May 2019

Expected return date:
End of October 2019		 Last updated:
18th September 2019 
Crystapen 600mg Powder for Solution for Injection or Infusion

PA0126/313/001 		 Benzylpenicillin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of September 2019

Expected return date:
Mid December 2019 		 Last updated:
25th September 2019 

HCP Letter
Cyklokapron 500mg Tablets

PA1332/003/001 		 Tranexamic acid Manufacturing delays

(multiple countries affected) 		 Date of shortage:
1st December 2018

Expected return date:
End of October 2019		 Last updated:
23rd September 2019
Cyklopron 500mg/5ml Solution for Injection/Infusion

PA0822/117/001 		 Tranexamic acid  Unexpected increase in demand  Date of shortage:
14th October 2019

Expected return date:
25th October 2019 		 Last updated:
10th October 2019 
Cytotec 200mcg Tablet

PA0822/118/001 		 Misoprostol  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of August 2019

Expected return date:
Mid October 2019 		 Last updated:
23rd September 2019 

HCP Letter
Dalacin 2% Vaginal Cream

PA0822/119/002 		 Clindamycin phosphate  Manufacturing delays  Date of shortage:
End of July 2019

Expected return date:
Mid October 2019 		 Last updated:
20th September 2019 
Difene 50mg Capsule

PA2256/001/002 		 Diclofenac  Manufacturing delays  Date of shortage:
Mid July 2019

Expected return date:
End of October 2019 		 Last updated:
25th September 2019 
Diovan 160mg Film Coated Tablet

PA0896/009/002 		 Valsartan  Unexpected increase in demand  Date of shortage:
Mid July 2019

Expected return date:
Awaiting update 		 Last updated:
3rd October 2019 
Doxatan 2mg Tablet

PA0126/202/002 		 Doxazosin  Unexpected increase in demand  Date of shortage:
Early August 2019

Expected return date:
16th December 2019 		 Last updated:
1st October 2019 
Emerade 150mcg Solution in a Pre-Filled Pen

PA1696/009/001 		 Adrenaline  Quality issue

(multiple countries affected) 		 Date of shortage:
30th September 2019

Expected return date:
Unknown at present 		 Last updated:
30th September 2019

Alternatives are available 
Emerade 300mcg Solution in a Pre-Filled Pen

PA1696/009/002 		 Adrenaline  Quality issue

(multiple countries affected) 		 Date of shortage:
30th September 2019

Expected return date:
Unknown at present 		 Last updated:
30th September 2019

Alternatives are available 
Emerade 500mcg Solution in a Pre-Filled Pen

PA1696/009/003 		 Adrenaline  Quality issue

(multiple countries affected) 		 Date of shortage:
30th September 2019

Expected return date:
Unknown at present 		 Last updated:
30th September 2019

Alternatives are available 
Epanutin Ready Mixed Parenteral 250mg/5ml Solution for Injection or Infusion

PA0822/011/006 		 Phenytoin  Manufacturing delays

(multiple countries affected)		 Date of shortage:
Mid July 2019

Expected return date:
January 2020 		 Last updated:
16th July 2019

HCP Letter
Erwinase 10000% v/v Powder for Solution for Injection

PA1020/002/001  		 Cristanspase Manufacturing delays

(multiple countries affected)		 Date of shortage:
5th October 2018

Expected return date:
Awaiting update
 Last updated:
25th September 2019
             

                         

 
Erythrocin 250mg Tablet

PA1142/008/002 		 Erythrocin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Early August 2019

Expected return date:
Unknown at present 		 Last updated:
16th October 2019 
Erythroped PI SF 125mg/5ml Granules for Oral Suspension

PA1142/006/002 		 Erythromycin  Manufacturing delays 

(multiple countries affected)		 Date of shortage:
End of June 2019

Expected return date:
Unknown at present 		 Last updated:
16th October 2019 
Estradot 100mcg Transdermal Patch

PA0896/010/004 		 Estradiol hemihydrate  Manufacturing delays  Date of shortage:
End of September 2019

Expected return date:
19th October 2019 		 Last updated:
4th October 2019 
Etoposide 20mg/ml Concentrate for Solution for Infusion

PA2315/207/001 		 Etoposide  Manufacturing delays  Date of shortage:
End of May 2019

Expected return date:
December 2019 		 Last updated:
26th August 2019 
Etoricoxib 60mg Film Coated Tablet

PA1986/002/002 		 Etoricoxib  Manufacturing delays  Date of shortage:
Early October 2019

Expected return date:
January 2020 		 Last updated:
3rd October 2019 
Evorel 50mcg Transdermal Patch

PA22612/014/001 		 Estradiol  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
October 2019

Expected return date:
Mid 2020 		 Last updated:
28th August 2019

HCP Letter
Evorel Conti 50mcg/170mcg Transdermal Patch

PA22612/015/001 		 Estradiol & Norethisterone Manufacturing delays

(multiple countries affected) 		 Date of shortage:
December 2019

Expected return date:
Mid 2020 		 Last updated:
28th August 2019

HCP Letter 
Femoston-Conti 0.5mg/2.5mg Tablet

PA2010/012/003 		 Estradiol & Dydrogesterone  Manufacturing delays  Expected start date:
Early October 2019

Expected return date:
Mid November 2019 		 Last updated:
10th October 2019 
Fluorouracil 25mg/ml Solution for Injection or Infusion

(2.5mg/100ml presentation only)

PA0822/223/001 		 Fluorouracil  Manufacturing delays

(multiple markets affected) 		 Date of shortage:
Early August 2019

Expected return date:
Mid October 2019		 Last updated:
8th August 2019 
Fluorouracil 25mg/ml Solution for Injection or Infusion

(500mg/20ml presentation only)

PA0822/223/001 		 Fluorouracil  Manufacturing delays

(multiple markets affected) 		 Date of shortage:
19th August 2019

Expected return date:
Unknown at present 		 Last updated:
26th August 2019 
Folinic Acid 10mg/ml Solution for Injection (100mg/10ml presentation only)

PA0822/198/003 		 Folinic acid  Manufacturing delays  Date of shortage:
5th July 2019

Expected return date:
End of January 2020 		 Last updated:
18th July 2019 
Gabitril 5mg Film coated Tablet

PA0749/199/001 		 Tiagabine  Manufacturing delays 

(multiple countries affected)		 Date of shortage:
Mid July 2019

Expected return date:
End of October 2019 		 Last updated:
3rd October 2019 
Galfer 305mg Capsule

PA0126/314/001 		 Ferrous Fumarate  Manufacturing delays  Date of shortage:
Early September 2019

Expected return date:
End of November 2019 		 Last updated:
24th September 2019
 
HCP Letter
Gerax 0.25mg Tablet

PA0577/010/001 		 Alprazolam  Unexpected increase in demand  Date of shortage:
18th June 2019

Expected return date:
Unknown at present		 Last updated:
1st October 2019 
Gerax 0.5mg Tablet

PA0577/010/002 		 Alprazolam  Unexpected increase in demand  Date of shortage:
Early September 2019

Expected return date:
January 2020		 Last updated:
17th September 2019 
Gerax 1mg Tablet

PA0577/010/003		 Alprazolam  Unexpected increase in demand  Date of shortage:
End of August 2019

Expected return date:
January 2020 		 Last updated:
28th August 2019 
Gertac 150mg Film Coated Tablet

PA0577/023/001 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
17th October 2019

MMP Guidance for Prescribers 
Gertac 300mg Film Coated Tablet

PA0577/023/002 		 Ranitidine  Active substance impurities

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
17th October 2019

MMP Guidance for Prescribers 
Hyaluronidase 1500IU Powder for Solution for Injection or Infusion

PA1339/011/001 		 Hyaluronidase  Manufacturing delays  Date of shortage:
23rd April 2019

Expected return date:
Unknown at present		 Last updated:
12th July 2019 
Hypovase 1mg Tablet

PA0822/195/002 		 Prazosin hydrochloride  Manufacturing delay 

(multiple countries affected)		 Date of shortage:
Mid June 2019

Expected return date:
Mid December 2019		 Last updated:
7th October 2019 
Innohep 10,000IU in 0.5ml Solution for Injection

PA0046/060/010 		 Tinzaparin sodium  Manufacturing delays 

(multiple countries affected)		 Date of shortage:
End of August 2019

Expected return date:
End of October 2019 		 Last updated:
16th September 2019
 
HCP Letter 
Innohep 14,000IU in 0.7ml Solution for Injection

PA0046/060/011 		 Tinzaparin sodium  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid September 2019

Expected return date:
End of October 2019 		 Last updated:
16th September 2019

HCP Letter 
Innovace 20mg Tablet

PA1286/011/004 		 Enalapril  Manufacturing delay  Date of shortage:
Mid September 2019

Expected return date:
End of October 2019
 		 Last updated:
20th September 2019 
Instanyl 100mcg Single Dose Nasal Spray

EU/1/09/531/014-017 		 Fentanyl citrate Manufacturing delays

(multiple countries affected) 		 Date of shortage:
January 2019

Expected return date:
October 2019		 Last updated:
12th September 2019 
Irbesartan 75mg Film Coated Tablet

PA0126/205/001 		 Irbesartan  Increase in demand  Date of shortage:
Mid May 2019

Expected return date:
January 2020		 Last updated:
18th September 2019 
Irbesartan 150mg Film Coated Tablet

PA0126/205/002 		 Irbesartan  Increase in demand  Date of shortage:
Mid May 2019

Expected return date:
January 2020 		 Last updated:
18th September 2019  
Irbesartan 300mg Film Coated Tablet

PA0126/205/003 		 Irbesartan  API Impurity  Date of shortage:
End of August 2019

Expected return date:
Unknown at present 		 Last updated:
20th September 2019 
Irprestan 150mg Film Coated Tablet

PA1380/021/002 		 Irprestan  Active substance impurity

(multiple countries affected) 		 Date of shortage:
February 2019

Expected return date:
Unknown at present		 Last updated:
8th August 2019 
Irprezide 150/12.5mg Film Coated Tablet


PA1380/080/001		 Irbesartan & Hydrochlorothiazide  Active substance impurity

(multiple countries affected)

            		Date of shortage:
21st December 2018

Expected return date:
Unknown at present		 Last updated:
1st October 2019
Irprezide 300/12.5mg Film Coated Tablet


PA1380/080/002		 Irbesartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)
 
 Date of shortage:
21st December 2018

Expected return date:
Unknown at present		 Last updated:
1st October 2019
Isoptin SR 240mg Prolonged Release Tablet

PA2010/003/005 		 Verapamil  Manufacturing delay  Date of shortage:
End of August 2019

Expected return date:
Mid October 2019 		 Last updated:
20th September 2019 
Losartan 50mg Tablet 

PA2315/059/002 		 Losartan  Manufacturing delays  Date of shortage:
25th September 2019

Expected return date:
Unknown at present 		 Last updated:
10th October 2019 
Losartan 100mg Tablet

PA2315/059/003 		 Losartan  Manufacturing delays  Date of shortage:
October 2019

Expected return date:
Unknown at present 		 Last updated:
10th October 2019 
Losartan Hydrochlorothiazide 100mg/25mg Tablet  Losartan & Hydrochlorothiazide  Manufacturing delays  Date of shortage:
End of September 2019

Expected return date:
Mid December 2019 		 Last updated:
9th October 2019 
Maxibar 98.45% w/w Powder for Oral Suspension

PA1826/002/001 		 Barium sulphate  Manufacturing delays  Date of shortage:
End of June 2019

Expected return date:
Awaiting update		 Last updated:
25th September 2019 
Mefac 250mg Capsule

PA0074/015/001 		 Mefenamic acid  Manufacturing delay  Date of shortage:
End of June 2019

Expected return date:
June 2020 		 Last updated:
27th June 2019
Methotrexate 5mg/2ml Injection

PA0822/206/001 		 Methotrexate sodium  Manufacturing delays  Date of shortage:
Early July 2019

Expected return date:
15th October 2019 		 Last updated:
19th September 2019

HCP Letter 
Minims Atropine Sulphate 1% Eye Drop Solution

PA0555/017/001 		 Atropine  Manufacturing delays  Date of shortage:
July 2019

Expected return date:
Late 2019 		 Last updated:
6th August 2019 
Miochol-E 20mg Powder and Solvent for Instillation Solution for Intraocular Use

PA1245/002/001 		 Acetylcholine chloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
5th August 2019

Expected return date:
Early November 2019 		 Last updated:
30th September 2019 
Miramel 0.088mg Tablet

PA0126/173/001 		 Pramipexole  Manufacturing delays  Date of shortage:
Mid July 2019

Expected return date:
Awaiting update		 Last updated:
9th October 2019 
Mitomycin Kyowa 10mg Powder for Solution for Injection

PA2288/002/001
  Mitomycin Manufacturing delays Date of shortage:
3rd October July 2019

Expected return date:
Awaiting update
 Last updated:
16th October 2019
Mitomycin Kyowa 40mg Powder for Solution for Injection

PA2288/002/002
  Mitomycin Manufacturing delays Date of shortage:
3rd October July 2019

Expected return date:
Awaiting update
 Last updated:
16th October 2019
Morphine Sulphate Injection BP 30mg/ml Solution for Injection

PA0361/004/005 		 Morphine Sulphate  Manufacturing delays  Date of shortage:
October 2018

Expected return date:
During 2020		 Last updated:
16th October 2019 
Muse 250mcg Urethral Stick

PA2010/028/002		 Alprostadil  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid March 2019
 
Expected return date:
End of November 2019		 Last updated:
23rd September 2019 
Muse 500mcg Urethral Stick

PA2010/028/003 		 Alprostadil  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid March 2019
 
Expected return date:
End of November 2019		 Last updated:
23rd September 2019 
Muse 1000mcg Urethral Stick

PA2010/028/004 		 Alprostadil  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Start of March 2019
 
Expected return date:
End of November 2019		 Last updated:
23rd September 2019 
Mysoline 250mg Tablet

PA1777/001/001 		 Primidone  Manufacturing delays  Date of shortage:
Mid July 2019

Expected return date:
End of December 2019		 Last updated:
12th August 2019 
Nasonex 50mcg/Actuation Nasal Spray

PA1286/038/001		 Mometasone furoate  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid September 2019

Expected return date:
4th November 2019 		 Last updated:
20th September 2019 
Neomercazole 5mg Tablet

PA1142/002/001 		 Carbimazole  Manufacturing delays

(multiple markets affected) 		 Date of shortage:
End of August 2019

Expected return date:
25th October 2019		 Last updated:
14th October 2019

HCP Letter
Noctamid 1mg Tablet

PA1410/009/001 		 Lormetazepam  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid June 2019

Expected return date:
December 2019		 Last updated:
9th October 2019

Product is on allocation 
Ondansetron 4mg Tablet

PA0749/009/001 		 Ondansetron  Manufacturing delays  Date of shortage:
Early October 2019

Expected return date:
November 2019 		 Last updated:
3rd October 2019 
Ondansetron 8mg Tablet

PA0749/009/002 		 Ondansetron  Manufacturing delays  Date of shortage:
End of August 2019

Expected return date:
November 2019 		 Last updated:
3rd October 2019 
Osteomel Once Weekly 70mg Tablet

PA0126/148/002 		 Alendronic acid  Manufacturing delays  Date of shortage:
End of September 2019

Expected return date:
End of October 2019 		 Last updated:
23rd September 2019 
Piperacillin with Tazobactam 2.25g Powder for Solution for Injection

PA1339/001/001 		 Piperacillin sodium & Tazobactam sodium Manufacturing delays

(multiple countries affected)		 Date of shortage:
January 2018

Expected return date:
Unknown at present		 Last updated:
12th July 2019
Piperacillin with Tazobactam 4.5g Powder for Solution for Injection

PA1339/001/002 		 Piperacillin sodium & Tazobactam sodium Manufacturing delays

(multiple countries affected)		 Date of shortage:
January 2018

Expected return date:
Unknown at present		 Last updated:
12th July 2019
Pravastatin 10mg Tablet

PA0436/046/001 		 Pravastatin  Manufacturing delays  Date of shortage:
Early September 2019

Expected return date:
End of October 2019 		 Last updated:
20th September 2019 
Prosentio 100mg Tablet

PA0126/190/001 		 Modafinil  Manufacturing delays  Date of shortage:
Mid May 2019

Expected return date:
21st October 2019 		 Last updated:
8th October 2019 
Questran 4g Powder for Oral Suspension

PA2239/005/001 		 Colestyramine  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid June 2019

Expected return date:
April 2020 		 Last updated:
2nd August 2019 
Selectol 200mg Tablet

PA0540/126/001 		 Celiprolol hydrochloride  Manufacturing delays  Date of shortage:
27th September 2019

Expected return date:
Early November 2019 		 Last updated:
25th September 2019 
Septrin 80mg/400mg Tablet

PA1691/010/001 		 Sulfamethoxazole & Trimethoprim  Manufacturing delays 

(multiple countries affected)		 Date of shortage:
27th April 2019

Expected return date:
20th December 2019 		 Last updated:
1st October 2019 
Septrin Paediatric 40mg/200mg Oral Suspension

(50ml presentation)

PA1691/010/003		 Sulfamethoxazole & Trimethoprim  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of September 2019

Expected return date:
End of October 2019 		 Last updated:
8th October 2019 
Sotoger 80mg Tablet

PA0577/021/001 		 Sotalol hydrochloride  Manufacturing delays  Date of shortage:
9th August 2019

Expected return date:
End of November 2019		 Last updated:
16th September 2019
Sterile Sodium Chloride Concentrate 30% w/v Solution for Infusion 

PA0274/001/001		 Sodium Chloride  Manufacturing delays  Date of shortage:
Start of April 2019
 
Expected return date:
Awaiting update		 Last updated:
4th October 2019 
Sublimaze 50mcg/ml Solution for Injection

PA0748/044/001 		 Fentanyl  Manufacturing delays  Date of shortage:
Early August 2019

Expected return date:
End of October 2019 		 Last updated:
20th September 2019 
Surmontil 25mg Film Coated Tablet

PA0540/128/005 		 Trimipramine Maleate  Unavailability of API

(multiple countries affected) 		 Date of shortage:
End of August 2019

Expected return date:
November 2019 		 Last updated:
27th August 2019

Pharmacist Communication

Prescriber Communication
Surmontil 50mg Capsules

PA0540/128/003		 Trimipramine Maleate Unavailability of API

(multiple countries impacted)		 Date of shortage:
27th May 2019
 
Expected return date:
November 2019		 Last updated:
27th August 2019

Pharmacist Communication

Prescriber Communication
Tadalafil Krka 10mg Film Coated Tablet

PA1347/071/003 		 Tadalafil Unexpected increase in demand  Date of shortage:
October 2018

Expected return date:
Awaiting update
 Last updated:
6th September 2019
Tamox 10mg Tablet

PA0711/022/001 		 Tamoxifen  Unavailability of API

(multiple countries affected)		 Date of shortage:
Early September 2019

Expected return date:
End of November 2019 		 Last updated:
14th October 2019
 
Prescriber Communication

Pharmacist Communication

Patients:
www.hse.ie/tamoxifen
 
Tamox 20mg Tablet

PA0711/022/002 		 Tamoxifen  Unavailability of API

(multiple countries affected)		 Date of shortage:
Early September 2019

Expected return date:
Mid November 2019 		 Last updated:
16th October 2019
 
Prescriber Communication

Pharmacist Communication

Patients:
www.hse.ie/tamoxifen
Tamoxifen 20mg Tablet

PA0577/207/001 		 Tamoxifen  Unexpected increase in demand  Date of shortage:
9th October 2019

Expected return date:
Early December 2019 		 Last updated:
14th October 2019
 
Prescriber Communication

Pharmacist Communication

Patients:
www.hse.ie/tamoxifen
Temozolomide 100mg Capsule

EU/1/09/606/005-006 		 Temozolomide  Manufacturing delays  Date of shortage:
26th September 2019

Expected return date:
January 2020 		 Last updated:
30th September 2019 
Tractocile 6.75mg/0.9ml Solution for Injection

EU/1/99/124/001 		 Atosiban  Unexpected increase in demand  Date of shortage:
Mid October 2019

Expected return date:
Early November 2019 		 Last updated:
10th October 2019 
Trandate 5mg/ml Solution for Injection

PA1638/006/001 		 Labetalol hydrochloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
16th May 2019

Expected return date:
End of November 2019 		 Last updated:
16th August 2019 
Trandate 100mg Film Coated Tablet

PA1638/006/002 		 Labetalol hydrochloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
July 2019

Expected return date:
Mid November 2019 		 Last updated:
16th August 2019 
Trandate 200mg Film Coated Tablet

PA1638/006/003 		 Labetalol hydrochloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
July 2019

Expected return date:
Mid November 2019 		 Last updated:
16th August 2019 
Tranexamic acid 100mg/ml Solution for Injection

PA2315/178/001 		 Tranexamic acid  Manufacturing delays  Date of shortage:
Early July 2019

Expected return date:
Awaiting update 		 Last updated:
8th October 2019 
Triapin 2.5mg/2.5mg Prolonged Release Tablet

PA0540/082/001 		 Ramipril & Felodipine  Manufacturing delays 

(multiple countries affected)		 Date of shortage:
27th September 2019

Expected return date:
11th October 2019 		 Last updated:
20th September 2019 
Ranitic 75mg Film Coated Tablet

PA0711/024/004 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
17th October 2019

MMP Guidance for Prescribers
Ranitic 150mg Film Coated Tablet

PA0711/024/001 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
17th October 2019

MMP Guidance for Prescribers
Ranitic 300mg Film Coated Tablet

PA0711/024/002 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
17th October 2019

MMP Guidance for Prescribers
Ranitidine 150mg/10ml Oral Solution

PA22741/009/001 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
17th October 2019

MMP Guidance for Prescribers
Ultiva 2mg Powder for Concentrate for Solution for Infusion

PA1691/032/002 		 Remifentanyl  Manufacturing delays  Date of shortage:
12th September 2019

Expected return date:
6th November 2019 		 Last updated:
25th September 2019 
Valsartan Actavis 40mg Film Coated Tablet 

PA1380/022/001		 Valsartan Active substance impurity

(multiple countries affected)
                        		 Date of shortage:
July 2018

Expected return date:
End of 2019		 Last updated: 
22nd May 2019
Valsartan Actavis 80mg Film Coated Tablet

PA1380/022/002
     		 Valsartan Active substance impurity

(multiple countries affected)		 Date of shortage:
July 2018

Expected return date:
End of 2019		 Last updated:
22nd May 2019
Valsartan Actavis 160mg Film Coated Tablet 

PA1380/022/003		 Valsartan Active substance impurity

(multiple countries affected)		 Date of shortage:
July 2018

Expected return date:
End of 2019
 		 Last updated:
22nd May 2019
Valsartan Mylan 40mg Film Coated Tablet

PA0577/134/001 		 Valsartan  Unexpected increase in demand 

(multiple countries affected)		 Date of shortage:
Early November 2018
 
Expected return date:
Unknown at present		 Last updated:
13th May 2019
Valsartan Mylan 80mg Film Coated Tablet

PA0577/134/002 		 Valsartan  Unexpected increase in demand 

(multiple countries affected)		 Date of shortage:
Early November 2018

Expected return date:
Unknown at present		 Last updated:
13th May 2019
Valsartan Mylan 160mg Film Coated Tablet

PA0577/134/003 		 Valsartan  Unexpected increase in demand

(multiple countries affected) 		 Date of shortage:
Early November 2018

Expected return date:
Unknown at present 		 Last updated:
13th May 2019 
Valsartan Mylan 320mg Film Coated Tablet 

PA0577/134/004		 Valsartan  Unexpected increase in demand

(multiple countries affected) 		 Date of shortage:
Early November 2018

Expected return date:
Unknown at present		 Last updated:
13th May 2019 
Valsartan Teva 40mg Film Coated Tablet

PA0749/084/001 		 Valsartan Unexpected increase in demand

(multiple countries affected) 		 Date of shortage: 
July 2018

Expected return date:
Unknown at present		 Last updated:
26th August 2019
Valsartan Teva 80mg Film Coated Tablet

PA0749/084/002 		 Valsartan Unexpected increase in demand

(multiple countries affected)		 Date of shortage:
July 2018

Expected return date:
Unknown at present		 Last updated:
26th August 2019
Valsartan Teva 160mg Film coated Tablet

PA0749/084/003 		 Valsartan  Unexpected increase in demand

(multiple countries affected)		 Date of shortage:
Awaiting update

Expected return date:
Unknown at present 		 Last updated:
26th August 2019 
Valsartan / Hydrochloride 80mg/12.5mg Film Coated Tablet

PA2315/181/001		 Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)		 Date of shortage:
July 2018

Expected return date:
End of 2019		 Last updated: 
22nd May 2019
Valsartan / Hydrochlorothiazide 160mg/12.5mg Film Coated Tablet 

PA2315/181/002		 Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)		 Date of shortage:
July 2018

Expected return date:
End of 2019		 Last updated:
22nd May 2019
Valsartan / Hydrochlorothiazide 160mg/ 25mg Film Coated Tablet

PA2315/181/003 		 Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)		 Date of shortage:
July 2018

Expected return date:
End of 2019		 Last updated: 
22nd May 2019
Valtan 40mg Film Coated Tablet 

PA0126/211/001 		 Valsartan Unexpected increase in demand

(multiple countries affected)		 Date of shortage:
24th October 2018

Expected return date:
Awaiting update		 Last updated:
6th September 2019
Valtan 80mg Film Coated Tablet

PA0126/211/002 		 Valsartan  Unexpected increase in demand

(multiple countries affected)		 Date of shortage:
26th September 2018
 
Expected return date:
Awaiting update
 Last updated:
25th September 2019
Valtan 160mg Film Coated Tablet

PA0126/211/003		 Valsartan  Unexpected increase in demand 

(multiple countries affected)		 Date of shortage:
24th October 2018

Expected return date:
Awaiting update		 Last updated:
6th September 2019
Vatan 40mg Film Coated Tablet

PA0711/183/001		 Valsartan  Active substance impurity

(multiple countries affected) 		 Date of shortage:
July 2018

Expected return date:
Awaiting update		 Last updated:
25th September 2019
Vatan 80mg Film Coated Tablets

PA0711/183/002 		 Valsartan  Active Substance Impurity

(multiple countries affected) 		 Date of shortage:
July 2018

Expected return date:
Awaiting update		 Last updated:
25th September  2019
Vatan 160mg Film Coated Tablets

PA0711/183/003 		 Valsartan Active Substance impurity

(multiple countries affected) 		  
Date of shortage:
July 2018

Expected return date:
Awaiting update		 Last updated:
25th September 2019
Venex XL 37.5mg Prolonged Release Capsules

PA0126/285/001 		 Venlafaxine  Manufacturing delay  Date of shortage:
17th September 2019

Expected return date:
7th October 2019 		 Last updated:
17th September 2019 
Voltarol 50mg Gastro-Resistant Tablet

PA0896/034/001 		 Dicloenac sodium  Unexpected increase in demand  Date of shortage:
Mid October 2019

Expected return date:
1st November 2019 		 Last updated:
8th October 2019 
Warfant 3mg Tablet

PA0073/139/002 		 Warfarin  Manufacturing delays  Date of shortage:
End of October 2019

Expected return date:
Mid March 2020 		 Last updated:
10th October 2019 

HCP Letter
Xanax 1mg Tablet

PA0822/141/001 		 Alprazolam  Manufacturing delay

(multiple countries affected) 		 Date of shortage:
Early August 2019

Expected return date:
Awaiting update		 Last updated:
3rd October 2019 
Zacin 0.025% w/w Cream

PA0827/008/001 		 Capsaicin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid July 2019

Expected return date:
November 2019 		 Last updated:
9th September 2019 
Zantac 25mg/ml Solution for Injection/Infusion

PA1077/013/001 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
17th October 2019

MMP Guidance for Prescribers
Zantac 75mg Film Coated Tablet

PA1186/013/001 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
17th October 2019

MMP Guidance for Prescribers
Zantac 150mg Effervescent Tablet

PA1077/013/005 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
17th October 2019

MMP Guidance for Prescribers
Zantac 150mg Film Coated Tablet

PA1077/013/003 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
17th October 2019

MMP Guidance for Prescribers
Zantac 150mg/10ml Oral Solution

PA1077/013/002		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
17th October 2019

MMP Guidance for Prescribers
Zantac 300mg Film Coated Tablet

PA1077/013/004 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
17th October 2019

MMP Guidance for Prescribers
Zestan 5mg Tablet

PA0126/112/002 		 Lisinopril dihydrate  Manufacturing delays  Date of shortage:
Mid February 2019

Expected return date:
11th December 2019		 Last updated:
1st October 2019 
Zineryt 40mg + 12mg Powder and Solvent for Cutaneous Solution

PA0046/065/001  		 Erythromycin & Zinc acetate dihydrate Unexpected increase in demand

(multiple countries impacted)		 Date of shortage:
30 August 2019

Expected return date:
Mid October 2019  		 Last updated:
2nd September 2019  
Zoely 2.5mg/1.5mg Film Coated Tablet 

EU/1/11/690/001		 Nomegestrol acetate & Esradiol  Unavailability of API

(multiple countries affected) 		 Date of shortage:
Early August 2019

Expected return date:
End of 2020		 Last updated:
25th September 2019 

HCP Letter

Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL
Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL
Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL




Contact us:

Medicinal Product Shortages Unit
Health Products Regulatory Authority 
Kevin O’Malley House
Earlsfort Terrace,
Dublin 2
Tel: +353 1 676 4971
Fax: +353 1 676 7836
shortages@hpra.ie