Medicinal Product Shortages

The HPRA is responsible for co-ordinating the management of shortages of medicines on the Irish market. The HPRA works with a variety of stakeholders including manufacturers, wholesale distributors, marketing authorisation holders, healthcare professionals, the Health Service Executive, patients and representative groups to respond to potential shortages and reduce the impact of shortages on patients.

The definition of a shortage is when the supply of a medicinal product is inadequate to meet the needs of the patient. 

The HPRA, in collaboration with stakeholders, has published a framework for a multi-stakeholder approach to handling shortages of human medicinal products. The aim of the framework is to help prevent shortages from occurring and to reduce the impact of shortages on patients by co-ordinating the management of potential or actual shortages as they arise.


Information on reporting shortages for:

Wholesale Distributors and Manufacturers

Patients and Healthcare Professionals

Please complete the  Report of a Medicinal Product Shortage from Patients and Healthcare Professionals form and return to  shortages@hpra.ie. When completing this form, please include as much information as possible.


Current and resolved shortages

The HPRA publishes a list of shortages currently affecting the Irish market that have been notified to us and that may have a medium or high impact on patients. This list can be found below. More information on the impact level can be found in the framework for a multi-stakeholder approach to handling shortages of human medicinal products.

The HPRA maintains a consolidated list of resolved shortages for a period of six months. Details of shortages that have been resolved in the last six months can be found here.


Please use search function below to find relevant product or active ingredient

Product name Active ingredient Reason for shortage Date of shortage
Additional information
Accupro 5mg Film Coated Tablet 

PA0822/007/001
Quinapril hydrochloride  Manufacturing delays

(multiple countries affected) 
Date of shortage:
5th April 2019

Expected return date:
May 2019 
Last updated:
10th April 2019 
Accupro 10mg Film Coated Tablet

PA0822/007/002 
Quinapril hydrochloride  Manufacturing delays

(multiple countries affected) 
Date of shortage:
Early March 2019

Expected return date:
May 2019 
Last updated:
16th April 2019 
Accupro 20mg Film Coated Tablet

PA0822/007/003 
Quinapril hydrochloride  Manufacturing delays

(multiple countries affected) 
Date of shortage:
Mid March 2019

Expected return date:
Mid May 2019
Last updated:
22nd March 2019
Accupro 40mg Film Coated Tablet 

PA0822/007/004 
Quinapril hydrochloride  Manufacturing delays 

(multiple countries affected)
Date of shortage:
End of November 2018

Expected return date:
End of April 2019 
Last updated:
16th April 2019
Accuretic 20/12.5mg Film Coated Tablet

PA0822/008/002 
Quinapril hydrochloride & Hydrochlorothiazide  Manufacturing delays 

(multiple countries affected)
Date of shortage:
Early January 2019

Expected return date:
End of May 2019
Last updated:
22nd March 2019
Aciclovir 25mg/ml Concentrate for Solution for Infusion

PA2299/041/001 
Aciclovir sodium  Manufacturing issue  Date of shortage:
December 2018

Expected return date:
Q3 2019 
Last updated:
12th March 2019 
Aciclovir 25mg/ml Concentrate for Solution for Infusion (500mg/20ml presentation only)

PA0822/215/001 
Aciclovir sodium  Unexpected increase in demand  Date of shortage:
End of March 2019

Expected return date:
1st May 2019 
Last updated:
26th March 2019

HCP Letter
Actelsar HCT 80/25mg Tablets 

EU/1/13/817/029-041
Telmisartan & Hydrochlorothiazide  Manufacturing delays  Date of shortage:
Early January 2019

Expected return date:
Awaiting update
Last updated:
17th April 2019
Adalat LA 20mg Prolonged Release Tablet

PA1410/025/005
Nifedipine  Manufacturing delays

(multiple countries affected)
Date of shortage:
November 2017
 
Expected return date:
End of 2019
Last updated:
24th January 2019
 
Adalat LA 30mg Prolonged Release Tablet

PA1410/025/006
Nifedipine  Manufacturing delays

(multiple countries affected)
Date of shortage:
24th June 2018

Expected return date:
End of 2019
Last updated:
24th January 2019 
 
Adalat LA 60mg Prolonged Release Tablet

PA1410/025/007 
Nifedipine Manufacturing delays

(multiple countries affected)
Date of shortage:
September 2018

Expected return date:
End of 2019
Last updated:
24th January 2019
 
Ativan 4mg/ml Solution for Injection

PA0822/090/002 
Lorazepam  Manufacturing delays

(multiple countries affected) 
Date of shortage:
5th April 2019
 
Expected return date:
June 2019
Last updated:
16th April 2019 

HCP Letter
Candist 4mg Tablet

PA0126/206/001 
Candesartan cilexetil  Unexpected increase in demand  Date of shortage:
End of February 2019

Expected return date:
Unknown at present
Last updated:
12th March 2019 
Cardura 2mg Tablet

PA0822/192/002
Doxazosin mesilate  Manufacturing delays  Date of shortage:
End of February 2019

Expected return date:
End of April 2019
Last updated:
9th April 2019 
Caverject 10mcg Powder for Solution for Injections

PA0822/115/002 
Alprostadil  Manufacturing delays

(multiple countries affected) 
Date of shortage:
January 2019

Expected return date:
4th June 2019
Last updated:
21st March 2019 
Clonactil 100mg Film Coated Tablet

PA0126/026/002 
Chlorpromazine hydrochloride  Manufacturing delays  Date of shortage:
Mid April 2019

Expected return date:
Start of May 2019 
Last updated:
3rd April 2019 

HCP Letter
Clopidogrel Teva 75mg Film Coated Tablet

EU/1/09/540/1-16 
Clopidogrel Hydrogen Sulphate  Unavailability of API

(multiple countries affected) 
Date of shortage:
Start of March 2019

Expected return date:
May 2019 
Last updated:
12th March 2019 
Co-Vatan 80mg/12.5mg Film Coated Tablet

PA0711/182/001 
Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)
Date of shortage:
July 2018

Expected date of return:
Awaiting update
Last updated: 
17th April 2019
Co-Vatan 160mg/12.5mg Film Coated Tablet

PA0711/182/002  
Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)
Date of shortage:
July 2018

Expected return date:
Awaiting update 
Last updated:
17th April 2019
Co-Vatan 160mg/25mg Film Coated Tablet 

PA0711/182/003
Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)
Date of shortage:
July 2018

Expected return date: 
Awaiting update
Last updated:
17th April 2019
Cyklokapron 500mg Tablets

PA1332/003/001 
Tranexamic acid Manufacturing delays

(multiple countries affected) 
Date of shortage:
1st December 2018

Expected return date:
Q2 2019 
Last updated:
4th December 2018
Denzapine 50mg/ml Oral Suspension

PA0126/235/005 
Clozapine  Manufacturing delays  Date of shortage:
9th April 2019

Expected return date:
8th May 2019 
Last updated:
9th April 2019 
Doxycycline Teva 100mg Hard capsules

PA1986/081/001 
Doxycycline hydrochloride  Manufacturing delays  Date of shortage:
February 2019

Expected return date:
Awaiting update
Last updated:
17th April 2019 
Erwinase 10000% v/v Powder for Solution for Injection

PA1020/002/001  
Cristanspase Manufacturing delays

(multiple countries affected)
Date of shortage:
5th October 2018

Expected return date:
Mid May 2019
Last updated:
12th April 2019

HCP Letter
                         

 
Estradot 50mcg/day Transdermal Patch

PA0896/010/002 
Estradiol hemihydrate  Manufacturing delays

(multiple countries affected) 
Date of shortage:
9th April 2019

Expected return date:
Mid May 2019 
Last updated:
11th April 2019 
Estradot 75mcg/day Transdermal Patch

PA0896/010/003 
Estradiol hemihydrate  Manufacturing delays

(multiple countries affected) 
Date of shortage:
26th March 2019

Expected return date:
Mid May 2019 
Last updated:
3rd April 2019 
Estradot 100mcg/day Transdermal Patch

PA0896/010/004 
Estradiol hemihydrate  Manufacturing delays

(multiple countries affected) 
Date of shortage:
1st April 2019

Expected return date:
Mid May 2019 
Last updated:
3rd April 2019 
Fentanyl 500mcg in 10ml Solution for Injection

PA0073/122/002 
Fentanyl citrate  Unexpected increase in demand  Date of shortage:
27th March 2019

Expected return date:
End of May 2019 
Last updated:
4th April 2019 
Floxapen 2000mg Powder for Solution for Injection or Infusion

PA1380/011/008 
Flucloxacillin  Manufacturing delays  Date of shortage:
Mid March 2019

Expected return date:
Awaiting update
Last updated:
17th April 2019 
Fucidin H 20mg/g + 10mg/g Cream
(15g pack)

PA0046/005/005 
Fusidic acid anhydrous & Hydrocortisone acetate  Manufacturing delays  Date of shortage:
Start of April 2019

Expected return date:
End of May 2019 
Last updated:
29th March 2019 
Fucidin H 20mg/g + 10mg/g Cream
(30g pack)

PA0046/005/005 
Fusidic acid anhydrous & Hydrocortisone acetate  Manufacturing delays  Date of shortage:
January 2019

Expected return date:
End of April 2019 
Last updated:
29th March 2019 
Gemcitabine 1g Powder for Solution for Infusion

PA1380/015/002 
Gemcitabine  Manufacturing delays  Date of shortage:
End of February 2019

Expected return date:
End of April 2019
 
Last updated:
26th February 2019
Hycamtin 1mg Powder for Concentrate for Solution for Infusion

EU/1/96/027/001 
Topotecan hydrochloride  Unexpected increase in demand  Date of shortage:
4th April 2019

Expected return date:
Awaiting update
Last updated:
17th April 2019 
Hycamtin 4mg Powder for Concentrate for Solution for Infusion

EU/1/96/027/003
Topotecan hydrochloride  Unexpected increase in demand  Date of shortage:
4th April 2019

Expected return date:
Awaiting update 
Last updated:
17th April 2019 
Instanyl 50mcg Single Dose Nasal Spray

EU/1/09/531/010-013 
Fentanyl citrate Manufacturing delays 

(multiple countries affected) 
Date of shortage:
17th August 2018

Expected return date:
Unknown at present
Last updated: 
8th April 2019
Instanyl 100mcg Single Dose Nasal Spray

EU/1/09/531/014-017 
Fentanyl citrate Manufacturing delays

(multiple countries affected) 
Date of shortage:
January 2019

Expected return date:
Unknown at present
Last updated:
8th April 2019 
Irprestan 150mg Film Coated Tablet

PA1380/021/002 
Irprestan  Active substance impurity

(multiple countries affected) 
Date of shortage:
February 2019

Expected return date:
July 2019 
Last updated:
15th April 2019 
Irprezide 150/12.5mg Film Coated Tablet

            PA1380/080/001
Irbesartan & Hydrochlorothiazide  Active substance impurity

           
Date of shortage:
21st December 2018

Expected return date:
Unknown at present
Last updated:
3rd April 2019
Irprezide 300/12.5mg Film Coated Tablet

            PA1380/080/002
Irbesartan & Hydrochlorothiazide Active substance impurity

Date of shortage:
21st December 2018

Expected return date:
Unknown at present
Last updated:
3rd April 2019
Isotode 5mg Tablet

PA1380/014/001 
Amlodipine besilate  Manufacturing delay  Date of shortage:
April 2019

Expected return date:
End of May 2019 
Last updated:
17th April 2019 
Memantine 10mg Film Coated Tablet

PA0126/255/002 
Memantine hydrochloride  Manufacturing delays  Date of shortage:
End of March 2019

Expected return date:
Start of May 2019 
Last updated:
2nd April 2019 
Mirapexin 0.088mg Tablet

EU/1/97/051/002 
Pramipexole  Unexpected increase in demand

(multiple countries affected) 
Date of shortage:
Mid April 2019

Expected return date:
9th May 2019 
Last updated:
17th April 2019 
Morphine Sulphate Injection BP 30mg/ml Solution for Injection

PA0361/004/005 
Morphine Sulphate  Manufacturing delays  Date of shortage:
October 2018

Expected return date:
Start of May 2019 
Last updated:
28th March 2019 
Muse 250mcg Urethral Stick

PA2010/028/002
Alprostadil  Manufacturing delays

(multiple countries affected) 
Date of shortage:
Mid March 2019
 
Expected return date:
Q3 2019 
Last updated:
11th April 2019 
Muse 500mcg Urethral Stick

PA2010/028/003 
Alprostadil  Manufacturing delays

(multiple countries affected) 
Date of shortage:
Mid March 2019
 
Expected return date:
Q3 2019 
Last updated:
11th April 2019 
Muse 1000mcg Urethral Stick

PA2010/028/004 
Alprostadil  Manufacturing delays

(multiple countries affected) 
Date of shortage:
Start of March 2019
 
Expected return date:
Q3 2019 
Last updated:
11th April 2019 
Naropin 2mg/ml Solution for Injection

PA1691/026/001
Ropivacaine hydrochloride Manufacturing delays

(multiple countries affected)
Date of shortage:
October 2017
 
Expected return date:
End of August 2019
 
Last updated:
25th February 2019
 
HCP Letter
Naropin 7.5mg/ml Solution for Injection

PA1691/026/002 
Ropivacaine hydrochloride Manufacturing delays

(multiple countries affected)
Date of shortage:
25th September 2017

Expected return date:
20th April 2019
Last updated:
12th April 2019
             
Noradrenaline 1:1000 Concentrate for Solution for Infusion 

PA0822/219/001 
Noradrenaline  Manufacturing delays

(multiple countries affected) 
Date of shortage:
6th May 2019

Expected return date:
End of May 2019 
Last updated:
12th April 2019

HCP Letter
Piperacillin with Tazobactam 2.25g Powder for Solution for Injection

PA1339/001/001 
Piperacillin sodium & Tazobactam sodium Manufacturing delays

(multiple countries affected)
Date of shortage:
January 2018

Expected return date:
Unknown at present
Last updated:
31st January 2019
Piperacillin with Tazobactam 4.5g Powder for Solution for Injection

PA1339/001/002 
Piperacillin sodium & Tazobactam sodium Manufacturing delays

(multiple countries affected)
Date of shortage:
January 2018

Expected return date:
Unknown at present
Last updated:
31st January 2019
Piperacillin Tazobactam 4g/0.5g Powder for Solution for Infusion

PA0577/204/002
Piperacillin sodium & Tazobactam sodium Manufacturing delays

(multiple countries affected) 
Date of shortage:
Early February 2019

Expected return date:
Unknown at present 
Last updated:
6th February 2019 

Product is on allocation
Propofol-Lipuro 1% (10mg/ml) Emulsion for Injection or Infusion
(100ml presentation only)

PA0736/018/002 
Propofol  Manufacturing delays  Date of shortage:
9th April 2019

Expected return date:
End of April 2019 
Last updated:
10th April 2019 
Quinine Sulphate 300mg Coated Tablet

PA1986/052/001 
Quinine Sulphate  Manufacturing delays  Date of shortage:
9th April 2019

Expected return date:
August 2019 
Last updated:
9th April 2019

HCP Letter
Sastravi 100/25/200mg Film Coated Tablet

PA1380/154/003 
Levodopa, Carbidopa & Entacapone Manufacturing delays Date of shortage:
October 2018

Expected return date:
Awaiting update
Last updated:
9th April 2019
Septrin Forte 160mg/800mg Tablet

PA1691/010/002 
Sulphamethoxazole & Trimethoprim  Manufacturing delays 

(multiple countries affected)
Date of shortage:
Mid January 2019

Expected return date:
17th April 2019
Last updated:
12th April 2019
Solpadol Caplets 500mg/30mg Tablet

PA0540/159/001 
Paracetamol & Codeine  Manufacturing delays  Date of shortage:
Mid April 2019

Expected return date:
Mid May 2019 
Last updated:
11th April 2019 
Solpadol Effervescent 500mg/30mg Tablet

PA0540/159/003 
Paracetamol & Codeine  Manufacturing delays  Date of shortage:
Mid April 2019

Expected return date:
End of April 2019 
Last updated:
11th April 2019 
Sterile Sodium Chloride Concentrate 30% w/v Solution for Infusion 

PA0274/001/001
Sodium Chloride  Manufacturing delays  Date of shortage:
Start of April 2019
 
Expected return date:
Start of May 2019 
Last updated:
28th March 2019 
Sublimaze 50mcg/ml Solution for Injection

PA2187/002/001 
Fentanyl citrate  Manufacturing delays  Date of shortage:
9th February 2019

Expected return date:
Awaiting update 
Last updated:
12th April 2019 
Tadalafil Krka 10mg Film Coated Tablet

PA1347/071/003 
Tadalafil Unexpected increase in demand  Date of shortage:
October 2018

Expected return date:
Awaiting update
Last updated:
17th April 2019
Tevanate Once Weekly 70mg Tablet

PA0749/016/001 
Alendronic acid  Manufacturing delays  Date of shortage:
Start of April 2019

Expected return date:
Unknown at present 
Last updated:
4th April 2019 
Teveten Plus 600mg/12.5mg Film Coated Tablet

PA2010/018/001 
Eprosartan & Hydrochlorothiazide  Manufacturing delays  Date of shortage:
End of February 2019

Expected return date:
Awaiting update
Last updated:
10th April 2019
Triapin 2.5mg/2.5mg Prolonged Release Tablet

PA0540/082/001 
Felodipine & Ramipril  Unexpected increase in demand  Date of shortage:
End of March 2019

Expected return date:
End of May 2019 
Last updated:
29th March 2019 
Triapin 5mg/5mg Prolonged Release Tablet

PA0540/082/002 
Felodipine & Ramipril  Manufacturing delays  Date of shortage:
Mid January 2019

Expected return date:
Unknown at present
Last updated:
11th March 2019 
Trimoptin 100mg Tablets

PA0298/014/001 
Trimethoprim Manufacturing delays  Date of shortage:
Early October 2018

Expected return date:
Unknown at present
Last updated:
3rd April 2019
Trimoptin 200mg Tablets

PA0298/014/002 
Trimethoprim  Manufacturing delays  Date of shortage:
Early October 2018

Expected return date:
Unknown at present
Last updated:
3rd April 2019
Valsartan Actavis 40mg Film Coated Tablet 

PA1380/022/001
Valsartan Active substance impurity

(multiple countries affected)
                        
Date of shortage:
July 2018

Expected return date:
July 2019
Last updated: 
14th January 2019
Valsartan Actavis 80mg Film Coated Tablet

PA1380/022/002
     
Valsartan Active substance impurity

(multiple countries affected)
Date of shortage:
July 2018

Expected return date:
July 2019
Last updated:
14th January 2019
Valsartan Actavis 160mg Film Coated Tablet 

PA1380/022/003
Valsartan Active substance impurity

(multiple countries affected)
Date of shortage:
July 2018

Expected return date:
July 2019
 
Last updated:
14th January 2019
Valsartan Mylan 40mg Film Coated Tablet

PA0577/134/001 
Valsartan  Unexpected increase in demand 

(multiple countries affected)
Date of shortage:
Early November 2018
 
Expected return date:
Unknown at present
Last updated:
17th April 2019
Valsartan Mylan 80mg Film Coated Tablet

PA0577/134/002 
Valsartan  Unexpected increase in demand 

(multiple countries affected)
Date of shortage:
Early November 2018

Expected return date:
Unknown at present
Last updated:
17th April 2019
Valsartan Mylan 320mg Film Coated Tablet 

PA0577/134/004
Valsartan  Unexpected increase in demand

(multiple countries affected) 
Date of shortage:
Early November 2018

Expected return date:
Unknown at present
Last updated:
17th April 2019 
Valsartan Teva 40mg Film Coated Tablet

PA0749/084/001 
Valsartan Unexpected increase in demand

(multiple countries affected) 
Date of shortage: 
July 2018

Expected return date:
Unknown at present
Last updated:
11th March 2018
Valsartan Teva 80mg Film Coated Tablet

PA0749/084/002 
Valsartan Unexpected increase in demand

(multiple countries affected)
Date of shortage:
July 2018

Expected return date:
Awaiting update
Last updated:
11th March 2018
Valsartan / Hydrochloride 80mg/12.5mg Film Coated Tablet

PA1380/101/001
Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)
Date of shortage:
July 2018

Expected return date:

July 2019
Last updated:
14th January 2019
Valsartan / Hydrochlorothiazide 160mg/12.5mg Film Coated Tablet 

PA1380/101/002
Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)
Date of shortage:
July 2018

Expected return date:
July 2019
Last updated:
14th January 2019
Valsartan / Hydrochlorothiazide 160mgmg/ 25mg Film Coated Tablet

PA1380/101/003 
Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)
Date of shortage:
July 2018

Expected return date:
July 2019
Last updated:
14th January 2019
Valtan 40mg Film Coated Tablet 

PA0126/211/001 
Valsartan Unexpected increase in demand

(multiple countries affected)
Date of shortage:
24th October 2018

Expected return date:
Intermittent supply expected for the foreseeable future
Last updated:
21st December 2018
Valtan 80mg Film Coated Tablet

PA0126/211/002 
Valsartan  Unexpected increase in demand

(multiple countries affected)
Date of shortage:
26th September 2018
 
Expected return date:
Unknown at present
Last updated:
17th April 2019
Valtan 160mg Film Coated Tablet

PA0126/211/003
Valsartan  Unexpected increase in demand 

(multiple countries affected)
Date of shortage:
24th October 2018

Expected return date:
Awaiting update
Last updated:
17th April 2019
Vancocin Matrigel 125mg Hard Capsule

PA1226/005/001 
Vancomycin hydrochloride  Manufacturing delay  Date of shortage;
Awaiting update

Expected return date:
End of May 2019 
Last updated:
18th April 2019 
Vatan 40mg Film Coated Tablet

PA0711/183/001
Valsartan  Active substance impurity

(multiple countries affected) 
Date of shortage:
July 2018

Expected return date:
Awaiting update
Last updated:
17th April 2019
Vatan 80mg Film Coated Tablets

PA0711/183/002 
Valsartan  Active Substance Impurity

(multiple countries affected) 
Date of shortage:
July 2018

Expected return date:
Awaiting update
Last updated:
17th April 2019
Vatan 160mg Film Coated Tablets

PA0711/183/003 
Valsartan Active Substance impurity

(multiple countries affected) 
 
Date of shortage:
July 2018

Expected return date:
Awaiting update
Last updated:
17th April 2019
Vepesid 100mg Capsules

PA2255/004/002 
Etoposide  Unexpected increase in demand

(multiple countries affected) 
Date of shortage:
End of February 2019

Expected return date:
Mid May 2019 
Last updated:
15th March 2019 

HCP Letter
Zestan 5mg Tablets

PA0126/112/002 
Lisinopril dihydrate  Manufacturing delays  Date of shortage:
Mid February 2019

Expected return date:
June 2019 
Last updated:
13th February 2019 
Zolpidem Tartrate Teva 10mg Film Coated Tablet

PA0749/095/002 
Zolpidem tartrate  Manufacturing delays  Date of shortage:
March 2019

Expected return date:
May 2019 
Last updated:
11th March 2019 

Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL
Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL
Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL



Contact us:

Medicinal Product Shortages Unit
Health Products Regulatory Authority 
Kevin O’Malley House
Earlsfort Terrace,
Dublin 2
Tel: +353 1 676 4971
Fax: +353 1 676 7836
shortages@hpra.ie