COVID-19 vaccines – suspected side effects reported in Ireland and the EU/EEA

This webpage provides summary information on the number of suspected side effects reported to the HPRA following COVID-19 vaccination. The figures were last updated on 16 September 2024 and include reports received up to 31 August.

Healthcare professionals and members of the public are reminded to refer to the product information for COVID-19 vaccines for information and advice on known side effects.

Reports of suspected side effects can be notified to the HPRA using our online reporting form

Reports of suspected side effects notified to the HPRA

Last update to HPRA data: 16 September 2024

Reports of suspected side effects are notified to the HPRA on a voluntary basis by healthcare professionals and members of the public. All COVID-19 vaccines have some side effects, the vast majority of which are mild to moderate in nature. These side effects need to be continuously balanced against the risk of COVID-19 illness and related complications, including hospitalisation and death.

Up to 31 August 2024, the HPRA has received a total of 21,222 reports describing suspected side effects in association with COVID-19 vaccines, of which 2,845 were received in 2022, 400 were received in 2023, and 91 were received in 2024. A breakdown of reports received by vaccine is provided in the table below.

mRNA vaccines (Comirnaty® and Spikevax®)

14,122

Adenoviral vector vaccines (Vaxzevria® and Jcovden® [previously Janssen])

6,750

Recombinant adjuvanted spike protein vaccine (Nuvaxovid®)

7

Brand unknown/not specified

361


Note on table above:

  1. The number of reports received for different COVID-19 vaccines are not directly comparable, given differences in how vaccines have been used.

  2. Some reports involved vaccination with more than one brand of vaccine, therefore the sum of the number of reports per vaccine type is greater than the total number of reports received.

Reports of suspected side effects notified in the EU/EEA

Anonymised data on reports of suspected side effects notified to the HPRA, as well as throughout the EU/EEA to other regulatory authorities, are publicly available through the European database of suspected adverse drug reaction reports. Please note that the number of reports available in the European database for Ireland can be less than the number of reports cited above. The number of HPRA reports includes some which do not meet the criteria for reporting to the European database, for example reports where the vaccine brand is unknown, or reports which describe a medication error with no side effect. At any given time, there are also a number of reports which remain under processing by the HPRA, following which they are submitted to the European database in accordance with regulatory reporting timelines.

The safety of COVID-19 vaccines is continuously monitored by the European Medicines Agency’s (EMA) Pharmacovigilance Risk Assessment Committee (PRAC), in which the HPRA participates. From January 2021 to December 2022, the EMA published safety updates for COVID-19 vaccines, outlining the outcomes from assessments by the PRAC of emerging worldwide safety data. 

From December 2022, the EMA is no longer publishing monthly updates. You can view the most up to date information for each vaccine and safety updates previously published on the EMA’s COVID-19 vaccine webpages using the links below. 


The EMA will continue publishing high-level information on reports of suspected side effects. Further information is available on the EMA’s COVID-19 vaccines safety webpage.

Understanding the data

Conclusions on the safety of a vaccine cannot be drawn based on information from suspected side effect reports alone. The HPRA receives reports based on a suspicion that a side effect may be associated with vaccination. This does not mean that the vaccine caused the side effect. Reports may describe coincidental events, which have occurred post-vaccination, but would have occurred even if vaccination had not taken place (e.g. they may be due to an underlying medical condition, or be signs and symptoms of another illness). Only a detailed evaluation and scientific assessment of all available data allows for robust conclusions to be drawn on the benefits and risks of a vaccine. For more information, please see our information about understanding the data and background information on the evaluation of suspected side effect reports.

Safety updates previously published by the HPRA

17 February 2023
Safety Update (#19): COVID-19 Vaccines

19 May 2022  Safety Update (#18): COVID-19 Vaccines

24 March 2022 Safety Update (#17): COVID-19 Vaccines

17 February 2022 Safety Update (#16): COVID-19 Vaccines
 
20 January 2022  Safety Update (#15): COVID-19 Vaccines

9 December 2021 Safety Update (#14): COVID-19 Vaccines
 
4 November 2021  Safety Update (#13): COVID-19 Vaccines
 
7 October 2021  Safety Update (#12): COVID-19 Vaccines
 
9 September 2021 Safety Update (#11): COVID-19 Vaccines
 
12 August 2021 Safety Update (#10): COVID-19 Vaccines
 
15 July 2021  Safety Update (#9): COVID-19 Vaccines
  
17 June 2021  Safety Update (#8): COVID-19 Vaccines

20 May 2021 Safety Update (#7): COVID-19 Vaccines 

22 April 2021

Safety Update (#6): COVID-19 Vaccines 

25 March 2021

Safety Update (#5): COVID-19 Vaccines

04 March 2021

Safety Update (#4): COVID-19 Vaccines

18 February 2021

Safety Update (#3): COVID-19 Vaccines 

04 February 2021

Safety Update (#2): COVID-19 Vaccines 

21 January 2021  Safety Update (#1): COVID-19 Vaccines