My HPRA: Register

Medicinal Product Shortages

The HPRA is responsible for co-ordinating the management of shortages of medicines on the Irish market. The HPRA works with a variety of stakeholders including manufacturers, wholesale distributors, marketing authorisation holders, healthcare professionals, the Health Service Executive, patients and representative groups to respond to potential shortages and reduce the impact of shortages on patients.

The definition of a shortage is when the supply of a medicinal product is inadequate to meet the needs of the patient. 

The HPRA, in collaboration with stakeholders, has published a framework for a multi-stakeholder approach to handling shortages of human medicinal products. The aim of the framework is to help prevent shortages from occurring and to reduce the impact of shortages on patients by co-ordinating the management of potential or actual shortages as they arise. You can see the shortages case study on Adrenaline auto-injectors (AAIs) as an example of how the framework operates in practice. 


Information on reporting shortages for:

Marketing Authorisation Holders

Please complete the  Notification of medicinal product shortage from marketing authorisation holder form and return to  shortages@hpra.ie and to the HSE Corporate Pharmaceutical Unit.

Wholesale Distributors and Manufacturers

Please complete the  Report of Medicinal Products Shortages from Wholesale Distributors and Manufacturers form and return this form to  shortages@hpra.ie.

Patients and Healthcare Professionals

Please complete the  Report of a Medicinal Product Shortage from Patients and Healthcare Professionals form and return to  shortages@hpra.ie. When completing this form, please include as much information as possible.


Current and resolved shortages

The HPRA publishes a list of shortages currently affecting the Irish market that have been notified to us and that may have a medium or high impact on patients. This list can be found below. More information on the impact level can be found in the framework for a multi-stakeholder approach to handling shortages of human medicinal products.

The HPRA maintains a consolidated list of resolved shortages for a period of six months. Details of shortages that have been resolved in the last six months can be found here.
 

Tamoxifen shortage

There is intermittent supply of tamoxifen affecting multiple countries, including Ireland. This is caused by an international shortage of the active pharmaceutical ingredient and is not related in any way to Brexit.

Alternative supplies of tamoxifen are available during the shortage although patients might have to use a different brand of the medicine. Patients can speak to their pharmacist or medical team if they have queries. Normal supplies are expected to resume by December 2019.

The HSE has established a website to provide information for patients at www.hse.ie/tamoxifen as well as providing guidance for healthcare professionals.

Both the HPRA and the HSE websites will be kept up to date as additional information becomes available.


Please use search function below to find relevant product or active ingredient

 
Product name Active ingredient Reason for shortage Date of shortage
 Additional information
Abstral 100mcg Sublingual Tablet

PA2288/004/002 		 Fentanyl  Manufacturing delays  Date of shortage:
22nd January 2020

Expected return date:
End of February 2020 		 Last updated:
28th January 2020 
Abstral 200mcg Sublingual Tablet

PA2288/004/003 		 Fentanyl  Manufacturing delays  Date of shortage:
22nd January 2020

Expected return date:
End of February 2020 		 Last updated:
28th January 2020 
Abstral 300mcg Sublingual Tablet

PA2288/004/004 		 Fentanyl  Manufacturing delays  Date of shortage:
22nd January 2020

Expected return date:
End of February 2020 		 Last updated:
28th January 2020 
Abstral 400mcg Sublingual Tablet

PA2288/004/005 		 Fentanyl  Manufacturing delays  Date of shortage:
22nd January 2020

Expected return date:
End of February 2020 		 Last updated:
28th January 2020 
Abstral 600mcg Sublingual Tablet

PA2288/004/006 		 Fentanyl  Manufacturing delays  Date of shortage:
22nd January 2020

Expected return date:
End of February 2020 		 Last updated:
28th January 2020 
Abstral 800mcg Sublingual Tablet

PA2288/004/007 		 Fentanyl  Manufacturing delays  Date of shortage:
22nd January 2020

Expected return date:
End of February 2020 		 Last updated:
28th January 2020 
Accupro 20mg Film Coated Tablet

PA0822/007/003 		 Quinapril hydrochloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid March 2019

Expected return date:
End of January 2020		 Last updated:
24th January 2020
 

 
Accuretic 20/12.5mg Film Coated Tablet

PA0822/008/002 		 Quinapril hydrochloride & Hydrochlorothiazide  Manufacturing delays 

(multiple countries affected)		 Date of shortage:
Early January 2019

Expected return date:
End of January 2020		 Last updated:
24th January 2020
 

 
           
Aciclovir 25mg/ml Concentrate for Solution for Infusion

PA2299/041/001 		 Aciclovir sodium  Manufacturing issue  Date of shortage:
December 2018

Expected return date:
January 2020		 Last updated:
19th December 2019 
Actonel 5mg Film Coated Tablet

PA2315/140/001 		 Risedronate  Manufacturing delay 

(multiple countries affected)		 Date of shortage:
June 2019

Expected return date:
January 2020 		 Last updated:
26th July 2019 
Adalat LA 20mg Prolonged Release Tablet

PA1410/025/005		 Nifedipine  Manufacturing delays

(multiple countries affected)		 Date of shortage:
November 2017
 
Expected return date:
Not before 2021		 Last updated:
29th November 2019
 
Adalat LA 30mg Prolonged Release Tablet

PA1410/025/006		 Nifedipine  Manufacturing delays

(multiple countries affected)		 Date of shortage:
24th June 2018

Expected return date:
Not before 2021
 Last updated:
29th November 2019 
 
Adalat LA 60mg Prolonged Release Tablet

PA1410/025/007 		 Nifedipine Manufacturing delays

(multiple countries affected)		 Date of shortage:
September 2018

Expected return date:
Not before 2021		 Last updated:
29th November 2019
 
Alendronate/Colecalciferol Teva 70mg/5600IU Tablet

PA0749/196/002 		 Alendronate & Colecalciferol  Manufacturing delays  Date of shortage:
January 2019

Expected return date:
Q2 2020 		 Last updated:
16th January 2020 
Alprazolam 0.25mg Tablet

PA0711/140/001 		 Alprazolam  Unexpected increase in demand  Date of shortage:
10th December 2019

Expected return date:
January 2020 		 Last updated:
13th December 2019 
Amisulpride 50mg Tablet

PA0577/182/001 		 Amisulpride  Manufacturing delays  Date of shortage:
July 2019

Expected return date:
End of March 2020 		 Last updated:
20th January 2020 
Amisulpride 200mg Tablet

PA0577/182/002 		 Amisulpride  Manufacturing delays  Date of shortage:
February 2019

Expected return date:
End of March 2020 		 Last updated:
20th January 2020 
Amoxil 500mg Powder for Solution for Injection or Infusion

PA1077/033/004 		 Amoxicillin  Unavailability of API

(multiple countries affected) 		 Date of shortage:
20th January 2020 

Expected return date:
10th February 2020		 Last updated:
28th January 2020 
Arava 20mg Tablet

EU/1/99/118/007 		 Leflunomide  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of December 2019

Expected return date:
7th February 2020		 Last updated:
24th January 2020
Areloger 15mg Film Coated Tablet

PA0577/057/002 		 Meloxicam  Manufacturing delays  Date of shortage:
Early August 2019

Expected return date:
January 2020 		 Last updated:
1st August 2019 
Axsain 0.075% w/w Cream

PA0827/004/001 		 Capsaicin  Manufacturing delays 

(multiple countries affected)		 Date of shortage:
Mid June 2019

Expected return date:
Q1 2020		 Last updated:
31st October 2019 
Azithromycin Teva 25omg Film coated Tablet

PA0749/039/002 		 Azithromycin  Manufacturing delays  Date of shortage:
Mid January 2020

Expected return date:
Mid February 2020 		 Last updated:
27th January 2020 
BCG-Medac Powder and Solvent for Suspension for Intravesical Use

PA0623/004/001 		 Bacillus Calmette Guerin bacteria  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
1st October 2019

Expected return date:
Unknown at present 		 Last updated:
7th November 2019 
Betnovate RD 0.025% w/w Cream

PA1077/001/004 		 Betamethasone  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Early October 2019

Expected return date:
End of January 2020 		 Last updated:
17th January 2020

HCP Letter
Betnovate RD 0.025% w/w Ointment

PA1077/001/005 		 Betamethasone  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Early September 2019

Expected return date:
Mid February 2020		 Last updated:
17th January 2020

HCP Letter
Blopress 4mg Tablet

PA2229/001/002 		 Candesartan  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid October 2019

Expected return date:
April 2020 		 Last updated:
22nd October 2019 
Candist 4mg Tablet

PA0126/206/001 		 Candesartan  Unexpected increase in demand  Date of shortage:
Mid December 2019

Expected return date:
Mid March 2020 		 Last updated:
19th December 2019 
Canesten Combi -  500mg Pessary & 2% w/w Cream

PA1410/039/001 		 Clotrimazole  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
January 2018

Expected return date:
End of January 2020 		 Last updated:
9th January 2020
             
HCP Letter
Canesten Duopack - 100mg Pessary & 1% w/w Cream

PA1410/039/005 		 Clotrimazole  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
February 2018

Expected return date:
Mid March 2020 		 Last updated:
9th January 2020
 
HCP Letter
Canesten 200mg Pessary

PA1410/039/008 		 Clotrimazole  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
February 2018

Expected return date:
Early April 2020 		 Last updated:
9th January 2020
 
HCP Letter
Canesten 500mg Pessary

PA1410/039/009 		 Clotrimazole  Manufacturing delay

(multiple countries affected) 		 Date of shortage:
January 2018

Expected return date:
Mid March 2020		 Last updated:
9th January 2020
             
HCP Letter
Caverject 10mcg Powder and Solvent for Solution for Injection

PA0822/115/002 		 Alprostadil  Unexpected increase in demand

(multiple countries affected) 		 Date of shortage:
Early December 2019

Expected return date:
March 2020 		 Last updated:
25th November 2019 
Cibacen 5mg Film Coated Tablet
 
PA2010/029/001		 Benazepril  Manufacturing delays  Date of shortage:
March 2019

Expected return date:
Mid January 2020 		 Last updated:
18th December 2019 
Cimeldine 400mg Film Coated Tablet

PA0126/077/002 		 Cimetidine  API delay  Date of shortage:
9th December 2019

Expected return date:
27th January 2020 		 Last updated:
20th December 2019 
Ciprofloxacin Teva 250mg Film Coated Tablet


PA0749/031/002 		 Ciprofloxacin  Manufacturing delays  Date of shortage:
Early September 2019

Expected return date:
Unknown at present 		 Last updated:
16th January 2020
Ciprofloxacin Teva 500mg Film Coated Tablet

PA0749/031/003 		 Ciprofloxacin  Manufacturing delays  Date of shortage:
Mid August 2019

Expected return date:
Unknown at present		 Last updated:
16th January 2020 
Ciproxin 500mg Tablet

PA1410/028/003 		 Ciprofloxacin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
September 2018

Expected return date:
Q2 2020 		 Last updated:
26th September 2019

HCP Letter
Ciproxin 750mg Tablet

PA1410/028/004 		 Ciprofloxacin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid October 2019

Expected return date:
Q2 2020 		 Last updated:
26th September 2019

HCP Letter 
Co-Amoxiclav 500mg/100mg Powder for Solution for Injection and Infusion

PA1457/001/001		 Amoxicillin & clavalunic acid Unexpected increase in demand Date of shortage:
24th May 2019

Expected return date:
End of April 2020		 Last updated:
27th January 2020 
Cordarone X Intravenous 150mg/3ml Concentrate for Solution for Infusion or Slow Injection

PA0540/142/003 		 Amiodarone  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
17th January 2020

Expected return date:
23rd March 2020 		 Last updated:
17th January 2020 
Co-Vatan 80mg/12.5mg Film Coated Tablet

PA0711/182/001 		 Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)		 Date of shortage:
July 2018

Expected date of return:
Unknown at present
 Last updated: 
13th May 2019
Co-Vatan 160mg/12.5mg Film Coated Tablet

PA0711/182/002  		 Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)		 Date of shortage:
July 2018

Expected return date:
Unknown at present 		 Last updated:
13th May 2019
Co-Vatan 160mg/25mg Film Coated Tablet 

PA0711/182/003		 Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)		 Date of shortage:
July 2018

Expected return date: 
Unknown at present		 Last updated:
13th May 2019
Cozaar 12.5mg Film Coated Tablet

PA1286/004/001 		 Losartan potassium  Manufacturing delays  Date of shortage:
18th January 2020

Expected return date:
End of February 2020 		 Last updated:
15th January 2020 
Cozatan 50mg Film Coated Tablet

PA0126/167/001 		 Losartan potassium  Active substance impurity  Date of shortage:
Mid June 2019

Expected return date:
April 2020		 Last updated:
18th November 2019 
Dectova 10mg/ml Solution for Infusion

EU/1/18/1349/001 		 Zanamivir  Unexpected increase in demand

(multiple countries affected) 		 Date of shortage:
2nd January 2020

Expected return date:
12th February 2020 		 Last updated:
8th January 2020 
Difene 25mg Capsule

PA2256/001/001 		 Diclofenac  Unexpected increase in demand  Date of shortage:
Early November 2019

Expected return date:
February 2020 		 Last updated:
12th November 2019 
Diovan 160mg Film Coated Tablet

PA0896/009/002 		 Valsartan  Unexpected increase in demand  Date of shortage:
Mid July 2019

Expected return date:
Awaiting update 		 Last updated:
26th November 2019 
Divigel 0.1% w/w Gel

PA1327/002/001 		 Estradiol  Unexpected increase in demand & Manufacturing delays  Date of shortage:
December 2019
 
Expected return date:
Mid February 2020 		 Last updated:
15th January 2020 
Donepezil Hydrochloride 10mg Tablet

PA0749/194/002 		 Donepezil  Manufacturing delays  Date of shortage:
Mid January 2020

Expected return date:
Mid February 2020 		 Last updated:
28th January 2020 
Doxatan 2mg Tablet

PA0126/202/002 		 Doxazosin  Unexpected increase in demand  Date of shortage:
Early August 2019

Expected return date:
Awaiting update		 Last updated:
23rd December 2019 
Emerade 150mcg Solution in a Pre-Filled Pen

PA1696/009/001 		 Adrenaline  Quality issue

(multiple countries affected) 		 Date of shortage:
30th September 2019

Expected return date:
Unknown at present 		 Last updated:
30th September 2019

Alternatives are available 
Emerade 300mcg Solution in a Pre-Filled Pen

PA1696/009/002 		 Adrenaline  Quality issue

(multiple countries affected) 		 Date of shortage:
30th September 2019

Expected return date:
Unknown at present 		 Last updated:
30th September 2019

Alternatives are available 
Emerade 500mcg Solution in a Pre-Filled Pen

PA1696/009/003 		 Adrenaline  Quality issue

(multiple countries affected) 		 Date of shortage:
30th September 2019

Expected return date:
Unknown at present 		 Last updated:
30th September 2019

Alternatives are available 
Epanutin Infatabs 50mg Chewable Tablets

PA0822/011/005		 Phenytoin Manufacturing delays

(multiple countries affected)		 Date of shortage:
Early November 2019

Expected return date:
Unknown at present		 Last updated:
30th October 2019

HCP Letter
Epanutin Ready Mixed Parenteral 250mg/5ml Solution for Injection or Infusion

PA0822/011/006 		 Phenytoin  Manufacturing delays

(multiple countries affected)		 Date of shortage:
Mid July 2019

Expected return date:
January 2020 		 Last updated:
16th July 2019

HCP Letter
Erwinase 10000% v/v Powder for Solution for Injection

PA1020/002/001  		 Cristanspase Manufacturing delays

(multiple countries affected)		 Date of shortage:
5th October 2018

Expected return date:
Awaiting update
 Last updated:
18th November 2019
             

                         

 
Erythrocin 250mg Tablet

PA1142/008/002 		 Erythrocin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Early August 2019

Expected return date:
Mid January 2020		 Last updated:
26th November 2019 
Erythroped PI SF 125mg/5ml Granules for Oral Suspension

PA1142/006/002 		 Erythromycin  Manufacturing delays 

(multiple countries affected)		 Date of shortage:
End of June 2019

Expected return date:
Unknown at present 		 Last updated:
16th October 2019 
Erythroped SF 250mg/5ml Granules for Oral Suspension

PA1142/006/001 		 Erythromycin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid November 2019

Expected return date:
Unknown at present 		 Last updated:
13th November 2019 
Etoposide 20mg/ml Concentrate for Solution for Infusion

PA2315/207/001 		 Etoposide  Manufacturing delays  Date of shortage:
End of May 2019

Expected return date:
Awaiting update		 Last updated:
17th December 2019 
Evorel 50mcg Transdermal Patch

PA22668/008/001 		 Estradiol  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
October 2019

Expected return date:
May 2020 		 Last updated:
10th January 2020
 
Evorel Conti 50mcg/170mcg Transdermal Patch

PA22668/009/001 		 Estradiol & Norethisterone Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Early January 2020

Expected return date:
May 2020 		 Last updated:
10th January 2020

             
Fluorouracil 25mg/ml Solution for Injection or Infusion

(500mg/20ml presentation only)

PA0822/223/001		 Fluorouracil  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
6th December 2019

Expected return date:
February 2020 		 Last updated:
3rd December 2019 
Folinic Acid 10mg/ml Solution for Injection (100mg/10ml presentation only)

PA0822/198/003 		 Folinic acid  Manufacturing delays  Date of shortage:
5th July 2019

Expected return date:
End of January 2020 		 Last updated:
18th July 2019 
Frumil 40mg/5mg Tablet

PA0540/101/002 		 Furosemide & Amiloride  Unavailability of API

(multiple countries affected) 		 Date of shortage:
20th January 2020

Expected return date:
End of February 2020 		 Last updated:
14th January 2020 
Furosemide 20mg in 2ml Solution for Injection

PA0073/059/004 		 Furosemide  Manufacturing delays  Date of shortage:
Mid January 2020

Expected return date:
End of January 2020 		 Last updated:
13th January 2020 
Genotropin 5.3mg Powder and Solvent for Solution for Injection

PA0822/128/001 		 Somatropin  Manufacturing delays

(multiple countries affected) 		 Date of shortage: 
Early December 2019

Expected return date:
Mid February 2020		 Last updated:
13th January 2020
 
HCP Letter

           
Genotropin 12mg Powder and Solvent for Solution for Injection

PA0822/128/002 		 Somatropin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
23rd December 2019

Expected return date:
Mid February 2020 		 Last updated:
21st January 2020

Product is on allocation
 
HCP Letter
Gerax 0.25mg Tablet

PA0577/010/001 		 Alprazolam  Unexpected increase in demand  Date of shortage:
18th June 2019

Expected return date:
Unknown at present		 Last updated:
17th December 2019 
Gerax 0.5mg Tablet

PA0577/010/002 		 Alprazolam  Unexpected increase in demand  Date of shortage:
Early September 2019

Expected return date:
End of January 2020		 Last updated:
17th December 2019 
Gerax 1mg Tablet

PA0577/010/003		 Alprazolam  Unexpected increase in demand  Date of shortage:
End of August 2019

Expected return date:
End of January 2020 		 Last updated:
17th December 2019 
Gerozac 20mg Capsule

PA0577/200/001 		 Fluoxetine  Manufacturing delays  Date of shortage:
Early December 2019

Expected return date:
Early February 2020 		 Last updated:
20th January 2020 
Gerozac 60mg Capsule

PA0577/071/001 		 Fluoxetine  Manufacturing delays  Date of shortage:
Early December 2020

Expected return date:
Unknown at present 		 Last updated:
20th January 2020 
Gertac 150mg Film Coated Tablet

PA0577/023/001 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers 

AHDMP Guidance for Prescribers
Gertac 300mg Film Coated Tablet

PA0577/023/002 		 Ranitidine  Active substance impurities

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers 

AHDMP Guidance for Prescribers
HBVAXPRO 40mcg Suspension for Injection

EU/1/01/183/015 		 Hepatitis B  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
12th November 2019

Expected return date:
End of 2020 		 Last updated:
13th November 2019 
Hypovase 1mg Tablet

PA0822/195/002 		 Prazosin hydrochloride  Manufacturing delay 

(multiple countries affected)		 Date of shortage:
Mid June 2019

Expected return date:
February 2020		 Last updated:
24th October 2019 
Innohep 16,000IU in 0.8ml Solution for Injection in Prefilled Syringe

PA0046/060/014 		 Tinzaparin sodium  Manufacturing delays  Date of shortage:
19th December 2019

Expected return date:
18th February 2020 		 Last updated:
15th January 2020 
Irbesartan 75mg Film Coated Tablet

PA0126/205/001 		 Irbesartan  Increase in demand  Date of shortage:
Mid May 2019

Expected return date:
January 2020		 Last updated:
18th September 2019 
Irinotecan Hydrochloride 40mg/2ml Concentrate for Solution for Infusion

PA1986/068/001 		 Irinotecan  Manufacturing delays  Date of shortage:
Mid October 2019

Expected return date:
End of February 2020 		 Last updated:
24th February 2020 
Irprestan 150mg Film Coated Tablet

PA1380/021/002 		 Irprestan  Active substance impurity

(multiple countries affected) 		 Date of shortage:
February 2019

Expected return date:
Unknown at present		 Last updated:
8th August 2019 
Isoptin 40mg Film Coated Tablet

PA2010/003/001 		 Verapamil hydrochloride  Manufacturing delays  Date of shortage:
Mid January 2020 

Expected return date:
Mid February 2020		 Last updated:
22nd January 2020 
Isoptin 80mg Film Coated Tablet

PA2010/003/002 		 Verapamil hydrochloride  Manufacturing delays  Date of shortage:
End of September 2019

Expected return date:
End of January 2020 		 Last updated:
23rd December 2019 
Lanoxin 500mcg/2ml Solution for Injection

PA1691/001/001 		 Digoxin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Early January 2020

Expected return date:
24th April 2020
 		 Last updated:
20th January 2020 
Lercanidipine 10mg Tablet

PA0126/187/001 		 Lercanidipine  Unexpected increase in demand  Date of shortage:
6th January 2020 

Expected return date:
14th March 2020		 Last updated:
7th January 2020 
Lercanidipine 20mg Tablet

PA0126/187/002 		 Lercanidipine  Unexpected increase in demand  Date of shortage:
6th January 2020

Expected return date:
21st February 2020 		 Last updated:
7th January 2020 
Lercanidipine Mylan 10mg Tablet

PA0577/155/001		 Lercanidipine  Unexpected increase in demand  Date of shortage:
Early November 2019

Expected return date:
October 2020 		 Last updated:
21st January 2020 
Lercanidipine Mylan 20mg Tablet

PA0577/155/002 		 Lercanidipine  Unexpected increase in demand  Date of shortage:
Early November 2019

Expected return date:
October 2020 		 Last updated:
21st January 2020
Letrozole Teva 2.5mg Film Coated Tablet

PA0749/085/001 		 Letrozole  Manufacturing delays  Date of shortage:
Mid December 2019

Expected return date:
End of April 2020 		 Last updated:
16th December 2019 
Losartan 50mg Tablet

PA0749/090/003 		 Losartan  Unavailability of API

(multiple countries affected) 		 Date of shortage:
24th November 2019

Expected return date:
Q2 2020		 Last updated:
28th January 2020 
Losartan 50mg Tablet 

PA2315/059/002 		 Losartan  Manufacturing delays  Date of shortage:
25th September 2019

Expected return date:
Unknown at present 		 Last updated:
10th October 2019 
Losartan 100mg Tablet

PA0749/090/004 		 Losartan  Unavailability of API

(multiple countries affected) 		 Date of shortage:
Early January 2020

Expected return date:
Q2 2020 		 Last updated:
28th January 2020 
Losartan 100mg Tablet

PA2315/059/003 		 Losartan  Manufacturing delays  Date of shortage:
October 2019

Expected return date:
Unknown at present 		 Last updated:
10th October 2019 
Losartan Hydrochlorothiazide 50mg/12.5mg Tablet

PA0749/026/001 		 Losartan & Hydrochlorothiazide  Unavailability of API

(multiple countries affected) 		 Date of shortage:
24th November 2019

Expected return date:
Q2 2020		 Last updated:
28th January 2020 
Losartan Hydrochlorothiazide 100mg/25mg Tablet

PA0749/026/002 		 Losartan & Hydrochlorothiazide  Manufacturing delays  Date of shortage:
End of September 2019

Expected return date:
Awaiting update		 Last updated:
23rd December 2019 
Marcain Heavy Steripack 0.5% w/v Solution for Injection

PA1691/024/003		 Bupivacaine hydrochloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of November 2019

Expected return date:
March 2020
 		 Last updated:
26th November 2019 
Maxibar 98.45% w/w Powder for Oral Suspension

PA1826/002/001 		 Barium sulphate  Manufacturing delays  Date of shortage:
End of June 2019

Expected return date:
Awaiting update		 Last updated:
26th November 2019 
Mefac 250mg Capsule

PA0074/015/001 		 Mefenamic acid  Manufacturing delays  Date of shortage:
End of June 2019

Expected return date:
June 2020 		 Last updated:
27th June 2019
Memantine 10mg Tablet

PA0126/255/002 		 Memantine  Manufacturing delays  Date of shortage:
Mid December 2019

Expected return date:
24th February 2020 		 Last updated:
19th December 2019 
Minims Atropine Sulphate 1% Eye Drop Solution

PA0555/017/001 		 Atropine  Manufacturing delays  Date of shortage:
July 2019

Expected return date:
Q1 2020		 Last updated:
12th November 2019 
Minims Phenylephrine 2.5% w/w Eye Drops

PA22698/013/002 		 Phenylephrine  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of November 2019

Expected return date:
January 2020 		 Last updated:
26th November 2019 
Minulet 75mcg/30mcg Coated Tablet

PA0822/093/001 		 Ethinylestradiol & Gestodene  Manufacturing delays  Date of shortage:
20th January 2020

Expected return date:
Early February 2020 		 Last updated:
15th January 2020 
Miochol-E 20mg Powder and Solvent for Instillation Solution for Intraocular Use

PA1245/002/001 		 Acetylcholine chloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
5th August 2019

Expected return date:
Awaiting update		 Last updated:
7th January 2020 
Mitomycin Kyowa 10mg Powder for Solution for Injection

PA2288/002/001
  Mitomycin Quality issue

(multiple countries affected)		 Date of shortage:
3rd October 2019

Expected return date:
Unknown at present
 Last updated:
13th December 2019
Mitomycin Kyowa 40mg Powder for Solution for Injection

PA2288/002/002
  Mitomycin Quality issue

(multiple countries affected)		 Date of shortage:
3rd October 2019

Expected return date:
Unknown at present
 Last updated:
13th December 2019
Morphine Sulphate Injection BP 30mg/ml Solution for Injection

PA0361/004/005 		 Morphine Sulphate  Manufacturing delays  Date of shortage:
October 2018

Expected return date:
During 2020		 Last updated:
16th October 2019 
Muse 250mcg Urethral Stick

PA2010/028/002		 Alprostadil  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid March 2019
 
Expected return date:
Awaiting update		 Last updated:
3rd January 2020
Muse 500mcg Urethral Stick

PA2010/028/003 		 Alprostadil  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid March 2019
 
Expected return date:
Awaiting update		 Last updated:
3rd January 2020
Muse 1000mcg Urethral Stick

PA2010/028/004 		 Alprostadil  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Start of March 2019
 
Expected return date:
Awaiting update		 Last updated:
3rd January 2020 
Mysoline 250mg Tablet

PA1777/001/001 		 Primidone  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid July 2019

Expected return date:
April 2020		 Last updated:
24th October 2019 
Neotigason 10mg Capsule

PA1380/050/001 		 Acitretin  Manufacturing delays  Date of shortage:
Mid February 2020

Expected return date:
Mid March 2020 		 Last updated:
3rd January 2020

HCP Letter
Neotigason 25mg Capsule

PA1380/050/002 		 Acitretin  Manufacturing delays  Date of shortage:
Early January 2020

Expected return date:
Mid March 2020 		 Last updated:
23rd December 2019

HCP Letter 
Noctamid 1mg Tablet

PA1410/009/001 		 Lormetazepam  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid June 2019

Expected return date:
Unknown at present		 Last updated:
24th January 2020

             
Olmesartan Medoxomil Clonmel 10mg Film Coated Tablet

PA0126/273/001 		 Olmesartan medoxomil  Manufacturing delay  Date of shortage:
2nd December 2019

Expected return date:
Mid March 2020 		 Last updated:
22nd January 2020 
Osteomel Once Weekly 70mg Tablet

PA0126/148/002 		 Alendronic acid  Manufacturing delays  Date of shortage:
End of September 2019

Expected return date:
17th February 2020		 Last updated:
15th January 2020 
Ovranette 30mcg/150mcg Film Coated Tablet

PA0822/094/001 		 Ethinylestradiol & Levonorgestrel  Manufacturing delays  Date of shortage:
8th January 2020

Expected return date:
End of January 2020 		 Last updated:
13th January 2020 
Oxaliplatin 5mg/ml Concentrate for Solution for Infusion

PA2059/049/001		 Oxaliplatin  Manufacturing delays  Date of shortage:
End of October 2019

Expected return date:
Awaiting update 		 Last updated:
6th November 2019 
Paramax 500mg/5mg Tablet

PA0540/154/001 		 Paracetamol & Metoclopramide  Manufacturing delays  Date of shortage:
End of December 2019

Expected return date:
End of February 2020 		 Last updated:
23rd December 2019 
Piperacillin with Tazobactam 2.25g Powder for Solution for Injection

PA1339/001/001 		 Piperacillin sodium & Tazobactam sodium Manufacturing delays

(multiple countries affected)		 Date of shortage:
January 2018

Expected return date:
Unknown at present		 Last updated:
12th July 2019
Piperacillin with Tazobactam 4.5g Powder for Solution for Injection

PA1339/001/002 		 Piperacillin sodium & Tazobactam sodium Manufacturing delays

(multiple countries affected)		 Date of shortage:
January 2018

Expected return date:
Unknown at present		 Last updated:
12th July 2019
Pneumovax 23 Solution for Injection in Pre-Filled Syringe

PA1286/055/002 		 Pneumococcal Polysaccharide Vaccine  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of October 2019

Expected return date:
February 2020 		 Last updated:
13th November 2019 
Proctosedyl Ointment

PA0540/062/001 		 Hydrocortisone, Framycetin; Aesculin & Cinchocaine  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of November 2019

Expected return date:
13th February 2020 		 Last updated:
15th January 2020 
Questran 4g Powder for Oral Suspension

PA2239/005/001 		 Colestyramine  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid June 2019

Expected return date:
April 2020 		 Last updated:
2nd August 2019 
Raporsin 8mg Prolonged Release Tablet

PA2315/005/001 		 Doxazosin  Manufacturing delays  Date of shortage:
Mid November 2019

Expected return date:
Awaiting update 		 Last updated:
9th December 2019 
Rebetol 40mg/ml Oral Solution

EU/1/99/107/004 		 Ribavirin  Unexpected increase in demand  Date of shortage:
7th January 2020

Expected return date:
End of February 2020 		 Last updated:
13th January 2020 

HCP Letter
Septrin Adult 80mg/400mg per 5ml Oral Suspension

PA1691/010/014 		 Sulfamethoxazole & Trimethoprim  Manufacturing delays  Date of shortage:
20th January 2020 

Expected return date:
End of February 2020		 Last updated:
15th January 2020 
Seretral 100mg Tablet

PA0749/023/002 		 Sertraline  Manufacturing delays  Date of shortage:
Mid December 2019

Expected return date:
End of February 2020 		 Last updated:
27th January 2020 
Serimel 50mg Tablet

PA0126/135/001 		 Sertraline  Manufacturing delays  Date of shortage:
6th January 2020

Expected return date:
17th February 2020 		 Last updated:
13th January 2020 
Serimel 100mg Tablet

PA0126/135/002 		 Sertraline  Manufacturing delays  Date of shortage:
6th January 2020

Expected return date:
24th February 2020 		 Last updated:
13th January 2020 
Sofradex Ear/Eye Drops

PA0540/070/002 		 Framycetin, Gramicidin & Dexamethasone  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid January 2020

Expected return date:
18th March 2020 		 Last updated:
15th January 2020 
Sprilon 12.5% Zinc Oxide & 1.04% Dimethicone Cutaneous Spray Suspension

PA22906/001/001 		 Zinc oxide & Dimethicone  Manufacturing delays  Date of shortage:
October 2019

Expected return date:
September 2020 		 Last updated:
3rd December 2019 
Suboxone 2mg/0.5mg Sublingual Tablet

EU/1/06/359/001-002 		 Naloxone & Buprenorphine  Delay in delivery  Date of shortage:
Early January 2020

Expected return date:
Mid to End January 2020 		 Last updated:
8th January 2020 
Sustiva 600mg Film Coated Tablet

EU/1/99/110/009 		 Efavirenz  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of January 2020
 
Expected return date:
End of March 2020 		 Last updated:
16th January 2020

HCP Letter
Syntocinon Ampoules 10IU/ml Concentrate for Solution for Infusion or Solution for Intramuscular Injection

PA2206/003/002 		 Oxytocin  Manufacturing delays  Date of shortage:
9th December 2019

Expected return date:
End of February 2020 		 Last updated:
16th December 2019 
Tamox 10mg Tablet

PA0711/022/001 		 Tamoxifen  Unexpected increase in demand Date of shortage:
18th October 2019
 
Expected return date:
February 2020		 Last updated:
6th November 2019
 
Prescriber Communication

Pharmacist Communication

Patients:
www.hse.ie/tamoxifen
 
Tamoxifen 20mg Tablet

PA0577/207/001 		 Tamoxifen  Unexpected increase in demand  Date of shortage:
9th October 2019

Expected return date:
Mid January 2020		 Last updated:
13th November 2019
 
Prescriber Communication

Pharmacist Communication

Patients:
www.hse.ie/tamoxifen
Tefin 75mg Suppositories

PA1684/001/001 		 Ibuprofen  Manufacturing delays  Date of shortage:
August 2019

Expected return date:
March 2020 		 Last updated:
13th November 2019 
Tefin 150mg Suppositories

PA1684/001/002 		 Ibuprofen  Manufacturing delays  Date of shortage:
August 2019

Expected return date:
March 2020 		 Last updated:
13th November 2019 
Trandate 5mg/ml Solution for Injection

PA1638/006/001 		 Labetalol hydrochloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
16th May 2019

Expected return date:
February 2020		 Last updated:
6th November 2019 
Trandate 100mg Film Coated Tablet

PA1638/006/002 		 Labetalol hydrochloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
July 2019

Expected return date:
Awaiting update		 Last updated:
28th January 2020 
Trandate 200mg Film Coated Tablet

PA1638/006/003 		 Labetalol hydrochloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
July 2019

Expected return date:
March 2020		 Last updated:
6th November 2019 
Tranexamic acid 100mg/ml Solution for Injection

PA2315/178/001 		 Tranexamic acid  Manufacturing delays  Date of shortage:
Early July 2019

Expected return date:
Unknown at present 		 Last updated:
13th November 2019 
Ranitic 75mg Film Coated Tablet

PA0711/024/004 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers
             
AHDMP Guidance for Prescribers
Ranitic 150mg Film Coated Tablet

PA0711/024/001 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers

AHDMP Guidance for Prescribers
 
Ranitic 300mg Film Coated Tablet

PA0711/024/002 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers
 
AHDMP Guidance for Prescribers
Ranitidine 150mg/10ml Oral Solution

PA22741/009/001 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers
 
AHDMP Guidance for Prescribers
Ultiva 2mg Powder for Concentrate for Solution for Infusion

PA1691/032/002 		 Remifentanyl  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
17th January 2020

Expected return date:
3rd March 2020 		 Last updated:
21st January 2020 
Valsartan Actavis 40mg Film Coated Tablet 

PA1380/022/001		 Valsartan Active substance impurity

(multiple countries affected)
                        		 Date of shortage:
July 2018

Expected return date:
Awaiting update		 Last updated: 
14th January 2020
Valsartan Actavis 80mg Film Coated Tablet

PA1380/022/002
     		 Valsartan Active substance impurity

(multiple countries affected)		 Date of shortage:
July 2018

Expected return date:
Awaiting update		 Last updated:
14th January 2020
Valsartan Actavis 160mg Film Coated Tablet 

PA1380/022/003		 Valsartan Active substance impurity

(multiple countries affected)		 Date of shortage:
July 2018

Expected return date:
Awaiting update
 		 Last updated:
14th January 2020
Valsartan Mylan 40mg Film Coated Tablet

PA0577/134/001 		 Valsartan  Unexpected increase in demand 

(multiple countries affected)		 Date of shortage:
Early November 2018
 
Expected return date:
Unknown at present		 Last updated:
13th May 2019
Valsartan Mylan 80mg Film Coated Tablet

PA0577/134/002 		 Valsartan  Unexpected increase in demand 

(multiple countries affected)		 Date of shortage:
Early November 2018

Expected return date:
Unknown at present		 Last updated:
13th May 2019
Valsartan Mylan 160mg Film Coated Tablet

PA0577/134/003 		 Valsartan  Unexpected increase in demand

(multiple countries affected) 		 Date of shortage:
Early November 2018

Expected return date:
Unknown at present 		 Last updated:
13th May 2019 
Valsartan Mylan 320mg Film Coated Tablet 

PA0577/134/004		 Valsartan  Unexpected increase in demand

(multiple countries affected) 		 Date of shortage:
8th January 2020

Expected return date:
Early February 2020		 Last updated:
20th January 2020 
Valsartan Teva 80mg Film Coated Tablet

PA0749/084/002 		 Valsartan Unexpected increase in demand

(multiple countries affected)		 Date of shortage:
July 2018

Expected return date:
March 2020		 Last updated:
16th January 2020
Valsartan Teva 160mg Film coated Tablet

PA0749/084/003 		 Valsartan  Unexpected increase in demand

(multiple countries affected)		 Date of shortage:
Awaiting update

Expected return date:
March 2020		 Last updated:
16th January 2020
Valsartan / Hydrochlorothiazide 160mg/ 25mg Film Coated Tablet

PA2315/181/003 		 Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)		 Date of shortage:
July 2018

Expected return date:
End of 2019		 Last updated: 
22nd May 2019
Valtan 40mg Film Coated Tablet 

PA0126/211/001 		 Valsartan Unexpected increase in demand

(multiple countries affected)		 Date of shortage:
24th October 2018

Expected return date:
Awaiting update		 Last updated:
18th November 2019
Valtan 80mg Film Coated Tablet

PA0126/211/002 		 Valsartan  Unexpected increase in demand

(multiple countries affected)		 Date of shortage:
26th September 2018
 
Expected return date:
Awaiting update
 Last updated:
18th November 2019
Valtan 160mg Film Coated Tablet

PA0126/211/003		 Valsartan  Unexpected increase in demand 

(multiple countries affected)		 Date of shortage:
24th October 2018

Expected return date:
Awaiting update		 Last updated:
18th November 2019
Vatan 40mg Film Coated Tablet

PA0711/183/001		 Valsartan  Active substance impurity

(multiple countries affected) 		 Date of shortage:
July 2018

Expected return date:
Awaiting update		 Last updated:
18th November 2019
Vatan 80mg Film Coated Tablets

PA0711/183/002 		 Valsartan  Active Substance Impurity

(multiple countries affected) 		 Date of shortage:
July 2018

Expected return date:
Awaiting update		 Last updated:
18th November 2019
Vatan 160mg Film Coated Tablets

PA0711/183/003 		 Valsartan Active Substance impurity

(multiple countries affected) 		  
Date of shortage:
July 2018

Expected return date:
Awaiting update		 Last updated:
18th November 2019
Warticon 0.15% w/w Cream 

PA1113/017/001 		 Podophyllotoxin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Early October 2019

Expected return date:
April 2020 		 Last updated:
12th November 2019

HCP Letter
Zacin 0.025% w/w Cream

PA0827/008/001 		 Capsaicin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid July 2019

Expected return date:
Q1 2020 		 Last updated:
31st October 2019 
Zantac 25mg/ml Solution for Injection/Infusion

PA1077/013/001 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers
 
AHDMP Guidance for Prescribers
Zantac 75mg Film Coated Tablet

PA1186/013/001 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers

AHDMP Guidance for Prescribers
 
Zantac 150mg Effervescent Tablet

PA1077/013/005 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers
 
AHDMP Guidance for Prescribers
Zantac 150mg Film Coated Tablet

PA1077/013/003 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers
 
AHDMP Guidance for Prescribers
Zantac 150mg/10ml Oral Solution

PA1077/013/002		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers
 
AHDMP Guidance for Prescribers
Zantac 300mg Film Coated Tablet

PA1077/013/004 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers
 
AHDMP Guidance for Prescribers
Zimovane 7.5mg Film Coated Tablet

PA2010/057/001 		 Zopiclone  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid October 2019

Expected return date:
Mid February 2020		 Last updated:
13th January 2020
Zoely 2.5mg/1.5mg Film Coated Tablet 

EU/1/11/690/001		 Nomegestrol acetate & Esradiol  Unavailability of API

(multiple countries affected) 		 Date of shortage:
Early August 2019

Expected return date:
End of 2020		 Last updated:
27th January 2020
 
HCP Letter
Zorclone 7.5mg Tablet

PA0840/001/002 		 Zopiclone  Manufacturing delays  Date of shortage:
19th January 2020

Expected return date:
Mid February 2020 		 Last updated:
27th January 2020 

Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL
Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL
Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL




Contact us:

Medicinal Product Shortages Unit
Health Products Regulatory Authority 
Kevin O’Malley House
Earlsfort Terrace,
Dublin 2
Tel: +353 1 676 4971
Fax: +353 1 676 7836
shortages@hpra.ie