My HPRA: Register

Medicinal Product Shortages

The HPRA is responsible for co-ordinating the management of shortages of human medicines on the Irish market. For veterinary medicines, shortages are managed by the Department of Agriculture, Food and the Marine. 

The HPRA works with a variety of stakeholders including manufacturers, wholesale distributors, marketing authorisation holders, healthcare professionals, the Health Service Executive, patients and representative groups to respond to potential shortages and reduce the impact of shortages on patients.

The definition of a shortage is when the supply of a medicinal product is inadequate to meet the needs of the patient. 

The HPRA, in collaboration with stakeholders, has published a framework for a multi-stakeholder approach to handling shortages of human medicinal products. The aim of the framework is to help prevent shortages from occurring and to reduce the impact of shortages on patients by co-ordinating the management of potential or actual shortages as they arise. You can see the shortages case study on Adrenaline auto-injectors (AAIs) as an example of how the framework operates in practice. 


Information on reporting shortages for:

Marketing Authorisation Holders

Please complete the  Notification of medicinal product shortage from marketing authorisation holder form and return to  shortages@hpra.ie and to the HSE Corporate Pharmaceutical Unit.

Wholesale Distributors and Manufacturers

Please complete the  Report of Medicinal Products Shortages from Wholesale Distributors and Manufacturers form and return this form to  shortages@hpra.ie.

Patients and Healthcare Professionals

Please complete the  Report of a Medicinal Product Shortage from Patients and Healthcare Professionals form and return to  shortages@hpra.ie. When completing this form, please include as much information as possible.

Veterinary Medicines

Please contact the Department of Agriculture, Food and the Marine.

 

Current and resolved shortages

The HPRA publishes a list of shortages currently affecting the Irish market that have been notified to us and that may have a medium or high impact on patients. This list can be found below. More information on the impact level can be found in the framework for a multi-stakeholder approach to handling shortages of human medicinal products.

The HPRA maintains a consolidated list of resolved shortages for a period of six months. Details of shortages that have been resolved in the last six months can be found here
 
 


Please use search function below to find relevant product or active ingredient

 
Product name Active ingredient Reason for shortage Date of shortage
 Additional information
Amisulpride 50mg Tablet

PA0577/182/001 		 Amisulpride  Manufacturing delays  Date of shortage:
July 2019

Expected return date:
Awaiting update		 Last updated:
1st April 2021 
Anastrazole 1mg Film Caoted Tablet

PA0749/028/001 		 Anastrazole  Unavailability of API

(multiple countries affected) 		 Date of shortage:
Week commencing 12th October 2020

Expected return date:
Early May 2021 		 Last updated:
22nd January 2021 
Angeliq 1mg/2mg Tablet

PA1040/013/001 		 Estradiol & Drospirenone  Unavailability of API

(multiple countries affected) 		 Date of shortage:
Early January 2021
 
Expected return date:
End of Q1 2022		 Last updated:
11th January 2021 
Aprovel 75mg Film Coated Tablet

EU/1/97/046/017 		 Irbesartan  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Early Janaury 2021

Expected return date:
16th April 2021 		 Last updated:
13th April 2021 
Aripiprazole 5mg Tablet

PA1986/019/001 		 Aripiprazole  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of November 2020

Expected return date:
May 2021 		 Last updated:
8th January 2021 
Aripiprazole 10mg Tablet

PA1986/019/002 		 Aripiprazole  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of November 2020

Expected return date:
May 2021 		 Last updated:
8th January 2021 
Aripiprazole 30mg Tablet

PA1986/019/004 		 Aripiprazole  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid July 2020

Expected return date:
May 2021		 Last updated:
8th January 2021 
Aripiprazole Sandoz 5mg Tablet

EU/1/15/1029/001-014 		 Aripiprazole  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
During 2019

Expected return date:
20th April 2021		 Last updated:
14th April 2021
Aripiprazole Sandoz 10mg Tablet

EU/1/15/1029/015-028 		 Aripiprazole  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
During 2019

Expected return date:
20th April 2021		 Last updated:
14th April 2021
Aripiprazole Sandoz 15mg Tablet

EU/1/15/1029/029-042 		 Aripiprazole  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
During 2019

Expected return date:
20th April 2021		 Last updated:
14th April 2021
Astilin 10mg Tablet

PA23163/001/001 		 Amitriptyline  Unexpected increase in demand  Date of shortage:
End of March 2021

Expected return date:
End of April 2021 		 Last updated:
30th March 2021 
Atecor CT 100mg/25mg Film Coated Tablet

PA0711/020/002 		 Atenolol & Chlortalidone  Manufacturing delays  Date of shortage:
Mid January 2021

Expected return date:
Late April 2021 		 Last updated:
16th March 2021 
Ativan 4mg/ml Solution for Injection

PA0822/090/002 		 Lorazepam  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Early August 2020

Expected return date:
Unknown at present		 Last updated:
11th March 2021 
 
HCP Letter
BCG-Medac Powder and Solvent for Suspension for Intravesical Use

PA0623/004/001 		 Bacillus Calmette Guerin bacteria  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
1st October 2019

Expected return date:
2022		 Last updated:
3rd February 2021
Beromun 1mg Powder for Solution for Infusion

EU/1/99/097/001 		 Tasonermin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
December 2020

Expected return date:
Mid 2021 		 Last updated:
2nd December 2020 
Caverject 20mcg Powder and Solvent for Solution for Injection

PA0822/115/003 		 Alprostadil  Manufacturing delays  Date of shortage:
Week commencing 22nd March 2021

Expected return date:
Awaiting update 		 Last updated:
15th April 2021 
Celebrex 200mg Capsules

PA0822/116/002		 Celecoxib Manufacturing delays 

(multiple countries affected)		 Date of shortage: 
Week commencing 5th April 2021

Expected return date:
Week commencing 3rd May 2021		 Last updated: 
24th March 2021
Centyl K 2.5mg + 573mg Tablet

PA22650/002/002 		 Bendroflumethiazide & Potassium hydrochloride  Unexpected Increase in demand  Date of shortage:
6th August 2020

Expected return date:
Mid May 2021 		 Last updated:
22nd February 2021 

HCP Letter
Champix 0.5mg Tablet

EU/1/06/360/001		 Varenicline tartrate Manufacturing delay Date of shortage:
Week commencing 19th April 2021

Expected return date: 
Week commencing 26th April 2021 		 Last updated:
12th April 2021

HCP letter
Chlorpromazine Elixir BP 25mg/5ml Oral Solution

PA0281/124/001 		 Chlorpromazine hydrochloride  Manufacturing delays  Date of shortage:
End of February 2021

Expected return date:
Awaiting update		 Last updated:
23rd February 2021
 
HCP Letter
 
 
Cimeldine 400mg Film Coated Tablet

PA0126/077/002 		 Cimetidine  Unexpected increase in demand  Date of shortage:
24th March 2021

Expected return date:
19th April 2021 		 Last updated:
26th March 2021 
Co-Amoxiclav 1000mg/200mg Powder for solution for injection/infusion

PA1457/001/002		 Amoxicillin & clavalunic acid Unexpected increase in demand Date of shortage:
5th February 2020

Expected return date:
Unknown at present
 Last updated:
11th February 2021
Desmopressin 100mcg/ml Nasal Drop Solution

PA1009/001/001 		 Desmopressin  Manufacturing delays due to quality issue

(multiple countries affected) 		 Date of shortage:
Mid December 2020

Expected return date:
2022 		 Last updated:
11th December 2020 
Desmospray Desmopressin Nasal Spray

PA1009/005/001 		 Desmopressin  Quality issue

(multiple countries affected) 		 Date of shortage:
22nd July 2020

Expected return date:
2022 		 Last updated:
11th December 2020 
Detrunorm XL 30mg Modified Release Capsule

PA1142/004/002 		 Propiverine  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of February 2021

Expected return date:
Mid May 2021 		 Last updated:
15th March 2021

HCP Letter 
Diazemuls 5mg/ml Emulsion for Injection

PA2315/098/001 		 Diazepam  Manufacturing delays  Date of shortage:
Mid February 2020

Expected return date:
Unknown at present		 Last updated:
30th March 2021 
Emerade 150mcg Solution in a Pre-Filled Pen

PA1696/009/001 		 Adrenaline  Quality issue

(multiple countries affected) 		 Date of shortage:
30th September 2019

Expected return date:
Unknown at present 		 Last updated:
18th December 2020

Alternatives are available 
Emerade 300mcg Solution in a Pre-Filled Pen

PA1696/009/002 		 Adrenaline  Quality issue

(multiple countries affected) 		 Date of shortage:
30th September 2019

Expected return date:
Unknown at present 		 Last updated:
18th December 2020

Alternatives are available 
Emerade 500mcg Solution in a Pre-Filled Pen

PA1696/009/003 		 Adrenaline  Quality issue

(multiple countries affected) 		 Date of shortage:
30th September 2019

Expected return date:
Unknown at present 		 Last updated:
18th December 2020

Alternatives are available 
Epaclob 1mg/ml Oral Solution

PA0549/026/001 		 Clobazam  Manufacturing delays  Date of shortage:
9th April 2021

Expected return date:
End of April 2021 		 Last updated:
13th April 2021 
Epaclob 2mg/ml Oral Solution

PA0549/026/002 		 Clobazam  Manufacturing delays  Date of shortage:
9th April 2021

Expected return date:
End of April 2021 		 Last updated:
13th April 2021
Epanutin Infatabs 50mg Chewable Tablets

PA0822/011/005		 Phenytoin Manufacturing delays

(multiple countries affected)		 Date of shortage:
Early November 2019

Expected return date:
Unknown at present		 Last updated:
4th June 2020
 
HCP Letter
Erythrocin 500mg Tablet

PA1142/008/003 		 Erythrocin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of February 2020

Expected return date:
Awaiting update		 Last updated:
30th March 2021 
Esomeprazole Ticerin 40mg Powder for Solution for Injection of Infusion

PA1852/002/001 		 Esomeprazole  Unavailability of API  Date of shortage:
Early October 2020

Expected return date:
Unknown at present 		 Last updated:
30th March 2021 
Fludarabine phosphate 25mg/ml Solution for Injection or Infusion

PA2315/035/001 		 Fludarabine phosphate  Unavailability of API

(multiple countries affected) 		 Date of shortage:
Early November 2020

Expected return date:
September 2021 		 Last updated:
25th February 2021
Flutiform 50mcg/5ml Per Metred Dose Pressurised Inhalation Suspension

PA1688/013/001 		 Fluticasone propionate & Formoterol fumarate Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of March 2021

Expected return date:
23rd April 2021		 Last updated:
16th April 2021 
Foznol 1000mg Chewable Tablet

PA1575/002/004 		 Lanthanum  Manufacturing delay

(multiple countries affected) 		 Date of shortage:
24th March 2021

Expected return date:
21st April 2021 		 Last updated:
15th April 2021 

HCP Letter
Furosemide 50mg/5ml Solution for Injection
 Furosemide Quality issue  Date of shortage: 
Late March 2021

Expected return date: 
Mid June 2021		 Last updated:
8th April 2021 
Gaviscon Advance Oral Suspension

PA0979/015/001 		 Sodium alginate & Potassium hydrogen carbonate  Manufacturing delays  Date of shortage:
June 2020

Expected return date:
Mid April 2021 		 Last updated:
1st March 2021 
Gentamicin 40 mg/ml Injection, vials

PA0822/203/001
 Gentamicin
 Manufacturing delays

(multiple countries affected)		 Date of shortage:
9th December 2019

Expected return date:
Unknown at present
 Last updated:
11th February 2021
Gerozac 20mg Capsule

PA0577/200/001 		 Fluoxetine  Manufacturing delays  Date of shortage:
Early December 2019

Expected return date:
Unknown at present		 Last updated:
11th February 2021 
Hydromorphone 20mg/ml Solution for Injection/Infusion

PA0549/030/001 		 Hydromorphone  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid June 2020

Expected return date:
Awaiting update 		 Last updated:
13th April 2021
Hydromorphone 50mg/ml Solution for Injection/Infusion

PA0549/030/002 		 Hydromorphone  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid August 2020

Expected return date:
Awaiting update 		 Last updated:
13th April 2021 
Imdur 60mg Prolonged Release Tablet

PA2129/001/001 		 Isosorbide mononitrate  Manufacturing delays  Date of shortage:
End of November 2020

Expected return date:
Early May 2021		 Last updated:
7th April 2021 
Lispril Hydrochlorothiazide 10mg/12.5mg Tablet

PA0711/051/001 		 Lisinopril & Hydrochlorothiazide  Manufacturing delays  Date of shortage:
22nd July 2020

Expected return date:
May 2021		 Last updated:
16th March 2021
Lispril Hydrochlorothiazide 20mg/12.5mg Tablet

PA0711/051/002 		 Lisinopril & Hydrochlorothiazide  Manufacturing delays  Date of shortage:
8th September 2020

Expected return date:
End May 2021		 Last updated:
14th April 2021
Losartan 50mg Tablet

PA0749/090/003 		 Losartan  API on allocation

(multiple markets affected) 		 Date of shortage:
23rd November 2020

Expected return date:
Early May 2021		 Last updated:
14th April 2021
Losartan 50mg Tablet 

PA2315/059/002 		 Losartan  Manufacturing delays  Date of shortage:
25th September 2019

Expected return date:
Unknown at present 		 Last updated:
13th April 2021
Losartan 100mg Tablet

PA2315/059/003 		 Losartan  Manufacturing delays  Date of shortage:
October 2019

Expected return date:
Unknown at present		 Last updated:
13th April 2021
Low Centyl K 1.25mg/573mg Modified Release Tablet

PA22650/002/001 		 Bendroflumethiazide & Potassium chloride  Unavailability of API

(multiple countries affected) 		 Date of shortage:
February 2021

Expected return date:
July 2021 		 Last updated:
4th Janaury 2021

HCP Letter
Manerix 150mg Film -coated Tablets

PA2010/023/001		 Moclobemide Manufacturing delays Date of shortage:
10th March 2021

Expected return date: 
Awaiting update
 
 Last updated: 
15th April 2021
Mefac 250mg Capsule

PA0074/015/001 		 Mefenamic acid  Manufacturing delays  Date of shortage:
End of June 2019

Expected return date:
Unknown at present		 Last updated:
26th March 2021
 
Metalyse 10,000Units Powder and Solvent for Solution for Injection

EU/1/00169/006 		 Tenecteplase  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Early March 2021

Expected return date:
October 2021 		 Last updated:
5th March 2021 
Metaraminol 10mg/ml Solution for Injection or Infusion 

PA22893/001/001		 Metaraminol  Awaiting update Date of shortage: 
Early April 2021 

Expected return date:
Awaiting update 		 Last updated: 
6th April 2021
Methotrexate 2.5mg Tablet

PA2315/062/002 		 Methotrexate  Manufacturing delays  Date of shortage:
Early January 2021

Expected return date:
June 2021 		 Last updated:
27th January 2021 
Methylthioninium chloride 5mg/ml Solution for Injection

EU/1/11/682/001 		 Methylthioninium chloride  Manufacturing delays  Date of shortage:
26th March 2021

Expected return date:
Unknown at present 		 Last updated:
23rd March 2021 
Neomercazole 5mg Tablets

PA1142/002/001
 Carbimazole Manufacturing delays Date of shortage: 
7th April 2021

Expected return date: 
13th April 2021		 Last updated:
7th April 2021
Nexium control 20mg Capsules

EU/1/13/860/003
 Esomeprazole Manufacturing delays Date of shortage: 
End November 2020

Expected return date:
Mid May 2021		 Last updated: 
25th March 2021
Nexium control 20mg Tablet

EU/1/13/860/001-002 		 Esomeprazole  Manufacturing delays  Date of shortage:
Mid April 2021

Expected return date:
Early May 2021 		 Last updated:
7th April 2021 
Nimbex 2mg/ml solution for injection/infusion

PA1691/030/001		  Cisatracurium Unexpected increase in demand

(Multiple countries affected)		 Date of shortage:
Early March 2021

Expected return date:
Late June 2021		 Last updated: 24th February 2021
Nytol One a night 50mg Tablet

PA1186/016/001 		 Diphenhydramine hydrochloride  Manufacturing delays  Date of shortage:
End of March 2021

Expected return date:
End of April 2021
 		 Last updated:
7th April 2021 
Odrik 2mg Capsule

PA2010/005/003 		 Trandoapril  Manufacturing delays  Date of shortage:
Early April 2021

Expected return date:
May 2021 		 Last updated:
30th March 2021 
Palexia 4mg/ml Oral Solution

PA2242/012/010 		 Tapentadol hydrochloride  Quality issue

(multiple countries affected) 		 Date of shortage:
15th February 2021

Expected return date:
Unknown at present 		 Last updated: 
22nd February 2021
Palexia 20mg/ml Oral Solution

PA2242/012/011 		 Tapentadol hydrochloride  Quality issue

(multiple countries affected) 		 Date of shortage:
15th February 2021

Expected return date:
Unknown at present 		 Last updated:
22nd February 2021 
Perinal Cutaneous Spray hydrocortisone 0.2% w/w / lidocaine hydrochloride monohydrate 1.0% w/w

PA0278/017/001
 Hydrocortisone & Lidocaine Hydrochloride  Manufacturing delay  Date of shortage:
February 2021

Expected return date:
January 2022		 Last updated: 
8th April 2021
Pneumovax 23 Solution for Injection in Pre-filled Syringe

PA1286/055/002 		 Pneumococcal Polysaccharide Vacine  Unexpected increase in demand

(multiple countries affected)		 Date of shortage:
16th March 2020

Expected return date:
September 2021		 Last updated:
24th September 2020 
Pregabalin Accord 200mg Hard Capsule

EU/1/15/1027/060 		 Pregabalin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of December 2020

Expected return date:
Late May 2021		 Last updated:
6th April 2021
Propafenone hydrochloride 300mg Tablet

PA2315/116/002 		 Propafenone hydrochloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of July 2020

Expected return date:
June 2021 		 Last updated:
13th April 2021 
 
HCP Letter
Questran 4g Powder for Oral Suspension

PA2239/005/001 		 Colestyramine  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid June 2019

Expected return date:
January 2022		 Last updated:
30th March 2021 
Rifadin 100mg/5ml Oral Suspension

PA0540/066/004 		 Rifampicin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of February 2021

Expected return date:
Unknown at present 		 Last updated:
16th March 2021 
Rifadin 150mg Capsule

PA0540/066/001 		 Rifampicin  Unexpected increase in demand & Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of September 2020

Expected return date:
20th April 2021		 Last updated:
7th April 2021 
Sprilon 12.5% Zinc Oxide & 1.04% Dimethicone Cutaneous Spray Suspension

PA22906/001/001 		 Zinc oxide & Dimethicone  Manufacturing delays  Date of shortage:
October 2019

Expected return date:
Unknown at present		 Last updated:
24th September 2020 
Technescan DMSA 1.2mg kit for radiopharmaceutical preparation

PA0690/011/001
  Succimer Regulatory issue

(multiple countries affected)		 Date of shortage: 
21st March 2021

Expected return date: 
September 2021		 Last updated:
26th March 2021
Tracrium 10mg/ml Solution for Injection or Infusion

25ml vial only

PA1691/029/002 		 Atracurium  Unexpected increase in demand

(multiple countries affected) 		 Date of shortage:
End of January 2021

Expected return date:
22nd April 2021		 Last updated:
9th March 2021
Trandate 100mg Film Coated Tablet

PA1638/006/002 		 Labetalol hydrochloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
July 2019

Expected return date:
May 2021		 Last updated:
6th April 2021
Trandate 200mg Film Coated Tablet

PA1638/006/003 		 Labetalol hydrochloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
July 2019

Expected return date:
May 2021		 Last updated:
6th April 2021
Ranitic 75mg Film Coated Tablet

PA0711/024/004 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers
             
AHDMP Guidance for Prescribers
Ranitic 150mg Film Coated Tablet

PA0711/024/001 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers

AHDMP Guidance for Prescribers
 
Ranitic 300mg Film Coated Tablet

PA0711/024/002 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers
 
AHDMP Guidance for Prescribers
Ranitidine 150mg/10ml Oral Solution

PA22741/009/001 		 Ranitidine  Active substance impurity

(multiple countries affected) 		 Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 		 Last updated:
22nd October 2019

MMP Guidance for Prescribers
 
AHDMP Guidance for Prescribers
Tradol SR 100mg Prolonged release Tablet

PA0711/029/006
  Tramadol  To be confirmed  Date of shortage: 15th March 2021 

Expected return date:
End April 2021		  Last updated:
14th April 2021
Vfend 200mg Powder for Solution for Infusion

EU/1/02/212/025		  Voriconazole Unexpected increase in demand 

(multiple countries affected)		 Date of shortage:
18th March 

Expected return date: 
May 2021		  Last updated: 19th March 2021
Zerbaxa 1g/0.5g Powder for Concentrate for Solution for Infusion

EU/1/15/1032/001 		 Ceftolozone & Tazobactam  Quality issue

(multiple countries affected) 		 Date of shortage:
18th December 2020

Expected return date:
Unknown at present 		 Last updated:
4th March 2021 
Zofran 4mg/2ml Solution for Injection or Infusion

PA0896/036/001		 Ondansetron  Unexpected increase in demand  Date of shortage:
8th February 2021

Expected return date:
July 2021 		 Last updated:
5th February 2021 
Zofran 8mg/4ml Solution for Injection or Infusion 

PA0896/036/002
 Ondansetron  Unexpected increase in demand Date of shortage: 15th April 2021

Expected return date: 
July 2021

 Last updated: 
6th April 2021

Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL
Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL
Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL




Contact us:

Medicinal Product Shortages Unit
Health Products Regulatory Authority 
Kevin O’Malley House
Earlsfort Terrace,
Dublin 2
Tel: +353 1 676 4971
Fax: +353 1 676 7836
shortages@hpra.ie