Medicinal Product Shortages

The HPRA is responsible for co-ordinating the management of shortages of medicines on the Irish market. The HPRA works with a variety of stakeholders including manufacturers, wholesale distributors, marketing authorisation holders, healthcare professionals, the Health Service Executive, patients and representative groups to respond to potential shortages and reduce the impact of shortages on patients.

The definition of a shortage is when the supply of a medicinal product is inadequate to meet the needs of the patient. 

The HPRA, in collaboration with stakeholders, has published a framework for a multi-stakeholder approach to handling shortages of human medicinal products. The aim of the framework is to help prevent shortages from occurring and to reduce the impact of shortages on patients by co-ordinating the management of potential or actual shortages as they arise.


Information on reporting shortages for:

Wholesale Distributors and Manufacturers

Patients and Healthcare Professionals

Please complete the  Report of a Medicinal Product Shortage from Patients and Healthcare Professionals form and return to  shortages@hpra.ie. When completing this form, please include as much information as possible.


Current and resolved shortages

The HPRA publishes a list of shortages currently affecting the Irish market that have been notified to us and that may have a medium or high impact on patients. This list can be found below. More information on the impact level can be found in the framework for a multi-stakeholder approach to handling shortages of human medicinal products.

The HPRA maintains a consolidated list of resolved shortages for a period of six months. Details of shortages that have been resolved in the last six months can be found here.


Please use search function below to find relevant product or active ingredient

Product name Active ingredient Reason for shortage Date of shortage
Additional information
Accupro 5mg Film Coated Tablet 

PA0822/007/001
Quinapril hydrochloride  Manufacturing delays

(multiple countries affected) 
Date of shortage:
5th April 2019

Expected return date:
End of September 2019 
Last updated:
1st July 2019 

HCP Letter
 
Accupro 10mg Film Coated Tablet

PA0822/007/002 
Quinapril hydrochloride  Unexpected increase in demand  Date of shortage:
30th May 2019

Expected return date:
End of September 2019
Last updated:
1st July 2019

HCP Letter
Accupro 20mg Film Coated Tablet

PA0822/007/003 
Quinapril hydrochloride  Manufacturing delays

(multiple countries affected) 
Date of shortage:
Mid March 2019

Expected return date:
End of September 2019
Last updated:
1st July 2019

HCP Letter
 
Accupro 40mg Film Coated Tablet 

PA0822/007/004 
Quinapril hydrochloride  Manufacturing delays 

(multiple countries affected)
Date of shortage:
End of November 2018

Expected return date:
End of September 2019 
Last updated:
1st July 2019

HCP Letter
 
Accuretic 20/12.5mg Film Coated Tablet

PA0822/008/002 
Quinapril hydrochloride & Hydrochlorothiazide  Manufacturing delays 

(multiple countries affected)
Date of shortage:
Early January 2019

Expected return date:

End of September 2019
Last updated:
1st July 2019

HCP Letter
 
           
Aciclovir 25mg/ml Concentrate for Solution for Infusion

PA2299/041/001 
Aciclovir sodium  Manufacturing issue  Date of shortage:
December 2018

Expected return date:
September 2019 
Last updated:
5th July 2019 
Actonel 5mg Film Coated Tablet

PA2315/140/001 
Risedronate  Manufacturing delay 

(multiple countries affected)
Date of shortage:
June 2019

Expected return date:
Mid October 2019 
Last updated:
26th June 2019 
Adalat LA 20mg Prolonged Release Tablet

PA1410/025/005
Nifedipine  Manufacturing delays

(multiple countries affected)
Date of shortage:
November 2017
 
Expected return date:
End of 2019
Last updated:
24th January 2019
 
Adalat LA 30mg Prolonged Release Tablet

PA1410/025/006
Nifedipine  Manufacturing delays

(multiple countries affected)
Date of shortage:
24th June 2018

Expected return date:
End of 2019
Last updated:
24th January 2019 
 
Adalat LA 60mg Prolonged Release Tablet

PA1410/025/007 
Nifedipine Manufacturing delays

(multiple countries affected)
Date of shortage:
September 2018

Expected return date:
End of 2019
Last updated:
24th January 2019
 
Alendronate/Colecalciferol Teva 70mg/5600IU Tablet

PA0749/196/002 
Alendronate & Colecalciferol  Manufacturing delays  Date of shortage:
January 2019

Expected return date:
September 2019 
Last updated:
23rd May 2019 
Alprazolam 0.25mg Tablet

PA0711/140/001 
Alprazolam  Unexpected increase in demand  Date of shortage:
Early June 2019

Expected return date:
Awaiting update 
Last updated:
11th July 2019 
Arcoxia 90mg Tablet

PA1997/001/003 
Etoricoxib  Manufacturing delays

(multiple countries affected) 
Date of shortage:
Early July 2019

Expected return date:
Unknown at present 
Last updated:
28th June 2019 
Atorvastatin 20mg Film Coated Tablet

PA1380/017/002 
Atorvastatin  Manufacturing delays  Date of shortage:
February 2019

Expected return date:
Awaiting update
Last updated:
12th July 2019 
Axsain 0.075% w/w Cream

PA0827/004/001 
Capsaicin  Manufacturing delays 

(multiple countries affected)
Date of shortage:
Mid June 2019

Expected return date:
October 2019 
Last updated:
13th June 2019 
Bisoprolol 2.5mg Tablet

PA22654/002/001 
Bisoprolol fumarate  Manufacturing delays  Date of shortage:
April 2019

Expected return date:
Awaiting update
Last updated:
12th July 2019 
Bisoprolol 5mg Tablet

PA2315/097/001 
Bisoprolol fumarate  Manufacturing delays  Date of shortage:
Early July 2019

Expected return date:
Mid August 2019 
Last updated:
10th July 2019 
Bupivacaine 2.5mg/ml Solution for Injection

PA2315/058/001
 
Bupivacaine  Manufacturing delays  Date of shortage:
June 2019

Expected return date:
October 2019 
Last updated:
17th July 2019 
Bupivacaine 5mg/ml Solution for Injection

PA2315/058/002
Bupivacaine Manufacturing delays Date of shortage:
June 2019

Expected return date:
October 2019
Last updated:
17th July 2019
Burinex 1mg Tablet

PA22650/001/001 
Bumetanide  Manufacturing delays

(multiple countries affected) 
Date of shortage:
13th June 2019

Expected return date:
Awaiting update 
Last updated:
11th July 2019 
Canesten HC Cream 1.0% w/w

PA1410/040/001 
Clotrimazole & Hydrocortisone  Manufacturing delays  Date of shortage:
February 2019

Expected return date:
Awaiting update 
Last updated:
12th July 2019 
Caverject 10mcg Powder for Solution for Injections

PA0822/115/002 
Alprostadil  Manufacturing delays

(multiple countries affected) 
Date of shortage:
January 2019

Expected return date:
Mid August 2019
Last updated:
17th July 2019
Caverject 20mcg Powder for Solution for Injection

PA0822/115/003
Alprostadil Manufacturing delays Date of shortage:
Mid July 2019

Expected return date:
Mid August 2019
Last updated:
17th July 2019
Co-Amoxiclav 500mg/100mg Powder for Solution for Injection and Infusion Amoxicillin & clavalunic acid Unexpected increase in demand Date of shortage:
24th May 2019

Expected return date:
Unknown at present
Last updated:
28th May 2019 
Co-Vatan 80mg/12.5mg Film Coated Tablet

PA0711/182/001 
Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)
Date of shortage:
July 2018

Expected date of return:
Unknown at present
Last updated: 
13th May 2019
Co-Vatan 160mg/12.5mg Film Coated Tablet

PA0711/182/002  
Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)
Date of shortage:
July 2018

Expected return date:
Unknown at present 
Last updated:
13th May 2019
Co-Vatan 160mg/25mg Film Coated Tablet 

PA0711/182/003
Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)
Date of shortage:
July 2018

Expected return date: 
Unknown at present
Last updated:
13th May 2019
Cozatan 50mg Film Coated Tablet

PA0126/167/001 
Losartan potassium  Active substance impurity  Date of shortage:
Mid June 2019

Expected return date:
Q3 2019 
Last updated:
13th June 2019 
Cozatan 100mg Film Coated Tablet

PA0126/167/002 
Losartan potassium  Active substance impurity  Date of shortage:
May 2019

Expected return date:
August 2019 
Last updated:
8th May 2019 
Cozatan Comp 50mg/12.5mg Film Coated Tablet

PA0126/184/001 
Losartan potassium & Hydrochlorothiazide  Active substance impurity  Date of shortage:
Early July 2019

Expected return date:
Q4 2019 
Last updated:
1st July 2019
Cozatan Comp 100mg/25mg Film Coated Tablet

PA0126/184/002 
Losartan potassium & Hydrochlorothiazide  Active substance impurity  Date of shortage:
May 2019

Expected return date:
August 2019 
Last updated:
8th May 2019 
Cyklokapron 500mg Tablets

PA1332/003/001 
Tranexamic acid Manufacturing delays

(multiple countries affected) 
Date of shortage:
1st December 2018

Expected return date:
Awaiting update
Last updated:
12th July 2019
Dalacin T Topical Lotion 10mg/ml Cutaneous Emulsion

PA0822/121/001 
Clindamycin phosphate  Manufacturing delays

Date of shortage:
Mid June 2019

Expected return date:
Awaiting update
Last updated:
18th July 2019 
Detrusitol 1mg Film Coated Tablet

PA0822/213/001 
Tolterodine  Manufacturing delays

(multiple countries affected) 
Date of shortage:
End of May 2019

Expected return date:
End of July 2019 
Last updated:
24th May 2019 
Detrusitol 2mg Film Coated Tablet

PA0822/213/002 
Tolterodine  Manufacturing delays

(multiple countries affected) 
Date of shortage:
End of May 2019

Expected return date:
End of July 2019 
Last updated:
24th May 2019 
Diovan 160mg Film Coated Tablet

PA0896/009/002 
Valsartan  Unexpected increase in demand  Date of shortage:
Mid July 2019

Expected return date:
8th August 2019 
Last updated:
17th July 2019 
Doxatan 4mg Tablet

PA0126/202/003 
Doxazosin  Manufacturing delays  Date of shortage:
July 2019

Expected return date:
Mid August 2019 
Last updated:
4th July 2019 
Duac Once Daily 10mg/g + 50mg/g Gel

PA1077/120/001 
Clindamycin phosphate & Benzoyl peroxide hydrous  Manufacturing delays

(multiple countries affected) 
Date of shortage:
26th June 2019

Expected return date:
Mid August 2019 
Last updated:
27th June 2019 
Epanutin Ready Mixed Parenteral 250mg/5ml Solution for Injection or Infusion

PA0822/011/006 
Phenytoin  Manufacturing delays

(multiple countries affected)
Date of shortage:
Mid July 2019

Expected return date:
January 2020 
Last updated:
16th July 2019

HCP Letter
Erwinase 10000% v/v Powder for Solution for Injection

PA1020/002/001  
Cristanspase Manufacturing delays

(multiple countries affected)
Date of shortage:
5th October 2018

Expected return date:
End of July 2019
Last updated:
17th July 2019
             

                         

 
Erythroped PI SF 125mg/5ml Granules for Oral Suspension

PA1142/006/002 
Erythromycin  Manufacturing delays 

(multiple countries affected)
Date of shortage:
End of June 2019

Expected return date:
Unknown at present 
Last updated:
9th July 2019 
Esbriet 267mg Film Coated Tablet

EU/1/11/667/016
Pirfenidone  Unexpected increase in demand  Date of shortage:
End of June 2019

Expected return date:
22nd July 2019 
Last updated:
4th July 2019

HCP Letter 
Etoposide 20mg/ml Concentrate for Solution for Infusion

PA2315/207/001 
Etoposide  Manufacturing delays  Date of shortage:
Early July 2019

Expected return date:
December 2019 
Last updated:
17th July 2019 
Faverin 50mg Film Coated Tablet

PA2010/031/001 
Fluvoxamine  Manufacturing delay  Date of shortage:
30th May 2019

Expected return date:
Early September 2019 
Last updated:
11th July 2019 
Faverin 100mg Film Coated Tablet

PA2010/031/002 
Fluvoxamine  Manufacturing delays  Date of shortage:
End of June 2019

Expected return date:
Early August 2019 
Last updated:
11th July 2019 
Fentanyl 500mcg in 10ml Solution for Injection

PA0073/122/002 
Fentanyl citrate  Unexpected increase in demand  Date of shortage:
27th March 2019

Expected return date:
22nd July 2019 
Last updated:
17th June 2019 
Floxapen 2000mg Powder for Solution for Injection or Infusion

PA1380/011/008 
Flucloxacillin  Manufacturing delays  Date of shortage:
End of June 2019

Expected return date:
Awaiting update
Last updated:
18th July 2019 
Folinic Acid 10mg/ml Solution for Injection
(50mg/5ml presentation only)

PA0822/198/003 
Folinic acid  Manufacturing delays  Date of shortage:
17th May 2019

Expected return date:
End of January 2020 
Last updated:
18th July 2019 
Folinic Acid 10mg/ml Solution for Injection (100mg/10ml presentation only)

PA0822/198/003 
Folinic acid  Manufacturing delays  Date of shortage:
5th July 2019

Expected return date:
End of January 2020 
Last updated:
18th July 2019 
Fybogel Mebeverine Granules for Oral Suspension

PA0979/010/001 
Ispaghula husk & Mebeverine hydrochloride  API issue  Date of shortage:
May 2019

Expected return date:
Unknown at present
Last updated:
19th July 2019 
Gabitril 5mg Film coated Tablet

PA0749/199/001 
Tiagabine  Manufacturing delays  Date of shortage:
Mid July 2019

Expected return date:
October 2019 
Last updated:
19th July 2019 
Gabitril 10mg Film coated Tablet

PA0749/199/002 
Tiagabine  Manufacturing delays  Date of shortage:
Mid July 2019

Expected return date:
October 2019 
Last updated:
19th July 2019 
Gabitril 15mg Film Coated Tablet

PA0749/199/003 
Tiagabine  Manufacturing delays  Date of shortage:
Mid July 2019

Expected return date:
October 2019 
Last updated:
19th July 2019 
Gerax 0.25mg Tablet

PA0577/010/001 
Alprazolam  Unexpected increase in demand  Date of shortage:
18th June 2019

Expected return date:
Awaiting update
Last updated:
11th July 2019 
Havrix Monodose Vaccine (Adult) Suspension for Injection in Prefilled Syringe

PA1077/026/002 
Hepatitis A Virus & Aluminium hydroxide Manufacturing delays

(multiple countries affected) 
Date of shortage:
End of May 2019

Expected return date:
October 2019 
Last updated:
4th June 2019

HCP Letter 
Hyaluronidase 1500IU Powder for Solution for Injection or Infusion

PA1339/011/001 
Hyaluronidase  Manufacturing delays  Date of shortage:
23rd April 2019

Expected return date:
Unknown at present
Last updated:
12th July 2019 
Hycamtin 1mg Powder for Concentrate for Solution for Infusion

EU/1/96/027/001 
Topotecan hydrochloride  Unexpected increase in demand  Date of shortage:
4th April 2019

Expected return date:
August 2019
Last updated:
24th April 2019 
Hypovase 1mg Tablet

PA0019/023/001 
Prazosin hydrochloride  Manufacturing delay  Date of shortage:
Mid June 2019

Expected return date:
Mid August 2019 
Last updated:
13th June 2019 
Imdur 60mg Prolonged Release Tablet

PA2129/001/001 
Isosorbide mononitrate  Manufacturing delay  Date of shortage:
End of June 2019

Expected return date:
Early August 2019 
Last updated:
10th July 2019 
Innohep 8,000IU in 0.4ml Solution for Injection

PA0046/060/012
Tinzaparin sodium  Manufacturing delays

(multiple countries affected) 
Date of shortage:
Early July 2019

Expected return date:
Awaiting update
Last updated:
17th July 2019

HCP Letter
Innohep 12,000IU in 0.6ml Solution for Injection

PA0046/060/013 
Tinzaparin sodium  Manufacturing delays

(multiple countries affected) 
Date of shortage:
Early July 2019

Expected return date:
Awaiting update
Last updated:
17th July 2019

HCP Letter
Instanyl 50mcg Single Dose Nasal Spray

EU/1/09/531/010-013 
Fentanyl citrate Manufacturing delays 

(multiple countries affected) 
Date of shortage:
17th August 2018

Expected return date:
Unknown at present
Last updated: 
8th April 2019
Instanyl 100mcg Single Dose Nasal Spray

EU/1/09/531/014-017 
Fentanyl citrate Manufacturing delays

(multiple countries affected) 
Date of shortage:
January 2019

Expected return date:
Unknown at present
Last updated:
8th April 2019 
Irbesartan 75mg Film Coated Tablet

PA0126/205/001 
Irbesartan  Increase in demand  Date of shortage:
Mid May 2019

Expected return date:
September 2019 
Last updated:
15th May 2019 
Irbesartan 150mg Film Coated Tablet

PA0126/205/002 
Irbesartan  Increase in demand  Date of shortage:
Mid May 2019

Expected return date:
September 2019 
Last updated:
15th May 2019  
Irprestan 150mg Film Coated Tablet

PA1380/021/002 
Irprestan  Active substance impurity

(multiple countries affected) 
Date of shortage:
February 2019

Expected return date:
Awaiting update
Last updated:
12th July 2019 
Irprezide 150/12.5mg Film Coated Tablet


PA1380/080/001
Irbesartan & Hydrochlorothiazide  Active substance impurity

           
Date of shortage:
21st December 2018

Expected return date:
Unknown at present
Last updated:
3rd April 2019
Irprezide 300/12.5mg Film Coated Tablet


PA1380/080/002
Irbesartan & Hydrochlorothiazide Active substance impurity

Date of shortage:
21st December 2018

Expected return date:
Unknown at present
Last updated:
3rd April 2019
Isotode 5mg Tablet

PA1380/014/001 
Amlodipine besilate  Manufacturing delay  Date of shortage:
April 2019

Expected return date:
Awaiting update 
Last updated:
2nd July 2019 
Letrozole Accord 2.5mg Film Coated Tablet  Letrozole Manufacturing delay Date of shortage:
May 2019

Expected return date:
1st August 2019 
Last updated:
28th May 2019 
Lipantil Supra 145mg Tablet

PA2010/015/003 
Fenofibrate  Manufacturing delays 

(multiple countries affected)
Date of shortage:
Mid June 2019

Expected return date:
End of July 2019 
Last updated:
13th June 2019 
Livial 2.5mg Tablet

PA1286/059/001 
Tibolone  Manufacturing delays  Date of shortage:
Early July 2019

Expected return date:
End of August 2019 
Last updated:
28th June 2019

HCP Letter
Mefac 250mg Capsule

PA0074/015/001 
Mefenamic acid  Manufacturing delay  Date of shortage:
End of June 2019

Expected return date:
June 2020 
Last updated:
27th June 2019

Memantine 10mg Film Coated Tablet

PA0126/255/002 
Memantine hydrochloride  Manufacturing delays  Date of shortage:
End of March 2019

Expected return date:
Awaiting update
Last updated:
18th July 2019 
Methotrexate 5mg/2ml Injection

PA0822/206/001 
Methotrexate sodium  Manufacturing delays  Date of shortage:
Early July 2019

Expected return date:
Early September 2019 
Last updated:
27th June 2019

HCP Letter 
Morphine Sulphate Injection BP 30mg/ml Solution for Injection

PA0361/004/005 
Morphine Sulphate  Manufacturing delays  Date of shortage:
October 2018

Expected return date:
Unknown at present 
Last updated:
12th July 2019 
MST Continus Suspension 60mg Prolonged Release Granules

PA1688/004/010 
Morphine Sulphate  Manufacturing delays  Date of shortage:
Mid June 2019

Expected return date:
End of July 2019 
Last updated:
14th June 2019 
Muse 250mcg Urethral Stick

PA2010/028/002
Alprostadil  Manufacturing delays

(multiple countries affected) 
Date of shortage:
Mid March 2019
 
Expected return date:
Q3 2019 
Last updated:
11th April 2019 
Muse 500mcg Urethral Stick

PA2010/028/003 
Alprostadil  Manufacturing delays

(multiple countries affected) 
Date of shortage:
Mid March 2019
 
Expected return date:
Q3 2019 
Last updated:
11th April 2019 
Muse 1000mcg Urethral Stick

PA2010/028/004 
Alprostadil  Manufacturing delays

(multiple countries affected) 
Date of shortage:
Start of March 2019
 
Expected return date:
Q3 2019 
Last updated:
11th April 2019 
Mysoline 250mg Tablet

PA1777/001/001 
Primidone  Manufacturing delays  Date of shortage:
Mid July 2019

Expected return date:
Unknown at present 
Last updated:
17th July 2019 
Naropin 2mg/ml Solution for Injection

PA1691/026/001
Ropivacaine hydrochloride Manufacturing delays

(multiple countries affected)
Date of shortage:
October 2017
 
Expected return date:
End of August 2019
 
Last updated:
16th July 2019
 
HCP Letter
Neoclarityn 0.5mg/ml Oral Solution

(100ml presentation only)

EU/1/00/161/062 
Desloratadine  Manufacturing delays

(multiple countries affected) 
Date of shortage:
14th June 2019

Expected return date:
Awaiting update
Last updated:
12th July 2019 
Neoclarityn 0.5mg/ml Oral Solution

(150ml presentation only)

EU/1/00/161/067 
Desloratadine  Unexpected increase in demand  Date of shortage:
28th June 2019

Expected return date:
Awaiting update 
Last updated:
12th July 2019
Noctamid 1mg Tablet

PA1410/009/001 
Lormetazepam  Manufacturing delays

(multiple countries affected) 
Date of shortage:
Mid June 2019

Expected return date:
November 2019
Last updated:
18th July 2019

Product is on allocation 
Notiabolfen XL 150mg Prolonged Release Tablet

PA2315/066/005 
Quetipaine fumarate  Manufacturing delays  Date of shortage:
End of May 2019

Expected return date:
Early August 2019 
Last updated:
2nd July 2019 
Oxynorm Dispersa 5mg Orodispersible Tablet

PA1688/006/007 
Oxycodone hydrochloride  Manufacturing delays  Date of shortage:
23rd May 2019

Expected return date:
Awaiting update
Last updated:
18th July 2019 
Piperacillin with Tazobactam 2.25g Powder for Solution for Injection

PA1339/001/001 
Piperacillin sodium & Tazobactam sodium Manufacturing delays

(multiple countries affected)
Date of shortage:
January 2018

Expected return date:
Unknown at present
Last updated:
12th July 2019
Piperacillin with Tazobactam 4.5g Powder for Solution for Injection

PA1339/001/002 
Piperacillin sodium & Tazobactam sodium Manufacturing delays

(multiple countries affected)
Date of shortage:
January 2018

Expected return date:
Unknown at present
Last updated:
12th July 2019
Prosentio 100mg Tablet

PA0126/190/001 
Modafinil  Manufacturing delays  Date of shortage:
Mid May 2019

Expected return date:
October 2019 
Last updated:
15th May 2019 
Protopic 0.03% Ointment

EU/1/02/201/001-002 
Tacrolimus monohydrate  Manufacturing delays 

(multiple markets affected) 
Date of shortage:
10th June 2019

Expected return date:
26th July 2019 
Last updated:
18th July 2019 
Questran 4g Powder for Oral Suspension

PA2239/005/001 
Colestyramine  Manufacturing delays

(multiple countries affected) 
Date of shortage:
Mid June 2019

Expected return date:
November 2019 
Last updated:
13th June 2019 
Quinine Sulphate 300mg Coated Tablet

PA1986/052/001 
Quinine Sulphate  Manufacturing delays  Date of shortage:
9th April 2019

Expected return date:
August 2019 
Last updated:
9th April 2019

HCP Letter
Relpax 40mg Film Coated Tablet

PA0822/006/002
 
Eletriptan  Manufacturing delays

(multiple countries affected) 
Date of shortage:
Mid June 2019

Expected return date:
End of July 2019 
Last updated:
12th June 2019 
Scheriproct 1mg Suppositories

PA1410/071/002

 
Prednisolone & Cinchocaine  Manufacturing delays

(multiple countries affected) 
Date of shortage:
Mid June 2019

Expected return date:
Unknown at present
Last updated:
2nd July 2019 
Septrin 80mg/400mg Tablet

PA1691/010/001 
Sulfamethoxazole & Trimethoprim  Manufacturing delays 

(multiple countries affected)
Date of shortage:
27th April 2019

Expected return date:
5th October 2019 
Last updated:
22nd May 2019 
Septrin Forte 160mg/800mg Tablet

PA1691/010/002 
Sulfamethoxazole & Trimethoprim  Manufacturing delays 

(multiple countries affected)
Date of shortage:
21st June 2019

Expected return date:
7th September 2019 
Last updated:
17th July 2019 
Sterile Sodium Chloride Concentrate 30% w/v Solution for Infusion 

PA0274/001/001
Sodium Chloride  Manufacturing delays  Date of shortage:
Start of April 2019
 
Expected return date:
Awaiting update
Last updated:
12th July 2019 
Suprax 200mg Film Coated Tablet

PA0540/016/002 
Cefixime  Manufacturing delays  Date of shortage:
31st May 2019

Expected return date:
August 2019 
Last updated:
10th June 2019 
Surmontil 50mg Capsules

PA0540/128/003
Trimipramine Maleate Unavailability of API

(multiple countries impacted)
Date of shortage:
27th May 2019
 
Expected return date:
End of October 2019
Last updated:
18th July 2019
Tadalafil Krka 10mg Film Coated Tablet

PA1347/071/003 
Tadalafil Unexpected increase in demand  Date of shortage:
October 2018

Expected return date:
Awaiting update
Last updated:
14th June 2019
Targin 80mg/40mg Prolonged Release Tablet

PA1688/010/009 
Oxycodone hydrochloride & Naloxone hydrochloride  Manufacturing delay  Date of shortage:
End of June 2019

Expected return date:
Awaiting update
Last updated:
18th July 2019 
Telmisartan 80mg Film Coated Tablet

PA0126/228/003 
Temisartan  Unexpected increase in demand  Date of shortage:
Mid June 2019

Expected return date:
End of July 2019 
Last updated:
11th July 2019 
Tevanate Once Weekly 70mg Tablet

PA0749/016/001 
Alendronic acid  Manufacturing delays  Date of shortage:
Start of April 2019

Expected return date:
September 2019
Last updated:
5th July 2019 
Tevaquel 25mg Film Coated Tablet

PA0749/060/001 
Quetiapine  Manufacturing delays

(multiple countries affected) 
Date of shortage:
End of April 2019

Expected return date:
Start of August 2019 
Last updated:
5th July 2019 
Tracrium 10mg/ml Solution for Injection/Infusion
(2.5ml x 5 presentation only)

PA1691/029/001 
Atracurium besilate  Manufacturing delays  Date of shortage:
Early July 2019

Expected return date:
Awaiting update
Last updated:
18th July 2019 
Trandate 5mg/ml Solution for Injection

PA1638/006/001 
Labetalol hydrochloride  Manufacturing delays

(multiple countries affected) 
Date of shortage:
16th May 2019

Expected return date:
31st October 2019 
Last updated:
21st June 2019 
Trandate 100mg Film Coated Tablet

PA1638/006/002 
Labetalol hydrochloride  Manufacturing delays

(multiple countries affected) 
Date of shortage:
July 2019

Expected return date:
End of October 2019 
Last updated:
2nd July 2019 
Trandate 200mg Film Coated Tablet

PA1638/006/003 
Labetalol hydrochloride  Manufacturing delays

(multiple countries affected) 
Date of shortage:
July 2019

Expected return date:
End of October 2019 
Last updated:
2nd July 2019 
Tranexamic acid 100mg/ml Solution for Injection

PA2315/178/001 
Tranexamic acid  Manufacturing delays  Date of shortage:
Early July 2019

Expected return date:
October 2019 
Last updated:
17th July 2019 
Trimoptin 100mg Tablets

PA0298/014/001 
Trimethoprim Manufacturing delays  Date of shortage:
Early October 2018

Expected return date:
Awaiting update
Last updated:
12th July 2019
Trimoptin 200mg Tablets

PA0298/014/002 
Trimethoprim  Manufacturing delays  Date of shortage:
Early October 2018

Expected return date:
Awaiting update
Last updated:
12th July 2019

Ultiva 2mg Powder for Concentrate for Solution for Infusion

PA1691/032/002 

 Remifentanyl Manufacturing delays

(multiple countries affected) 
Date of shortage:
24th July 2019

Expected return date:
16th September 2019
Last updated:
28th June 2019
Valsartan Actavis 40mg Film Coated Tablet 

PA1380/022/001
Valsartan Active substance impurity

(multiple countries affected)
                        
Date of shortage:
July 2018

Expected return date:
End of 2019
Last updated: 
22nd May 2019
Valsartan Actavis 80mg Film Coated Tablet

PA1380/022/002
     
Valsartan Active substance impurity

(multiple countries affected)
Date of shortage:
July 2018

Expected return date:
End of 2019
Last updated:
22nd May 2019
Valsartan Actavis 160mg Film Coated Tablet 

PA1380/022/003
Valsartan Active substance impurity

(multiple countries affected)
Date of shortage:
July 2018

Expected return date:
End of 2019
 
Last updated:
22nd May 2019
Valsartan Mylan 40mg Film Coated Tablet

PA0577/134/001 
Valsartan  Unexpected increase in demand 

(multiple countries affected)
Date of shortage:
Early November 2018
 
Expected return date:
Unknown at present
Last updated:
13th May 2019
Valsartan Mylan 80mg Film Coated Tablet

PA0577/134/002 
Valsartan  Unexpected increase in demand 

(multiple countries affected)
Date of shortage:
Early November 2018

Expected return date:
Unknown at present
Last updated:
13th May 2019
Valsartan Mylan 160mg Film Coated Tablet

PA0577/134/003 
Valsartan  Unexpected increase in demand

(multiple countries affected) 
Date of shortage:
Early November 2018

Expected return date:
Unknown at present 
Last updated:
13th May 2019 
Valsartan Mylan 320mg Film Coated Tablet 

PA0577/134/004
Valsartan  Unexpected increase in demand

(multiple countries affected) 
Date of shortage:
Early November 2018

Expected return date:
Unknown at present
Last updated:
13th May 2019 
Valsartan Teva 40mg Film Coated Tablet

PA0749/084/001 
Valsartan Unexpected increase in demand

(multiple countries affected) 
Date of shortage: 
July 2018

Expected return date:
Unknown at present
Last updated:
10th May 2019
Valsartan Teva 80mg Film Coated Tablet

PA0749/084/002 
Valsartan Unexpected increase in demand

(multiple countries affected)
Date of shortage:
July 2018

Expected return date:
Unknown at present
Last updated:
10th May 2019
Valsartan Teva 160mg Film coated Tablet

PA0749/084/003 
Valsartan  Unexpected increase in demand

(multiple countries affected)
Date of shortage:
Awaiting update

Expected return date:
Unknown at present 
Last updated:
10th May 2019 
Valsartan / Hydrochloride 80mg/12.5mg Film Coated Tablet

PA2315/181/001
Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)
Date of shortage:
July 2018

Expected return date:

End of 2019
Last updated: 
22nd May 2019
Valsartan / Hydrochlorothiazide 160mg/12.5mg Film Coated Tablet 

PA2315/181/002
Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)
Date of shortage:
July 2018

Expected return date:
End of 2019
Last updated:
22nd May 2019
Valsartan / Hydrochlorothiazide 160mgmg/ 25mg Film Coated Tablet

PA2315/181/003 
Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)
Date of shortage:
July 2018

Expected return date:
End of 2019
Last updated: 
22nd May 2019
Valtan 40mg Film Coated Tablet 

PA0126/211/001 
Valsartan Unexpected increase in demand

(multiple countries affected)
Date of shortage:
24th October 2018

Expected return date:
Awaiting update
Last updated:
14th June 2019
Valtan 80mg Film Coated Tablet

PA0126/211/002 
Valsartan  Unexpected increase in demand

(multiple countries affected)
Date of shortage:
26th September 2018
 
Expected return date:
Awaiting update
Last updated:
12th July 2019
Valtan 160mg Film Coated Tablet

PA0126/211/003
Valsartan  Unexpected increase in demand 

(multiple countries affected)
Date of shortage:
24th October 2018

Expected return date:
Awaiting update
Last updated:
5th June 2019
Vatan 40mg Film Coated Tablet

PA0711/183/001
Valsartan  Active substance impurity

(multiple countries affected) 
Date of shortage:
July 2018

Expected return date:
Unknown at present
Last updated:
13th May 2019
Vatan 80mg Film Coated Tablets

PA0711/183/002 
Valsartan  Active Substance Impurity

(multiple countries affected) 
Date of shortage:
July 2018

Expected return date:
Unknown at present
Last updated:
13th May 2019
Vatan 160mg Film Coated Tablets

PA0711/183/003 
Valsartan Active Substance impurity

(multiple countries affected) 
 
Date of shortage:
July 2018

Expected return date:
Unknown at present
Last updated:
13th May 2019
Zacin 0.025% w/w Cream

PA0827/008/001 
Capsaicin  Manufacturing delays

(multiple countries affected) 
Date of shortage:
Mid July 2019

Expected return date:
October 2019 
Last updated:
18th July 2019 
Zanaflex 2mg Tablet

PA0749/054/001 
Tizanidine  Manufacturing delays  Date of shortage:
Early May 2019

Expected return date:
End of August 2019 
Last updated:
1st July 2019 
Zanaflex 4mg Tablet

PA0749/054/002 
Tizanidine  Manufacturing delays  Date of shortage:
Early May 2019

Expected return date:
End of August 2019 
Last updated:
1st July 2019 
Zestan 5mg Tablet

PA0126/112/002 
Lisinopril dihydrate  Manufacturing delays  Date of shortage:
Mid February 2019

Expected return date:
August 2019
Last updated:
4th July 2019 
Zestan 10mg Tablet 

PA0126/112/003
Lisinopril dihydrate  Manufacturing delays  Date of shortage:
End of May 2019

Expected return date:
August 2019 
Last updated:
24th May 2019 
Zestan 20mg Tablet

PA0126/112/004 
Lisinopril dihydrate  Manufacturing delays  Date of shortage:
End of May 2019

Expected return date:
August 2019 
Last updated:
24th May 2019 
Zineryt 40mg + 12mg Powder and Solvent for Cutaneous Solution

PA0046/065/001 
Erythromycin & Zinc Acetate  Unexpected increase in demand

(multiple countries affected) 
Date of shortage:
19th June 2019

Expected return date:
End of July 2019 
Last updated:
12th July 2019 

Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL
Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL
Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL



Contact us:

Medicinal Product Shortages Unit
Health Products Regulatory Authority 
Kevin O’Malley House
Earlsfort Terrace,
Dublin 2
Tel: +353 1 676 4971
Fax: +353 1 676 7836
shortages@hpra.ie