Medicinal Product Shortages

The HPRA is responsible for co-ordinating the management of shortages of human medicines on the Irish market. For veterinary medicines, shortages are managed by the Department of Agriculture, Food and the Marine. 

The HPRA works with a variety of stakeholders including manufacturers, wholesale distributors, marketing authorisation holders, healthcare professionals, the Health Service Executive, patients and representative groups to respond to potential shortages and reduce the impact of shortages on patients.

The definition of a shortage is when the supply of a medicinal product is inadequate to meet the needs of the patient. 

The HPRA, in collaboration with stakeholders, has published a framework for a multi-stakeholder approach to handling shortages of human medicinal products. The aim of the framework is to help prevent shortages from occurring and to reduce the impact of shortages on patients by co-ordinating the management of potential or actual shortages as they arise. You can see the shortages case study on Adrenaline auto-injectors (AAIs) as an example of how the framework operates in practice. 


Information on reporting shortages for:

Wholesale Distributors and Manufacturers

Patients and Healthcare Professionals

Please complete the  Report of a Medicinal Product Shortage from Patients and Healthcare Professionals form and return to  shortages@hpra.ie. When completing this form, please include as much information as possible.

Veterinary Medicines

 

Current and resolved shortages

The HPRA publishes a list of shortages currently affecting the Irish market that have been notified to us and that may have a medium or high impact on patients. This list can be found below. More information on the impact level can be found in the framework for a multi-stakeholder approach to handling shortages of human medicinal products.

The HPRA maintains a consolidated list of resolved shortages for a period of six months. Details of shortages that have been resolved in the last six months can be found here
 

 


Please use search function below to find relevant product or active ingredient

 
Product name Active ingredient Reason for shortage Date of shortage
Additional information
Amisulpride 50mg Tablet

PA0577/182/001 
Amisulpride  Manufacturing delays  Date of shortage:
July 2019

Expected return date:
Awaiting update
Last updated:
1st April 2021 
Anastrazole 1mg Film Caoted Tablet

PA0749/028/001 
Anastrazole  Unavailability of API

(multiple countries affected) 
Date of shortage:
Week commencing 12th October 2020

Expected return date:
Early May 2021 
Last updated:
22nd January 2021 
Angeliq 1mg/2mg Tablet

PA1040/013/001 
Estradiol & Drospirenone  Unavailability of API

(multiple countries affected) 
Date of shortage:
Early January 2021
 
Expected return date:
End of Q1 2022
Last updated:
11th January 2021 
Aprovel 75mg Film Coated Tablet

EU/1/97/046/017 
Irbesartan  Manufacturing delays

(multiple countries affected) 
Date of shortage:
Early Janaury 2021

Expected return date:
16th April 2021 
Last updated:
13th April 2021 
Aripiprazole 5mg Tablet

PA1986/019/001 
Aripiprazole  Manufacturing delays

(multiple countries affected) 
Date of shortage:
End of November 2020

Expected return date:
May 2021 
Last updated:
8th January 2021 
Aripiprazole 10mg Tablet

PA1986/019/002 
Aripiprazole  Manufacturing delays

(multiple countries affected) 
Date of shortage:
End of November 2020

Expected return date:
May 2021 
Last updated:
8th January 2021 
Aripiprazole 30mg Tablet

PA1986/019/004 
Aripiprazole  Manufacturing delays

(multiple countries affected) 
Date of shortage:
Mid July 2020

Expected return date:
May 2021
Last updated:
8th January 2021 
Aripiprazole Sandoz 5mg Tablet

EU/1/15/1029/001-014 
Aripiprazole  Manufacturing delays

(multiple countries affected) 
Date of shortage:
During 2019

Expected return date:
20th April 2021
Last updated:
14th April 2021
Aripiprazole Sandoz 10mg Tablet

EU/1/15/1029/015-028 
Aripiprazole  Manufacturing delays

(multiple countries affected) 
Date of shortage:
During 2019

Expected return date:
20th April 2021
Last updated:
14th April 2021
Aripiprazole Sandoz 15mg Tablet

EU/1/15/1029/029-042 
Aripiprazole  Manufacturing delays

(multiple countries affected) 
Date of shortage:
During 2019

Expected return date:
20th April 2021
Last updated:
14th April 2021
Astilin 10mg Tablet

PA23163/001/001 
Amitriptyline  Unexpected increase in demand  Date of shortage:
End of March 2021

Expected return date:
End of April 2021 
Last updated:
30th March 2021 
Atecor CT 100mg/25mg Film Coated Tablet

PA0711/020/002 
Atenolol & Chlortalidone  Manufacturing delays  Date of shortage:
Mid January 2021

Expected return date:
Late April 2021 
Last updated:
16th March 2021 
Ativan 4mg/ml Solution for Injection

PA0822/090/002 
Lorazepam  Manufacturing delays

(multiple countries affected) 
Date of shortage:
Early August 2020

Expected return date:
Unknown at present
Last updated:
11th March 2021 
 
HCP Letter
BCG-Medac Powder and Solvent for Suspension for Intravesical Use

PA0623/004/001 
Bacillus Calmette Guerin bacteria  Manufacturing delays

(multiple countries affected) 
Date of shortage:
1st October 2019

Expected return date:
2022
Last updated:
3rd February 2021
Beromun 1mg Powder for Solution for Infusion

EU/1/99/097/001 
Tasonermin  Manufacturing delays

(multiple countries affected) 
Date of shortage:
December 2020

Expected return date:
Mid 2021 
Last updated:
2nd December 2020 
Caverject 20mcg Powder and Solvent for Solution for Injection

PA0822/115/003 
Alprostadil  Manufacturing delays  Date of shortage:
Week commencing 22nd March 2021

Expected return date:
Awaiting update 
Last updated:
15th April 2021 
Celebrex 200mg Capsules

PA0822/116/002
Celecoxib Manufacturing delays 

(multiple countries affected)
Date of shortage: 
Week commencing 5th April 2021

Expected return date:
Week commencing 3rd May 2021
Last updated: 
24th March 2021
Centyl K 2.5mg + 573mg Tablet

PA22650/002/002 
Bendroflumethiazide & Potassium hydrochloride  Unexpected Increase in demand  Date of shortage:
6th August 2020

Expected return date:
Mid May 2021 
Last updated:
22nd February 2021 

HCP Letter
Champix 0.5mg Tablet

EU/1/06/360/001
Varenicline tartrate Manufacturing delay Date of shortage:
Week commencing 19th April 2021

Expected return date: 
Week commencing 26th April 2021 
Last updated:
12th April 2021

HCP letter
Chlorpromazine Elixir BP 25mg/5ml Oral Solution

PA0281/124/001 
Chlorpromazine hydrochloride  Manufacturing delays  Date of shortage:
End of February 2021

Expected return date:
Awaiting update
Last updated:
23rd February 2021
 
HCP Letter
 
 
Cimeldine 400mg Film Coated Tablet

PA0126/077/002 
Cimetidine  Unexpected increase in demand  Date of shortage:
24th March 2021

Expected return date:
19th April 2021 
Last updated:
26th March 2021 
Co-Amoxiclav 1000mg/200mg Powder for solution for injection/infusion

PA1457/001/002
Amoxicillin & clavalunic acid Unexpected increase in demand Date of shortage:
5th February 2020

Expected return date:
Unknown at present
Last updated:
11th February 2021
Desmopressin 100mcg/ml Nasal Drop Solution

PA1009/001/001 
Desmopressin  Manufacturing delays due to quality issue

(multiple countries affected) 
Date of shortage:
Mid December 2020

Expected return date:
2022 
Last updated:
11th December 2020 
Desmospray Desmopressin Nasal Spray

PA1009/005/001 
Desmopressin  Quality issue

(multiple countries affected) 
Date of shortage:
22nd July 2020

Expected return date:
2022 
Last updated:
11th December 2020 
Detrunorm XL 30mg Modified Release Capsule

PA1142/004/002 
Propiverine  Manufacturing delays

(multiple countries affected) 
Date of shortage:
End of February 2021

Expected return date:
Mid May 2021 
Last updated:
15th March 2021

HCP Letter 
Diazemuls 5mg/ml Emulsion for Injection

PA2315/098/001 
Diazepam  Manufacturing delays  Date of shortage:
Mid February 2020

Expected return date:
Unknown at present
Last updated:
30th March 2021 
Emerade 150mcg Solution in a Pre-Filled Pen

PA1696/009/001 
Adrenaline  Quality issue

(multiple countries affected) 
Date of shortage:
30th September 2019

Expected return date:
Unknown at present 
Last updated:
18th December 2020

Alternatives are available 
Emerade 300mcg Solution in a Pre-Filled Pen

PA1696/009/002 
Adrenaline  Quality issue

(multiple countries affected) 
Date of shortage:
30th September 2019

Expected return date:
Unknown at present 
Last updated:
18th December 2020

Alternatives are available 
Emerade 500mcg Solution in a Pre-Filled Pen

PA1696/009/003 
Adrenaline  Quality issue

(multiple countries affected) 
Date of shortage:
30th September 2019

Expected return date:
Unknown at present 
Last updated:
18th December 2020

Alternatives are available 
Epaclob 1mg/ml Oral Solution

PA0549/026/001 
Clobazam  Manufacturing delays  Date of shortage:
9th April 2021

Expected return date:
End of April 2021 
Last updated:
13th April 2021 
Epaclob 2mg/ml Oral Solution

PA0549/026/002 
Clobazam  Manufacturing delays  Date of shortage:
9th April 2021

Expected return date:
End of April 2021 
Last updated:
13th April 2021
Epanutin Infatabs 50mg Chewable Tablets

PA0822/011/005
Phenytoin Manufacturing delays

(multiple countries affected)
Date of shortage:
Early November 2019

Expected return date:
Unknown at present
Last updated:
4th June 2020
 
HCP Letter
Erythrocin 500mg Tablet

PA1142/008/003 
Erythrocin  Manufacturing delays

(multiple countries affected) 
Date of shortage:
End of February 2020

Expected return date:
Awaiting update
Last updated:
30th March 2021 
Esomeprazole Ticerin 40mg Powder for Solution for Injection of Infusion

PA1852/002/001 
Esomeprazole  Unavailability of API  Date of shortage:
Early October 2020

Expected return date:
Unknown at present 
Last updated:
30th March 2021 
Fludarabine phosphate 25mg/ml Solution for Injection or Infusion

PA2315/035/001 
Fludarabine phosphate  Unavailability of API

(multiple countries affected) 
Date of shortage:
Early November 2020

Expected return date:
September 2021 
Last updated:
25th February 2021
Flutiform 50mcg/5ml Per Metred Dose Pressurised Inhalation Suspension

PA1688/013/001 
Fluticasone propionate & Formoterol fumarate Manufacturing delays

(multiple countries affected) 
Date of shortage:
End of March 2021

Expected return date:
23rd April 2021
Last updated:
16th April 2021 
Foznol 1000mg Chewable Tablet

PA1575/002/004 
Lanthanum  Manufacturing delay

(multiple countries affected) 
Date of shortage:
24th March 2021

Expected return date:
21st April 2021 
Last updated:
15th April 2021 

HCP Letter
Furosemide 50mg/5ml Solution for Injection
Furosemide Quality issue  Date of shortage: 
Late March 2021

Expected return date: 
Mid June 2021
Last updated:
8th April 2021 
Gaviscon Advance Oral Suspension

PA0979/015/001 
Sodium alginate & Potassium hydrogen carbonate  Manufacturing delays  Date of shortage:
June 2020

Expected return date:
Mid April 2021 
Last updated:
1st March 2021 
Gentamicin 40 mg/ml Injection, vials

PA0822/203/001
Gentamicin
Manufacturing delays

(multiple countries affected)
Date of shortage:
9th December 2019

Expected return date:
Unknown at present
Last updated:
11th February 2021
Gerozac 20mg Capsule

PA0577/200/001 
Fluoxetine  Manufacturing delays  Date of shortage:
Early December 2019

Expected return date:
Unknown at present
Last updated:
11th February 2021 
Hydromorphone 20mg/ml Solution for Injection/Infusion

PA0549/030/001 
Hydromorphone  Manufacturing delays

(multiple countries affected) 
Date of shortage:
Mid June 2020

Expected return date:
Awaiting update 
Last updated:
13th April 2021
Hydromorphone 50mg/ml Solution for Injection/Infusion

PA0549/030/002 
Hydromorphone  Manufacturing delays

(multiple countries affected) 
Date of shortage:
Mid August 2020

Expected return date:
Awaiting update 
Last updated:
13th April 2021 
Imdur 60mg Prolonged Release Tablet

PA2129/001/001 
Isosorbide mononitrate  Manufacturing delays  Date of shortage:
End of November 2020

Expected return date:
Early May 2021
Last updated:
7th April 2021 
Lispril Hydrochlorothiazide 10mg/12.5mg Tablet

PA0711/051/001 
Lisinopril & Hydrochlorothiazide  Manufacturing delays  Date of shortage:
22nd July 2020

Expected return date:
May 2021
Last updated:
16th March 2021
Lispril Hydrochlorothiazide 20mg/12.5mg Tablet

PA0711/051/002 
Lisinopril & Hydrochlorothiazide  Manufacturing delays  Date of shortage:
8th September 2020

Expected return date:
End May 2021
Last updated:
14th April 2021
Losartan 50mg Tablet

PA0749/090/003 
Losartan  API on allocation

(multiple markets affected) 
Date of shortage:
23rd November 2020

Expected return date:
Early May 2021
Last updated:
14th April 2021
Losartan 50mg Tablet 

PA2315/059/002 
Losartan  Manufacturing delays  Date of shortage:
25th September 2019

Expected return date:
Unknown at present 
Last updated:
13th April 2021
Losartan 100mg Tablet

PA2315/059/003 
Losartan  Manufacturing delays  Date of shortage:
October 2019

Expected return date:
Unknown at present
Last updated:
13th April 2021
Low Centyl K 1.25mg/573mg Modified Release Tablet

PA22650/002/001 
Bendroflumethiazide & Potassium chloride  Unavailability of API

(multiple countries affected) 
Date of shortage:
February 2021

Expected return date:
July 2021 
Last updated:
4th Janaury 2021

HCP Letter
Manerix 150mg Film -coated Tablets

PA2010/023/001
Moclobemide Manufacturing delays Date of shortage:
10th March 2021

Expected return date: 
Awaiting update
 
Last updated: 
15th April 2021
Mefac 250mg Capsule

PA0074/015/001 
Mefenamic acid  Manufacturing delays  Date of shortage:
End of June 2019

Expected return date:
Unknown at present
Last updated:
26th March 2021
 
Metalyse 10,000Units Powder and Solvent for Solution for Injection

EU/1/00169/006 
Tenecteplase  Manufacturing delays

(multiple countries affected) 
Date of shortage:
Early March 2021

Expected return date:
October 2021 
Last updated:
5th March 2021 
Metaraminol 10mg/ml Solution for Injection or Infusion 

PA22893/001/001
Metaraminol  Awaiting update Date of shortage: 
Early April 2021 

Expected return date:
Awaiting update 
Last updated: 
6th April 2021
Methotrexate 2.5mg Tablet

PA2315/062/002 
Methotrexate  Manufacturing delays  Date of shortage:
Early January 2021

Expected return date:
June 2021 
Last updated:
27th January 2021 
Methylthioninium chloride 5mg/ml Solution for Injection

EU/1/11/682/001 
Methylthioninium chloride  Manufacturing delays  Date of shortage:
26th March 2021

Expected return date:
Unknown at present 
Last updated:
23rd March 2021 
Neomercazole 5mg Tablets

PA1142/002/001
Carbimazole Manufacturing delays Date of shortage: 
7th April 2021

Expected return date: 
13th April 2021
Last updated:
7th April 2021
Nexium control 20mg Capsules

EU/1/13/860/003
Esomeprazole Manufacturing delays Date of shortage: 
End November 2020

Expected return date:
Mid May 2021
Last updated: 
25th March 2021
Nexium control 20mg Tablet

EU/1/13/860/001-002 
Esomeprazole  Manufacturing delays  Date of shortage:
Mid April 2021

Expected return date:
Early May 2021 
Last updated:
7th April 2021 
Nimbex 2mg/ml solution for injection/infusion

PA1691/030/001
 Cisatracurium Unexpected increase in demand

(Multiple countries affected)
Date of shortage:
Early March 2021

Expected return date:
Late June 2021
Last updated: 24th February 2021
Nytol One a night 50mg Tablet

PA1186/016/001 
Diphenhydramine hydrochloride  Manufacturing delays  Date of shortage:
End of March 2021

Expected return date:
End of April 2021
 
Last updated:
7th April 2021 
Odrik 2mg Capsule

PA2010/005/003 
Trandoapril  Manufacturing delays  Date of shortage:
Early April 2021

Expected return date:
May 2021 
Last updated:
30th March 2021 
Palexia 4mg/ml Oral Solution

PA2242/012/010 
Tapentadol hydrochloride  Quality issue

(multiple countries affected) 
Date of shortage:
15th February 2021

Expected return date:
Unknown at present 
Last updated: 
22nd February 2021
Palexia 20mg/ml Oral Solution

PA2242/012/011 
Tapentadol hydrochloride  Quality issue

(multiple countries affected) 
Date of shortage:
15th February 2021

Expected return date:
Unknown at present 
Last updated:
22nd February 2021 
Perinal Cutaneous Spray hydrocortisone 0.2% w/w / lidocaine hydrochloride monohydrate 1.0% w/w

PA0278/017/001
Hydrocortisone & Lidocaine Hydrochloride  Manufacturing delay  Date of shortage:
February 2021

Expected return date:
January 2022
Last updated: 
8th April 2021
Pneumovax 23 Solution for Injection in Pre-filled Syringe

PA1286/055/002 
Pneumococcal Polysaccharide Vacine  Unexpected increase in demand

(multiple countries affected)
Date of shortage:
16th March 2020

Expected return date:
September 2021
Last updated:
24th September 2020 
Pregabalin Accord 200mg Hard Capsule

EU/1/15/1027/060 
Pregabalin  Manufacturing delays

(multiple countries affected) 
Date of shortage:
End of December 2020

Expected return date:
Late May 2021
Last updated:
6th April 2021
Propafenone hydrochloride 300mg Tablet

PA2315/116/002 
Propafenone hydrochloride  Manufacturing delays

(multiple countries affected) 
Date of shortage:
End of July 2020

Expected return date:
June 2021 
Last updated:
13th April 2021 
 
HCP Letter
Questran 4g Powder for Oral Suspension

PA2239/005/001 
Colestyramine  Manufacturing delays

(multiple countries affected) 
Date of shortage:
Mid June 2019

Expected return date:
January 2022
Last updated:
30th March 2021 
Rifadin 100mg/5ml Oral Suspension

PA0540/066/004 
Rifampicin  Manufacturing delays

(multiple countries affected) 
Date of shortage:
End of February 2021

Expected return date:
Unknown at present 
Last updated:
16th March 2021 
Rifadin 150mg Capsule

PA0540/066/001 
Rifampicin  Unexpected increase in demand & Manufacturing delays

(multiple countries affected) 
Date of shortage:
End of September 2020

Expected return date:
20th April 2021
Last updated:
7th April 2021 
Sprilon 12.5% Zinc Oxide & 1.04% Dimethicone Cutaneous Spray Suspension

PA22906/001/001 
Zinc oxide & Dimethicone  Manufacturing delays  Date of shortage:
October 2019

Expected return date:
Unknown at present
Last updated:
24th September 2020 
Technescan DMSA 1.2mg kit for radiopharmaceutical preparation

PA0690/011/001
 Succimer Regulatory issue

(multiple countries affected)
Date of shortage: 
21st March 2021

Expected return date: 
September 2021
Last updated:
26th March 2021
Tracrium 10mg/ml Solution for Injection or Infusion

25ml vial only

PA1691/029/002 
Atracurium  Unexpected increase in demand

(multiple countries affected) 
Date of shortage:
End of January 2021

Expected return date:
22nd April 2021
Last updated:
9th March 2021
Trandate 100mg Film Coated Tablet

PA1638/006/002 
Labetalol hydrochloride  Manufacturing delays

(multiple countries affected) 
Date of shortage:
July 2019

Expected return date:
May 2021
Last updated:
6th April 2021
Trandate 200mg Film Coated Tablet

PA1638/006/003 
Labetalol hydrochloride  Manufacturing delays

(multiple countries affected) 
Date of shortage:
July 2019

Expected return date:
May 2021
Last updated:
6th April 2021
Ranitic 75mg Film Coated Tablet

PA0711/024/004 
Ranitidine  Active substance impurity

(multiple countries affected) 
Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 
Last updated:
22nd October 2019

MMP Guidance for Prescribers
             
AHDMP Guidance for Prescribers
Ranitic 150mg Film Coated Tablet

PA0711/024/001 
Ranitidine  Active substance impurity

(multiple countries affected) 
Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 
Last updated:
22nd October 2019

MMP Guidance for Prescribers

AHDMP Guidance for Prescribers
 
Ranitic 300mg Film Coated Tablet

PA0711/024/002 
Ranitidine  Active substance impurity

(multiple countries affected) 
Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 
Last updated:
22nd October 2019

MMP Guidance for Prescribers
 
AHDMP Guidance for Prescribers
Ranitidine 150mg/10ml Oral Solution

PA22741/009/001 
Ranitidine  Active substance impurity

(multiple countries affected) 
Date of shortage:
23rd September 2019

Expected return date:
Unknown at present 
Last updated:
22nd October 2019

MMP Guidance for Prescribers
 
AHDMP Guidance for Prescribers
Tradol SR 100mg Prolonged release Tablet

PA0711/029/006
 Tramadol  To be confirmed  Date of shortage: 15th March 2021 

Expected return date:
End April 2021
 Last updated:
14th April 2021
Vfend 200mg Powder for Solution for Infusion

EU/1/02/212/025
 Voriconazole Unexpected increase in demand 

(multiple countries affected)
Date of shortage:
18th March 

Expected return date: 
May 2021
 Last updated: 19th March 2021
Zerbaxa 1g/0.5g Powder for Concentrate for Solution for Infusion

EU/1/15/1032/001 
Ceftolozone & Tazobactam  Quality issue

(multiple countries affected) 
Date of shortage:
18th December 2020

Expected return date:
Unknown at present 
Last updated:
4th March 2021 
Zofran 4mg/2ml Solution for Injection or Infusion

PA0896/036/001
Ondansetron  Unexpected increase in demand  Date of shortage:
8th February 2021

Expected return date:
July 2021 
Last updated:
5th February 2021 
Zofran 8mg/4ml Solution for Injection or Infusion 

PA0896/036/002
Ondansetron  Unexpected increase in demand Date of shortage: 15th April 2021

Expected return date: 
July 2021

Last updated: 
6th April 2021

Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL
Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL
Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL




Contact us:

Medicinal Product Shortages Unit
Health Products Regulatory Authority 
Kevin O’Malley House
Earlsfort Terrace,
Dublin 2
Tel: +353 1 676 4971
Fax: +353 1 676 7836
shortages@hpra.ie