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Medicinal Product Shortages

The HPRA is responsible for co-ordinating the management of shortages of human medicines on the Irish market. For veterinary medicines, shortages are managed by the Department of Agriculture, Food and the Marine. 

The HPRA works with a variety of stakeholders including manufacturers, wholesale distributors, marketing authorisation holders, healthcare professionals, the Health Service Executive, patients and representative groups to respond to potential shortages and reduce the impact of shortages on patients.

The definition of a shortage is when the supply of a medicinal product is inadequate to meet the needs of the patient. 

The HPRA, in collaboration with stakeholders, has published a framework for a multi-stakeholder approach to handling shortages of human medicinal products. The aim of the framework is to help prevent shortages from occurring and to reduce the impact of shortages on patients by co-ordinating the management of potential or actual shortages as they arise. You can see the shortages case study on Adrenaline auto-injectors (AAIs) as an example of how the framework operates in practice. 


Information on reporting shortages for:

Marketing Authorisation Holders

Please complete the  Notification of medicinal product shortage from marketing authorisation holder form and return to  shortages@hpra.ie and to the HSE Corporate Pharmaceutical Unit.

Wholesale Distributors and Manufacturers

Please complete the  Report of Medicinal Products Shortages from Wholesale Distributors and Manufacturers form and return this form to  shortages@hpra.ie.

Patients and Healthcare Professionals

Please complete the  Report of a Medicinal Product Shortage from Patients and Healthcare Professionals form and return to  shortages@hpra.ie. When completing this form, please include as much information as possible.

Veterinary Medicines

Please contact the Department of Agriculture, Food and the Marine.

 

Current and resolved shortages

The HPRA publishes a list of shortages currently affecting the Irish market that have been notified to us and that may have a medium or high impact on patients. This list can be found below. More information on the impact level can be found in the framework for a multi-stakeholder approach to handling shortages of human medicinal products.

The HPRA maintains a consolidated list of resolved shortages for a period of six months. Details of shortages that have been resolved in the last six months can be found here.
 


Please use search function below to find relevant product or active ingredient

 
Product name Active ingredient Reason for shortage Date of shortage
 Additional information
Allopurinol 300mg Tablets

PA2315/056/002
 Allopurinol		  Manufacturing delays Date of shortage: 
Week commencing 21st June 2021. 

Expected return date: 
Week commencing 2nd August 2021		 Last updated: 
19th July 2021
Allopurinol Teva 300 mg Tablets

PA0749/099/003
  Allopurinol Unexpected increase in demand  Date of Shortage:
Week commencing 5th July 2021

Expected return date: 
August 2021		 Last updated: 28th June 2021
Angeliq 1mg/2mg Tablet

PA1040/013/001 		 Estradiol & Drospirenone  Unavailability of API

(multiple countries affected) 		 Date of shortage:
Early January 2021
 
Expected return date:
End of Q1 2022		 Last updated:
11th January 2021 
Aprovel 150mg Tablets

EU/1/97/046/022
 Irbesartan Quality issue 

Multiple countries impacted  		 Date of shortage: 
22nd July 2021

Expected return date: 
Late October 2021		 Last updated: 
29th July 2021
Ativan 4mg/ml Solution for Injection

PA0822/090/002 		 Lorazepam  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Early August 2020

Expected return date:
Unknown at present		 Last updated:
14th May 2021 
 
HCP letter
BCG-Medac Powder and Solvent for Suspension for Intravesical Use

PA0623/004/001 		 Bacillus Calmette Guerin bacteria  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
1st October 2019

Expected return date:
2022		 Last updated:
3rd February 2021
Beromun 1mg Powder for Solution for Infusion

EU/1/99/097/001 		 Tasonermin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
December 2020

Expected return date:
November 2021		 Last updated:
1st June 2021
Calcium Acetate 500mg Tablets

PA0281/063/001
 Calcium Acetate API unavailability  Date of shortage: 
Week commencing 26th July 2021

Expected return date: 
October 2021 		 Last updated: 
26th July 2021
Catapres Tablets 100mcg

PA2256/003/001
  Clonidine Manufacturing delays

(multiple countries affected)		 Date of shortage: 
25th July 2021

Expected return date: 
25th October 2021		 Last updated: 
21st June 2021 
Centyl K 2.5mg + 573mg Tablet

PA22650/002/002 		 Bendroflumethiazide & Potassium hydrochloride  Unexpected Increase in demand  Date of shortage:
6th August 2020

Expected return date:
31st August 2021		 Last updated:
21st June 2021 

HCP letter
Champix 0.5mg Film Coated Tablet

EU/1/06/360/001
 Varenicline 
 Quality issue

(multiple countries affected)		 Date of shortage: 
Week commencing 21st June 2021 

Expected return date: 
Unknown at present 		 Last updated:
18th June 2021

HCP letter
Champix 1mg Film Coated Tablet

EU/1/06/360/005
 Varenicline Quality issue

(multiple countries affected)		 Date of shortage: 
Week commencing 21st June

Expected return date: 
Unknown at present 		 Last updated: 
18th June 2021

HCP letter
Champix 0.5 mg + 1 mg Film Coated Tablet

EU/1/06/360/003
 Varenicline 
 Quality issue 

(multiple countries affected)		 Date of shortage: 
Week commencing 21st June 

Expected return date: 
Unknown at present 		 Last updated: 
18th June 2021

HCP letter
Chlorpromazine Elixir BP 25mg/5ml Oral Solution

PA0281/124/001 		 Chlorpromazine hydrochloride  Manufacturing delays  Date of shortage:
End of February 2021

Expected return date:
September 2021		 Last updated:
22nd June 2021
 
HCP letter
 
Ciprofloxacin 2mg/ml Solution for Infusion 

(100ml presentation only)

PA1122/005/001
 Ciprofloxacin   Unexpected increase in demand  Date of shortage: 
4th June 2021

Expected return date: 
Mid-August 2021		 Last updated: 
5th July 2021
Co-Amoxiclav 1000mg/200mg Powder for Solution for Injection/Infusion

PA1457/001/002		 Amoxicillin & clavalunic acid Unexpected increase in demand Date of shortage:
5th February 2020

Expected return date:
October 2021
 Last updated:
15th June 2021
Co-Aprovel 150mg/12.5mg Film Coated Tablets

EU/1/98/086/012 
 Irbesartan & Hydrochlorothiazide
 Quality issue  Date of shortage: 
2nd July 2021

Expected return date: 
Unknown at present  		 Last updated: 
28th June 2021
Co-Aprovel 300mg/12.5mg Film Coated Tablets

EU/1/98/086/017         
 Irbesartan & Hydrochlorothiazide

  Quality issue Date of shortage: 
2nd July 2021

Expected return date: 
Unknown at present 		 Last updated: 
28th June 2021
Co-Aprovel 300mg/25mg Film Coated Tablets

EU/1/98/086/024             
 Irbesartan & Hydrochlorothiazide
  Quality issue Date of shortage: 
2nd July 2021

Expected return date:
End July 2021		 Last updated: 
22nd July 2021 
Depo-Provera 150mg/ml Suspension for Injection 

PA0822/124/001
 Medroxyprogestrone
  Regulatory issue Date of shortage: 
End July 2021

Expected return date:
Late August 2021  		 Last updated: 
28th July 2021
Desloratadine 5mg Film Coated Tablets 

PA2315/016/001
 Desloratadine Manufacturing delay  Date of shortage: 
Week commencing 21st June 2021

Expected return date: 
Week commencing 16th August 2021		 Last updated: 
23rd June 2021
Desmopressin 100mcg/ml Nasal Drop Solution

PA1009/001/001 		 Desmopressin  Manufacturing delays due to quality issue

(multiple countries affected) 		 Date of shortage:
Mid December 2020

Expected return date:
2022 		 Last updated:
11th December 2020 
Desmospray Desmopressin Nasal Spray

PA1009/005/001 		 Desmopressin  Quality issue

(multiple countries affected) 		 Date of shortage:
22nd July 2020

Expected return date:
2022 		 Last updated:
11th December 2020 
Diazemuls 5mg/ml Emulsion for Injection

PA2315/098/001 		 Diazepam  Manufacturing delays  Date of shortage:
Mid February 2020

Expected return date:
Unknown at present		 Last updated:
30th March 2021 
Emerade 150mcg Solution in a Pre-Filled Pen

PA1696/009/001 		 Adrenaline  Quality issue

(multiple countries affected) 		 Date of shortage:
30th September 2019

Expected return date:
Unknown at present 		 Last updated:
18th December 2020

Alternatives are available 
Emerade 300mcg Solution in a Pre-Filled Pen

PA1696/009/002 		 Adrenaline  Quality issue

(multiple countries affected) 		 Date of shortage:
30th September 2019

Expected return date:
Unknown at present 		 Last updated:
18th December 2020

Alternatives are available 
Emerade 500mcg Solution in a Pre-Filled Pen

PA1696/009/003 		 Adrenaline  Quality issue

(multiple countries affected) 		 Date of shortage:
30th September 2019

Expected return date:
Unknown at present 		 Last updated:
18th December 2020

Alternatives are available 
Epanutin Infatabs 50mg Chewable Tablets

PA0822/011/005		 Phenytoin Manufacturing delays

(multiple countries affected)		 Date of shortage:
Early November 2019

Expected return date:
Unknown at present		 Last updated:
4th June 2020
 
HCP Letter
Esomeprazole Ticerin 40mg Powder for Solution for Injection of Infusion

PA1852/002/001 		 Esomeprazole  Unavailability of API  Date of shortage:
Early October 2020

Expected return date:
Unknown at present 		 Last updated:
30th March 2021 
Fludarabine phosphate 25mg/ml Solution for Injection or Infusion

PA2315/035/001 		 Fludarabine phosphate  Unavailability of API

(multiple countries affected) 		 Date of shortage:
Early November 2020

Expected return date:
September 2021 		 Last updated:
25th February 2021
Fostepor Once Weekly 70mg tablets

PA0577/086/002
 Alendronic Acid Shipping delays  Date of shortage: 
Late June 2021

Expected return date: 
Mid-August 2021		  Last updated: 29th July 2021
Furosemide 50mg/5ml Solution for Injection

PA0073/059/005
 Furosemide Quality issue  Date of shortage: 
Late March 2021

Expected return date: 
August 2021		 Last updated:
7th July 2021 
Gentamicin 40 mg/ml Injection, vials

PA0822/203/001
 Gentamicin
 Manufacturing delays

(multiple countries affected)		 Date of shortage:
9th December 2019

Expected return date:
Unknown at present
 Last updated:
11th February 2021
Hydromorphone 20mg/ml Solution for Injection/Infusion

PA0549/030/001 		 Hydromorphone  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid June 2020

Expected return date:
Unknown at present 		 Last updated:
1st July 2021
Hydromorphone 50mg/ml Solution for Injection/Infusion

PA0549/030/002 		 Hydromorphone  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid August 2020

Expected return date:
Unknown at present 		 Last updated:
1st July 2021 
Ibandronic Acid Mylan 150mg Film Coated Tablets

PA0577/111/001
 Ibandronic acid Regulatory issue Date of shortage: 
20th May 2021

Expected return date: 
September 2021		 Last updated: 
3rd June 2021
Innohep 3,500 IU, Solution for Injection

PA0046/060/009
 Tinzaparin sodium
 Shipping delay  Date of shortage:
19th July 2021 

Expected return date: 
25th August 2021		 Last updated: 
28th July 2021

HCP letter
Instanyl 100mcg Nasal Spray 

EU/1/09/531/014-017
 Fentanyl  Quality issue

(multiple countries affected) 		 Date of shortage: 
2nd April 2021

Expected return date: 
September 2021 		 Last updated: 
25th May 2021
Instanyl 200mcg Nasal Spray

EU/1/09/531/018-021
 Fentanyl  Quality issue

(multiple countries affected) 		 Date of shortage: 
2nd April 2021

Expected return date: 
September 2021		 Last updated:
25th May 2021
Lercanidipine 20mg Film Coated Tablets

PA0126/187/002
 Lercanidipine Regulatory Issue Date of shortage:
Week commencing 14th June 2021

Expected return date: 
16th August 2021		 Last updated:
26th July 2021 
Lispril Hydrochlorothiazide 10mg/12.5mg Tablet

PA0711/051/001 		 Lisinopril & Hydrochlorothiazide  Manufacturing delays  Date of shortage:
22nd July 2020

Expected return date:
August 2021		 Last updated:
20th July 2021
Lispril Hydrochlorothiazide 20mg/12.5mg Tablet

PA0711/051/002 		 Lisinopril & Hydrochlorothiazide  Manufacturing delays  Date of shortage:
8th September 2020

Expected return date:
October 2021		 Last updated:1
22nd July 2021
Losartan 50mg Tablet 

PA2315/059/002 		 Losartan  Manufacturing delays  Date of shortage:
25th September 2019

Expected return date:
Unknown at present 		 Last updated:
13th April 2021
Losartan 100mg Tablet

PA2315/059/003 		 Losartan  Manufacturing delays  Date of shortage:
October 2019

Expected return date:
Unknown at present		 Last updated:
13th April 2021
Low Centyl K 1.25mg/573mg Modified Release Tablet

PA22650/002/001 		 Bendroflumethiazide & Potassium chloride  Unavailability of API

(multiple countries affected) 		 Date of shortage:
February 2021

Expected return date:
24th September 2021		 Last updated:
21st June 2021

HCP letter
Lyrica 75 mg Capsules

EU/1/04/279/011-013
 Pregabalin  Manufacturing delays Date of shortage: 
1st August 2021

Expected return date: 
Mid August 2021		 Last updated: 
28th July 2021
Marcain 0.25% w/v with Adrenaline (Epinephrine, 5 micrograms per ml) (1:200,000) Solution for Injection

PA1691/025/001
 Bupivacaine & Adrenaline Manufacturing delay

(multiple countries affected) 		 Date of shortage: 
1st July 2021

Expected return date: 
26th August 2021
 Last updated: 
18th June 2021 
Mefac 250mg Capsule

PA0074/015/001 		 Mefenamic acid  Manufacturing delays  Date of shortage:
End of June 2019

Expected return date:
Unknown at present		 Last updated:
23rd April 2021
 
Metalyse 10,000Units Powder and Solvent for Solution for Injection

EU/1/00169/006 		 Tenecteplase  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Early March 2021

Expected return date:
October 2021 		 Last updated:
5th March 2021 
Metaraminol 10mg/ml Solution for Injection or Infusion 

PA22893/001/001		 Metaraminol  Awaiting update Date of shortage: 
Early April 2021 

Expected return date:
Awaiting update		 Last updated: 
30th June 2021
Methotrexate 2.5mg Tablet

PA2315/062/002 		 Methotrexate  Manufacturing delays  Date of shortage:
Early January 2021

Expected return date:
Week commencing 26th July 2021		 Last updated:
22nd July 2021
Methylthioninium chloride 5mg/ml Solution for Injection

EU/1/11/682/001 		 Methylthioninium chloride  Manufacturing delays  Date of shortage:
26th March 2021

Expected return date:
Unknown at present 		 Last updated:
23rd March 2021 
Ondansetron 2mg/ml Solution for Injection or Infusion
 
PA0711/068/001
 Ondansetron   Awaiting information Date of shortage: 
21st July 2021

Expected return date: 
Mid August 2021 		 Last updated: 
22nd July 2021 
Palexia 4mg/ml Oral Solution

PA2242/012/010 		 Tapentadol hydrochloride  Quality issue

(multiple countries affected) 		 Date of shortage:
15th February 2021

Expected return date:
Unknown at present 		 Last updated: 
22nd February 2021
Parlodel 2.5mg Tablet

PA2010/042/001 		 Bromocriptine  Manufacturing delays  Date of shortage:
6th May 2021

Expected return date:
August 2021 		 Last updated:
3rd June 2021
Perinal Cutaneous Spray hydrocortisone 0.2% w/w / lidocaine hydrochloride monohydrate 1.0% w/w

PA0278/017/002
 Hydrocortisone & Lidocaine Hydrochloride  Manufacturing delay  Date of shortage:
February 2021

Expected return date:
January 2022		 Last updated: 
8th April 2021
Praxbind 50mcg/ml Solution for Injection/Infusion 

EU/1/15/1056/001
 Idarucizumab Awaiting information Date of shortage: 
July 2021

Expected return date: 
End July 2021 		 Last updated: 
28th July 2021
Pregabalin Accord 200mg Hard Capsule

EU/1/15/1027/060 		 Pregabalin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of December 2020

Expected return date:
Mid-August 2021		 Last updated:
7th July 2021
Prevymis 240mg Film Coated Tablet

EU/1/17/1245/001
 Letermovir Unexpected increase in demand  Date of shortage:
Early August 2021 

Expected return date: 
Mid-September 2021

 Last updated:
26th July 
Questran 4g Powder for Oral Suspension

PA2239/005/001 		 Colestyramine  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
Mid June 2019

Expected return date:
January 2022		 Last updated:
30th March 2021 
Rifadin 300mg Capsules

PA0540/066/002
  Rifampicin Quality issues

(multiple countries affected)		 Date of shortage:
6th June 2021

Expected return date: 
9th August 2021		 Last updated:
28th July 2021

AMRIC guidance v2
Rifadin 100mg/5ml Oral Suspension

PA0540/066/004 		 Rifampicin  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
End of February 2021

Expected return date:
2nd August 2021 		 Last updated:
28th July 2021

AMRIC guidance v2
Rifater 50mg/300mg/120mg Tablets

PA0822/143/002
 Isoniazid & Pyrazinamide & Rifampicin Quality issue

(Multiple countries impacted)		 Date of shortage: 
23rd July 2021

Expected return date: 
Late September 2021		 Last updated:
22nd July 2021

AMRIC guidance v2
RoActemra 162mg Solution for Injection in Pre Filled Pen

EU/1/08/492/009-10
Tocilizumab		 API unavailability 

(multiple countries affected) 		 Date of shortage:
30th June 2021 

Expected return date: 
Early September		 Last updated: 
13th July 2021

HCP Letter
RoActemra 162mg Solution for Injection in Pre Filled Syringe

EU/1/08/492/007
 Tocilizumab  API unavailability 

(multiple countries affected) 
 Date of shortage:
23rd July 2021 

Expected return date: 
Early September
 Last updated: 
13th July 2021

HCP Letter
Sirdupla 25mcg/125mcg Per Metered Dose Pressurised Inhalation, Suspension 

PA0577/201/001
 Salmeterol & Fluticasone Manufacturing delays Date of shortage: 
8th February 2021

Expected return date: 
Awaiting update		 Last updated: 
26th July 2021
Sprilon 12.5% Zinc Oxide & 1.04% Dimethicone Cutaneous Spray Suspension

PA22906/001/001 		 Zinc oxide & Dimethicone  Manufacturing delays  Date of shortage:
October 2019

Expected return date:
Late July 2021		 Last updated:
4th June 2021
Stesolid rectal solution 10mg

PA2315/137/002
  Diazepam Manufacturing delays  Date of shortage: 
Week commencing 19th July 2021. 

Expected return date: 
November 2021		 Last updated: 
21st July 2021
Technescan DMSA 1.2mg kit for radiopharmaceutical preparation

PA0690/011/001
  Succimer Regulatory issue

(multiple countries affected)		 Date of shortage: 
21st March 2021

Expected return date: 
September 2021		 Last updated:
26th March 2021
Teicoplanin 200 mg Powder and Solvent for Solution for Injection/Infusion or Oral Solution

PA1122/009/001
  Teicoplanin Manufacturing delay Date of shortage: 
Week commencing 12th July 2021

Expected return date: 
Mid-August 2021		 Last updated: 
21st July 2021
Telmisartan 20mg Tablets

PA2315/014/001
  Telmisartan Awaiting update Date of shortage: 
10th June 2021

Expected return date:
30th July 2021
 Last updated: 
7th June 2021
Telmisartan 40mg Tablets

PA2315/014/002
 Telmisartan  Awaiting update  Date of shortage: 
10th June 2021

Expected return date: 
15th August 2021		 Last updated: 
7th June 2021
Tipuric 300mg Tablets

PA0126/038/002
 Allopurinol   Regulatory issue Date of shortage: 
23rd March 2021

Expected return date: 
Week commencing 26th July 2021		 Last updated: 
26th July 2021
Trandate 100mg Film Coated Tablet

PA1638/006/002 		 Labetalol hydrochloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
July 2019

Expected return date:
Late July 2021		 Last updated:
1st July 2021
Trandate 200mg Film Coated Tablet

PA1638/006/003 		 Labetalol hydrochloride  Manufacturing delays

(multiple countries affected) 		 Date of shortage:
July 2019

Expected return date:
September 2021		 Last updated:
1st July 2021
Valaciclovir Teva 500mg Film Coated Tablets

PA0749/036/001
  Valaciclovir API unavailability  Date of shortage:
Week commencing 31st May 2021 

Expected return date: 
September 2021		  Last updated: 
30th June 2021
Visudyne 15mg Powder for Solution for Infusion

EU/1/00/140/001
 Verteporfin  Manufacturing delay  Date of shortage: 
May 2021

Expected return date: 
January 2022		 Last updated: 
28th July 2021

HCP letter
Vfend 200mg Powder for Solution for Infusion 

EU/1/02/212/025
 Voriconazole Manufacturing delays Date of shortage: 
4th June 2021

Expected return date:
Awaiting update		 Last updated: 
7th July 2021
Voriconazole 200mg Powder for Solution for Infusion

PA2059/020/001
 Voriconazole Unexpected increase in demand Date of shortage: Mid-July 2021

Expected return date: 
Mid-August 2021		 Last updated: 
1st July 2021 
Zerbaxa 1g/0.5g Powder for Concentrate for Solution for Infusion

EU/1/15/1032/001 		 Ceftolozone & Tazobactam  Quality issue

(multiple countries affected) 		 Date of shortage:
18th December 2020

Expected return date:
Unknown at present 		 Last updated:
4th March 2021 
Xomolix 2.5mg/ml Solution for Injection

PA2288/003/002
 Droperidol  Quality issue

(multiple countries affected)		 Date of shortage: 
29th May 2021

Expected return date: 
Unknown at present  		 Last updated: 
2nd July 2021
Xylocaine 2% with Adrenaline (Epinephrine) (1:200,000) Solution for Injection

PA1691/027/001
 Lidocaine & adrenaline  Manufacturing delays

(multiple countries affected)		 Date of shortage: 
1st August 2021

Expected return date: 
31st August 2021		 Last updated: 
19th July 2021
Zofran 4mg/2ml Solution for Injection or Infusion

PA0896/036/001		 Ondansetron  Unexpected increase in demand  Date of shortage:
8th February 2021

Expected return date:
19th August 2021		 Last updated:
7th July 2021 

HCP Letter
Zofran 8mg/4ml Solution for Injection or Infusion 

PA0896/036/002
 Ondansetron  Unexpected increase in demand Date of shortage: 15th April 2021

Expected return date: 
19th August 2021
 Last updated: 
7th July 2021

HCP Letter
Zyvox 2mg/ml solution for infusion 

PA0822/143/002
  Linezolid Manufacturing delays

(multiple countries affected)		 Date of shortage: 
Week commencing 19th July 2021

Expected return date:
Late August 2021

 Last updated: 
18th July 2021

Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL
Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL
Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL



Date of shortage: 
2nd July 2021

Expected return date: 
Unknown at present  
Date of shortage: 
2nd July 2021

Expected return date: 
Unknown at present  


Contact us:

Medicinal Product Shortages Unit
Health Products Regulatory Authority 
Kevin O’Malley House
Earlsfort Terrace,
Dublin 2
Tel: +353 1 676 4971
Fax: +353 1 676 7836
shortages@hpra.ie