Medicinal Product Shortages

The HPRA is responsible for co-ordinating the management of shortages of medicines on the Irish market. The HPRA works with a variety of stakeholders including manufacturers, wholesale distributors, marketing authorisation holders, healthcare professionals, the Health Service Executive, patients and representative groups to respond to potential shortages and reduce the impact of shortages on patients.

The definition of a shortage is when the supply of a medicinal product is inadequate to meet the needs of the patient. 

The HPRA, in collaboration with stakeholders, has published a framework for a multi-stakeholder approach to handling shortages of human medicinal products. The aim of the framework is to help prevent shortages from occurring and to reduce the impact of shortages on patients by co-ordinating the management of potential or actual shortages as they arise.


Information on reporting shortages for:

Wholesale Distributors and Manufacturers

Patients and Healthcare Professionals

Please complete the  Report of a Medicinal Product Shortage from Patients and Healthcare Professionals form and return to  shortages@hpra.ie. When completing this form, please include as much information as possible.


Current and resolved shortages

The HPRA publishes a list of shortages currently affecting the Irish market that have been notified to us and that may have a medium or high impact on patients. This list can be found below. More information on the impact level can be found in the framework for a multi-stakeholder approach to handling shortages of human medicinal products.

The HPRA maintains a consolidated list of resolved shortages for a period of six months. Details of shortages that have been resolved in the last six months can be found here.


Please use search function below to find relevant product or active ingredient

Product name Active ingredient Reason for shortage Date of shortage
Additional information
Accupro 10mg Film Coated Tablet

PA0822/007/002 
Quinapril hydrochloride  Manufacturing delays

(multiple countries affected) 
Date of shortage:
Early March 2019

Expected return date:
Mid April 2019 
Last updated:
22nd March 2019 
Accupro 20mg Film Coated Tablet

PA0822/007/003 
Quinapril hydrochloride  Manufacturing delays

(multiple countries affected) 
Date of shortage:
Mid March 2019

Expected return date:
Mid May 2019
Last updated:
22nd March 2019
Accupro 40mg Film Coated Tablet 

PA0822/007/004 
Quinapril hydrochloride  Manufacturing delays 

(multiple countries affected)
Date of shortage:
End of November 2018

Expected return date:
Mid April 2019 
Last updated:
22nd March 2019
Accuretic 20/12.5mg Film Coated Tablet

PA0822/008/002 
Quinapril hydrochloride & Hydrochlorothiazide  Manufacturing delays 

(multiple countries affected)
Date of shortage:
Early January 2019

Expected return date:
End of May 2019
Last updated:
22nd March 2019
Aciclovir 25mg/ml Concentrate for Solution for Infusion

PA2299/041/001 
Aciclovir sodium  Manufacturing issue  Date of shortage:
December 2018

Expected return date:
Q3 2019 
Last updated:
12th March 2019 
Actelsar HCT 80/25mg Tablets 

EU/1/13/817/029-041
Telmisartan & Hydrochlorothiazide  Manufacturing delays  Date of shortage:
Early January 2019

Expected return date:
1st April 2019 
Last updated:
11th March 2019
Adalat LA 20mg Prolonged Release Tablet

PA1410/025/005
Nifedipine  Manufacturing delays

(multiple countries affected)
Date of shortage:
November 2017
 
Expected return date:
End of 2019
Last updated:
24th January 2019
 
Adalat LA 30mg Prolonged Release Tablet

PA1410/025/006
Nifedipine  Manufacturing delays

(multiple countries affected)
Date of shortage:
24th June 2018

Expected return date:
End of 2019
Last updated:
24th January 2019 
 
Adalat LA 60mg Prolonged Release Tablet

PA1410/025/007 
Nifedipine Manufacturing delays

(multiple countries affected)
Date of shortage:
September 2018

Expected return date:
End of 2019
Last updated:
24th January 2019
 
Aprovel 300mg Tablet

EU/1/97/046/027 
Irbesartan  Unexpected increase in demand

(multiple countries affected) 
Date of shortage:
Mid March 2019

Expected return date:
5th April 2019 
Last updated:
13th March 2019 
Arava 10mg Tablet

EU/1/99/118/003 
Leflunomide  Manufacturing delays

(multiple countries affected) 
Date of shortage:
Mid March 2019

Expected return date:
31st March 2019 
Last update:
13th March 2019 
Ativan 4mg/ml Solution for Injection

PA0822/090/002 
Lorazepam  Manufacturing delays

(multiple countries affected) 
Date of shortage:
End of March 2019

Expected return date:
End of April 2019 
Last updated:
21st March 2019 
Axsain 0.075% w/w Cream

PA0827/004/001 
Capsaicin  Manufacturing delays  Date of shortage:
February 2019

Expected return date:
Mid April 2019
Last updated:
21st February 2019 
Candist 4mg Tablet

PA0126/206/001 
Candesartan cilexetil  Unexpected increase in demand  Date of shortage:
End of February 2019

Expected return date:
Unknown at present
Last updated:
12th March 2019 
Cardura 2mg Tablet

PA0822/192/002
Doxazosin mesilate  Manufacturing delays  Date of shortage:
End of February 2019

Expected return date:
Early April 2019 
Last updated:
21st February 2019 
Caverject 10mcg Powder for Solution for Injections

PA0822/115/002 
Alprostadil  Manufacturing delays

(multiple countries affected) 
Date of shortage:
January 2019

Expected return date:
4th June 2019
Last updated:
21st March 2019 
Clopidogrel Teva 75mg Film Coated Tablet

EU/1/09/540/1-16 
Clopidogrel Hydrogen Sulphate  Unavailability of API

(multiple countries affected) 
Date of shortage:
Start of March 2019

Expected return date:
May 2019 
Last updated:
12th March 2019 
Coaprovel 300/12.5mg Tablets

EU/1/98/086/004 
Irbesartan & Hydrochlorothiazide  Unexpected increase in demand  Date of shortage:
21st December 2018

Expected return date:
12th April 2019 
Last updated:
14th March 2019
Co-Vatan 80mg/12.5mg Film Coated Tablet

PA0711/182/001 
Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)
Date of shortage:
July 2018

Expected date of return:
Awaiting update
Last updated: 
30th January 2019
Co-Vatan 160mg/12.5mg Film Coated Tablet

PA0711/182/002  
Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)
Date of shortage:
July 2018

Expected return date:
Awaiting update 
Last updated:
30th January 2019
Co-Vatan 160mg/25mg Film Coated Tablet 

PA0711/182/003
Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)
Date of shortage:
July 2018

Expected return date: 
Awaiting update
Last updated:
30th January 2019 
Coversyl Arginine 10mg Tablet

PA0568/002/006 
Perindopril arginine  Manufacturing delays  Date of shortage:
23rd February 2019

Expected return date:
15th March 2019 
Last updated:
26th February 2019 
Cyklokapron 500mg Tablets

PA1332/003/001 
Tranexamic acid Manufacturing delays

(multiple countries affected) 
Date of shortage:
1st December 2018

Expected return date:
Q2 2019 
Last updated:
4th December 2018
Detrusitol SR 4mg Prolonged Release Capsules

PA0822/125/002 
Tolterodine  Manufacturing delays

(multiple countries affected) 
Date of shortage:
End of February 2019

Expected return date:
1st May 2019 
Last updated:
7th March 2019 
Doxycycline Teva 100mg Hard capsules

PA1986/081/001 
Doxycycline hydrochloride  Manufacturing delays  Date of shortage:
February 2019

Expected return date:
Mid April 2019 
Last updated:
21st February 2019 
Epanutin Ready Mixed Parenteral 250mg/5ml Solution for Injection or Infusion

PA0822/011/006 
Phenytoin Sodium  Manufacturing delays  Date of shortage:
Mid February 2019

Expected return date:
May 2019 
Last updated:
14th February 2019
 
HCP Letter
Erwinase 10000% v/v Powder for Solution for Injection

PA1020/002/001  
Cristanspase Manufacturing delays

(multiple countries affected)
Date of shortage:
5th October 2018

Expected return date:
Awaiting update
Last updated:
6th March 2019
             
HCP Letter
 
Estradot 75mcg/day Transdermal Patch

PA0896/010/003 
Estradiol hemihydrate  Manufacturing delays

(multiple countries affected) 
Date of shortage:
Mid March 2019

Expected return date:
End of May 2019 
Last updated:
21st March 2019 
Estradot 100mcg/day Transdermal Patch

PA0896/010/004 
Estradiol hemihydrate  Manufacturing delays

(multiple countries affected) 
Date of shortage:
Mid March 2019

Expected return date:
End of May 2019 
Last updated:
21st March 2019 
Floxapen 2000mg Powder for Solution for Injection or Infusion

PA1380/011/008 
Flucloxacillin  Manufacturing delays  Date of shortage:
Mid March 2019

Expected return date:
End of March 2019 
Last updated:
15th March 2019 
Gemcitabine 1g Powder for Solution for Infusion

PA1380/015/002 
Gemcitabine  Manufacturing delays  Date of shortage:
End of February 2019

Expected return date:
End of April 2019
 
Last updated:
26th February 2019
Hydrea 500mg Capsules

PA0002/027/001 
Hydroxycarbamide  Unexpected increase in demand  Date of shortage:
15th March 2019

Expected return date:
25th March 2019
Last updated:
14th March 2019

HCP Letter 
Innohep 12,000IU in 0.6ml Solution for Injection

PA0046/060/013 
Tinzaparin sodium  Manufacturing delays Date of shortage:
End of February 2019

Expected return date:
End of March 2019
 
Last updated:
6th March 2019
 
HCP Letter
Instanyl 50mcg Single Dose Nasal Spray

EU/1/09/531/010-013 
Fentanyl citrate Manufacturing delays 

(multiple countries affected) 
Date of shortage:
17th August 2018

Expected return date:
April 2019
Last updated: 
11th January 2019
Instanyl 100mcg Single Dose Nasal Spray

EU/1/09/531/014-017 
Fentanyl citrate Manufacturing delays

(multiple countries affected) 
Date of shortage:
January 2019

Expected return date:
April 2019 
Last updated:
11th January 2019 
Irbesartan / Hydrochlorothiazide Teva 150/12.5mg Film Coated Tablet

EU/1/09/583/1-24 
Irbesartan & Hydrochlorothiazide  Active substance impurity

           
Date of shortage:
21st December 2018

Expected return date:
Unknown at present
Last updated:
21st December 2018 
Irbesartan / Hydrochlorothiazide Teva 300/12.5mg Film Coated Tablet

EU/1/09/583/25-48
Irbesartan & Hydrochlorothiazide Active substance impurity

Date of shortage:
21st December 2018

Expected return date:
Unknown at present
Last updated:
21st December 2018
Konverge 40mg/5mg Film Coated Tablet

PA0865/017/002
Olmesartan medoxomil & Amlodipine besylate  Manufacturing delays  Date of shortage:
6th March 2019

Expected return date:
22nd March 2019 
Last updated:
15th March 2019 
Konverge 40mg/10mg Film Coated Tablet

PA0865/017/003 
Olmesartan medoxomil & Amlodipine besylate  Manufacturing delays  Date of shortage:
12th March 2019

Expected return date:
29th March 2019 
Last updated:
15th March 2019
Marcain Polyamp Steripack 0.25% w/v Solution for Injection
 

PA1691/024/001
Bupivacaine hydrochloride Manufacturing delays

(multiple countries affected)
Date of shortage:
14th February 2018
 
Expected return date:
End of March 2019 
Last updated:
19th December 2018
 
             
Marcain Polyamp Steripack 0.5% w/v Solution for Injection

PA1691/024/002
Bupivacaine hydrochloride Manufacturing delays

(multiple countries affected)
Date of shortage:
12th November 2017
 
Expected return date:
End of March 2019
 
Last updated:
19th December 2018
             
Minulet 75mcg/30mcg Coated Tablets

PA0822/093/001  
Ethinyloestradiol & Gestodene  Manufacturing delays  Date of shortage:
31st December 2018

Expected return date:
Mid May 2019 
Last updated:
17th December 2018
Naropin 2mg/ml Solution for Injection

PA1691/026/001
Ropivacaine hydrochloride Manufacturing delays

(multiple countries affected)
Date of shortage:
October 2017
 
Expected return date:
End of August 2019
 
Last updated:
25th February 2019
 
HCP Letter
Naropin 7.5mg/ml Solution for Injection

PA1691/026/002 
Ropivacaine hydrochloride Manufacturing delays

(multiple countries affected)
Date of shortage:
25th September 2017

Expected return date:
End of March 2019
Last updated:
19th December 2018
             
Nebimel 5mg Tablet

PA0126/165/001 
Nebivolol hydrochloride  Manufacturing delays  Date of shortage:
Mid February 2019

Expected return date:
End of March 2019 
Last updated:
13th February 2019
Perdamel 4mg Film Coated Tablet

PA0126/169/006 
Risperidone  Unexpected increase in demand  Date of shortage:
End of February 2019

Expected return date:
Early April 2019
 
Last updated:
20th February 2019 
Perindopril Tosilate/ Amlodipine Teva 5mg/5mg Tablet

PA0749/197/001
Perindopril tosilate & Amlodipine  Manufacturing delays  Date of shortage:
Mid February 2019

Expected return date:
Early April 2019 
Last updated:
20th February 2019 
Piperacillin with Tazobactam 2.25g Powder for Solution for Injection

PA1339/001/001 
Piperacillin sodium & Tazobactam sodium Manufacturing delays

(multiple countries affected)
Date of shortage:
January 2018

Expected return date:
Unknown at present
Last updated:
31st January 2019
Piperacillin with Tazobactam 4.5g Powder for Solution for Injection

PA1339/001/002 
Piperacillin sodium & Tazobactam sodium Manufacturing delays

(multiple countries affected)
Date of shortage:
January 2018

Expected return date:
Unknown at present
Last updated:
31st January 2019
Piperacillin Tazobactam 4g/0.5g Powder for Solution for Infusion

PA0577/204/002
Piperacillin sodium & Tazobactam sodium Manufacturing delays

(multiple countries affected) 
Date of shortage:
Early February 2019

Expected return date:
Unknown at present 
Last updated:
6th February 2019 

Product is on allocation
Pred Forte 1% w/v Eye Drop Suspension

PA0148/027/001 
Prednisolone acetate  Manufacturing delays

(multiple countries affected)
Date of shortage:
August 2018

Expected return date:
End of March 2019 
Last updated:
14th December 2018 
Sastravi 100/25/200mg Film Coated Tablet

PA1380/154/003 
Levodopa, Carbidopa & Entacapone Manufacturing delays Date of shortage:
October 2018

Expected return date:
19th March 2019
Last updated:
11th March 2019
Selectol 200mg Tablet

PA0540/126/001 
Celiprolol hydrochloride  Manufacturing delays  Date of shortage:
Mid March 2019

Expected return date:
25th March 2019 
Last updated:
13th March 2019 
Septrin 480mg per ampule Solution for Infusion

PA1691/010/005 
Trimethoprim and Sulfamethoxazole Manufacturing delays

(multiple countries affected)
Date of shortage:
27th October 2018

Expected return date:
26th March 2019
 
Last updated:
12th February 2019
             
HCP Letter
Septrin Forte 160mg/800mg Tablet

PA1691/010/002 
Sulphamethoxazole & Trimethoprim  Manufacturing delays 

(multiple countries affected)
Date of shortage:
Mid January 2019

Expected return date:
6th April 2019 
Last updated:
14th February 2019
Sublimaze 50mcg/ml Solution for Injection

PA2187/002/001 
Fentanyl citrate  Manufacturing delays  Date of shortage:
9th February 2019

Expected return date:
Awaiting update 
Last updated:
13th February 2019 
Tadalafil Krka 10mg Film Coated Tablet

PA1347/071/003 
Tadalafil Unexpected increase in demand  Date of shortage:
October 2018

Expected return date:
Awaiting update
Last updated:
11th March 2019
Teveten Plus 600mg/12.5mg Film Coated Tablet

PA2010/018/001 
Eprosartan & Hydrochlorothiazide  Manufacturing delays  Date of shortage:
End of February 2019

Expected return date:
End of March 2019 
Last updated:
27th February 2019 
Triapin 5mg/5mg Prolonged Release Tablet

PA0540/082/002 
Felodipine & Ramipril  Manufacturing delays  Date of shortage:
Mid January 2019

Expected return date:
Unknown at present
Last updated:
11th March 2019 
Trimoptin 100mg Tablets

PA0298/014/001 
Trimethoprim Manufacturing delays  Date of shortage:
Early October 2018

Expected return date:
Unknown at present
Last updated:
6th February 2019
Trimoptin 200mg Tablets

PA0298/014/002 
Trimethoprim  Manufacturing delays  Date of shortage:
Early October 2018

Expected return date:
Unknown at present
Last updated:
6th February 2019
Valsartan Actavis 40mg Film Coated Tablet 

PA1380/022/001
Valsartan Active substance impurity

(multiple countries affected)
                        
Date of shortage:
July 2018

Expected return date:
July 2019
Last updated: 
14th January 2019
Valsartan Actavis 80mg Film Coated Tablet

PA1380/022/002
     
Valsartan Active substance impurity

(multiple countries affected)
Date of shortage:
July 2018

Expected return date:
July 2019
Last updated:
14th January 2019
Valsartan Actavis 160mg Film Coated Tablet 

PA1380/022/003
Valsartan Active substance impurity

(multiple countries affected)
Date of shortage:
July 2018

Expected return date:
July 2019
 
Last updated:
14th January 2019
Valsartan Mylan 40mg Film Coated Tablet

PA0577/134/001 
Valsartan  Unexpected increase in demand 

(multiple countries affected)
Date of shortage:
Early November 2018
 
Expected return date:
Unknown at present
Last updated:
15th January 2019
Valsartan Mylan 80mg Film Coated Tablet

PA0577/134/002 
Valsartan  Unexpected increase in demand 

(multiple countries affected)
Date of shortage:
Early November 2018

Expected return date:
Unknown at present
Last updated:
15th January 2019
Valsartan Mylan 320mg Film Coated Tablet 

PA0577/134/004
Valsartan  Unexpected increase in demand

(multiple countries affected) 
Date of shortage:
Early November 2018

Expected return date:
Unknown at present
Last updated:
15th January 2019 
Valsartan Teva 40mg Film Coated Tablet

PA0749/084/001 
Valsartan Unexpected increase in demand

(multiple countries affected) 
Date of shortage: 
July 2018

Expected return date:
Unknown at present
Last updated:
11th March 2018
Valsartan Teva 80mg Film Coated Tablet

PA0749/084/002 
Valsartan Unexpected increase in demand

(multiple countries affected)
Date of shortage:
July 2018

Expected return date:
Awaiting update
Last updated:
11th March 2018
Valsartan / Hydrochloride 80mg/12.5mg Film Coated Tablet

PA1380/101/001
Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)
Date of shortage:
July 2018

Expected return date:

July 2019
Last updated:
14th January 2019
Valsartan / Hydrochlorothiazide 160mg/12.5mg Film Coated Tablet 

PA1380/101/002
Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)
Date of shortage:
July 2018

Expected return date:
July 2019
Last updated:
14th January 2019
Valsartan / Hydrochlorothiazide 160mgmg/ 25mg Film Coated Tablet

PA1380/101/003 
Valsartan & Hydrochlorothiazide Active substance impurity

(multiple countries affected)
Date of shortage:
July 2018

Expected return date:
July 2019
Last updated:
14th January 2019
Valtan 40mg Film Coated Tablet 

PA0126/211/001 
Valsartan Unexpected increase in demand

(multiple countries affected)
Date of shortage:
24th October 2018

Expected return date:
Intermittent supply expected for the foreseeable future
Last updated:
21st December 2018
Valtan 80mg Film Coated Tablet

PA0126/211/002 
Valsartan  Unexpected increase in demand

(multiple countries affected)
Date of shortage:
26th September 2018
 
Expected return date:
Unknown at present
Last updated:
5th October 2018
Valtan 160mg Film Coated Tablet

PA0126/211/003
Valsartan  Unexpected increase in demand 

(multiple countries affected)
Date of shortage:
24th October 2018

Expected return date:
February 2019
Last updated:
5th October 2018
Vatan 40mg Film Coated Tablet

PA0711/183/001
Valsartan  Active substance impurity

(multiple countries affected) 
Date of shortage:
July 2018

Expected return date:
Awaiting update
Last updated:
21st December 2018 
Vatan 80mg Film Coated Tablets

PA0711/183/002 
Valsartan  Active Substance Impurity

(multiple countries affected) 
Date of shortage:
July 2018

Expected return date:
Awaiting update
Last updated:
21st December 2018
Vatan 160mg Film Coated Tablets

PA0711/183/003 
Valsartan Active Substance impurity

(multiple countries affected) 
 
Date of shortage:
July 2018

Expected return date:
Awaiting update
Last updated:
21st December 2018
Vepesid 100mg Capsules

PA2255/004/002 
Etoposide  Unexpected increase in demand

(multiple countries affected) 
Date of shortage:
End of February 2019

Expected return date:
Mid May 2019 
Last updated:
15th March 2019 

HCP Letter
Zestan 5mg Tablets

PA0126/112/002 
Lisinopril dihydrate  Manufacturing delays  Date of shortage:
Mid February 2019

Expected return date:
June 2019 
Last updated:
13th February 2019 
Zolpidem Tartrate Teva 10mg Film Coated Tablet

PA0749/095/002 
Zolpidem tartrate  Manufacturing delays  Date of shortage:
March 2019

Expected return date:
May 2019 
Last updated:
11th March 2019 

Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL
Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL
Menveo (EU/1/10/614/003) Meningococcal Group A, C, W135 and Y conjugate vaccine PIL



Contact us:

Medicinal Product Shortages Unit
Health Products Regulatory Authority 
Kevin O’Malley House
Earlsfort Terrace,
Dublin 2
Tel: +353 1 676 4971
Fax: +353 1 676 7836
shortages@hpra.ie